• 대한한방내과학회지
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• 제41권4호
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• pp.583-598
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• 2020

Objective: The aims of this study were to analyze deficiency-excess pattern identification and to compare the blood cytokines in patients with asthma. Methods: A total of 112 patients with asthma who met the inclusion and exclusion criteria were divided into deficiency syndrome and excess syndrome groups. Blood was examined for eotaxin, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-13, and tumor necrosis factor (TNF)-α. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), a Visual Analogue Scale (VAS), and heart rate variability (HRV) tests were administered to both groups. Results: Pattern identification divided the 112 patients into two categories: a deficiency syndrome group (N=52) and an excess syndrome group (N=60). Analysis of blood cytokines showed higher levels of IL-4, IL-5, and IL-13 in the deficient pattern than in the excess pattern group, but the difference was not statistically significant. Analysis of the HRV revealed a significantly higher mean value for the very-low-frequency (VLF) and high-frequency (HF) bands in the deficiency than in the excess syndrome group. The morbidity duration was longer in the deficiency than in the excess syndrome group, but the difference was not statistically significant. Analysis of the QLQAKA and VAS scores showed a negative correlation, whereas BMI and VAS showed a positive correlation. Conclusions: Levels of blood cytokines, including eotaxin, IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α, did not differ statistically between the deficiency and excess syndrome groups. The development of a more accurate asthma-specific pattern identification tool would be useful in asthma control.

• 수면정신생리
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• 제25권1호
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• pp.15-20
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• 2018

목 적 : 본 연구는 우울장애 환자를 대상으로 안정 시와 기립 시기, 정신적 스트레스 시기에 심박변이도 지수(heart rate variability index, HRV index) 검사를 시행하여 자율신경계 불균형이 육체적 및 정신적 스트레스에서 어떻게 변화되는 지 알아보고자 하였다. 방 법 : 우울장애 환자 62명을 대상으로 연구를 수행하였다. 안정 시기, 기립 시기, 정신적 스트레스 자극을 준 시기동 안 각각 심박변이도 지수를 측정하였다. 긴장 정도와 스트레스 정도에 대해 visual analogue scale (VAS) score로 측정하였고, Beck depression inventory (BDI), state trait anxiety inventory-I, II (STAI-I, II)를 사용하여 불안증상과 우울증상 의 심각도를 평가하였다. 통계적 검증은 안정 시기와 기립 시기, 안정 시기와 정신적 스트레스 시기 간의 각각의 자율신경계 관련 지수 변화를 보기 위해 paired t-test로 분석하였고, 성별 차이를 보기 위해 ANCOVA로 비교 분석하였다. 결 과: 안정 시기와 비교하여 기립 시기에서 SDNN, LF/ HF의 유의한 증가(p < 0.01) 및 NN50(p < 0.05), pNN50(p < 0.01)의 유의한 감소를 보였다. 안정 시기와 비교하여 스트레스 시기에서 SDNN (p < 0.01), RMSSD (p < 0.05) 유의한 증가를 보였다. 기립 시기와 비교하여 스트레스 시기에 SDNN, NN50, pNN50 지수가 유의하게 높은 결과를 보였다. 결 론: 기립 시기만 안정 시기와 비교하여 자율신경계 불균형과 관련된 LF/HF ratio의 유의한 상승을 보였으나, 정신적 스트레스와 안정 시기, 두 스트레스 간 LF/HF ratio의 차이는 보이지 않았다. 정신적 스트레스에 비해서 기립시기에서 SDNN, NN50 및 pNN50의 유의 한 증가하였다는 것은 우울증 환자들이 정신적 스트레스에 비해 신체적 스트레스에 보다 좀 더 민감하게 반응하는 경향이 있다는 것을 제시할 수 있다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2000년도 추계학술대회 논문집
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• pp.48-52
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• 2000

본 연구에서는 긴장 스트레스를 평가하기 위하여 작업 중에 긴장 조건을 부가하고 행동량, 주관량, 생리량을 계측하여 통계적으로 긴장 상태 유무와 작업 난이도에 따른 변화를 분석하였다. 긴장 스트레스를 유발시키기 위하여 20대 남자 대학생 3D명에게 세 가지 레벨의 트랙킹 작업을 수행하게 하면서 긴장상태를 유발하여 행동량, 주관신고와 생리신호를 측정하였다. 행동량과 주관신고의 결과를 사용하여 본 연구에서 상정된 작업난이도와 긴장조건이 적절한 가를 살펴보고 생리신호를 사용하여 작업난이도와 긴장감을 분석하였다. 난이도가 낮을 때 HRV의 회귀도와 GSR의 평균값은 긴장 조건이 있을 때가 없을 때에 비해서 통계적으로 유의하게 높게 나타났으며 난이도가 높을 때에는 피부온도의 값이 긴장 조건이 있을 때가 없을 때에 비해서 통계적으로 유의하게 높게 나타났다. 또한 긴장 조건이 있는 경우 작업의 난이도가 높을 때에 낮을 때에 비해서 호흡수의 값이 높게 나타났다. 따라서, 본 연구에서 상정한 긴장감은 양호하게 부가되었고 긴장감은 생리신호를 사용하여 측정할 수 있을 것으로 분석되었다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1999년도 춘계학술발표논문집 논문집
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• pp.243-248
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• 1999

There is substantial evidence that anatomical connections and functional interactions exist between vestibular and autonomic systems. Heart rate variability (HRV) including mean, standard deviation, coefficient of variation (CV), power spectrum was analyzed for evaluation of the physiological role of the vestibular system on control of heart rate in rabbits. In anesthetized rabbits, electrical stimulation of the vagus nerve decreased heart rate and decreased LF/HF by increasing HF. On the cervical sympathetic nerve increased heart rate and increased LF/HF by increasing LF. Atropine, cholinergic blocker, increased heart rate and increased LF/HF by reducing HF, and propranolol, ${\beta}$-adrenergic blocker, decreased heart rate and decreased LF/HF by reducing LF> In unanesthetized rabbits, stimulation of the vestibular system induced by rotation or caloric increased heart rate and increased LF/HF by increasing LF> Also electrical stimulation of the vestibular nerve produced the same of effects as rotation or caloric in anesthetized rabbits. These results suggest that Stimulation of the vestibular system increased heart rate not by inhibiting the parasympathetic nerve but by activating the sympathetic nerve.

• 정보학연구
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• 제9권1호
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• pp.9-19
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• 2006

Medications or conitive-behavior methods have been mainly used as a treatment of alcoholism. lately the virtualy technology has been applied to the kink of alcoholic disorders. A virtual environment makes him having avility to over come the drink. In this study, we were implemented by making panorama images and 3D object modules using 3D MAX, VRML, JAVA. And the BAR stimulator that composed with a position sensor, head mount display, and audio system, is suggested. To illustrate the physiological difference between a person who has a alcoholism and without a liquor bottle, heart rate was measured during experiment, and also measured a person's HR after the virtual reality training. The system measures the Physiological signals such as ECG, Temperature, analyzes those data automatically. The system has two parts, one is physiological data acquisition part which gets the body signal, and the other one is mobile nuit which includes signal processing and transmission functions, And Bluetooth allows two parts to communicate with each other. we demonstrated the subjective effectiveness of virtual reality psychotherapy through the clinical experiment.

• 대한물리의학회지
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• 제4권4호
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• pp.241-247
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• 2009

Purpose：The purpose of this study is to investigate the effect of transcutaneous electrical stimulation on autonomic nervous system using heart rate variability analysis. Methods：31 subjects were evaluated with HRV before and after a single high-frequency TENS for 15minutes treatment. The standard deviation of all the normal RR-interval(SDNN) and lower frequency/high frequency ratio(LF/HF ratio) were recorded with TAS-9. Results：After single TENS treatment, autonomic adaptation as analyzed by SDNN was increased from $42.47\pm12.96$ to $4.43\pm16.76$(p>0.05) and autonomic balance as analyzed by LF/HF ratio was increased from $1.4\pm0.45$ to $1.45\pm0.41$(p>0.05). Conclusion：In this study, SDNN and LF/HF ratio changed in health young students as a result of single TENS treatment. But there is no significant difference between pre-treatment and post-treatment of SDNN and LF/HF ratio.

• 대한의생명과학회지
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• 제24권4호
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• pp.319-328
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• 2018

The purpose of this study is to identify the factors influencing the stress of the elderly women by various tools and to provide basic data for adaptation to the aging women. For this purpose, stress was measured by stress measuring equipment (HRV) and stress measurement questionnaire (SRI) in 31 elderly women over 60 years old. In summary, the results of this study suggest that the worse the subjective health, and when there is a spouse, it predicts a stress. In order to reduce the stress of elderly women based on these results, physical health management and environmental factors that can enhance the intimacy between husband and wife are also necessary.

• 한국환경과학회지
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• 제30권1호
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• pp.1-10
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• 2021

The purpose of this study is to verify the physiological and psychological benefits of indoor garden to humans and to analyze the comparison according to Type A behavior pattern. The subjects included 18 male university students. Heart rate variation was used as a parameter of physiological assessment, and Semantic Differential (SD), Profile of Mood States-Brief (POMS), and State-Trait Anxiety Inventory (STAI) were used as tools for psychological evaluation. The participants were subjected to a psychological evaluation when they were present in a garden. As a result, the parasympathetic nervous activity was increased in the indoor garden. In the analysis of psychological evaluation, indoor garden improved the positive mood states and decreased negative feelings with significant changes only in Type A group. This study supported that indoor garden can have physiological and psychological relaxing effects, which could be more significant in Type A group than Type B.

• 수면정신생리
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• 제24권1호
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• pp.32-37
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• 2017

목 적 : 폐쇄성 수면무호흡 증후군(obstructive sleep apnea syndrome, OSAS)에서 앙와위는 비앙와위보다 수면무호흡을 증가시키는 것으로 알려져 있다. 앙와위 자세시간(supine position time, SPT)과 OSAS의 무호흡-저호흡 지수(apnea-hypopnea index, AHI)의 관련성에 대해서 많은 연구가 있었으나, SPT가 OSAS에서 어떤 변수의 영향을 받는지는 알려져 있지 않다. OSAS에서 수면다원검사상 어떤 변수가 SPT과 관련이 있는지를 평가하였다. 방 법 : 수면다원검사로 진단된 치료받지 않은 365 명의 OSAS 남자 환자를 선정하였다. SPT($276.4{\pm}92.3$ 분)가 인구 통계학적 데이터, 수면구조 관련변수, OSAS 관련변수 및 심박변이도(Heart rate variability, HRV)와 상관관계가 있는지 분석했다. SPT에 영향을 주는 요인을 알아보기 위해 SPT에 대해 다중회귀분석을 시행하였다. 결 과 : 전체 대상군의 상관분석에서 SPT는 총수면시간(total sleep time, TST) (r = 0.443, p < 0.001)과 수면 효율(r = 0.300, p < 0.001)과 가장 유의한 상관관계가 있었고, 코골이 시간(r = 0.238, p < 0.001), 산소포화도 90 % 미만시간(r = 0.188, p < 0.001), AHI (r = 0.180, p = 0.001), 산소탈포화지수(oxygen desaturation index, ODI), (r = 0.149, p = 0.004), NN50 count(r = 0.137, p = 0.036)와 SPT 간에 유의한 상관관계가 있었다. 다중회귀분석 결과 SPT에 유의한 영향을 끼치는 요인으로 TST (t = 7.781, p < 0.001), 코골이 시간(t = 3.794, p < 0.001), AHI (t = 3.768, p < 0.001), NN50 count (t = 1.993, p = 0.047)가 있었다. 결 론 : SPT는 OSAS 관련변수보다 수면구조 관련변수와 더 높은 상관관계를 보였다. 특히 SPT는 TST과 AHI 뿐만 아니라 NN50 count와도 밀접하게 관련되어 있었다. 이것은 SPT가 OSAS의 심각도뿐만 아니라 수면구조와 심박변이도에 의해서도 결정될 가능성이 있음을 시사한다.

• 동의생리병리학회지
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• 제23권1호
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• pp.237-244
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• 2009

We investigated the effects of acupuncture stimulation on pulse wave variables and heart rate variability (HRV) in healthy adults. To evaluate twenty healthy volunteers (10 men, 10 women) had acupuncture into both Hapkok (Ll4) and Taechung (Liv3) for 15 minutes. Radial pulse, Heart Rate Variability, body temperature and blood pressure were checked before and after acupuncture to evaluate Pulse Wave Variability and Autonomous Function. The results were as follows; Heart rate was significantly increased while systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) were significantly increased after acupuncture treatment. Sixteen subjects didn't change representative pulse wave variables after acupuncture treatment. Energy, height of main peak (H1), height of pre-dicrotic valley (H2) and height of descending valley (H4) were decreased while height of dicrotic peak (H5) was significantly decreased after acupuncture treatment. Time to main peak (T1), time to pre-dicrotic valley (T2), time to dicrotic peak (T5), total time (T) and T-T4 were decreased while time to descending valley (T4) was increased after acupuncture treatment. Total area (At), area of main peak (Aw) and ratio of diastolic period area (Ad) were decreased while ratio of systolic period area (As) and angle of main peak (MPA) were increased after acupuncture treatment. The standard deviation of all normal RR intervals (SDNN) was increased while the root mean square of successive differences between the normal heart beats (RMSSD) was significantly increased after acupuncture treatment by time domain analysis. Low frequency power (LF) and LF/HF ratio were decreased while high frequency power (HF) was significantly increased after acupuncture treatment by frequency domain analysis. This study suggests that acupuncture treatment changes pulse wave variability and heart rate variability. Further study on various acupuncture treatment for pulse wave variability and heart rate variability is required.