• 한국통신학회논문지
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• 제41권1호
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• pp.66-76
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• 2016

본 논문은 DVB-NGH 내 계층(HP : High Priority) 신호와 향상 계층(LP : Low Priority) 신호로 구성된 계층변조 기법에서 LP 신호의 성능저하 문제를 개선하기 위해 LP 신호에 성상회전(Constellation-Rotation) 변조기법을 적용한 새로운 계층변조 기법을 제안한다. 제안된 기법은 연속된 LP 신호들에 대하여 기존의 성상회전 선부호기를 적용하여 수신단에서 향상된 다이버시티 이득을 획득으로 성능 향상이 발생하며, 더불어 HP 신호들의 성능 저하는 거의 발생하지 않는다. 본 논문에서는 또한 제안된 새로운 계층변조 기법에 대한 수신 방법으로 HP 복조는 기존의 HP 수신기를 사용하고 LP 신호에 대하여만 CR 기반의 ML 복조를 수행하는 새로운 저 복잡도 수신 방법도 제시한다.

• 대한임상검사과학회지
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• 제42권1호
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• pp.38-45
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• 2010

The aim of this study was to assess the Clinical Usefulness of Helicobacter pylori Stool Antigen (HpSA) immunochromatographic assay for the diagnosis of H. pylori infection. In this study, we had compared HpSA-immunochromatographic assay with CLO test and UBT test. From a total of 140 patients (M:F=88:52) with upper endoscopy, biopsy specimens were obtained for CLO test. Stool specimens was collected from all patients and tested using a HpSA-immunochromatic assay. H. pylori infection status was defined as infected if the results of both CLO test and UBT test were positive. CLO test and UBT test findings showed that 92 patients were H. pylori positive and 48 patients were H. pylori negative. According to this definition, the sensitivity, specificity, and positive or negative predictive value (PPV, NPV) of HpSA-immunochromatographic assay were 97.8%, 100%, 100%, and 96%, respectively. Cross reactivity test of HpSA-immunochromatographic assay were performed with 10 enteric bacteria strains in fecal habitat, and there were no false positive reaction. We evaluated the usefulness of HpSA assay for eradication therapy with 10 of 92 H. pylori positive patients, positive results of them at pre-eradication therapy were converted to negative at post-eradication. The HpSA-immunochromatographic assay is a highly sensitive and specific non-invasive diagnostic method for detection of H. pylori infection, a useful diagnostic method for H. pylori in post eradication stage.

• Laboraroty Animal Research
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• 제34권4호
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• pp.216-222
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• 2018

The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of Lactobacilllus paracasei (L. paracasei) HP7, isolated from kimchi, to inhibit H. pylori growth. The effects of L. paracasei HP7 on H. pylori adhesion and H. pylori-induced inflammation were examined in AGS human gastric adenocarcinoma epithelial cells and a mouse model of H. pylori SS1 infection. L. paracasei HP7 reduced H. pylori adhesion to AGS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. H. pylori colonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with L. paracasei HP7. Additionally, L. paracasei HP7 decreased gastric inflammation and epithelial lesions in the stomach of H. pylori-infected mice. These results demonstrate that L. paracasei HP7 treatment can inhibit H. pylori growth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by H. pylori infection.

• 한국안광학회지
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• 제15권3호
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• pp.269-274
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• 2010

목적: 새로운 적청사위시표(Red-Blue phoria chart; RBP) 검사의 신뢰성을 평가하였다. 방법: 38명을 대상으로 원거리(5m), 근거리(40cm) 사위량을 측정하였다. RBP 시표 사위검사, 하웰시표 사위검사(HP), 그리고 Muscle Imbalance Measure (MIM) 시표 사위검사를 실시하고 검사에 대한 신뢰도를 서로 비교하였다. 결과: 수평 사위도는 원거리 RBP $-0.6{\pm}0.727{\Delta}$, HP $-0.87{\pm}1.051{\Delta}$, MIM $-1.50{\pm}1.346{\Delta}$, 근거리 RBP $-2.57{\pm}2.352{\Delta}$, HP $-2.80{\pm}2.411{\Delta}$, MIM $-3.84{\pm}2.603{\Delta}$로 측정되었다. 검사 신뢰도는 원거리의 경우 RBP>MIM>HP 순이었고, 근거리의 경우 MIM>RBP>HP 순으로 나타났다. 결론: RBP 검사법은 신뢰도가 높은 사위검사법으로 판명되었다.

• 한국축산식품학회지
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• 제29권3호
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• pp.317-324
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• 2009

In order to reduce the increased hardness of beef bulgogi due to hydrostatic pressure (HP), kiwifruit (Actinidia chinensis) was applied. To understand the changes of shear force in beef bulgogi with kiwifruit induced by HP, changes in chemical properties of myofibril (Mf) with 10% kiwifruit induced by HP were investigated. From the SDS-PAGE patterns of Mf with 10% kiwifruit, there was an observed increase in the degradation of myosin heavy chain (MHC) by HP (300-500 MPa) to that by 0.1 MPa. This result indicates that HP may enhance enzyme action from a kiwifruit for the degradation of MHC, and the similar phenomenon occurred in the beef bulgogi with kiwifruit induced by HP. The shear force of beef bulgogi without a kiwifruit induced by 400 and 500 MPa significantly increased compared to that by 0.1 MPa (p<0.05). However, in the beef bulgogi with 10% or 20% kiwifruit, the shear force induced by 400 or 500 MPa was similar or slightly lower than that by 0.1 MPa. Consequently, adding kiwifruit to bulgogi could reduce the hardness of HP-induced beef bulgogi due to the enzyme action in the kiwifruit accelerated by HP.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4541-4544
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• 2012

Background: Breast cancer is the most common malignancy with the highest incidence rates among women worldwide. Triple-negative breast cancer (TNBC) disease is diagnosed more frequently in younger women, and is associated with a poor prognosis. Elevated levels of serum haptoglobin protein (Hp) are observed in many malignant diseases including breast cancer. We evaluated the expression and prognostic value of Hp among patients with TNBC. Materials and Methods: Serum Hp levels were determined by Elisa in 41 patients with TNBC and 10 normal individuals. Hp status was correlated with other clinico-pathological parameters including patient survival. Results: Of the 41 patients with TNBC, Hp over expression was detected in 24 (59%) by Elisa. Hp up-regulation was confirmed by Elisa based quantification in the serum of 41 TNBC patients against lower grades and 10 normal individuals. Survival analysis revealed that Hp ($p=2.016{\times}10^{-5}$), stage ($p=2.166{\times}10^{-5}$), distant metastasis ($p=2.217{\times}10^{-5}$), tumor size ($p=1.053{\times}10^{-5}$), and tumor grade (p=0.001), correlated with patient survival on univariate analysis. Multivariate analysis revealed that Hp (p=0.001), and grade of the disease (p=0.008) were independent predictors of survival. Conclusion: Our results indicate that serum levels of Hp may play a role as a potential serum biomarker and prognostic indicator among TNBC patients. Thus, Hp may present a new promising prognostic biomarker in TNBC patients, but independent validations are now necessary for confirmation.

• 생명과학회지
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• 제18권4호
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• pp.537-541
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• 2008

백색지방조직(white adipose tissue)은 에너지 저장뿐만 아니라 다양한 adipokines을 분비하는 중요한 내분비 기관이다. 급성기반응 단백질로 알려져 있는 합토글로빈(haptoglobin)도 adipokine의 한 종류로서 지방세포에서 합성되고 분비된다. 그러나 adipokine으로서의 기능과 지방조직에서의 역할은 아직까지 규명되지 않았다. 본 연구에서는 3T3-L1 지방전구세포를 합토글로빈 유전자로 transfection 시켜 합토글로빈을 과발현하는 세포를 만들고 세포증식, 염증관련 인자들의 발현조절 및 단구세포의 유인성을 조사하였다. 그 결과, 합토글로빈은 3T3-L1 세포의 성장에는 별 영향을 미치지 않았으나 IL-6와 COX-2 발현을 저해하고 HO-1 합성을 증가하였다. 또한 THP-1 단구세포를 이용한 invasion assay에서는 합토글로빈이 단구세포의 이동을 저해하였다. 이러한 결과들은 합토글로빈이 지방조직에서 항염증 반응에 관여함을 시사한다. 만성적 염증상태(chronic low-grade inflammatory state)로 인식되고 있는 비만은 염증관련 인자들에 의한 인슐린저항성이 유도되는 바, 합토글로빈은 비만 관련 인슐린저항성을 방지하고 인슐린민감성을 향상시키는 데에도 기여할 것으로 생각된다.

• 한국멀티미디어학회논문지
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• 제17권6호
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• pp.725-732
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• 2014

The Pancake graph is node symmetric and useful interconnection network in the field of data sorting algorithm. The Half Pancake graph is a new interconnection network that reduces the degree of the Pancake graph by approximately half and improves the network cost of the Pancake graph. In this paper, we analyze topological properties of the Half Pancake graph $HP_n$. Fist, we prove that $HP_n$ has maximally fault tolerance and recursive scalability. In addition, we show that in $HP_n$, there are isomorphic graphs of low-dimensional $HP_n$. Also, we propose that the Bubblesort $B_n$ can be embedded into Half Pancake $HP_n$ with dilation 5, expansion 1. These results mean that various algorithms designed for the Pancake graph and the Bubble sort graph can be executed on $HP_n$ efficiently.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1992년도 제1회 신약개발 연구발표회 초록집
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• pp.63-63
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• 1992

할로페리돌(HP)은 정신분열증 환자에 널리 사용되는 Dopamine D$_2$-receptor의 antagonist인 antipsychotic drug이다. 이 약물의 혈장농도와 임상 반응사이의 'curvilinear'한 상관성 존재여부와 여기에 대한 대사체(reduced haloperidol, RH)의 영향에 대해 논란은 많지만, 본 연구 팀에서도 위의 상관성이 존재하며 또한 여기에 RH가 영향을 미칠 것으로 보고한바 있다. 따라서 본 연구에서는 앞의 결과에 대한 기전을 밝히고, 궁극적으로 효율적인 뇌송달 시스템의 개발가능성을 검토하기위한 1차적 인구로 HP의 약물속도론적 연구를 사람, 랫트 및 가토에서 실시하여 그특성을 비교하였다. 사람경우는 13명의 정신분열증 초기환자를 대상으로 경구(20mg HP, 5명) 및 주사(10mg HP, 8명) 투여한 후, 또한 랫트 및 가토의 경우는 마리당 5mg의 HP 및 RH를 각각 정맥주사한 후 경시적으로 혈장중 HP 및 RH의 농도를 측정하여 체내동태 특성을 검토하였다.

• International Journal of Oral Biology
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• 제35권4호
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• pp.145-151
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• 2010

Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E, upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1$\beta$ and COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP. HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.