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Protective Effect of HP08-0111 on Ligature-Induced Periodontitis  

Park, Young-Ran (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
Cho, Hyoung-Kwon (HanPoong Pharmaceutical Co., LTD)
Soh, Yun-Jo (Department of Dental Pharmacology, School of Dentistry, Chonbuk National University)
Publication Information
International Journal of Oral Biology / v.35, no.4, 2010 , pp. 145-151 More about this Journal
Abstract
Periodontitis is an inflammatory disorder of the periodontium and is characterized by destruction of the tooth supporting tissues, mediated by the upregulation of synthesis and release of a variety of pro-inflammatory factors. Inflammatory cytokines and prostaglandins upregulate RANKL and its subsequent binding to RANK stimulates osteoclast formation, resorption activity, and survival. In our present study, we investigated the effects of HP08-0111, composed of Coptis japonica (Thunb.) Makino, vitamin C and vitamin E, upon inflammatory responses, osteoclastogenesis and alveolar bone loss. HP08-0111 decreased the expression of IL-1$\beta$ and COX2 on LPS-induced RAW 264.7 cells and inhibited osteoclast-specific genes such as c-Fos, MMP-9, and TRAP. HP08-0111 also exhibited protective effects against alveolar bone loss in rats with ligature-induced periodontitis. Our results suggest that HP08-0111 is potentially an important therapeutic tool for the treatment of disorders associated with bone loss such as periodontitis.
Keywords
HP08-0111; periodontitis; anti-inflammatory; osteoclastogenesis;
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