• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제34권6호
• /
• pp.611-615
• /
• 2008

The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, and tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark's and Breslow's classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to analyze key determinants of outcome, We analysed 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital on recent 7 years and reviewed the literatures. Immunohistochemical study on S 100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Three patients who were treated by surgery, chemotherapy are alive, but a patients who couldn't received benefit care surgically due to poor condition was died of distant metastasis, and two patients who refused to surgery are still alive. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be considered as supporting therapy for malignant melanoma.

• Journal of Chest Surgery
• /
• 제35권9호
• /
• pp.697-700
• /
• 2002

50세 여자가 전흉부의 통증을 주소로 내원하였다. 흉부단층촬영에서 우상엽을 침범하고 있는 전종격동의 종괴가 발견되었으며, 수술로서 완전절제하였다. 조직검사에서 악성 흑색종을 진단할 수 있었고, 원발병소의 가능성이 있는 피부, 구강, 안저, 비강, 직장, 항문, 질 등을 각각의 전문의에게 검사를 받았으나 이상소견이 없었다. 원발병소가 자연적으로 소멸된 경우가 아니라면 종격동에 원발한 악성 흑색종이라고 생각된다. 종격동에 발생하는 악성 흑색종은 아주 드문 질환으로 세계적으로 8례만이 보고되고 있고, 한국에서는 아직 예가 없기에 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
• /
• 제53권2호
• /
• pp.196-201
• /
• 2002

악성 흑색종은 멜라닌세포에서 발생하는 종양으로 전체 악성 종양의 3%를 차지하고, 피부, 안구, 피부주위점막에서 호발한다. 이들은 주로 피부, 림프절, 폐, 간, 골 등으로 전이되고 폐의 전이는 약 5~15%에서 일어난다. 그러나 기관지 점막으로의 전이는 흔하지 않다. 특히 기관지 및 폐장으로 전이된 원발불명의 악성 흑색종은 아직 보고된 예가 없다. 이에 저자들은 기침과 검은색 객담을 주소로 내원하였던 34세 남자환자에서 굴곡성 기관지 내시경 및 조직검사를 시행하여 vimentin, S-100 protein, HMB-45 염색에 양성을 보이는 양측 폐장 및 기관지점막으로 전이된 악성 흑색종을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한세포병리학회지
• /
• 제9권2호
• /
• pp.233-239
• /
• 1998

Clear ceil sarcoma(CCS) is an uncommon soft tissue sarcoma that occurs in tendons and aponeuroses, usually of the lower extremities and is believed to be of neural crest origin that have a capability to produce melanin. These tumors commonly metastasize and have a very poor prognosis. The fine needle aspiration cytologic finding of CCS is not well documented. We recently experienced a case of CCS. The patient was a 54-year-old male with painful swelling of the right inguinal area. Fine needle aspiration cytology revealed polygonal or fusiform tumor cells with clear or granular cytoplasm and vesicular nuclei containing one or two nucleoli. Immunohistochemical staining for S-100 protein and HMB-45 revealed strong positivity and variable developing stages of premelanosomes were observed by electron microscopy in the excised specimen.

• 대한수의학회지
• /
• 제35권2호
• /
• pp.375-381
• /
• 1995

Two intraocular tumors were identified in low and medium dosed groups of a carcinogenicity study using 200 males and 200 females Sprague-Dawley rats in Screening & Toxicology Research Center, Korea Research Institute of Chemical Technology. The tumors were grossly observed as white or yellow, unilateral nodules. They were approximately $1-2{\times}3-5mm$ in size. The tumors located in the region of iris and/or ciliary body invaded peripheral cornea. The microscopic features were usually composed of spindle cells arranged in parallel, forming gently curving bundles or whorls. The spindle cells had poorly defined cell boundaries, scant to moderate cytoplasm, fusiform nuclei and indistinct nucleoli. Mitotic figures were rare and areas of necrosis were present. The spindle cells had positive immunoreactivity for S-100 protein and vimentin but negative for desmin, collagen and HMB-45 antibody. In special histochemical studies, the spindle cells react with Gomori's stain for argyrophih fibers, Prussian blue stain for iron but negative with Masson-Fontana's stain for melanin granules. Ultrastructurally, cytoplasmic premelanosomes were not observed in the tumor cells due to the poor preservation of tumor masses. Based on the results, the tumors were diagnosed as amelanotic melanoma.

• Journal of Yeungnam Medical Science
• /
• 제16권1호
• /
• pp.108-113
• /
• 1999

저자들은 최근 58세 여자의 좌측 대퇴하부에 발생한 투명세포육종 1예를 경험하였기에 문헌고찰과 함께 보고한다.

• Archives of Plastic Surgery
• /
• 제35권3호
• /
• pp.312-315
• /
• 2008

Purpose: Amelanotic melanoma represents a melanoma with an absence or a small number of melanin pigments and comprises 2% of all melanomas. These melanomas are frequently misdiagnosed, probably because of its nonspecific clinical features and difficulty in diagnosis, resulting in delayed diagnosis and treatment. We report a patient with amelanotic melanoma, who underwent surgical treatment with sentinel lymph node biopsy using gamma probe. Methods: A 32-year-old female was presented with a slowly growing ill-defined, hypopigmented nonerythematous lesion with nail defect on right index finger tip. Preoperative punch biopsy was performed, showing an amelanotic melanoma. Sentinel lymph node biopsy was done using gamma probe(Crystal probe system, CRYSTAL PHOTONICS GmbH, Germany) and confirmed no evidence of regional lymph node metastases. The patient underwent amputation at the proximal interphalangeal joint. Results: Histopathologic findings showed superficial spreading melanoma. There were no melanin pigments in Hematoxylin & Eosin stain but positive immunohistochemical stainings for S-100 protein and Hmb45, which were consistent with amelanotic melanoma. Patient's postoperative course was uneventful without any complication and had no evidence of recurrence of tumor in 6 months follow-up period. Conclusion: Amelanotic melanoma is extremely rare subtype of malignant melanoma with histopathologic findings of atypical melanocytes without melanin pigments. Early detection is crucial since survival is strongly related to tumor thickness and tissue invasion at the time of diagnosis. Wide excision is the treatment of choice and other conjunctive therapy has not been successful.