• Journal of the Korea Institute of Military Science and Technology
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• v.23 no.4
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• pp.417-425
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• 2020

Multi-resolution modeling(MRM) is required when simulating objects in variable resolution and can be applied for interoperating systems, which simulate objects in fixed resolution. However, most interoperation middleware do not support MRM, so participating models must handle several issues to simulate MRM system. In this paper, we propose an interoperation system, which is composed of several different resolution models, based on the High Level Architecture and Run-Time Infrastructure(HLA/RTI). In the proposed architecture, each model participates to a HLA federation through MRM adapter application, which supports data resolution conversion and HLA services while communicating with the model. MRM adapter application can be implemented based on an MRM adapter, and an adapter application development tool is proposed to support developing the application. Using the tool, developers can easily implement data resolution conversion component plugged-in HLA adapter. A case study is implemented in the proposed MRM system, and shows that models of different resolution works successfully with dynamic resolution changes.

• BMB Reports
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• v.30 no.1
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• pp.26-32
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• 1997

Of all HLA class I molecules, HLA-C gene products are most poorly understood because they express at a low level on the cell surface compared to HLA-A and -B. In order to identify serologically detectable and undetectable HLA-C antigens, we have established a DNA-based tissue typing method for the HLA-C locus by PCR-SSP (polymerase chain reaction-sequence specific primers). Genomic DNA prepared from Iymphoblastoid 21 B-cell lines and 120 Korean individuals by proteinase K digestion and pheno/chloroform extractions have been typed by PCR-SSP (23 primer mixes were used). The PCR-SSP results of control cell lines were discrepant from serology in 1 case among 21 cases: Cw6 which was negative by serology but positive by PCR-SSP (cell line: MANIKA). Twenty four HLA-Cw "blank" antigens among fifty Korean individuals were completely determined by PCR-SSP DNA typing. HLA-Cw*0101 (15.3%), Cw*1401 (12.3%) and Cw*0701 (11.7%) alleles were frequently found in 120 Korean individual samples. In conclusion. the high level of discrimination for HLA-C alleles may prove useful and informative in the study of transplant survival, and identify the importance of allelic differences, not readily detectable by serology, on host and donor compatibility.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4427-4433
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• 2013

Cervical cancer is the second most common cancer in women. HLA class I and II alleles polymorphisms have been shown to be associated with cervical cancer risk, but results have varied among different populations. In this study, the HLA-A, -B, and -DRB1 alleles among 100 southern Chinese women with cervical squamous cell carcinoma (SCC) were compared to 254 controls. Our results showed that $B^*51$:01:02 allele frequency was significantly higher in patients with SCC than in healthy controls ($P=3.17{\times}10^{-5}$, $P_c$=0.005, OR=26.7). Statistical analysis also revealed a significantly decreased frequency of $B^*51$:01:02 ($P=7.01{\times}10^{-4}$, $P_c$=0.03, OR=0.12) in patients with SCC when compared with healthy controls. These results indicate that HLA-$B^*51$:01:02 may confer susceptibility to SCC and HLA-$B^*51$:01:02 may contribute to resistance to the development of SCC in Chinese women. None of the HLA-A-B or HLA-A-B-DRB1 haplotypes were significantly different in cases and controls after multiple testing corrections, indicating the individual allele associations to be independent of the identified haplotypes. These results support the hypothesis that some HLA-B alleles could be involved with susceptibility for developing SCC.

• The KIPS Transactions:PartD
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• v.9D no.6
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• pp.1137-1144
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• 2002

Possibility of federation improvement requires flexibility and adaptability of member federates. Moreover, to develop and convert a non-HLA(High Level Architecture) compliant model as a HLA federate and allow this federate to be integrated with a changeable federation, more time and efforts will be necessary. In this research, I proposed a method to design and implement a ROM (RTI Object Model) Framework as a solution to this problem. ROM completely separates RTI (Run-Time Infrastructure) programming and simulation programming therefore providing epochal efficiencies in cost and productivity to the development a HLA federate that supports a changeable FOM. That is, ROM contains two layers : 1) a management layer that manages RTI services between the RTI and the federate and 2) a Foundation Class layer that actually updates/reflects objects and interactions. These two layers allow federate developers to use more generalized HLA services and automates the iterative, low-level RTI programming process.

• Journal of the Korea Society for Simulation
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• v.26 no.1
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• pp.1-11
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• 2017

During the past several years the ROK military has made an effort to build LVC synthetic battlefield that reflects the real world environment. In spite of its efforts, little has been accomplished. The disappointing achievement is mainly due to the lack of operational requirements and concepts, and policies or systematic approaches on the architecture and technology. Furthermore, there is insufficient understanding on the basic concepts and principles, and conflicting interests between organizations. In this study, I propose to construct an LVC based on the HLA that focuses on the system view and technical standard view, rather than the operational view. The proposed approach employs the information centric integration, focuses on an architecture convergence efforts based on the HLA/RTI, emphasizes the HLA compliance test and federation test, adapts to DSEEP, DMAO, and FEAT, and finally invents and implements an LVC Compliance Test System.

• Journal of the military operations research society of Korea
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• v.30 no.1
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• pp.81-91
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• 2004

Since HLA (High Level Architecture) was selected as a standardized distributed simulation architecture by US DoD in order to guarantee interoperability among all types of simulations, weapons system and C4I systems, to improve reusability of developed models in mid 1990s, a large number of federates have been developed and certified in accordance with HLA specifications. This paper illustrates case studies on HLA compliance test which are helpful for developers and managers. Based on experiences obtained from international HLA compliance test of CJ21_NG being developed for ground warfare simulation during ROKA's BCTP and UFL exercises, compliance procedures of US Defense and Modelling Simulation Office (DMSO) are introduced, and detail information at each phase of compliance test is provided.

• IE interfaces
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• v.13 no.3
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• pp.528-538
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• 2000

HLA is a general-purpose software architecture for distributed simulation designed to support a wide range of simulation approaches and application. The US DoD's HLA for modeling and simulation can certainly be regarded as the state of the art in distributed simulation. It is a mandatory standard for military simulation. The purpose of this paper is to describe applications of HLA/RTI in multiple domains across the manufacturing systems society. In many and large scale industrial systems, enormous data is generated, and is to be managed in an effective way. It needs a high performance common network library. Furthermore, it must satisfy the real function of system facilities as much as possible. The RTI is an implementation of the interface specification, provided as a set of services. Some applications focusing on the area of a small manufacturing system were demonstrated. The integration could be achieved using the HLA, together with interface modules for each of the subsystems. We have found that HLA/RTI are cable of meeting the functional requirements for a given system environment.

• Proceedings of the Korea Information Processing Society Conference
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• 2001.10b
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• pp.1253-1256
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• 2001

최근 모델링 및 시뮬레이션(M&S) 체계 구축 관련 기술들이 미 국방부를 중심으로 활발히 연구됨은 물론 민간 사업으로 확산되는 등 그 소요가 급속히 증가하고 있다. 또한 기존의 모형 및 개발 모형들도 차세대 연동 체계인 RTI(Run_Time Infrastructure)를 모형에 적용함으로써 HLA(High Level Architecture)를 포함한 차세대 M&S 체계의 핵심 기술을 조기에 획득하여 이를 개발하고 운용하는 능력을 확보하는 것이 시급히 요구되고 있다. 본 논문에서는 첨단 정보 기술의 결집체인 HLA 의 핵심 기술을 이용한 HLA 시뮬레이션 방법을 제시하였으며, HLA가 보장하는 상호 운용성과 재사용성을 모형 확장을 통해 확인하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.05a
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• pp.955-958
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• 2005

HLA는 상호운영성과 재사용성을 목적으로 미국 국방성 산하 기관인 DMSO에서 개발되어진 분산 시스템 프레임워크이다. 이러한 HLA가 민간 부분 적용을 위해 표준이 발표되었고, HLA는 여러 분야의 범용성을 가지기 위해 복잡한 구현 시스템을 가지게 된다. 특히, federate들내에 존재하는 객체와 객체의 속성을 사용하기 위해서는 복잡한 절차를 구현해한다. 또한 객체의 속성변화를 반영하기 위해서는 많은 통신 부하가 발생한다. 이런 단점을 해결하기 위해 HLA 기반의 시뮬레이션에서 객체를 분리 관리하는 방안을 제안한다.

• International Journal of Naval Architecture and Ocean Engineering
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• v.4 no.3
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• pp.211-227
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• 2012

To implement a combined discrete event and discrete time simulation such as submarine diving simulation in a distributed environment, e.g., in the High Level Architecture (HLA)/Run-Time Infrastructure (RTI), a HLA interface, which can easily connect combined models with the HLA/RTI, was developed in this study. To verify the function and performance of the HLA interface, it was applied to the submarine dive scenario in a distributed environment, and the distributed simulation shows the same results as the stand-alone simulation. Finally, by adding a visualization model to the simulation and by editing this model, we can confirm that the HLA interface can provide user-friendly functions such as adding new model and editing a model.