• Korean Journal of Microbiology
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• v.31 no.1
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• pp.17-21
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• 1993

Eight strains of Bacillus thuringiensis were isolated from soil in Korea and characterized. The isolates were named HL-24, HL-25, HL-33, HL-34, HL-35, HL-38, HL-39, HL-40. Strains HL-24 and HL-25 produced irregular parasporal crystals, HL-33 and HL-35 produced bipyramidal crystals, and others were round form in their cells. The biochemical characteristics of the eight isolates were only minor different in specific characteristics to the known serotypes of Bacillus thuringiensis. The HL-25, HL-33 and HL-34 strains showed resistances to cephalothin, colistin and penicillin G, and HL-39 and HL-40 strains were resistant to penicilin G. The strains of HL-24, HL-25, HL-33 and HL-34 were toxic to Bombyx mori lavae and HL-24, HL-25, HL-38, HL-39 and HL-40 strains killed Culex pipiens 3rd instar larvae. The HL-24 and H25 strains showed lethal activity against two kinds of the larvae, however lethality against mosquito larvae was low.

• Annual Conference on Human and Language Technology
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• 2019.10a
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• pp.454-455
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• 2019

의료정보 교환을 위한 국제 표준인 HL7 메시지의 처리와 HL7의 다양한 버전 간 호환성 문제를 해결하기 위해 객체 지향적 구조에 기반한 HL7 파서(Parser)가 개발되었다. 그러나 개발된 파서를 의료정보시스템과 연동하여 사용하기 위해서는 의료분야 전문가와 소프트웨어 전문가의 협력이 필수적이다. 또한, 이들 전문가의 협업을 위해서는 각 분야의 전문지식에 대한 상호 이해가 전제되어야 하는데, 이를 위해서는 오랜 시간 상호간의 많은 노력이 필요한 과정이다. 따라서 본 연구에서는 버전 간 호환 가능한 HL7 파서를 기반으로 하여 HL7 메시지의 생성과 변환을 가능하게 하는 HL7 GUI 도구를 설계한다. 이를 통해, 컴퓨터 프로그래밍 언어에 익숙하지 않은 의료 분야의 전문가들도 HL7 GUI 도구를 통해 개념적으로 표현되는 그래프를 직접 디자인하여 의료정보시스템 간의 다양한 버전의 HL7 메시지를 처리하고 교환할 수 있는 환경을 제공한다.

• Annual Conference on Human and Language Technology
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• 2018.10a
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• pp.520-521
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• 2018

의료정보 교환 국제 표준인 HL7의 처리를 위한 인터페이스 소프트웨어에서 다양한 버전 사이의 호환성 문제의 해결 방법으로 객체 지향적 구조에 기반한 HL7 파서(Parser)의 구조가 설계되었다. 그러나 수천개의 HL7 메시지 및 구성요소를 처리할 수 있는 HL7 파서를 직접 구현하기 위해서 많은 시간과 인력이 필요하다. 또한, 구현된 파서의 기능 변경 시 수천 개의 파일을 프로그래머가 직접 수정하는 방법은 매우 비효율적이다. 따라서 본 연구에서는 버전 상호 호환 가능한 HL7 파서의 설계에 따라 HL7 파서를 효과적인 구현할 수 있는 방법을 제안한다. 제안한 방법에 따라 HL7 파서를 구현하고, HL7 메시지의 버전 간 변환 테스트를 수행하여 개발한 파서의 효용성을 확인한다.

• Microbiology and Biotechnology Letters
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• v.20 no.4
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• pp.377-383
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• 1992

Seven strains of Bacillus thuringiensis were isolated from soil in Korea and characterized. The isolates were named HL-8, 10, 12, 13, 14, 15 and 16 which produced parasporal crystals and endospores in their cells. The biochemical characteristics of the seven isolates were only minor different in specific chracteristics to the known serotypes of Bacillus thuringiensis. The number of the plasmid DNA elements from the isolates were studied. The computerized molecular weights of the six plasmid elements in the HL-8 and HL-lO strains were from 3.01 to 15.1 Md, four plasmid elements in the HL-12 were from 5.4 to 21.9 Md, four plasmid elements in HL-13 were from 5.1 to 20 Md, three plasmid elements in HL-15 were from 3.4 to 11.3 Md and three plasmid elements in the HL-16 were from 2.4 to 20.1 Md. The seven isolates showed resistances to ampicillin, bacitracin, cephalothin, methicillin and penicillin G. The strains of HL-8, HL-lO, HL12, HL-14, HL-15 and HL-16 showed lethalities against Culex pipiens 3rd instar larvae. The HL8 and 14 strains showed 100% lethality to the larvae within 48 hours. HL-13 strain did not have toxicity against the larvae.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.7
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• pp.4290-4300
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• 2014

The previous HL7 interface should be developed as a separate package or conversion module for each version to process HL7 messages from different versions. This study designed and developed an HL7 parser compatible among different versions based on the requirements of compatibility defined in HL7 V2.5. According to the structure of the parser, the inheritance concept in object-oriented programming was adopted so that the class object of the HL7 message from the lower version could be inherited to the class object of the upper version. Therefore, every version's HL7 messages could be processed using only the upper class' object regardless of the version. To evaluate the compatibility of the developed parser, 700 data sets about inpatients with rheumatoid arthritis were used. The 700 cases underwent the compatibility test successfully. In the near future, further research on the Inter-compatibility HL7 parser is planned.

• Journal of KIISE:Computing Practices and Letters
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• v.8 no.1
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• pp.96-106
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• 2002

this paper, we propose a flexible, reusable, and extensible HL7 encoding and decoding framework using a Message Object Model (MOM) and Message Definition Repository (MDR). The MOM provides an abstract HL7 message form represented by a group of objects and their relationships. It reflects logical relationships among the standard HL7 message elements such as segments, fields, and components, while enforcing the key structural constraints imposed by the standard. Since the MOM completely eliminates the dependency of the HL7 encoder and decoder on platform-specific data formats, it makes it possible to build the encoder and decoder as reusable standalone software components, enabling the interconnection of arbitrary heterogeneous hospital information systems(HISs) with little effort. Moreover, the MDR, an external database of key definitions for HL7 messages, helps make the encoder and decoder as resilient as possible to future modifications of the standard HL7 message formats. It is also used by the encoder and decoder to perform a well formedness check for their respective inputs (i. e., HL7 message objects expressed in the MOM and encoded HL7 message strings). Although we implemented a prototype version of the encoder and decoder using JAVA, they can be easily packaged and delivered as standalone components using the standard component frameworks like ActiveX, JAVABEAN, or CORBA component.

• Proceedings of the Korean Information Science Society Conference
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• 2002.04b
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• pp.79-81
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• 2002

정보기술의 발달로 보건의료분야에서도 정보화가 가속화되고 있으며, 이런 디지털 의료환경에서 개인의 의료정보를 체계적이고 지속적으로 관리하기 위해서는 의료정보의 교환 및 공유를 위한 표준데이터 교환 환경이 구축되어야 한다. 본 논문에서는 HL7을 이용하여 표준데이터 교환 환경을 구축할 것을 제안하고, 특정 클라이언트 및 데이터베이스 스키마로부티 독립적으로 HL7 메시지를 생성할 수 있는 HL7 메시지 서버를 설계하고 구현한다. 이질적인 여러 데이터베이스에 대해서 HL7 데이터 요소에 대한 일관된 관점을 제공해 주기 위해서 공통 HL7 데이터 요소를 갖는 임상검사결과 뷰 스키마를 설계하였으며, HL7 메시지 서버가 특정 데이터베이스 스키마에 상관없이 제공된 단순 뷰를 조회하는 것으로 HL7 메시지를 생성할수 있도록 한다. 이를 통하여 타 의교기관의 정보시스템에서도 쉽게 본 HL7 메시지 서버 시스템을 활용할수 있도록 한다.

• Parasites, Hosts and Diseases
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• v.26 no.4
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• pp.229-238
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• 1988

In vitro culture of Toxoplasma gondii in HL-60 cells and cell-mediates immunity against Toxoplasma in dimethylsulfoxide(DMSO) -induced HL-60 cells, i.e., differentiation into granulocytes, were pursued. HL-60 calls were treated with various concentrations of DMSO, and 1.3%(v/v) for 3 day incubation was chosen as the optimal condition icy differentiation into granulocytes. The degree of differentiation was assayed in physiological and functional aspects in addition to morphological point. When treated with 1.3% DMSO for 3 days, HL-60 cells did not synthesiar DNA materials beyond background level, and showed active chemotactic response to chemotactic peptide, formal-methionyl-leucyl-phenylalanine(FMLP). Morphologically promyelocytes of high nuclearlcytoplasmic(NIC) ratio changed to granulocytes of relatively low WJC ratio. The relationships between HL-60 cells or DMSO-induced HL-60 cells and Toxoplasma were examined after stain with Giemsa and Buorescent dye (acridine orange). HL-60 cells did not show any sign of torso- plasmacidal activity but showed intracellular proliferation of Texoplasma to form rosette for 72 hr co-culture. In contrast, OMSO-induced HL-60 cells phagocytosed Toxoplasma within 1 hr, and performed a process of intracellular digestion of Toxoplasma thereafter. With the above results, it is suggested that phagosome-Iysosome fusion is one of the critical events for the parasitism by Toxoplasma or for susceptibility of host cells. The in vitro culture system of this study has offered a defined condition to study the protozoan parasite-host cell interactions.

• KIISE Transactions on Computing Practices
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• v.21 no.3
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• pp.183-191
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• 2015

Recent developments in IT have made real-time ECG monitoring possible, and this represents a promising application for the emerging HL7 standard for the exchange of clinical information. However, applying the HL7 standard directly to real-time ECG monitoring causes problems, because the partial duplication of data within an HL7 message increases the amount of data to be transmitted, and the time taken to process it. We reduce these overheads by Feature Scaling, by standardizing the range of independent variables or features of data, while nevertheless generating HL7-compliant messages. We also use a De-Duplication algorithm to eliminate the partial repetition of the OBX field in an HL7 ORU message. Our strategy shortens the time required to create messages by 51%, and reduces the size of messages by 1/8, compared to naive HL7 coding.

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.11
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• pp.1544-1547
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• 2011

Lotus (Nelumbo nucifera) leaf is known to be effective for 'overcoming body heat' and stopping bleeding. It is commonly used as a traditional curing plant for the treatment of hematemesis, epistaxis, hemoptysis, hematuria, and metrorrhagia in traditional Chinese medicine. This study investigated on the effect of oral administration of lotus (Nelumbo nucifera) leaf extract on the serum and liver lipid levels of rats fed a high fat diet. Experimental rats were divided into five different experimental groups, including the general diet group (Cont), high fat diet with lotus leaf extract groups (HL40, HL80, HL120), and high fat diet group (HFG). Body weight significantly decreased in the HL120 sample compared to that of Cont. The weights of the livers and kidneys of rats corresponded to the increase in body weight. Total cholesterol and triglyceride contents in liver tissues of rats were lowest in the sample HL120 sample. The levels of total lipids, total cholesterol, and triglycerides in serum were lower in the HL120 sample compared to the HFG.