• Title/Summary/Keyword: HIV integrase

Search Result 21, Processing Time 0.015 seconds

Synthesis of Bis(pyronyl)acrylic Acid Ester Derivatives (Bis(pyronyl)acrylic Acid Ester 유도체의 합성)

  • Nam, Seung-Ok;Kim, Dong-Han;Lee, Yong-Sup
    • YAKHAK HOEJI
    • /
    • v.53 no.2
    • /
    • pp.89-92
    • /
    • 2009
  • Dicaffeoyltartaric acid has a structural feature consisting of two caffeic acid units separated by tartaric acid linker and has been found to be a potent inhibitor of HIV-1 integrase and an antioxidant. In this study, bis(pyronyl)acrylic acid esters joined through a 5-membered ring as a linker were synthesized as the analogues of dicaffeoyltartaric acid.