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Synthesis of Bis(pyronyl)acrylic Acid Ester Derivatives  

Nam, Seung-Ok (Medicinal Chemistry Laboratory, Department of Life and Nanopharmaceutical Science, Kyung Hee University)
Kim, Dong-Han (Medicinal Chemistry Laboratory, Department of Life and Nanopharmaceutical Science, Kyung Hee University)
Lee, Yong-Sup (Medicinal Chemistry Laboratory, Department of Life and Nanopharmaceutical Science, Kyung Hee University)
Publication Information
YAKHAK HOEJI / v.53, no.2, 2009 , pp. 89-92 More about this Journal
Abstract
Dicaffeoyltartaric acid has a structural feature consisting of two caffeic acid units separated by tartaric acid linker and has been found to be a potent inhibitor of HIV-1 integrase and an antioxidant. In this study, bis(pyronyl)acrylic acid esters joined through a 5-membered ring as a linker were synthesized as the analogues of dicaffeoyltartaric acid.
Keywords
dicaffeoyltartaric acid; chicoric acid; bis(pyronyl)acrylic acid; caffeic acid; antioxidant;
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