• Plant Resources
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• 제4권3호
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• pp.192-195
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• 2001

Human immunodeficiency virus (HIV), the causative agent of AIDS, still continues to spread rapidly in the world population, especially in Africa and Southeast Asia. At present, two kinds of therapeutic approaches are used for treatment of AIDS. One is to target HIV reverse transcriptase, which is responsible for the viral genome transcription. The other is to inhibit HIV pretense PR, which is essential for the processing of viral proteins. Drug combinations based on these approaches can reduce the blood virus to an undetectable level. However, a small amount of virus may lurk inside the immune cells in a dormant state. Another major obstacle of long-term treatment of the disease is remarkable mutation in HIV. Most of the clinical chemotherapeutic agents have one or more of these problems. High cost and harmful side-effects further reduced the desirability of these drugs. In the course our studies on development of anti-HIV agents from natural products, we investigated various crude drugs for their inhibitory activity against HIV-induced cytopathic effects (CPE) in culture cells, HIV-pretense (PR), HIV-reverse transcriptase (RT) including ribonuclease H (RNase H), and HIV integrase (INT). In the present paper, some inhibitory substances relating to the development of anti-HIV agents are reported.

• Journal of Hospice and Palliative Care
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• 제12권1호
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• pp.14-19
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• 2009

목적: HIV/AIDS환자의 영적 안녕과 영적 요구 정도를 파악하여 간호실무 면에서 HIV/AIDS 환자의 영적 건강 사정과 영적 간호 중재 방안을 마련하는데 기초 자료를 제공하고자 본 연구를 시도하게 되었다. 방법: HIV/AIDS 환자의 영적 안녕과 영적 요구와의 관계를 파악하기 위한 관계성 조사연구(Correlation Survey Research)이며, 연구 대상은 20세에서 70세 사이의 HIV/ AIDS 환자 51명이다. 결과: 1. HIV/AIDS환자의 영적 안녕 점수는 평균 54.59점이었고, 영적 안녕의 하위 영역인 실존적 안녕은 27.78점, 종교적 안녕은 26.80점으로 모두 중 정도 이상으로 나타났다. 따라서 HIV/AIDS환자들은 자신의 영적인 안녕 상태에 대해 중 정도로 지각하고 있다고 볼 수 있으며, 종교적 안녕보다 실존적 안녕의 점수가 높게 나타났다. 2. HIV/AIDS환자의 영적 요구 점수는 평균 108.67점이고 영역별로는 사랑과 관심에 대한 요구가 37.80점, 의미와 목적을 갈망하는 요구가 42.35점, 용서받고 싶은 요구가 28.51점으로 의미와 목적을 갈망하는 요구, 사랑과 관심에 대한 요구, 용서받고 싶은 요구 순으로 높게 나타났다. 3. 영적 안녕과 영적 요구의 상관 관계에서 HIV/AIDS환자의 총 영적 안녕과 총 영적요구는 약한 순 상관관계를 나타냈다(r=0.344, P=0.013). 영적 안녕의 하위영역인 실존적 안녕과는 통계적으로 유의하지 않게 나타났으며, 종교적 안녕과는 순 상관관계를 보였다. 결론: HIV/AIDS환자의 영적 안녕과 영적 요구는 중 정도 수준 이상으로 나타났으며, 영적 안녕과 영적 요구간의 약한 순 상관관계를 나타냈다. HIV/AIDS환자들은 의미와 목적을 갈망하는 요구도가 높으므로 이에 대한 영적 간호를 제공하여 현재 위기 상태의 경험에서 삶의 의미와 목적을 찾도록 하여 실존적 영적 안녕 정도가 증진되도록 지지하고, 앞으로 대상자 수를 확대한 연구와 영적 안녕을 증진시키는 간호 중재에 대한 연구가 계속되어야 하리라고 사료된다.

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.235-254
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• 2003

The purpose of this descriptive study was to investigate the general knowledge and attitude of physical therapist to patient with HIV/AIDS. Many physical therapists are afraid of AIDS patients because they have a little information of AIDS and fear of HIV infection from AIDS patients at work site. This study was carried out from June to October in 2003 for collecting data. The 271 physical therapists volunteered for a this study and completed questionnaires. The findings of this study can be summarized as follows. 1)The knowledge of prevention of HIV/AIDS influences the attitude of physical therapists to patients with HIV/AIDS. 2)The knowledge of symptoms of HIV/AIDS influences the attitude of physical therapists to patients with HIV/AIDS. 3)The knowledge of transmission routes of HIV/AIDS influences the attitude of physical therapists to patients with HIV/AIDS. 4)84.9 percentage of participant in survey suggested college should have curriculum about HIV/AIDS. In conclusion, physical therapists with more knowledge of HIV/ADIS could positively treat HIV/AIDS patients.

• 한국학교ㆍ지역보건교육학회지
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• 제10권1호
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• pp.105-122
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• 2009

Objectives: The aim of this study was to describe HIV/AIDS knowledge, attitudes (discrimination towards HIV/AIDS and lives with HIV infected persons) and HIV/AIDS related sexual behaviors among middle school and high school students in Seoul, Korea. Methods: The population of this study was junior and senior high school students in Seoul, Korea. Eight junior high schools and eight senior high schools were randomly selected from Seoul City. Two thousand nine hundred and ninety-six responses from the sixteen schools were analyzed (fifty-nine were excluded). A self-administered questionnaire measuring socio-demographic variables, knowledge of HIV/AIDS, as well as discriminatory attitudes of HIV/AIDS was utilized. Results: The level of HIV/AIDS knowledge was low and the levels of discriminatory attitudes were high. The results indicated that students had considerable misconceptions about HIV transmission as well as stigmatizing attitudes towards HIV-infected people and their lives. The proportions of sexual intercourse were 1.3 % for middle school students and 7.7% for high school students. Only 30.7% of current sexually active subjects were to use condoms at the last step of sexual intercourse. The HIV/AIDS related risk-taking behavior were predicted by gender, school types, parents' marital status, reported academic performances, and attitudes towards to homosexuals. Conclusions: It is important to design HIV prevention strategies that improve in the knowledge of HIV transmission for adolescents in Korea.

• 성인간호학회지
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• 제12권4호
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• pp.497-506
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• 2000

The purpose of this phenomenological study was to explore and describe the experience of people with HIV/AIDS. Three men and three women with HIV/AIDS participated in the study. They were asked open-ended and descriptive questions in order for them to talk about their experience in their own terms. Interviews were audiotaped and transcribed to maintain data integrity and to reduce perceptual bias. The transcripts were analyzed by the Colaizzi method. Member checks from the participants were used to validate the emergent themes. Seven themes emerged from the analysis. 1. People with HIV/AIDS have a strong impact and emotional reaction when receiving positive HIV test results. 2. All people with HIV/AIDS attempt to conceal HIV infection because of fear of stigma or rejection. 3. After the initial brief traumatic reaction to HIV/AIDS diagnosis, all participants feel lonely because they had no one to express or share their own experiences. 4. People with HIV/AIDS reflect on their life, think about the death and dying process and they become depressed. 5. Most participants feel that the family members who know his/her diagnosis are a big source of support. 6. According to the normativeness of infection route of HIV, the degree of guilty feeling differs among participants. 7. Although all participants think medication is a lifeline, the adherence to medication is not maintained because of side effects, denial and concealment of HIV/AIDS. The results of this study may help nurses and other health care workers to implement more efficient nursing strategies for people with HIV/AIDS by more deeply understanding their experience.

• 한국자원식물학회지
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• 제25권2호
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• pp.169-175
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• 2012

능소화 추출물의 HIV-1에 대한 항바이러스 효과를 복제 관련 효소에 대한 억제실험과 바이러스 복제억제 실험을 통하여 살펴보았다. 역전사효소 억제활성을 ELOSA 방법으로 실험한 결과 능소화 줄기의 물 추출물이 100 ${\mu}g$/ml 농도에서 각각 37.9%의 활성을 나타내었고, 능소화 잎과 줄기의 메탄올 추출물에서 33.6% 및 31.5%의 HIV-1 protease 억제활성 나타 내었다. 그리고 HIV-1 복제 억제활성은 MT-4 세포에 대한 HIV-1 유도 세포변성억제를 광학현미경으로 관찰하여 살펴본 결과 줄기의 물 추출물이 100 ${\mu}g$/ml 농도에서 HIV-1 바이러스 증식을 완전히 억제하였다.

• 가정∙방문간호학회지
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• 제24권2호
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• pp.142-150
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• 2017

Purpose: The purpose of this study was to examine the relationships of attitudes, stigma, and moral sensitivity of nurses toward HIV/AIDS. Methods: The participants were 530 nurses working in general hospitals in South Korea. A structured questionnaire regarding attitudes, stigma toward HIV/AIDS, and moral sensitivity was used. The data were analyzed using t-tests, ANOVAs, and Pearson correlation coefficients. Results: Nurses' attitudes toward HIV/AIDS differed by job position; nurses' moral sensitivity toward HIV/AIDS differed by age, marital status, education level, clinical practice career, and job position; and nurses' stigma toward HIV/AIDS differed by age, clinical practice career, subjective economic status, HIV/AIDS education experience, and HIV/AIDS patient care experience. Attitudes of nurses toward HIV/AIDS were more negative when stigma toward HIV/AIDS was higher (r=-0.58, p<.001), these attitudes were not correlated with moral sensitivity. Conclusions: The attitudes of nurses toward HIV/AIDS were more negative when stigma toward HIV was higher, and these attitudes were not correlated with moral sensitivity. Therefore, nurses should be provided education that takes their age, marital status, clinical practice career, and experiences in HIV-related education and caregiving into account.

• Journal of Korean Medical Science
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• 제33권46호
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• pp.304.1-304.7
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• 2018

Background: The Republic of Korea has a very low prevalence of human immunodeficiency virus (HIV) infection, but the number of new HIV diagnoses has steadily risen, strongly indicating a large number of undetected HIV infections. Thus, it is important for Korean public health authorities to adopt and encourage cost-effective HIV detection tools, such as rapid HIV screening tests. In this study, we aimed to evaluate the cost-effectiveness of enzyme-linked immunosorbent assays (ELISA) and rapid tests in a public health center (PHC) setting. Methods: We developed a decision analytic model to assess the per-examinee cost and the cost-effectiveness of identifying HIV patients in a PHC setting using two HIV testing strategies: conventional HIV screening by ELISA versus rapid HIV testing. Analysis was performed in two scenarios: HIV testing in an average-risk population and in a high-risk population. Results: Compared to the ELISA, the rapid test was cost-saving and cost-effective. The per-examinee cost was USD 1.61 with rapid testing versus USD 3.38 with ELISA in an average-risk population, and USD 4.77 with rapid testing versus USD 7.62 with ELISA in a high-risk population. The cost of identifying a previously undiagnosed HIV case was USD 26,974 with rapid testing versus USD 42,237 with ELISA in an average-risk population, and USD 153 with rapid testing versus USD 183 with ELISA in a high-risk population. Conclusion: Rapid testing would be more cost-effective than using conventional ELISA testing for identifying previously undiagnosed HIV-infected cases in Korea, a country with extremely low HIV prevalence.

• 생명과학회지
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• 제32권9호
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• pp.734-741
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• 2022

전세계적으로 약 4천만 명의 사람들이 인체면역결핍증바이러스(HIV) 감염이 되어 있으며, HIV에 감염된 세포의 수가 치명적인 수준에 다르면 후천성면역결핍증후군을 일으키게 된다. HIV에 감염이 되면 완치 치료가 어려우며 현재 알려진 치료방법으로는 감염, 복제 및 바이러스 방출 억제를 위해 항레트로 바이러스 치료법이 병용되고 있다. 하지만 HIV 바이러스는 지속적인 돌연변이 유발 및 약물에 대한 내성을 갖게 하므로 장기간 약물복용 시 심각한 부작용을 초래한다. 이에 새로운 치료방법과 효능약물에 대한 연구가 필요한 실정이다. 식물유래 천연물은 수많은 생리활성물질들이 보고되어 있으며, 이는 항HIV 효능 지닌 잠재성을 가진 후보 물질이 될 수 있다. 1990년 세계보건기구에서는 플라보노이드, 쿠마린, 탄닌 및 테르펜의 항 HIV 효능을 보고하였으며, 이러한 물질은 SARS-CoV-2와 같은 바이러스 감염을 또한 억제하는 것으로 밝혀졌다. 따라서, 본 연구에서는 항 HIV 효능을 나타내는 식물 추출물 및 파이토케미컬에 대한 최신 연구동향(2021-현재)을 검토하였으며, 이를 통해 항HIV 효능을 지닌 새로운 천연물 발굴의 기초자료로 활용될 것으로 사료된다.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.634-639
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• 1998

Seven transmembrane segment (7TMS) receptors for chemokines and related molecules have been demonstrated to be essential, in addition to CD4, for HIV and SIV infection. The beta-chemokine receptor CCR5 is the primary, perhaps sole, coreceptor for HIV-1 during the early and chronic phases of infection, and supports infection by most primary HIV-1 and many SIV isolates. Late-stage primary and laboratory-adapted HIV-1, HIV-2, and SIV isolates can use other 7TMS receptors. CXCR4 appears especially important in late-stage HIV infection; several related receptors can also be used. The specificity of SIV viruses is similar. Commonalities among these receptors, combined with analyses of mutated molecules, indicate that discrete, conformationally-depenclent sites on the chemokine receptors determine their association with the third variable and conserved regions of viral envelope glycoproteins. These studies are useful for elucidating the mechanism and molecular determinants of HIV-1 entry, and of inhibitors to that entry.