• 디지털콘텐츠학회 논문지
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• 제12권4호
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• pp.585-592
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• 2011

경매 매물 정보시스템은 수요자의 상황과 특성에 맞춰 원하는 경매매물의 고급 정보만을 제공하는 것을 목표로 한다. 특히, 시시각각으로 변하는 조회수와 같은 실시간 정보와 경매가 예측을 위한 고도의 분석결과를 제공받기 위해서 상황인식에 기반한 모바일 정보시스템이 요구된다. 이에 따라 본 연구는 스마트폰 환경에서 수요자의 위치, 특정 매물 조회수, 현재 입찰자 수 등과 같은 경매정보를 제공해주는 상황인식 기반의 경매매물 정보시스템을 연구한다.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 1999년도 KOBA 방송기술 워크샵 KOBA Broadcasting Technology Workshop
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• pp.97.1-102
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• 1999

This paper porposes and efficient coding scheme for remote medical communication systems, or“telemedicine systems”. These systems require a technique which is able to transfer large volume of data such as X-ray images effectively. We have already developed a hierarchical image coding and transmission scheme (HITS), which achieves an efficient transmission of medical images simply[1]. In this paper, a new coding scheme for HITS is proposed, which used hierarchical context modeling for the purpose of improving the coding efficiency. The hierarchical context modeling divides wavelet coefficients into several sets by the value of a correspondent coefficient in their higher class, or“a parent”, optimizes a Golomb-Rice (GR) code parameter in each set, and then encodes the coefficients with the parameter. Computer simulation shows that the proposed scheme is effective with simple implementation. This is due to fact that a wavelet coefficient has dependence on its parent. As a result, high speed data transmission is achieved even if the telemedicine system consists of simple personal computers.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.249.1-249.1
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• 2003

The Korea Chemical Bank (KCB) has more than 80,000 compound collections. provided from many companies, academies and institutes. KCB has supported high-throughput screening (HTS) against 80 biological targets and identified a number of hits over 20 targets. These hits were first validated by confirming the purity and novelty of anticipated compound. We also determined their physiochemical properties. (omitted)

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2011년도 춘계학술발표대회
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• pp.1243-1244
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• 2011

블로그 이용이 활성화됨에 따라 포스트 랭킹 방법의 필요성이 증가하고 있다. 기존 연구에서는 HITS 에 기반을 둔 포스트 랭킹 방법인 BAITS 와 BAITS 를 수정한 포스트 랭킹 방법들을 제안한바 있다. 본 논문에서는 이러한 포스트 랭킹 방법들을 다양한 척도를 이용한 비교 실험을 통해 비교하여 가장 정확도가 높은 랭킹 방법을 판별하고자 한다.

• Structural Engineering and Mechanics
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• 제84권2호
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• pp.253-268
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• 2022

Using non-destructive Acoustic Emission (AE) and optical Digital Image Correlation (DIC) methods, the moment-curvature behavior of steel and GFRP bars reinforced concrete beams under flexure was explored in this study. In the tension zone, laboratory studies were carried out on steel-RC and GFRP-RC beams with varying percentages of longitudinal reinforcement ratios of 0.33 %, 0.52%, and 1.11%. The distinct mechanism of cracking initiation and fracture progression of failure in steel-RC and GFRP-RC beams were effectively correlated and picked up using AE waveform characteristics of the number of AE hits and their amplitudes, AE energy as well as average frequency and duration. AE XY event plots and longitudinal strain profiles using DIC gives an online and real-time visual display of progressive AE activity and strains respectively to efficaciously depict the crack evolution and their advancement in steel-RC and GFRP-RC beams. They display a close matching with the micro and macro-cracks visually observed in the actual beams at various stages of loading.

• 대한교통학회지
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• 제35권6호
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• pp.525-544
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• 2017

빅데이터 시대에 발맞추어, 데이터에 기반한 실효성 있는 국토공간 개편의 바람직한 방향을 제시하기 위해 교통 데이터를 활용한 국토개발에 대한 관심이 높아지고 있다. 하지만 현재 교통 데이터에 대한 연구는 데이터 정리 혹은 보정하는 수준에만 머물고 있다. 본 연구는 여기서 더 나아가 데이터를 가공함으로써 국토공간에 존재하는 숨겨진 가치를 제시하고자 한다. 이에 교통 데이터가 네트워크 구조와 유사하다는 점에 착안하여, 네트워크 분석에 사용되는 알고리즘을 통하여 국토공간에 존재하는 가치를 찾고자 하였다. 본 연구는 중심지를 파악하기 위해 PageRank와 HITS알고리즘을 활용하였다. 알고리즘의 거점 평가 지표로서의 성능을 확인하기 위해 TCS데이터를 이용하여 단순교통량과 비교하여 성능을 확인하였다. 이를 통해 단순히 교통량에만 의지하여 제시되었던 중심지들을 더 세분화된 특성에 맞추어 파악할 수 있었다. 알고리즘을 이용하여 찾은 중심지는 시간적, 기능적 특성을 세분화하여 담고 있으므로 경제권 내의 중심지를 판단하는 객관적인 근거로서 지역 거점 선정과 같은 정책적 결정을 위한 기초자료로 활용할 수 있을 것이다.

• Smart Structures and Systems
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• 제30권1호
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• pp.49-62
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• 2022

Experimental and discrete element methods were used to investigate the effects of triple joints lengths and triple joint angle on the failure behavior of rock mass under uniaxial compressive test. Concrete samples with dimension of 20 cm × 20 cm × 5 cm were prepared. Within the specimen, three imbedded joint were provided. The joint lengths were 2 cm, 4cm and 6 cm. In constant joint lengths, the angle between middle joint and other joints were 30°, 60°, 90°, 120° and 150°. Totally 15 different models were tested under compression test. The axial load rate on the model was 0.05 mm/min. Concurrent with experimental tests, the models containing triple joints, length and joint angle are similar to the experiments, were numerical by Particle flow code in two dimensions (PFC2D). Loading rate in numerical modelling was 0.05 mm/min. Tensile strength of material was 1 MPa. The results show that the failure behaviors of rock samples containing triple joints were governed by both of the angle and the length of the triple joints. The uniaxial compressive strengths (UCS) of the specimens were related to the fracture pattern and failure mechanism of the discontinuities. Furthermore, it was shown that the compressive behavior of discontinuities is related to the number of the induced tensile cracks which are increased by decreasing the joint length. Along with the damage failure of the samples, the acoustic emission (AE) activities are excited. There were only a few AE hits in the initial stage of loading, then AE hits rapidly grow before the applied stress reached its peak. In addition, every stress drop was accompanied by a large number of AE hits. Finally, the failure pattern and failure strength are similar in both methods i.e., the experimental testing and the numerical simulation methods.

• Advances in concrete construction
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• 제13권 2호
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• pp.199-213
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• 2022

Experimental and discrete element approaches were used to examine the effects of F shape non-persistent joints on the failure behaviour of concrete under uniaxial compressive test. concrete specimens with dimensions of 200 cm×200 cm×50 cm were provided. Within the specimen, F shape non-persistent joint consisting three joints were provided. The large joint length was 6 cm, and the length of two small joints were 2 cm. Vertical distance between two small joints change from 1.5 cm to 4.5 cm with increment of 1.5 cm. In constant joint lengths, the angle of large joint change from 0° to 90° with increments of 30°. Totally 12 different models were tested under compression test. The axial load rate on the model was 0.05 mm/min. Concurrent with experimental tests, numerical simulation (Particle flow code in two dimension) were performed on the models containing F shape non-persistent joint. Distance between small joints and joint angles were similar to experimental one. the results indicated that the failure process was mostly governed by both of the Distance between small joints and joint angles. The axial loading rate on the model was 0.05 mm/min. The compressive strengths of the samples were related to the fracture pattern and failure mechanism of the discontinuities. Furthermore, it was shown that the compressive behaviour of discontinuities is related to the number of the induced tensile cracks which are increased by increasing the joint angle. In the first, there were only a few acoustic emission (AE) hits in the initial stage of loading, and then AE hits rapidly grow before the applied stress reached its peak. Furthermore, a large number of AE hits accompanied every stress drop. Finally, the failure pattern and failure strength are similar in both approaches i.e., the experimental testing and the numerical simulation approaches.

• Molecules and Cells
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• 제39권5호
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• pp.375-381
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• 2016

MicroRNAs (miRNAs) are small non-coding RNAs (~22 nucleotides) regulating gene expression at the post-transcriptional level. By directing the RNA-induced silencing complex (RISC) to bind specific target mRNAs, miRNA can repress target genes and affect various biological phenotypes. Functional miRNA target recognition is known to majorly attribute specificity to consecutive pairing with seed region (position 2-8) of miRNA. Recent advances in a transcriptome-wide method of mapping miRNA binding sites (Ago HITS-CLIP) elucidated that a large portion of miRNA-target interactions in vivo are mediated not only through the canonical "seed sites" but also via non-canonical sites (~15-80%), setting the stage to expand and determine their properties. Here we focus on recent findings from transcriptome-wide non-canonical miRNA-target interactions, specifically regarding "nucleation bulges" and "seed-like motifs". We also discuss insights from Ago HITS-CLIP data alongside structural and biochemical studies, which highlight putative mechanisms of miRNA target recognition, and the biological significance of these non-canonical sites mediating marginal repression.

• Genomics & Informatics
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• 제15권4호
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• pp.147-155
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• 2017

Apurinic/apyrimidinic endonuclease 1 (APE1) is an enzyme responsible for the initial step in the base excision repair pathway and is known to be a potential drug target for treating cancers, because its expression is associated with resistance to DNA-damaging anticancer agents. Although several inhibitors already have been identified, the identification of novel kinds of potential inhibitors of APE1 could provide a seed for the development of improved anticancer drugs. For this purpose, we first classified known inhibitors of APE1. According to the classification, we constructed two distinct pharmacophore models. We screened more than 3 million lead-like compounds using the pharmacophores. Hits that fulfilled the features of the pharmacophore models were identified. In addition to the pharmacophore screen, we carried out molecular docking to prioritize hits. Based on these processes, we ultimately identified 1,338 potential inhibitors of APE1 with predicted binding affinities to the enzyme.