• 대한한방소아과학회지
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• 제37권4호
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• pp.34-52
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• 2023

Objective This study aimed to evaluate the effect of herbal medicines on transient hip synovitis (TSH) in children. Methods We searched 10 Korean, English, Japanese, and Chinese databases for studies published up to September 19, 2023. Randomized controlled trials (RCTs) evaluating the effect of herbal medicines on TSH levels in children were included. The Cochrane risk of bias was used to evaluate the quality of the studies. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), visual analog score (VAS), time to pain relief, and hip joint mobility disorder disappearance time, using the Review Manager website. Results Eleven RCTs were included in this study. TER in the treatment group was significantly higher than in the control group. The duration of pain relief was significantly shorter in the treatment group than in the control group. The VAS score of the treatment group was significantly lower than that of the control group, although the statistical heterogeneity was substantial. The hip joint mobility disorder disappeared in the treatment group treated with external therapy, which was significantly shorter than in the control group. Regarding safety, two of the 11 studies reported that there were no adverse events. Conclusions Herbal medicines are effective in the treatment of TSH in children. However, the safety of herbal medicines should be carefully considered due to the lack of data.

• 한국식품영양과학회지
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• 제41권12호
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• pp.1663-1670
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• 2012

Primary culture된 연골세포 in vitro 실험모델을 이용하여 칠레와 덴마크 두 지역으로부터 생산된 로즈힙 추출물의 관절염 관련 효과를 비교 확인하였다. 먼저 MTT 시험법을 통해 세포 사용 적정농도를 600 ${\mu}g/mL$ 이하로 결정하였고 이를 근간으로 연골세포사멸억제, 염증관련인자(TNF-${\alpha}$, NO, Cox-2) 및 연골세포조직의 이화작용과 동화작용에 관여하는 인자의 유전적 발현을 측정하였다. $H_2O_2$ 처리에 따른 산화적 독성으로 연골세포 사멸을 유도한 실험에서 로즈힙 추출물은 정상세포 수준으로 사멸을 억제하였으며 이러한 효과는 칠레산에서 비교적 높게 나타났다. TNF-${\alpha}$의 생성 억제는 로즈힙 추출물 처리 시 27.4~31.9% 정도의 저해효과가 나타났지만 농도 의존적이지는 않았으며 두 지역 간의 유의성도 나타나지 않았다. NO의 생성 억제의 경우 농도의존적인 감소를 보였으며 고농도에서는 덴마크산이 보다 효과적인 것으로 확인되었다. Cox-2의 발현억제는 농도의존적인 경향을 나타내었으며 칠레산에서 다소 효과적인 것으로 여겨졌다. 연골세포조직의 동화작용과 이화작용에 관여하는 인자들 중 동화작용 인자인 collagen type I의 경우 고농도에서 정상세포 수준으로 발현을 촉진시킨 것으로 나타났지만 collagen type II의 발현에는 영향이 없었음을 확인하였다. 특히 aggrecan의 경우는 정상세포군에 비해서는 미비하였지만 $H_2O_2$ 처리군에 비해서는 유의적으로 증가한 것으로 나타났다. 하지만 측정하였던 동화작용 인자들 중에서는 지역적인 차이를 나타내지는 않았다. 이화작용에 관여하는 인자로서 MMP3, 7, 13의 유전자 발현을 측정한 결과 $H_2O_2$ 처리군에 비해 유의적으로 감소시킨 것으로 확인되었는데, 특히 MMP13에서 가장 큰 감소 효과를 나타내었다. 두 지역 간의 비교에서는 MMP3의 경우 고농도에서 덴마크산이 다소 효과가 높은 것으로 인지된 반면, MMP7, 13의 경우는 지역적인 차이가 유의적으로 나타나지는 않았다. 실험한 결과를 종합해 보면 로즈힙 추출물은 primary culture된 in vitro 실험모델에서 관절염 형성 억제효과가 있을 것으로 확인되었지만 지역적인 차이는 크지 않은 것으로 생각된다. 본 실험의 한계점으로는 기존에 사용되던 관절염 치료제 또는 건강기능식품을 양성대조군으로 사용하지 못하였기 때문에 로즈힙 추출물의 효과를 정량화하여 비교하지 못한점이 있음으로 향후 이 점을 보완할 필요성이 있을 것으로 생각된다.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2001년도 추계 학술발표강연 및 논문개요집
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• pp.111-111
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• 2001

• Journal of Trauma and Injury
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• 제28권3호
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• pp.91-97
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• 2015

Purpose: Occult hip fracture is not evident on radiographs and the diagnosis is often missed or delayed. This study was undertaken in order to identify the clinical characteristics and complications of patients with a delayed diagnosis of an occult hip fracture. Methods: We retrospectively reviewed patients with occult hip fracture who had normal findings on initial radiographs, the diagnosis was made on additional studies between August 2006 and February 2012. Patients who were diagnosed as having occult hip fractures at the first visit were categorized as non-delayed group and those who were not diagnosed at the first visit were categorized as delayed group. Results: Non-delayed group included 43 patients (86%). In the remaining 7 patients (delayed group), the diagnosis was delayed by a mean of 9.6 days (range 3~19 days). Patients who were diagnosed with an occult fracture on the initial visit presented later than those with a delayed diagnosis (41/43 .vs. 3/7, p=0.002). Other clinical features were no difference between the two groups. Patients in the delayed diagnosis group were more likely to have fracture displacement (4/7 .vs. 0/43)15patients in non-delayed group (34.9%) needed operative treatment, whereas all delayed patients (100%) needed operative treatment. Conclusion: A delayed diagnosis of occult hip fractures was associated with increased rate of displacement and operation. In patients suspected of having occult hip fractures, additional studies should be recommended.

• 한방재활의학과학회지
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• 제32권2호
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• pp.95-103
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• 2022

Objectives This study was conducted to assess the effect of chuna manual therapy after hip arthroplasty. Methods We searched across 9 electronic databases (PubMed, Cochrane Library, Wangfang data, China National Knowledge Infrastructure [CNKI], Oriental Medicine Advanced Searching Integrated System [OASIS], National Digital Science Library [NDSL], Korean Medical Database [KMBASE], Koreanstudies Information Service System [KISS], Research Information Sharing Service [RISS]) to find randomized controlled clinical trials for chuna manual therapy after hip arthroplasty. Results On inclusion criteria, 11 appropriate studies were included and analyzed. The deep vein thrombosis incidence of the chuna manual therapy group was statistically lower than the conventional treatment group (p=0.0002). Chuna manual therapy significantly improved the Harris hip score compared with conventional treatment (p<0.00001). Also, chuna manual therapy combined with herbal fumigation therapy significantly elevated the hip joint function score of Harris hip score compared with the conventional therapy group (p<0.00001). Conclusions The systematic review showed that chuna manual therapy had significant effects on hip arthroplasty. Nonetheless, considering the high risk of bias and geographic bias, further research with well-designed studies is required to support the effectiveness of chuna manual therapy.

• 한국임상수의학회지
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• 제31권2호
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• pp.125-128
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• 2014

38 kg, 7년령의 골든리트리버가 대퇴관절 탈구증으로 의뢰되었다. 신체검사에서는 왼쪽 뒷다리를 신전시킬 때 통증과 염발음이 확인되었다. 방사선 검사를 통해 왼쪽 대퇴관절 탈구증 및 경도의 퇴행성 골변화가 관찰되었다. 치료로서 TightRope$^{(R)}$를 이용한 최소침습 관절경적 정복을 하였으나, 수술 후 한달이 지나 재탈구가 발생하였다. 이에 대해 무시멘트형 대퇴관절 전치환술을 실시하였다. 수술 후 10개월 경과된 결과, 환자는 정상적으로 앉기, 서기, 보행을 보였으며, 특이한 파행없이 편안하게 뛸 수 있었다. 수술한 뒷다리의 허벅지둘레는 반대쪽 다리의 그것에 비해 108.6%였다. 이 증례를 통해 대퇴관절 전치환술은 대퇴관절 정복이 실패하여 재탈구된 개의 대퇴관절 탈구 치료에 효과적인 수술법이 될 수 있다.

• 한방재활의학과학회지
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• 제28권4호
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• pp.113-124
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• 2018

This study is designed to report three cases of postoperative care after hip surgery using conventional Korean Medicine treatments including phototherapy. Three patients undergone hip fracture surgery were treated with acupuncture, herbal medicine, and phototherapy. We used Visual analogue scale (VAS), EuroQol five dimension scale (EQ-5D), and hip disability and osteoarthritis outcome score (HOOS) to evaluate treatment effectiveness. After the treatment, VAS score was improved in all three cases, while EQ-5D and HOOS showed different results by items. EQ-5D (pain/discomfort) and HOOS (pain, symptoms, activities of daily living) were improved in all three cases. EQ-5D (self-care) and HOOS (quality of life) showed improvements in two cases. EQ-5D (mobility, usual activities, anxiety/depression) and HOOS (sports/recreation) were improved in one case. Conventional Korean Medicine treatments including phototherapy can be effectively used to alleviate pain and symptoms after hip fracture surgery.

• 턱관절균형의학회지
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• 제9권1호
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• pp.12-17
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• 2019

Objectives: The purpose of this study is to report the effect of Postural Yinyang Correction of Temporomandibular Joint (Functional Cerebrospinal Therapy, FCST) on a patient with Osteoarthritis of the hip caused by Hip dysplasia and Lumbar spinal stenosis. Methods: A patient with Osteoarthritis of the hip caused by Hip dysplasia and Lumbar spinal stenosis was treated at Dept. of Acupuncture & Moxibustion, ○○ University Korean Medicine Hospital from Nov 8th, 2019 to Dec 6th, 2019 and received a Korean-Western medical treatment mainly managed with FCST. This study was measured with VAS (Visual Analogue Scale), ODI (Oswestry Disability Index) and questionnaire. Results: After treatment, the patient's pain was controlled and gait ability was improved, also VAS, ODI and questionnaire score were improved. Conclusions: Korean-Western Medical Treatment mainly managed with FCST may be helpful in controling pain with Osteoarthritis of the hip caused by Hip dysplasia and Lumbar spinal stenosis, but the further researches are needed.

• 한국주조공학회지
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• 제36권5호
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• pp.167-173
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• 2016

The effect of various types of heat-treatment on the mechanical properties of cast Alloy 718 has been investigated. Cast Alloy 718 bars were subjected to 'standard heat-treatment'_(SHT), 'HIP (Hot Isostatic Pressing) heat-treatment'_(HHT), and 'HIP-simulated heat-treatment'_(HS). In the absence of long time high temperature heat-treatment, a small amount of Laves phase remained in the 'SHT' specimen, and needle shaped ${\delta}$ precipitated in the vicinity of the Laves phase. Due to the formation of the Laves and ${\delta}$ phases in the 'SHT' specimen, it exhibited lower tensile properties than those of the others_specimens. On the other hand, the Laves phase was completely dissolved into the matrix after 'HHT' and 'HS' treatments. It is known that isostatic pressure reduces the self-diffusion coefficient, because of the lower self-diffusivity under HIP conditions in the interdendritic region, Nb segregation and the high amount of ${\gamma}^{{\prime}{\prime}}$ precipitation that occurs. Due to the higher fraction of coarse ${\gamma}^{{\prime}{\prime}}$ phases, the 'HHT' treated Alloy 718 showed excellent tensile strength.

• 한방재활의학과학회지
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• 제26권3호
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• pp.153-164
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• 2016

The objective of this study was to propose a rehabilitation protocol for total hip replacement in Korean medicine and to report its effectiveness. Three patients who had undergone total hip replacement were treated using the rehabilitation protocol in Korean medicine. We evaluated the outcome evaluating physical examination findings of the hip joint, numeric rating scale, pain disability index, Harris hip score, and walking state. After the treatment, we observed that hip movement and muscular strength improved. Moreover numeric rating scale, pain disability index, Harris hip score, and walking state of patients improved. A rehabilitation in Korean medicine can be effectively used for total hip replacement patients. The limitation of this study was the insufficient number of cases. Further studies are needed to design a rehabilitation protocol in Korean medicine.