• 한국운동역학회지
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• 제29권3호
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• pp.197-204
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• 2019

Objective: The purpose of this study was to identify the effect of high-heels (HH) modification on metatarsal stress in female workers. Method: Seven females who work in clothing stores ($heights=160.4{\pm}3.9cm$; $weights=47.4{\pm}4.1kg$; $age=31.3{\pm}11.1yrs$; $HH\;wear\;career=8{\pm}6.5yrs$) wore two types of HH (original and modified). The modified HH had been grooved with 1.5 cm radius and 0.2 cm depth around the first metatarsal area inside of the shoes using the modified shoe-last. Participants were asked to walk for 15 minutes on a treadmill and to stand for 10 minutes with original and modified HH, respectively. Kinetics data were collected by the F-scan in-shoe system. After each test, participants were asked to rate their perceived exertion using the Borg's 15-grade RPE scale and interviewed about their feeling of HH. Nonparametric Wilcoxon signed-rank test and effect size (Cohen's d) were used to determine the difference of the variables of interest between the original and modified HH. Results: In the present study, modified HH of the peak contact pressure of 1st metatarsal (PCP) left, PCP right, pressure time integral (PTI) left, peak pressure gradient (PPG) left during standing and PPG right during walking are greater than original HH. And even it didn't show statistically significant, the average in all pressure values of modified HH showed bigger than original HH. It surmised to be related to awkward with modified HH. Even though they said to feel the comfortable cause of big space inside of HH in the interview, they seemed to be not enough time to adapt with new HH. So their walking and standing postures were unstable. Conclusion: Modified the fore-medial part of HH can reduce the stress in the first metatarsal head and big toe area during standing and walking.

• 대한골관절종양학회지
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• 제13권2호
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• pp.67-74
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• 2007

목적: 골의 거대세포종양의 재발과 면역조직화학적 표지자와의 연관성을 연구하였다. 대상 및 방법: 골에서 유발된 거대세포종양 10례를 대상으로 하였다. 6명은 남자, 4명은 여자였다. 모든 환자는 수술 전 생검을 통해 확진 후 수술을 시행하였다. 방사선학적 분류는 Enneking grading system에 의하여 이루어졌다. 면역조직화학적 연구를 위해 MCM3, Ki-67 그리고 HH3 표지자가 사용되었다. 면역조직화학적 검사는 Microarray block을 사용하여 시행하였다. 결과: 10례 중 3례(30%)에서 같은 위치에서 재발되었다. 재발된 3례 중 2례는 방사선학적 단계 상 단계 2였고, 1례는 단계 1이었다. 면역조직화학적 표지자의 발현율이 방사선학적 단계 1보다 2, 3에서 증가되었다. 하지만 결과의 일관성이 없어 세포 증식율과 방사선학적 단계의 연관성은 판별하기 어렵다. 평균 MCM3 표지자의 발현율은 재발하지 않은 종양에서 11.2%, 재발한 종양에서 7.2%였다. Ki-67은 12%, 8.9% 였고, HH3는 66.9%, 75.4%였다. MCM3 와 Ki-67 표지자는 재발한 종양에서 오히려 감소된 결과를 보여 재발율과는 연관이 없을 것으로 생각된다. HH3표지자는 재발한 종양에서 증가된 소견을 보여 거대세포종양의 재발과 연관이 있음을 보여주었다. 결론: 본 연구는 면역조직화학적 표지자 중 HH3표지자가 거대세포종양의 재발 가능성을 판정하는데 기준이 될 수 있을 것으로 생각된다.

• 천문학회보
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• 제40권1호
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• pp.69.1-69.1
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• 2015

Classical T Tauri star DG Tau is suggested as the driving source of parsec-scale jet which expands up to 650" (0.4 pc). To investigate the kinematics and physical properties of the jet, we have obtained the optical emission lines of $H{\alpha}$, [O I] ${\lambda}{\lambda}$6300, 6363, [N II] ${\lambda}{\lambda}$6548,6584, and [S II] ${\lambda}{\lambda}$6716, 6731 from HH 158 ad HH 702. The radial velocity of HH 158 is in the range of -50 to $-250km\;s^{-1}$. For HH 702, located at 650" from the source, it shows ~ $-80km\;s^{-1}$. In HH 158, the electron density ($n_e$) close to the star is ${\sim}10^4cm^{-3}$ and it decreases to ${\sim}10^2cm^{-3}$ at 14" away from the star. Electron temperature ($T_e$) is decreasing from >15,000 K to ~5,000 K with distance. Ionization fraction ($x_e$) is increasing from almost zero to > 0.4 along the distance. In HH 702, the values of $n_e$, $T_e$, and $x_e$ are similar to those estimated at 14" from source, where knot C of HH 158 is located. This may imply that the physical properties of the knot could persist through such a long distance in the space, and the gas could be re-excited by the shock during propagation of the jet. On the other hand, we cannot avoid the possibility that HH 702 is driven by another source rather than DG Tau because HH 158 and HH 702 show somewhat large difference in their inclination angles (${\Delta}i=21-35^{\circ}$).

• 지역사회간호학회지
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• 제30권1호
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• pp.99-107
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• 2019

Purpose: This study aimed to assess hand hygiene (HH) compliance among visitors at a long-term care hospital in South Korea. Methods: The study was conducted at a 502-bed long-term care hospital located in Gyeonggi-do Province. From July 1 to August 15, 2017, including more than 6 weekends and one holiday, a trained observer covertly assessed visitors' HH at all five units (360 beds in total) of the study hospital building until the completion of 1,000 HH opportunities (i.e., 200 opportunities per unit). The modified World Health Organization (WHO) HH observation form was used. Instead of professional categories and the "before clean/aseptic procedure" moment, the estimated age range for each visitor were recorded in four categories: children (<14 years old), adolescents (14~18), adults (19~64), and the elderly (${\geq}65$). The collected data were analyzed using SPSS 22.0. Results: A total of 1,000 HH opportunities were observed from 766 visitors (an average of 1.31 per visitor) and the overall HH compliance rate was 20.3%. Overall, 53.7% of the HH cases were performed with soap and water. Among the 4 HH moments, the "after body fluid exposure risk" moment showed the highest compliance rate (83.5%); 93.9% used soap and water. The most commonly exposed potential body fluid among visitors was saliva (48.1%). Conclusion: For hospital visitors in long-term care hospitals, HH education programs including HH moments need to be developed and implemented. Further studies are necessary to evaluate visitors' HH compliance in various hospital settings and find the related variables influencing visitors' HH.

• Journal of Preventive Medicine and Public Health
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• 제51권3호
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• pp.121-129
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• 2018

Objectives: To assess the nurses' hand hygiene (HH) knowledge, perception, attitude, and self-reported performance in small- and medium-sized hospitals after Middle East Respiratory Syndrome outbreak. Methods: The structured questionnaire was adapted from the World Health Organization's survey. Data were collected between June 26 and July 14, 2017. Results: Nurses showed scores on knowledge ($17.6{\pm}2.5$), perception ($69.3{\pm}0.8$), self-reported HH performance of non-self ($86.0{\pm}11.0$), self-reported performance of self ($88.2{\pm}11.0$), and attitude ($50.5{\pm}5.5$). HH performance rate of non-self was $Y_1=36.678+0.555X_1$ (HH performance rate of self) (adjusted $R^2=0.280$, p<0.001). The regression model for performance was $Y_4=18.302+0.247X_{41}(peception)+0.232X_{42}(attitude)+0.875X_{42}(role model)$; coefficients were significant statistically except attitude, and this model significant statistically (adjusted $R^2=0.191$, p<0.001). Conclusions: Advanced HH education program would be developed and operated continuously. Perception, attitude, role model was found to be a significant predictors of HH performance of self. So these findings could be used in future HH promotion strategies for nurses.

• Perspectives in Nursing Science
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• 제12권1호
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• pp.7-13
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• 2015

Purpose: This observational study was aimed to determine the influence of the Hawthorne effect on the adherence to hand hygiene (HH) among healthcare workers (HCWs) in South Korea. Methods: HCWs were monitored in 2 periods regarding adherence to HH when there were indications for HH. In first period, HCWs recognized that their behavior of hand hygiene being observed (overt observation), and did not recognize in second period (covert observation). Results: The overall difference in HH rate between two periods was 45.0% point (77.8% vs 32.8%). There were significant differences between profession but in nurse aids. The differences in HH rate between two periods were 46.1% point in nurses, 29.9% point in physicians, 64.0% in radiologists, 62.5% point in laboratory technicians, 36.4% point in physio-therapist, and 1.0% point in nurse aids. The Hawthorne effect on the adherence to HH lasted more than 3 months. Conclusion: The Hawthorne effect markedly influence on the adherence to HH regardless of profession except nurse aids. Therefore, Hawthorne effect can be useful tool to improve and sustain the adherence to HH among HCWs in South Korea.

• 한국가금학회지
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• 제41권1호
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• pp.53-59
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• 2014

본 실험에서는 시중에서 주로 유통되고 있는 2종의 토종닭인 HH종과 WD종 닭고기를 비교하기 위해 일반 육계(BR)와 더불어 육질 및 관능 특성을 분석하였다. 토종닭 내에서 HH종의 가슴육만 일반 육계보다 다소 낮은 지방함량을 보였다. 육색에서는 가슴육과 다리육 두 부위 모두에서 HH종의 명도($L^*$)와 적색도($a^*$)가 WD종보다 유의적으로 높게 나타났다(p<0.05). 항산화력 측정을 위한 DPPH 라디칼 소거능과 pH가 WD종이 HH종보다 유의적으로 높았다(p< 0.05). 가슴육에서 C18:1은 일반 육계가 다른 두 품종의 토종닭보다 유의적으로 높았다(p<0.05). 대표적인 n-3 지방산인 C18:3의 경우, WD종이 HH종보다 유의적으로 높았으며(p<0.05), C20:4와 C22:6의 경우, 토종닭이 일반 육계에 비해 약 2.5배이상 높은 조성을 보였다(p<0.05). 관능평가 맛 부분에서는 가슴육에서 WD종이 일반 육계나 다른 HH 토종닭보다 유의적으로 우수한 수치를 보였다(p<0.05). 특히 WD종의 연도가 다른 품종에 비해 매우 우수한 것으로 나타났으며(p<0.05), 전체적인 기호도에서도 WD종이 유의적으로 높은 점수를 보였다(p<0.05). 국내에서 대표적으로 시판되는 토종닭 2품종의 품질 및 관능 특성은 요인별로 유의적 차이를 보이기도 했으며(p<0.05), 이를 바탕으로 소비자 기호에 적합한 새로운 품종의 토종닭 개발을 위한 기초 자료 활용이 가능할 것이다. 그러나 육질 특성은 품종 이외에도 급여한 사료 및 사양 방식에 따라 다른 것이므로, 보다 많은 시료 수를 바탕으로 한 추가적인 연구가 요구된다.

• 대한화장품학회지
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• 제37권3호
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• pp.199-210
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• 2011

본 연구는 항염증 효능을 가지는 한방처방제 휘발성 향기추출물을 이용하여 염증질환 치료 한방화장품 기능성 소재를 개발하고자 하였다. 먼저 전보에서 항염증 효능이 있는 것으로 알려진 천궁, 당귀, 박하 및 애엽을 비롯하여 5가지 생약(적작약, 숙지황, 황금, 인삼 및 감초)으로 구성된 4가지 한방처방제(HH-1: 천궁, 당귀, 적작약, 숙지황, HH-2: 천궁, 당귀, 적작약, 숙지황, 황금, 인삼, 감초, HH-3: 천궁, 당귀, 박하, 애엽, HH-4: 천궁, 당귀, 박하, 애엽, 황금, 인삼, 감초)를 선정한 후 연속수증기증류법(simultaneous steam distillation extraction, SDE)을 이용하여 추출한 휘발성 향기추출물의 항산화 및 항염증 활성을 1,1-diphenyl-2-picrylhydrazyl (DPPH) 및 soybean lipoxygenase (SLO)를 이용하여 각각 측정한 결과, HH-2가 다소 높은 항산화 활성뿐 아니라 SLO 저해활성이 가장 높게 나타났다. 따라서 항염증 활성이 강한 HH-2의 항염증 효능을 보다 상세하게 확인하기 위해 lipopolysaccharide (LPS) 유발한 RAW 264.7 세포를 이용하여 염증 유발매개인자인 nitric oxide (NO)와 prostaglandin $E_2$ ($PGE_2$) 및 interleukin-6 (IL-6) 생성 억제효과를 측정한 결과, HH-2가 강한 NO 생성 억제 효과뿐 아니라 $PGE_2$ 및 IL-6를 강하게 억제하여 우수한 항염증 활성을 나타내었다. 항염증 활성이 높은 HH-2의 휘발성향기성분을 GC-MS로 분석한 결과, eugenol, paeonol, butyl phthalide, ${\beta}$-eudesmol 및 butylidene dihydrophthalide로 확인되었다. 이러한 연구결과로부터 항산화뿐만 아니라 항염증활성이 높은 HH-2를 피부노화 및 염증질환 치료용 한방화장품의 기능성 소재 개발 가능성을 확인하였다.

• Journal of Microbiology
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• 제38권3호
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• pp.160-168
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• 2000

A-factor I a microbial hormone that can positively control cell differentiation leading to spore formation and secondary metabolite formation in Streptomyces griseus. to identify a protease that is deeply involved in the morphological and physiological differentiation of Streptomyces, the proteases produced by Streptomyces griseus IFO 13350 and its A-factor deficient mutant strain, Streptomyces griseus HH1, as well as Streptomyces griseus HH1 transformed with the afsA gene were sturdied. In general Streptomyces griseus showed a higher degree of cell growth and protease activity in proportion to its ability to produce a higher amount of A-factor. In particular, the specific activity of the trypsin of Streptomyces griseus IFO 13350 was greatly enhanced more than twice compared with that of Streptomyces griseus HH1 in the later stage of growth. The specific activity of the metalloprotease of Streptomyces griseus HH1 was greatly enhanced more than twice compared with that of Streptomyces griseus IFO 13350, and this observation was reversed in the presence of thiostreptione, However, Streptomyces griseus HH1 transformed with the afsA gene showed a significantly decreased level of trypsin and metalloprotease activity compared with that of the HH1 strain. There was no significant difference between Streptomyces griseus IFO 13350 and HH1 strain in their chymotrypsin and thiol protease activity, yet the level of leu-amionpeptidase activity was 2 times higher in Streptomyces griseus HH1 than in strain IFO 13350 . Streptomyces griseus HH1 harboring afsA showed a similar level of enzyme activity , however, all the three protease activities sharply increased and the thiol protease activity was critically increased at the end of the fermentation. When a serine protease inhibitor, pefabloc SC, and metalloprotease inhibitor, EDTA, were applied to strain IFO 13350 to examine the in vivo effects of the protease inhibitors on the morpholofical differentiation, the formation of aerial meycelium and spores was delayed by two or three days.

• 한국산학기술학회논문지
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• 제16권9호
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• pp.6160-6168
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• 2015

의료기관 종사자의 손 위생 수행은 의료관련 감염의 전파를 예방하는 가장 효과적인 방법이다. 본 연구는 직종별 손 위생 수행 측정과 분석을 위해 세계보건기구(WHO)의 손 위생 수행 평가도구를 이용한 직접관찰방법으로 2010년 10월 25일부터 12월 31일까지 수행되었으며, SPSS 21.0으로 기술분석, 교차분석, 다중로지스틱분석을 하였다. 총 8,644 건의 손 위생 상황이 관찰되었고, 손 위생 수행률은 94.1%였으며 의사가 가장 낮았다(83.3%; OR:0.209, 95%CI:0.174-0.252). 직종별 수행률(p<0.001), WHO에서 권고하는 5개 상황(WHO's 5Moments)별 수행률은(p<0.001) 유의한 차이를 보였으며, 간호사(p=0.003)와 의료기사직(p<0.001)이었다. 본 연구결과 손 위생 수행률 향상을 위한 직종별 특성화된 손 위생 전략과 WHO's 5Moments에 따라 차별화된 전략 개발이 필요할 것으로 사료된다.