Browse > Article
http://dx.doi.org/10.15230/SCSK.2011.37.3.199

Anti-Inflammatory Effects of Volatile Flavor Extract from Herbal Medicinal Prescriptions Including Cnidium officinale Makino and Angelica gigas Nakai  

Leem, Hyun-Hee (Department of Food Science and Nnutrition, Catholic University of Daegu)
Kim, Eun-Ok (Department of Food Science and Nnutrition, Catholic University of Daegu)
Seo, Mi-Jae (Skylake, Co.)
Choi, Sang-Won (Department of Food Science and Nnutrition, Catholic University of Daegu)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.37, no.3, 2011 , pp. 199-210 More about this Journal
Abstract
This study was conducted to develop functional sources of herbal cosmetics for treatment of skin aging and inflammatory disorders using volatile flavor extracts of four different herbal medicinal prescriptions including Cnidium officinale Makino (COM), Angelica gigas Nakai (AGN), Mentha arvense L. (MAL), Artemisiae argyi Folium (AAF), Paeonia lactiflora Pall (PLP), Rehmanniae Radix Preparata (RRP), Scutellaria baicalensis Georgi (SBG), Panax ginseng C.A. Meyer (PGM), Glycyrrhiza uralensis Fisch (GUF). The volatile flavor extracts of four different herbal medicinal prescriptions (HH-1: COM, AGN, PLP, RRP, HH-2: COM, AGN, PLP, RRP, SBG, PGM, GUF, HH-3: COM, AGN, MAL, AAF, HH-4: COM, AGN, MAL, AAF, SBG, PGM, GUF) were extracted using SDE and their antioxidant and anti-inflammatory effects were measured by using DPPH radical and SLO, respectively. As a result, HH-2 showed moderate DPPH radical scavenging activity (68.24 %) and the strongest SLO inhibitory activity (83.96 %) at 100 ${\mu}g$/mL. Moreover, HH-2 of four different prescriptions significantly inhibited NO production on LPS-stimulated RAW 264.7 cells in a dose-dependent manner without considerable cell cytotoxicity at range of 2.0 ~ 50 ${\mu}g$/mL. Additionally, HH-2 also effectively suppressed the production of $PGE_2$ and IL-6, which are responsible for promoting the inflammatory process. Major volatile components of HH-2 were identified as eugenol, paeonol, butyl phthalide, ${\beta}$-eudesmol and butylidene dihydrophthalide by GC-MS analysis. Thus, these results suggest that HH-2 may be useful as a potential source of anti-inflammatory agents in herbal medicinal cosmetics.
Keywords
Cnidium officinale Makino; Angelica gigas Nakai; four different herbal medicinal prescriptions; volatile flavor extract; anti-inflammatory;
Citations & Related Records
Times Cited By KSCI : 17  (Citation Analysis)
연도 인용수 순위
1 M. R. Kim, A. M. A. El-Aty, J. H. Choi, K. B. Lee, and J. H. Shim, Identification of volatile components in Angelica species using supercritical-CO2 fluid extraction and solid phase microextraction coupled to gas chromatography-mass spectometry, Biomed. Chromatogr., 20, 1267 (2006).   DOI   ScienceOn
2 H. J. Park and M. Y. Choi, In vitro antiinflammatory activity of paeonol from the essential oil and its derivative methylpaeonol, Kor. J. Pharmacogn., 36(2), 116 (2005).
3 H. H. Leem, E. O. Kim, and S. W. Choi, Antioxidant and anti-inflammatory activity of eugenol derivatives of clove(Eugenia caryophyllata Thunb.), J. Korean Sco. Food Sci. Nutr., 2011 (in print).
4 M. Yamashita, Analysis of the mechanism for the anti-inflammatory effect of the anti-rheumatic drug auranofin, Yakugaku Zasshi., 120(3), 265 (2000).   DOI
5 M. Ramalingam and P. Yong-Ki, Free radical scavenging activities of Cinidium officinale Makino and Ligusticum chuanxiong Hort. methanolic extracts, Pharmacogn. Mag., 6(24), 323 (2010).   DOI   ScienceOn
6 H. Yoshigi, Physiological activity of essential oils, Fragrance J., 6, 88 (1986).
7 J. M. Jeong, Antioxidative and antiallergic effects of Aronia (Aronia melanocarpa) extract, J. Korean Soc. Food Sci. Nutr., 37(9), 1109 (2008).   DOI
8 M. Tagashira and Y. Ohtake, A new antioxidative 1,3-benzo-dioxole from Melisa offocinalis, Planta Med., 64, 555 (1988).
9 T. H. Schultz, R. A. Flath, T. R. Mon, S. B. Eggling, and R. Teranishi, Isolation of volatile components from a model system, J. Agric. Food Chem., 25, 446 (1977).   DOI
10 E. S. Sehagen, F. Abbrahansom, and W. Mclafferty, The Wiley/NBS registry of mass spectral data, John Wiley and Sons, NY, USA (1974).
11 E. Block, R. Iyer, S. Grisoni, C. Saha, S. Belman, and P. Lossing, Lipoxygenase inhibitors from the essential oil of gaic. Markovnikov addition of the allydithio radical to olefins, J. Am. Chem. Soc., 110, 7813 (1988).   DOI   ScienceOn
12 D. S. Bredt and S. H. Snyder, Nitric oxide: a physiologic messenger molecule, Ann. Rev. Biochem., 63, 175 (1994).   DOI   ScienceOn
13 L. C. Green, D. A. Wagner, J. Glogowski, P. L. Skipper, J. S. Wishnok, and S. R. Tannenbaum, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal. Biochem., 126, 131 (1982).   DOI   ScienceOn
14 H. M. Kim, J. S. Kang, S. K. Park, K. Lee, J. Y. Kim, Y. J. Kim, J. T. Hong, Y. Kim, and S. B. Han, Antidiabetic activity of angelan isolated from Angelica gigas Nakai, Arch. Pharm. Res., 31, 1489 (2008).   DOI
15 SAS Institute, Inc. SAS User's statistical analysis system institute, Cary, NC, USA, (1985).
16 K. W. Park, S. R. Choi, M. Y. Shon, I. Y. Jeong, K. S. Kang, S. T. Lee, K. H. Shim, and K. I. Seo, Cytotoxic effects of decursin from Angelica gigas NaKai in human cancer cells, J. Korean. Soc. Food Sci. Nutr., 36, 1385 (2007).   DOI
17 S. Shin, J. H. Jeon, D. Park, J. Y. Jang, S. S. Joo, B. Y. Hwang, S. Y. Choe, and Y. B. Kim, Anti-inflammatory effects of and ethanol extract of Angelica gigas in a carrageenan-airpouch inflammation model, Exp. Anim., 58, 431 (2009).   DOI   ScienceOn
18 H. H. Leem, Y. J. Lee, E. O. Kim, W. J. Lee, M. J. Seo, and S. W. Choi, Anti-inflammatory activity of volatile extract of Cnidium officinale and Angelica gigas, Annual Meeting of Korean Society of Food Sci & Technology, Daegu, P11-140 (2011).
19 G. S. Kim, C. G. Park, T. S. Jeong, S. W. Cha, N. I. Baek, and K. S. Song, ACAT(Acyl-CoA:cholesterol acyltransferase) inhibitory effect and quantification of pyranocurmarin in different parts of Angelica gigas Nakai, J. Appl. Biol. Chem., 52(4), 187 (2009).   DOI
20 M, Kubo and A, Yoshikawa, Herbal medicine ․ crude drug, Hirokawa Publishing Co., Tokyo, Japan (2003).
21 M. Konoshima, H. J. Chi, and K. Hata, Coumarins from the root of Angelica gigas Nakai, Chem. pharm. Bull., 16, 1139 (1968).   DOI   ScienceOn
22 S. Y. Kang and Y. C. Kim, Neuroprotective coumarins from the root of Angelica gigas: structure- activity relationships, Arch. Pharm. Res., 30, 1368 (2007).   DOI
23 S. H. Kim and I. C. Kim, Antioxidant properties and whitening effects of the Eucommiae cortex, Salviae miltiorrhizae Radix, Aurantii nobilis pericarpium and Cnidii rhizoma, J. East Asian Soc. Dietary Life, 18(4), 618 (2008).
24 S. B. Han, Y. H. Kim, C. W. Lee, S. M. Park, H. Y. Lee, K. S. Ahn, I. H. Kim, and H. M. Kim, Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai, Immunopharmacol., 40, 39 (1998).   DOI   ScienceOn
25 S. A. Kang, J. A. Han, K. H. Jang, and R. W. Choue, DPPH radical scavenger activity and antioxidant effects of Cham-Dang-Gui(Angilica gigas), J. Korean Soc. Food Sci. Nutr., 33, 1112 (2004).   DOI
26 K. S. Nam, O. L. Son, K. H. Lee, H. J. Cho, and Y. H. Shon, Effect of Cnidii rhizoma on proliferation of breast cancer cell, nitric oxide production and ornithine decarboxylase activity, Kor. J. Pharmacogn., 35(4), 283 (2004).
27 J. H. Lee, H. S. Choi, M. S. Chung, and M. S. Lee, Volatile flavor components and free radical scavenging activity of Cnidium officinale, Korean J. Food Sci. Technol., 34(2), 330 (2002).
28 Y. P. Cheon, M. L. Mollah, C. H. Park, J. H. Hong, G. D. Lee, J. C. Song, and K. S. Kim, Inhibition effects of water extract of Bulnesia sarmienti on inflammatory responce in LPS-induced RAW 264.7 cell line, J. Life Science, 19, 479 (2009).   DOI
29 Y. Y. Lee, S. H. Lee, J. L. Jin, and H. S. Yun-Choi, Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas, Arch. Pharm. Res., 26(9), 723 (2003).   DOI
30 D. E. Lee, J. R. Lee, T. W. Kim, Y. K. Kwon, S. H. Byun, S. W. Shin, S. I. Suh, T. K. Kwon, J. S. Byun, and S. C. Kim, Inhibition of lipopolysaccharide- inducible nitric oxide synthase, TNF-$\alpha$, IL-1$\beta$ and COX-2 expression by flower and whole plant of Lonicera japonica, Korean J. Oriental Physiology & Pathology, 19, 481 (2005).
31 M. K. Yoon, A. Choi, I. H. Cho, M. J. You, J. W. Kim, M. S. Cho, J. M. Lee, and Y. S. Kim, Characterization of volatile components in Eoyuk-jang, Korean J. Food Sci. Technol., 39(4), 366 (2007).
32 M. K. Yoon, M. J. Kwon, S. M. Lee, J. W. Kim, M. S. Cho, J. M. Lee, and Y. S. Kim, Characterization of volatile components according to fermentation periods in Gamdongchotmoo Kimchi, Korean J. Food Sci. Technol., 40(5), 497 (2008).
33 G. A. Reineccius, Flavour-isolation techniques. In flavours and fragrances: Chemistry, bioprocessing and sustainability, berger RG, ed., 409, Springer-Verlag, Heidelberg (2007).
34 M. Higuchi, N. Higashi, H. Taki, and T. Osawa, Cytolytic mechanism of activated macrophages. tumor necrosis factor and L-arginine dependent mechanism acts as synergistically as the major cytolytic mechanism of activated macrophages, J. Immunol., 144, 1425 (1990).
35 K. S. Yun, J. H. Hong, and Y. H. Choi, Characteristics of Elsholtzia splendens extracts on simultaneous steam distillation extraction conditions, Korean J. Food Preserv., 13, 623 (2006).
36 J. G. Lee, H. J. Jang, J. J. Kwang, and D. W. Lee, Comparison of the volatile components of Korean ginger (Zingiber Officinale Roscoe) by different extraction methods, Korean J. Food Nutr., 13, 66 (2000).
37 C. L. Arthur, L. M. Killam, K. D. Buchholz, J. Pawliszyn, and J. R. Berg, Automation and aptimization of solid-phase microextraction, Anal. Chem., 64, 1960 (1992).   DOI
38 S. S. Jew, O. N. Bae, and J. H. Chung, Anti-inflammatory effects of asiaticoside on inducible nitric oxide synthase and cyclooxygenase-2 in RAW 264.7 cell line, J. Toxicol. Pub. Health, 19, 33 (2003).