• Asian-Australasian Journal of Animal Sciences
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• 제20권5호
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• pp.622-626
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• 2007

Using multi-trait animal model BLUP, selection was conducted over seven generations for growth rate (DG), real-time ultrasound loin-eye muscle area (LEA), backfat thickness (BF), and intramuscular fat content (IMF) to develop a new line of purebred Duroc pigs with enhanced meat production and meat quality. This study was intended to investigate the relationship between restriction fragment length polymorphism (RFLP) of a heart fatty acid-binding protein (H-FABP) gene and intramuscular fat content (IMF) of this Duroc purebred population. The present experiment examined the RFLP of 499 slaughtered pigs. The DNA was separated from the blood or ear tissue of the pigs, which were slaughtered at 105 kg of body weight. Intramuscular fat content of the longissimus muscle was measured using chemical analysis. A significant difference was detected in the breeding value of IMF among the H-FABP PCR RFLP genotypes. The AA genotype has a significantly larger positive effect on the IMF breeding value than do the Aa and aa genotypes for the MspI RFLP. In addition, the DD genotype has a significantly greater positive effect on IMF breeding value than the Dd and dd genotypes for the HaeIII RFLP. For the HinfI RFLP, the hh genotype has a significantly larger positive effect on IMF breeding value than the HH genotype. Multiple regression analysis was performed using the IMF breeding values as the dependent variable and the three H-FABP genotypes as independent variables. Results revealed that the contribution of the genotypes to variation in IMF breeding values was approximately 40%. These results demonstrated that H-FABP RFLPs affect IMF in this Duroc population.

• The Korean Journal of Physiology and Pharmacology
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• 제18권4호
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• pp.313-320
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• 2014

The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control), high altitude hypoxia (HH), and high altitude hypoxia + vitamin E (250 mg/kg $BW^*d$) (HV) groups. After the third day, the HH and HV groups were placed in a hypobaric chamber at a stimulated elevation of 7000 m for 5 days. The rats in the HV group were given vitamin E by gavage daily for 8 days. The other rats were given equal volume saline. The results showed that high altitude hypoxia caused the enlargement of heart, liver, lung and kidney, and intestinal villi damage. Supplementation with vitamin E significantly alleviated hypoxia-caused damage to the main organs including intestine, increased the serum superoxide dismutase (SOD) (p< 0.05), diamino oxidase (DAO) (p< 0.01) levels, and decreased the serum levels of interleukin-2 (IL-2) (p< 0.01), interleukin-4 (IL-4) (p<0.001), interferon-gamma ($IFN-{\gamma}$) (p<0.01) and malondialdehyde (MDA) (p<0.001), and decreased the serum erythropoietin (EPO) activity (p<0.05). Administration of vitamin E significantly increased the S-IgA (p<0.001) in ileum and significantly improved the expression levels of occludin and $I{\kappa}B{\alpha}$, and decreased the expression levels of hypoxia-inducible factor 1 alpha and 2 alpha ($HIF-1{\alpha}$ and $HIF-2{\alpha}$), Toll-like receptors (TLR4), P-$I{\kappa}B{\alpha}$ and nuclear factor-${\kappa}B$ p65(NF-${\kappa}B$ P65) in ileum compared to the HH group. This study suggested that vitamin E protectis from intestinal injury caused by high altitude hypoxia environment. These effects may be related to the HIF and TLR4/NF-${\kappa}B$ signaling pathway.

• 한국환경생태학회지
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• 제25권1호
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• pp.57-64
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• 2011

신평천 인공습지 조성 후 3년간의 식생 및 생활형 변화 연구를 위하여 2005년 6월부터 2007년 9월까지 현지조사를 실시하였다. 2004년에 조성된 신평천 인공습지의 식재종은 14과 18속 15종 5변종으로 총 20종류가 식재되었다. 식재종의 생활형 구성비는 전체의 65%인 대부분을 다년생이 차지하고 있으며 목본류는 물푸레나무와 왕버들, 동백나무, 남천 4종류가 식재되었다. 3년간의 조사 기간 동안 생활형의 변화는 수생식물(HH)이 가장 많은 비율을 차지하며 증가하였고 소형지상식물(M), 대형지상식물(MM), 지표식물(Ch), 미소지상식물(N), 다년생식물(H)과 지표식물(Ch) 등도 증가하였다. 식생면적 변화는 애기부들, 달뿌리풀, 갈대 등은 군락면적이 증가하였으나, 다른 식재종의 면적은 급격히 감소하였다. 생활형 면적변화를 살펴보면 수생식물(HH), 1년생 수습식물(Th(w))은 점차 증가하였으며 소형지상식물(M), 지중식물(G), 미소지상식물(N) 등은 감소를 보였다. 결론적으로 식재 식물의 선정은 인공습지의 미래를 결정하는 중요한 요인이며 습지 조성 후 정착된 식물상의 파악 및 이들 식물들의 생활형을 분석하여 인공습지 초기정착에 유리한 종, 천이가 진행되면서 습지의 안정화 및 다양성을 유도하는 종을 선정하는 것은 매우 중요하다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2001년도 추계학술대회논문집 II
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• pp.922-926
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• 2001

This paper deals with sensing ability of smart sensor that has a sensing ability to distinguish materials according to frequency changing. We have developed a new signal processing method that can distinguish among different materials. The smart sensor was developed for recognition of materials. We estimated the sensing ability of smart sensor with the $R_{SAI}$ method according to frequency changing. Experiments and analysis were executed to estimate the ability to recognize objects according to frequency changing. Sensing ability of smart sensors was evaluated relatively through a new $R_{SAI}$ method. Applications of smart sensors are for finding abnormal conditions of objects (auto-manufacturing), feeling of objects (medical product), robotics, safety diagnosis of structure, etc.etc.

• 한국환경복원기술학회지
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• 제25권1호
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• pp.41-55
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• 2022

Social interest in the fine particulate matter has increased significantly since the 2010s, and various efforts have been made to reduce it through environmental plans and policies. To support such environmental planning, in this study, spatial cluster characteristics of fine particulate matter (PM2.5) concentrations were analyzed in the metropolitan area to identify high-risk areas spatially, and the correlation with local environmental characteristics was also confirmed. The PM2.5 concentration for the recent 5 years (2016-2020) was targeted, and representative spatial statistical methods Getis-Ord Gi^* and Local Moran's I were applied. As a result of the analysis, the cluster form was different in Getis-Ord Gi^* and Local Moran's I, but they show high similarity in direction, therefore complementary results could be obtained. In the high concentration period, the hotspot concentration of the Getis-Ord Gi* method increased, but in Local Moran's I, the HH region, the high concentration cluster, showed a decreasing trend. Hotspots of the Getis-Ord Gi^* technique were prominent in the Pyeongtaek-Hwaseong and Yeoju-Icheon regions, and the HH cluster of Local Moran's I was located in the southwest, and the LL cluster was located in the northeast. As in the case of the metropolitan area, in the results of Seoul, there was a phenomenon of division between the northeast and southwest regions. The PM2.5 concentration showed a high correlation with the elevation, vegetation greenness and the industrial area ratio. During the high concentration period, the relation with vegetation greenness increased, and the elevation and industrial area ratio increased in the case of the annual average. This suggests that the function of vegetation can be maximized at a high concentration period, and the influence of topography and industrial areas is large on average. This characteristic was also confirmed in the basic statistics for each major cluster. The spatial clustering characteristics of PM2.5 can be considered in the national land and environmental plan at the metropolitan level. In particular, it will be effective to utilize the clustering characteristics based on the annual average concentration, which contributes to domestic emissions.

• Reproductive and Developmental Biology
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• 제30권2호
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• pp.143-156
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• 2006

Major characteristics of embryonic stem cells (ESCs) are sustaining of sternness and pluripotency by self-renewal. In this report, transcriptional profiles of the molecules in the developmentally important signaling pathways including Wnt, BMP4, $TGF-\beta$, RTK, Hh, Notch, and JAK/STAT signaling pathways were investigated to understand the self-renewal of mouse ESCs (mESCs), J1 line, and compared with the NIH3T3 cell line and mouse embryonic fibroblast (MEF) cells as controls. In the Wnt signaling pathway, the expression of Wnt3 was seen widely in mESCs, suggesting that the ligand may be an important regulator for self-renewal in mESCs. In the Hh signaling pathway, the expression of Gli and N-myc were observed extensively in mESCs, whereas the expression levels of in a Shh was low, suggesting that intracellular molecules may be essential for the self-renewal of mESCs. IGF-I, IGF-II, IGF-IR and IGF-IIR of RTK signaling showed a lower expression in mESCs, these molecules related to embryo development may be restrained in mESCs. The expression levels of the Delta and HESS in Notch signaling were enriched in mESCs. The expression of the molecules related to BMP and JAK-STAT signaling pathways were similar or at a slightly lower level in mESCs compared to those in MEF and NIH3T3 cells. It is suggested that the observed differences in gene expression profiles among the signaling pathways may contribute to the self-renewal and differentiation of mESCs in a signaling-specific manner.

• 대한음성학회지:말소리
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• 제21_24호
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• pp.43-89
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• 1992

In this thesis, the prominent aspect of word accent in standard Korean is studied by auditory test and acoustic analysis experiment. The definition of 'accent' is, following Hoyoung Lee's discussion(1990), to be described as 'the means whereby a focused part of an utterance is made to stand out in order to concentrate the hearer's attention on it.' That is to say, the ten of 'accent' may be described in terms of phonological phenomenon and the accented syllable can be phonetically prominent as the result of those phonological process. Prosodic features may have different characteristics in different languages whether they contain linguistically important functions or not. Thus the characteristics of word accent in standard Korean will be determined as the content and trait of prosodic features. Following this viewpoint, present study looked over prosodic features which may effect the characteristics of word accent in standard Korean, through systematic experimental procedure. And the result of this experiment has been verified by statistical method, the T-test, for the purpose of identifying the relatedness among prosodic features(parameters). This thesis, therefore, aimed to investigate the intrinsic acoustic and physical qualities of the word accent in standard Korean. Nonsense words composed by 'mal' and 'ma' which can be divided into 'heavy syllable' and 'light syllable' quoted from Hyman(1975) have been classified into 28 types with respect to syllable numbers(2 syl., 3 sy1., 4 syl.) and these words have become the target of auditory test and acoustic experiment. As the result of those experimental Procedures, the word accent in standard Korean may be said that it has a tendency of fixing first two syllables regardless of syllable numbers. The syllable types of HH, HL, LL in the first two syllables may be prominent at first syllable and the type of H may be at second syllable. Various prosodic features(parameters) including duration, intensity, and Fo(purely phonetic terms) were also strengthened in those positions. The result of this experiment can be cleared up like these : 1. The most important feature is proved as 'duration', the feature of intensity resulted in more subsidiary one than the feature of duration. 2. Fo( fundamental frequency) could be observed as having some coherent contour through almost all syllable types(99 ％), that is, in 2 syllable types, it had rising contour, in 2 syllable types, rising-falling contour, and in 4 syllable types, it contained rising-falling-rising contour. The result of auditory test was different with those contour forms of all Fo surveyed. With respect to these results, the discuss for Fo is determined' to be excluded comparing other features. 3. Finally, this thesis resulted in a decision that the word accent in standard Korean may has fixed(somewhat weaker) accent, especially fixed at first two syllables in almost all words. 4. Various kinds of syllable types related with 2,3,4 syllables, therefore, can be reclassified into 4 types of HH, HL, LH, LL following the concept of accent fixing placement(i.e. first two syllables). In these 4 types, the types of HH, HL, LL were prominent at the position of the first syllable , and the type of LH was prominent at the second syllable otherwise.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.426-426
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• 2012

본 연구에서는 GaAs p-i-n 접합 구조에 InAs 양자점을 삽입한 양자점 태양전지(Quantum Dot Solar Cell; QDSC)의 내부 전기장(internal electric field)을 조사하기 위하여 Photoreflectance (PR) 방법을 이용하였다. QDSC 구조는 GaAs p-i-n 구조의 공핍층 내에 8주기의 InAs 양자점 층을 삽입하였으며 각 양자점 층은 40 nm 두께의 i-GaAs로 분리하였다. InAs/GaAs QDSC는 분자선박막 성장장치(molecular beam epitaxy; MBE)를 이용하여 성장하였다. 이 때 양자점의 형성은 InAs 2.0 ML(monolayer)를 기판온도 $470^{\circ}C$에서 증착하였다. QDSC 구조에서 여기광원의 세기에 따른 전기장의 변화를 조사하였다. 아울러 양자점 층 사이의 i-GaAs 층 내에 6.0 nm의 AlGaAs 퍼텐셜 장벽(potential barrier)을 삽입하여 퍼텐셜 장벽 유무에 따른 전기장 변화를 조사하였다. PR 측정에서 여기광원으로는 633 nm의 He-Ne 레이저를 이용하였으며 여기광의 세기는 $2mW/cm^2$에서 $90mW/cm^2$까지 변화를 주어 여기광세기 의존성실험을 수행하였다. 여기광의 세기가 증가할수록 photovoltaic effect에 의한 내부 전기장의 변화를 관측할 수 있었다. PR 결과로부터 p-i-n 구조의 p-i 영역과 i-n 접합 계면의 junction field를 검출하였다. p-i-n의 i-영역에 양자점을 삽입한 경우 PR 신호에서 Franz-Keldysh oscillation (FKO)의 주파수가 p-i-n 구조와 비교하여 변조됨을 관측하였다. 이러한 FKO 주파수성분은 fast Fourier transform (FFT)을 이용하여 검출하였다. FKO의 주파수 성분들은 고전기장하에서 electron-heavyhole (e-hh)과 electron-lighthole (e-lh) 전이에 의해 나타나는 성분으로 확인되었다.

• 대한한의학회지
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• 제29권4호
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• pp.68-82
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• 2008

Objective: The purpose of our study was to show the effects of Hwalhyulmaksung-bang (Huoxiemoxing-fang, HHMSB) treatment on cBSA-induced in MN Mouse Model. Methods: We divided the 20 mice into 4 groups. One group, named NR, was not treated. The second group, named CT, was treated with cBSA (7mg/kg i.p) only. The third group, named HH-250, was treated with cBSA (7mg/kg i.p) and HHMSB extract (250mg/kg, p.o). The fourth group, named HH-500, was treated with cBSA (7mg/kg i.p) and HHMSB extract (500mg/kg, p.o). 4 weeks after cBSA, proteinuria, serum albumin, total cholesterol, serum creatinine, BUN, total cell number of spleen and kidney of all groups were measured. CD3e+/CD19+ and CD4+/CD8 cells ratio of peripheral blood, kidney and spleen of all groups were analyzed. $IL-1{\beta}$ and TNF-$\alpha$, IL-6, IgG, IgM, and IFN-$\gamma$ levels of all groups were gauged. Histological analysis of kidney tissue and immunohistochemical staining (CD4, CD8) of kidney were observed. Results: The level of proteinuria significantly decreased and serum albumin increased in the group treated with cBSA and HHMSB extract compared with the control. Total cholesterol decreased but not significantly. CD3e+/CD19cells ratio of peripheral blood is decreased, but CD4+/CD8cells ratio has no significancy. CD3e+/CD19+ and CD4+/CD8 cells percentage of kidney and spleen has no significancy. Level of $IL-1{\beta}$, IL-6 is significantly decreased, and IFN-$\gamma$ is significantly increased on HHMSB compared with control. Total IgG level significantly decreased on HHMSB compared with the control. Thickness of GBM decreased on histological analysis of kidney. Deposition of CD4 and CD8 decreased on immunohistochemical staining of kidney. Conclusions: We conclude that Hwalhyulmaksung-bang treatment may could be a useful remedy agents for treating Membranous Neuropathy(MN) induced by cationized bovine serum albumin.

• 한국초등과학교육학회지:초등과학교육
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• 제39권3호
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• pp.382-398
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• 2020

This study aims to analyze the relationship between scientific content knowledge of science-gifted elementary students and their expression of scientific creativity, and the characteristics of divided groups according to the levels of their scientific content knowledge and scientific creativity. A science-gifted program was implemented to 33 forth-graders in the Science-Gifted Education Center of an education office in Seoul, Korea. The method of evaluating scientific knowledge was divided into well-structured paper-pencil test (asking specific and limited range of content knowledge of plants) and ill-structured descriptive test (stating all the knowledge they know about plants) to find out which methods were more related to scientific creativity. In addition, in order to find out the characteristics of each group according to the level of scientific content knowledge and scientific creativity, students were required to answer a questionnaire about their own self-perception of scientific knowledge and scientific creativity and how to obtain scientific knowledge. The main results of this study are as follows. First, Both well-structured paper-pencil test (r=.38) and ill-structured descriptive test (r=.51) results of elementary science gifted students were significantly correlated with scientific creativity. Second, As a result of the regression analysis on scientific creativity of science-gifted elementary students, both the knowledge measured by the two evaluation methods have the ability to explain scientific creativity. Third, the students were categorized into four groups according to the levels of their scientific content knowledge and their expression of scientific creativity, and the result showed that the higher the knowledge of science, the higher the scientific creativity. Fourth, the description about self-perception of scientific knowledge revealed that the highest percentage of Type LL students of all 13 students (53.8%, 7 students) answered 'I have little knowledge of plants because I have little interest in them.' Fifth, the description about self-perception of scientific knowledge revealed that the highest percentage of Type HH students of all 15 students (40%, 6 students) answered 'I think my science creativity is high through my experience of scientific creativity. Sixth, the responses to the Questionnaire revealed that 'reading' was the most popular way to obtain scientific knowledge, with 27 out of total 33 students choosing it. In particular, all 18 students from Type HH (high scientific knowledge and high scientific creativity) and Type HL (high scientific knowledge and low scientific creativity) - those with high scientific knowledge - gave that response. On the basis of this research, we should explore practical teaching methods and environment for gifted students to improve their scientific creativity by revealing the nature of the factors that affect scientific creativity and analyzing relationship between knowledge and scientific creativity.