• 제목/요약/키워드: HER2-negative

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Impact of Bilateral Breast Cancer on Prognosis: Synchronous Versus Metachronous Tumors

  • Ibrahim, Noha Y.;Sroor, Mahmoud Y.;Darwish, Dalia O.
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권3호
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    • pp.1007-1010
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    • 2015
  • Background: The clinical significance of bilateral breast cancer is unclear and its influence on prognosis is controversial. Materials and Methods: Between 2005 and 2009 we identified 110 cases of bilateral breast cancer (BBC) ; 49 patients had synchronous (duration between the occurrence of carcinoma in both breasts was less than 12 months) and 61 had metachronous (duration was more than one year with no ipsilateral local recurrence). We compared the patient characteristics including age, menopausal status, clinical stage, tumor size, histological classification, lymph node status, and hormone receptor and Her-2 status. We also compared the treatment given and overall and disease free survival (DFS) of both groups. Results: Synchronous cases tend to present more aggressively than metachronous cases and age at first presentation adversely affects survival. The 5 year overall survival was 78.7% for metachronous and 60% for synchronous. Patients with positive hormonal status had better five year disease free survival in metachronous compared to synchronous cases, at 76% and 63%, respectively. Age at first presentation >45years had better DFS (65%) compared to those with age ${\leq}45$ years (52%) at 5 years follow up. Conclusions: Patients with synchronous breast cancer may have worse prognosis. Young age and hormone receptor negative were risk factors in our study. Close follow up and early detection of contralateral breast cancer is mandatory.

어머니의 신생아에 대한 지각사정에 관한 연구 (A Study on Assessment of Mothers Perception of a Newborn Baby)

  • 이자형
    • 대한간호학회지
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    • 제16권3호
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    • pp.67-77
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    • 1986
  • The research was carried out in order to assess, at an early stage, the potential barrier in mother-child relationship in the childs' development by using the screening tool. Consequently, after modifying the Neonatal Perception Inventory developed by Broussard and testing its reliability. It has been applied to 152 mothers at the hospital of three universities in Seoul from August 1 to September 30, 1986. The data was analyzed by S.P.S.S. pro-gram and the results were as follows: 1) Mothers perceived the newborn as an individual, and evaluated their baby higher than other babies. 2) Mothers indicated difficulties in their role performance in the fellowing order-bathing, safety, detecting pain or suffering, and feeding. 3) Mothers' perception of a newborn was positive for 75% of the mothers. 4) The factor analysis of the modified tool using principal components analysis and Varimax rotation resulted in the two factors: Factor 1, Baby as an individual: Factor Ⅱ, Performances are required to meet the new-born's needs. 5) The difference in mothers' individual characteristics such as the number of childbirth, the desire to get pregnant or not, the type of deli-very, and the sex of the newborn did not influence on a mothers' perception of her newborn. As seen above, most of the mothers perceived their newborns as able individuals and expressed difficulties involved in taking care of the newborn. Also most of the mothers perceived their babies positively. My point here is, we ought to observe those mothers who perceive their babies negatively, and then compare them with those mothers who perceive their babies extremely positive or extremely negative. In the future, for more comprehensive assessment tool for maternal perception of the newborn, a repetitive verification and modification of this tool is demanded. At the same time, father's perception of the newborn should be included.

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인터넷 이용자들의 웹사이트 재방문 빈도에 관한 실증적 연구 (An Empirical Study of Customer's Repeat Visit Frequency on the Internet)

  • 이석규
    • 마케팅과학연구
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    • 제11권
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    • pp.129-146
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    • 2003
  • 본 연구는 소비자들의 선택모형에서 널리 사용된 NBD (Negative Binomial Distribution) 타입의 계랑적 모델 접근법이 온라인 상에서 소비자들이 특정한 기업의 웹사이트를 방문하는 행위를 설명하는데 적용될 수 있는지를 탐구한다. 본 연구에서는 다음의 두 가지 연구 주제를 다루고 있다. 첫째, 소비자들이 웹사이트를 반복하여 방문하는 행위의 빈도에 관한 분포를 확률적으로 규정하며, 둘째로는 그러한 소비자들의 반복된 이용빈도의 분포에 소비자들의 일반적인 인터넷 사용패턴과 인구 통계적인 변수들이 어떤 영향을 미치는지를 조사하고 있다. 일련의 실증적 분석을 통하여, 이 논문은 마케팅의 선택모형 (Choice Model)들에서 널리 사용된 NBD 타입의 모댈들이 인터넷상의 사이트 방문빈도 연구에도 잘 적용될 수 있음을 보여주고 있다. 그리고 이 연구는 이러한 소비자들의 이용빈도에 관한 모델개발이 온라인 기업의 당면문제에 어떠한 영향을 미치는 지를 설명한다. 특히 본 연구는 반복된 이용빈도와 소비자들의 일반적인 인터넷사용 특징 및 인구 통계적인 변수들과의 상호관계를 규명했다. 본 연구에서 제시된 모델들을 추정하고 검정하기 위해 800,000번의 방문 기록과 1000개 이상의 상이한 방문사이트 수로 구성된 웹 패널 데이터를 사용하여 실증분석을 연구에서 제시하는 모델을 개발하고 검증하였다.

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Pathological, immunohistochemical, and bacteriological findings in dogs infected with Brucella canis

  • Jung, Ji-Youl;Yoon, Soon-Seek;Lee, Seunghee;Park, Jung-Won;Lee, JinJu;Her, Moon;So, ByungJae;Kim, Jae-Hoon
    • 대한수의학회지
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    • 제60권1호
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    • pp.9-14
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    • 2020
  • This study describes pathological, immunohistochemical, and bacteriological findings in adult dogs and fetuses naturally infected with Brucella (B.) canis. A total of 42 dogs including 40 dogs and 2 aborted fetuses were examined. The most common gross lesions in infected dogs were swelling of lymph nodes and spleen. The testes showed marked swelling with multifocal to diffuse reddish discoloration. The most significant histopathological lesions were observed in the placenta. Placental trophoblasts were markedly hypertrophied due to the accumulation of intra-cellular gram-negative bacteria. Lymphocytic inflammation of varying severity was observed in the reproductive organs such as male testis, epididymis, and prostate gland and female uterus. Strong immunolabelling was observed in the cytoplasm of most trophoblasts in the placental tissues using immunohistochemistry. However, immunohistochemical staining did not demonstrate any organisms in other organs of dogs and fetuses. B. canis isolates were most frequently obtained from the whole blood (82.5%) and superficial inguinal lymph node (77.5%) in both sexes. In addition, the isolation rate was higher in male genital organs than in those of females. Hence, management of male dogs is most important because infected dogs can play a role as carriers.

국내 액상 발효유용 유산균 스타터 미생물의 동정 및 생리적 특성 (Identification and Characterization of Lactic Acid Bacteria Starters Isolated from the Commercial Drink-Yogurt Products)

  • 전상록;송태석;김지연;신원철;허송욱;윤성식
    • 한국축산식품학회지
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    • 제27권4호
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    • pp.509-516
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    • 2007
  • Starters of lactic acid bacteria(LAB) were isolated from the commercial yoghurt products and the four isolates have been studied on their identification and some physiological characteristics. For the purpose of identification, microscopic examination, API test, and 16s rRNA gene sequencing were conducted. Isolate A from a yogurt product of local dairy company A was shown to be Gram-positive rod-shaped bacterium. All strains isolated were turned out to be as Lactobacillus paracasei by using a API 50 CHL kit. In contrast, isolate A was identified as a strain of Lactobacillus helveticus based on the 16S rRNA sequencing data, and L. casei ssp. casei for both B and D and L. paracasei for C. All the isolates survived the simulated gastric juice, pH 2.0 within 3 hours and sharply decreased in viability so that no viable cell was observed after 4.5 hours incubation. In addition, the four isolated strains were almost identical in antibiotic susceptibility to six different kinds of antibiotics including erythromycin ($15\;{\mu}g$), ampicillin ($10\;{\mu}g$), gentamycin ($10\;{\mu}g$), neomycin ($30\;{\mu}g$), but rather resistant to colistin ($10\;{\mu}g$) and streptomycin ($10\;{\mu}g$). It was noteworthy that four isolates were confirmed to produce antibacterial substance against foodborne pathogens of Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli 0157:H7 as test organisms based on the inhibitory zones on an MRS soft agar medium. At presence, the inhibitory factor is unknown so that further studies are required to ascertain the active factor responsible for the inhibitory activities.

포도주, 광기 그리고 나쁜 피 -『제인 에어』 속 제국주의 다시 읽기 (Wine, Madness and Bad Blood: Re-Reading Imperialism in Jane Eyre)

  • 김경숙
    • 영어영문학
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    • 제57권2호
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    • pp.339-365
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    • 2011
  • Charlotte $Bront{\ddot{e}}^{\prime}s$ novel Jane Eyre has long been doted on as one of the canonized texts of British literature since its publication. Seemingly, this romantic novel has nothing to do with plantation based on slave trade. However, paying a keen attention to the fact that Jane's enormous inheritance results from wine plantation at a colony, this essay re-interprets Bertha's drinking and madness as evidence of imperialism. For the porter/jin Bertha and Grace Poole enjoy might have some suspicious connection with wine, the very root of Jane's great expectations. Jean Ryes' Wide Sargasso Sea, writing Jane Eyre back, records Bertha as "a white resident of the West Indies, a colonizer of European descent" (326). However, Jane Eyre, in my interpretation, describes Bertha pretty much as a black Creole. At any rate, the view that the white West Indians are tainted by miscegenation proves contemporary racism and is reflected in the text through Bertha and her mother's intemperate drinking and madness. Drinking and madness are stigmatized as the evidence of the so-called "bad blood"; embodying the stereotypes of drinking, madness, and sexual corruption, Creoles, the very inescapable product of imperialism, provide a convenient excuse for justifying imperialism for purity, civilization, and moral cleanness. In this way, Jane Eyre needs to be re-interpreted politically and historically in the context of colonialism. British imperialism pursues a tremendous amount of profits through grape plantation and wine trades; however, it cleverly leaves in the colony the associated images such as intemperate drinking and madness. Bertha, transferred from Jamaica to Britain, takes in these negative images of "savageness." Transcending the narrow confines of feminist criticism obsessed with doubling between Bertha and Jane, this essay, accordingly, reads Bertha the prisoner in the attic as the captive for perpetuating imperialism. This reading hinges upon interpreting Rochester and St John as colonizers bearing the so-called "white men's burden" to cultivate and civilize savages much like crops such as grapes and sugarcane in the colonial plantation.

식욕부진을 주소로 내원한 노인 환자 증례 2례 - 복약력 확인 및 감염 관리의 중요성 (Two Case Reports of Elderly Patients with Anorexia: the Importance of Confirming Medication and a Potential Infectious Disease)

  • 주성희;안소연;허소영;장은경;김영철;이장훈
    • 대한한방내과학회지
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    • 제40권3호
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    • pp.491-498
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    • 2019
  • Objectives: This study aimed to put clinical emphasis on the importance of considering medical precautions, such as drug history and a possible infection, when treating elderly patients. Methods: We closely observed two elderly female patients aged 79 and 76 who had been hospitalized for the treatment of anorexia at the Department of Hepato-Hemopoietic System, Kyung Hee University Korean Medicine Hospital in April 2018 for 5 and 9 days, respectively. Results: Through an elaborate medical investigation including a detailed inquiry and laboratory examinations, modifying some drugs and treating a urinary tract infection were preferentially needed to treat these two patients. In the first case, her overall symptoms, including anorexia, were improved after taking Dansambohyeol-tang combined with three types of antacids adjusted by holding 10 drugs in total, including nonsteroidal anti-inflammatory drugs that mainly causing chronic gastric ulcer. In the second case, the urinary tract infection was detected by blood test and urine analysis during the hospitalization period. After taking Geummogpaljeong-san and antibiotics for the treatment of the infection, the chief complaints including anorexia and the negative reaction to nitrite in the urinary analysis were improved. Conclusion: Considering the clinical precautions, including medications and infection possibility, is important especially when treating elderly patients.

혼밥이 건강한 메뉴 선택에 미치는 영향: 소비 목적 지향과 메뉴 영양 정보 표시의 역할 (Can Dining Alone Lead to Healthier Menu Item Decisions than Dining with Others? The Roles of Consumption Orientation and Menu Nutrition Information)

  • 허은솔
    • 대한지역사회영양학회지
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    • 제26권3호
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    • pp.155-166
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    • 2021
  • Objectives: Driven by a growth of single-person households and individualized lifestyles, solo dining in restaurants is an increasingly recognizable trend. However, a research gap exists in the comparison of solo and group diners' menu-decision making processes. Based on the self-control dilemma and the temporal construal theory as a theoretical framework, this study compared the ordering intentions of solo vs. group diners with healthy vs. indulgent (less healthy) entrées. The mediating role of consumption orientation and the moderating role of amount of menu nutrition information were further explored to understand the mechanism and a boundary condition. Methods: A scenario-based online survey was developed using a 2 (dining social context: solo vs. with others) × 3 (amount of menu nutrition information: no nutrition information vs. calories vs. calories/fat/sodium), between-subjects, experimental design. Consumers' level of nutrition involvement was controlled. A nationwide survey data (n = 224) were collected from a crowdsourcing platform in the U.S. Data were analyzed using multivariate analysis of covariance, independent t-test, univariate analysis of covariance, and moderated mediation analyses. Results: Findings reveal that solo (vs. group) diners have less (vs. more) intentions to order indulgent menu items due to a more utilitarian (vs. more hedonic) consumption orientation in restaurant dining. Findings also show that solo (vs. group) diners have more (vs. less) intentions to order healthy menu items when the restaurant menu presented nutrition information including calories, fat, and sodium. Conclusions: The findings contribute to the literature of foodservice management, healthy eating, and consumer behavior by revealing a mechanism and an external stimuli of solo vs. group diners' healthy menu-decision making process in restaurants. Furthermore, the findings provide restauranteurs and health professionals with insights into the positive and negative impacts of menu nutrition labelling on consumers' menu-decisions.

아버지와 어머니의 헬리콥터 부모역할이 고등학생의 진로준비 행동에 미치는 영향: 학업성패귀인과 진로결정자기효능감의 순차적 매개효과 (The Effect of Paternal and Maternal Helicopter Parenting on the Career Preparation Behavior of High-School Students: Sequential Mediation Effects of Academic Achievement Attribution and Career Decision-Making Self-Efficacy)

  • 김윤서;강민주
    • Human Ecology Research
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    • 제61권3호
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    • pp.401-414
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    • 2023
  • This study examined the sequential mediation effects of academic achievement attribution and career decision-making self-efficacy on the effect of paternal and maternal helicopter parenting on high-school students' career preparation behavior. A total of 285 (119 male and 166 female) Korean high-school students in the second grade participated in the study. Research variables were measured using the Career Preparation Behavior Scale (Kim, 1997), Helicopter Parenting Scale (LeMoyne & Buchanan, 2011), Attribution Questionnaire (Weiner, 1979), and Career Decision-Making Self-Efficacy Scale-Short Form (Betz et al., 1996). To examine the sequential mediating effect, data analysis was performed using SPSS 29.0 and PROCESS MACRO (v4.2) Model 6. The results revealed no correlations between helicopter parenting and academic failure attribution. However, higher paternal and maternal helicopter parenting were found to indirectly reduce high-school students' career preparation behavior through lower internal academic success attribution (effort and ability) and higher external academic success attribution (task difficulty and luck), which reduced career decision-making self-efficacy. These findings can be employed to develop more effective intervention programs comprising career guidance for adolescents, which emphasizes the negative effect of helicopter parenting. This study expands the research field, as previous findings on helicopter parenting mostly focus on college students.

중년 기혼남녀의 성공적 결혼 조건에 대한 태도와 결혼만족도 간 관련성 (Associations between Attitudes toward Factors Underpinning a Successful Marriage and Marital Satisfaction among Married Men and Women in Midlife)

  • 유계숙;주수산나;박하영
    • Human Ecology Research
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    • 제61권2호
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    • pp.219-231
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    • 2023
  • This study examined attitudes toward factors underpinning a successful marriage and their associations with marital satisfaction among married men and women in midlife. The sample comprised 201 married men and women aged between 40 and 59 living in Seoul, South Korea, and the data were collected by a self-report survey in 2019. Attitudes toward factors underpinning a successful marriage were measured using 12 items from the European Values Study Master Questionnaire 2008 and marital satisfaction was measured using three items from the Kansas Marital Satisfaction Scale. Exploratory and confirmatory factor analysis were performed in order to identify the factors deemed important for a successful marriage, as well as a t-test to explore gendered domains. Additionally, regression analysis was conducted to examine the association between attitudes toward factors underpinning a successful marriage and marital satisfaction. The results revealed two factors that were deemed important for a successful marriage: 'marital exchange based on conditions' and 'qualitative interaction based on sharing.' Women were more likely to believe that both factors were important for a successful marriage than men. The regression analysis revealed that 'qualitative interaction based on sharing' had a positive association with marital satisfaction, while 'marital exchange based on conditions' had a negative association with marital satisfaction, and also that these associations did not differ by gender. The findings imply that a successful marriage can be achieved when married partners make efforts to maintain their relationships through positive interactions and share intimacy in midlife.