• 제목/요약/키워드: HER2 positive

검색결과 404건 처리시간 0.024초

분석심리학적 견지에서 본 한국민담 '나그네와 여우'의 해석 (An Interpretation of a Korean Fairy Tale "The Traveller and the Fox" from the Perspective of Analytical Psychology)

  • 이상익
    • 심성연구
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    • 제25권2호
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    • pp.123-162
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    • 2010
  • 저자는 한국민담 "나그네와 여우"의 분석을 시도하였다. 이야기의 요점은 다음과 같다. 산속을 헤매던 나그네가 불빛이 있는 집을 찾는다. 그곳에는 아름다운 여인이 있어 친절히 음식과 잠자리를 제공한다. 그러나 그녀는 칼로 그를 죽이려는 여우였다. 그는 한 동이의 물을 가져다 달라고 하고는 그것으로 벽을 허물고 도망친다. 여우가 쫓아오고 그는 절벽에서 뛰어내려 호랑이 등에 타게 된다. 호랑이는 호랑이굴로 뛰어가 그를 새끼에게 먹이로 준다. 그는 새끼들을 돌을 던져 죽이고 굴 밖으로 나와 나무에 올라간다. 여우들과 호랑이가 돌아와 서로 죽인다. 나그네는 여우와 호랑이의 가죽을 벗겨서 마을로 돌아간다. 저자는 이 이야기의 내용을 상징적으로 이해하고 분석심리학의 견지에서 해석하고자 하였고, 결론적으로 다음과 같이 해석하였다. 나그네는 개성화과정 중에서 여우와 호랑이로 상징된 부정적 아니마와 부정적 모성원형을 대면하게 되고 그 부수적인 부정적 속성에 해당하는 호랑이 새끼들을 처치하는 것을 시작으로 부정적 아니마와 모성의 극복을 경험하게 되었다. 그는 의식적인 각성상태를 유지하고 지속적인 주의를 기울이고자 노력했기에, 그 상태를 벗어나 새로운 인식에 도달할 수 있었다. 이 과정에 각각 물과 나무로 상징된 긍정적 모성원형과 자기의 적절한 도움을 능동적으로 얻을 수 있었던 것이 의미가 있었다.

Prevalence state of canine brucellosis in South Korea during 2015 and 2016

  • Jung, Ji-Youl;Yoon, Soon-Seek;Lee, Seung-Hee;Park, Jung-Won;Lee, Jin-Ju;Her, Moon;So, ByungJae;Kim, Jae-Hoon
    • 대한수의학회지
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    • 제58권3호
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    • pp.125-129
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    • 2018
  • We investigated the prevalence of canine brucellosis in companion and stray dogs between March 2015 and December 2016 and determined the disease characteristics based on the geographic distribution, sex and age of the dogs in South Korea. We conducted a large-scale survey using serological and bacteriological tests. Samples were collected from 2,394 dogs (1,825 companions and 569 strays). Thirty (1.3%) samples were positive for Brucella canis antibodies including 16 (0.9%) from companion dogs and 14 (2.5%) from stray dogs. Two (1.0%) of the 196 samples cultured from the stray dogs were positive. When compared with male dogs, the female companion and stray dogs had a significantly higher prevalence of brucellosis. Moreover, the prevalence of canine brucellosis was significantly higher in stray dogs older than 6 years and the prevalence of the disease in companion dogs was highest in Incheon (2.1%) and Jeolla (2.1%) provinces. Stray dogs from the Daejeon metropolitan area had the highest prevalence of brucellosis (7.9%). National control measures for canine brucellosis have not previously been implemented. Our findings suggest that appropriate screening tests and control measures are necessary to improve the health of dogs and to protect public health in Korea, particularly with the rapid growth of the companion animal industry.

신체적·재무적·심리적 요인이 고령자의 생활만족도에 미치는 영향 (The Impact of Physical, Financial, and Psychological Factors on Elderly Life Satisfaction)

  • 이해랑;김지혜;나종연
    • Human Ecology Research
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    • 제62권2호
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    • pp.261-278
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    • 2024
  • This study aims to enhance the life satisfaction of the elderly population in South Korea by exploring their satisfaction levels and identifying influencing factors. Utilizing data from the 17th Korean Welfare Panel, which includes 6,260 individuals aged 65 and older, this study employs independent sample t-tests, one-way ANOVA, and hierarchical regression analysis. The results showed that, in general, the life satisfaction of the elderly population was somewhat lower than that of the general adult population in all areas, except for job satisfaction and satisfaction with housing. Key factors influencing life satisfaction among the elderly population include demographic characteristics (gender, age, economic activity, residence, education level), subjective health status factors, financial factors (disposable income, monthly living expenses), and psychological factors (depression, self-esteem). Notably, psychological factors, particularly self-esteem and depression, profoundly affect all life satisfaction domains. Enhancing life satisfaction necessitates fostering positive self-perception and capabilities in the elderly population, suggesting the need for programs focused on positive emotional experiences. Moreover, depression significantly reduces life satisfaction, underscoring the importance of policy interventions to address negative emotions in this demographic. This study is expected to provide basic data for establishing concrete and effective policies for improving the quality of life for the elderly population. Additionally, by highlighting the importance of positive psychological factors, it is anticipated that the study will offer a new direction for improving the life satisfaction of the elderly population.

영유아기 자녀를 둔 어머니의 모-자녀관계와 결혼만족도가 주관적 안녕감에 미치는 영향 (The Effects of the Mother-Child Relationship and Marital Satisfaction on the Subjective Well-Being of Mothers with Young Children)

  • 박희경;윤갑정
    • 아동학회지
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    • 제33권2호
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    • pp.243-261
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    • 2012
  • This study examined the effects of the mother-child relationship and marital satisfaction on the subjective well-being of mothers with young children. The subjects consisted of 237 mothers with young children. Data were analyzed by means of multiple regression analysis, T-test and one way ANOVA. The results included that 1) There were clear differences in terms of the mother's level of education, her monthly income in household, and job satisfaction when it came to the subjective well-being of mothers. 2) The mother-child relationship and marital satisfaction were both positively correlated with the cognitive and affective factor (positive affects) of subjective well-being, whereas there were negative correlations with regard to affective factors (negative affects) of subjective well-being. 3) The mother-child relationship and marital satisfaction accounted for 32.5% of subjective well-being. More specifically, marital satisfaction was the most influential variable when it came to determining the level of life satisfaction (which is also a cognitive factor of subjective well-being), whereas the mother-child relationship was the most influential variable when it came to the affective factor of subjective well-being.

40세 이상의 한국 성인에서 과체중 및 비만환자 선별을 위한 목둘레 기준 (Neck Circumference Criteria for Identifying Overweight and Obesity Patients in Korean Adults Aged 40 or Older )

  • 허은실
    • 한국산업융합학회 논문집
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    • 제27권4_2호
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    • pp.877-883
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    • 2024
  • This study targeted 15,580 Korean adults aged 40 or older from the 2019-2022 KNHA-NES and aimed to confirm neck circumference criteria for identifying overweight and obesity according to BMI standards using the reportROC package. Pearson's correlation coefficients indicated a strong positive association between neck circumference and BMI in both male (r=0.802, p<0.001) and female (r=0.762, p<0.001). The ROC analysis results to determine the neck circumference cutoff levels for overweight according to BMI (≥23.0 kg/m2 ) were 37.1 cm (AUC=0.890, accuracy=0.808) for male and 32.5 cm for female (AUC=0.863, accuracy=0.776). Neck circumference 37.8 cm (AUC=0.879, accuracy=0.784) for male and 33.1 cm (AUC=0.873, accuracy=0.786) for female were the best cutoff levels for determining the subjects with obesity by BMI (≥25.0 kg/m2 ). This study proposed a cutoff levels for neck circumference that can be used in screening tests to determine overweight and obesity, and for clinical use, additional research is needed to exclude factors affecting neck circumference.

얼굴 매력성과 의복 적절성이 특질 판단에 미치는 영향 (The Effects of Facial Attractiveness and Appropriateness of Clothing on The Trait Evaluation)

  • 정명선;김재숙
    • 대한가정학회지
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    • 제39권2호
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    • pp.131-146
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    • 2001
  • The main purpose of this study, based on implicit personality theory and attribution theory, was to examine whether there exist the physical attractiveness stereotype, "what is beautiful is good," in the present Korea, and if exist, what is the content of it. The index of the physical attractiveness of this study was the facial attractiveness judged by 30 female university students. The appropriateness of clothing was manipulated by 4 types of clothing perceived appropriate for two assumed situations by female university students. Three female faces having high, medium, and low attractiveness were simulated with the same body dressed four types of clothing using CAD system, and a total of 12 stimulus persons were created. A total of 524 male and female(262 of male, 262 of female) university students from 3 universities in Kwangju, Korea were participated as subjects in this study. The design for the experiment was a 3$\times$4$\times$2 randomaized factorial, with three levels of facial attractiveness (high, medium, low), and four types attire(formal-masculine, formal-feminine, casual-masculine, casual-feminine), two kinds of context (job interview, dating) in which perceptions were occurred. The data were analysed using factor analysis, MANOVA, t-test and Duncan test. The results were as follows: 1. The facial attractiveness exerted significant positive effects on the evaluation of sociability, adjustment, and potency of her in both of two assumed situations (p<.001, respectively). 2. The appropriateness of stimulus person′s clothing had significant positive erect on the evaluation of sociability of stimulus person in dating context(p<.001). 3. The gender of subjects did not influenced the trait evaluations in both of two assumed situations.

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Androgen Receptor Expression and its Correlation with Other Risk Factors in Triple Negative Breast Cancers: a Report from Western Iran

  • Payandeh, Mehrdad;Shazad, Babak;Madani, Seyed-Hamid;Ramezani, Mazaher;Sadeghi, Masoud
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권7호
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    • pp.3321-3324
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    • 2016
  • Background: Androgen receptors (ARs) are expressed in more than 70% of breast cancers (BCs) and have been implicated in BC pathogenesis. Some triple negative (TN)BC tumors express AR and may benefit from AR-targeted therapies. The aim of this study was to evaluate survival and the prevalence of AR expression and its correlation with other risk factors in triple negative BCs in women from Western Iran. Materials and Methods: In a retrospective study between 2009-2015, 41 patients with TNBC were referred to the Private Clinic of Oncology, Kermanshah city, Iran. ER, PR and AR-positive expression was defined as ${\geq}10%$ nuclear staining and also HER2 (2+), FISH was performed. Nuclear staining was considered representative for Ki67 and P53. The mean follow-up for the patients was 25 months. In this time, 5 patients died and 4 lost to follow-up were censored from survival analysis. Results: The mean age at diagnosis was 46.9 years (range, 24-71 years) and all patients were female. The OS rates for AR-positive and AR-negative patients were 90% and 85.1%, respectively, and the mean OS was 26.3 and 23.2 months. Therefore, there was no significant difference between the two groups (Hazard ratio: 0.580, 95% CI: 0.086-3.893, P=0.575). Conclusions: In TNBC patients, evaluation of AR status may provide additional information on prognosis and treatment. The results of studies showed that the prevalence AR expression may differ in the world and probably ethnicity can be an influencing factor.

어머니의 사회심리적(社會心理的) 역량(力量) 및 자녀에 대한 수용성(受容性)과 아동의 사회적(社會的) 역량(力量)과의 관계 (The Relationship between Maternal Psychosocial Competence, Acceptance and Children's Social Competence)

  • 박호준;정영숙
    • 한국생활과학회지
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    • 제2권1호
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    • pp.1-15
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    • 1993
  • The purpose of this study is to identify what relationship exists between the children's social competence and psychosocial competence of mother, mother's acceptance for her children and is to clarify how children's sex, the demographic backgrounds of the families are affecting for the children's social competence. The detailed research areas which were dealt with in this study can be described as follows :1) Are there any relationships between mother's psychosocial competence and children's social competence? 2) Are there any relationships between mother's acceptance and children's social competence? 3) Are there any differences in children's social competence according to their sex? 4) Are there any differences in children's social competence according to familie's demographic backgrounds? Third grade 314 children who attend primary-school in Chongju were randomly selected as the subjects for the study and their mothers were also involved as subjects. Among them, mother-daughter pairs are 151 and mother-son pairs are 163. The result of this study is as follows: 1. There appeared significant positive correlations between the mothers' psychosocial competence and children's social competence. 2. There appeared significant positive correlations between the maternal acceptance and children's social competance. As the result of a stepwise multiple regression analysis, maternal acceptance appeared as a variable which indicates children's social competence. 3. There appeared differences in competence between boys and girls, and girls' social competence was higher than that of boys. 4. There appeared children's social competence differences according to the socioeconomic status of a family. Among demographic backgrounds of a family, mothers' academic careers, mothers' age, fathers' jobs, income were the variables which affect children's social competence.

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우울한 내담자를 위한 MI(Music & Imagery) 치료사례 (Case study of Music & Imagery for Woman with Depression)

  • 송인령
    • 인간행동과 음악연구
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    • 제5권1호
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    • pp.67-90
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    • 2008
  • MI란 Music and Imagery의 약자로 심리치료의 한 방법인 GIM(Guided Imagery and Music)을 현실에 맞게 축약적으로 접목시킨 방법이다. 이는 치료목표에 적합한 음악감상을 통해 다양한 심상을 경험함으로 인간의 내면세계를 탐색, 직면, 통찰, 해결하게 한다. 본 치료사례는 MI기법을 활용하여 우울한 내담자의 긍정적 내적자원에 따른 심상을 체험하고, 그 체험을 언어적으로 표현한다. 또한 그 이미지들을 일상생활에 긍정적인 변화를 적용할 수 있도록 유도하는 지지적 수준의 개인 치료사례이다. 지지적인 수준(Supportive Level)에서의 MI는 음악 안에서 안전하게 서로 지지하는 수준에서만 사용한다. 개인세션 도입은 특정 느낌이나 주제, 단어 혹은 시각적 이미지를 연상하고, 이러한 이미지는 갈등적인 내용이 아닌 긍정적인 경험을 유도한다. MI의 한 회기 별 첫 번째 단계는 초기면담(Prelude)으로 상담의 초기면담과 같이 구체적인 목표를 정한다. 두 번째 단계는 전환(Transition)으로 여러 가지 내담자의 이야기 중에 가장 지지적인 주제를 좀 더 초점화하여 구체적으로 느끼고 표현 할 수 있도록 한다. 세 번째 단계는 긴장완화 및 음악 감상(Music Listening)으로 여러 긴장이완법 등을 사용하여 음악 감상하는 동안 심상이 잘 떠오를 수 있도록 이완 시킨다. 그리고 음악 감상 동안 음악이 가져다주는 여러 가지 심상들을 탐색하고 연상 할 수 있도록 한다. 마지막 단계는 마무리(Process)시간으로 음악 감상 동안 경험되어진 심상을 그림으로 표현하고, 개인적인 심상경험을 언어적인 과정을 통해 치료사와 공유함으로써 긍정적인 경험을 확장시켜 내적인 힘을 키운다. A 내담자의 경우 내담자와의 라포 형성하기(공감, 이해, 지지), 내담자의 긍정적인 자원탐색(어린시절, 가족), 내담자의 감정표현 및 긍정적 지지(현재의 나)의 구체적인 목표를 설정하였다. 음악은 내담자가 선호하는 음악과 치료사가 선정한 음악 중에서 음의 전개가 단순하고, 멜로디가 반복적이며, 리듬이 규칙적이며, 협화음으로 구성된 안정적이고 구조화된 음악을 사용하였다. 그 결과 A는 1, 2회기에는 방어기제를 많이 사용하고 우울로 인한 감정조절의 어려움을 보였으나 3회기 이후 자신이 좋아하는 음악과 지지적인 음악을 치료사가 제공하는 것으로 인해 공감과 지지를 경험할 수 있게 되었다. 이를 통하여 4회기부터 안정감을 갖고 세션 안에서 부정적 정서를 긍정적인 정서로 전환하고, 자신의 내재된 힘을 발견하게 되었다. 6회기에는 과거 힘들었던 시간들이 앞으로 갖게 될 좋은 시간을 준비하는 단계라고 인식하기 시작하였다. B 내담자의 경우 내담자와의 라포 형성 및 탐색하기(공감, 이해, 지지), 내담자의 문제 탐색 및 긍정적 인식(어린시절, 가족), 내담자의 감정표현 및 통찰하기(현재와 미래의 나)의 구체적인 목표를 설정하였다. 음악은 1, 2회기에는 안정적이고 구조적인 음악을 사용하였으나, 3회기 이후 곡의 전개가 점점 커지고 주제 멜로디의 변주로 음의 고저가 많으며, 협화음과 불협화음이 넘나드는 고전파와 낭만파의 음악을 사용하였다. 그 결과 B 내담자는 1,2회기에서는 대인관계의 어려움을 종교적인 관계로 전환하여 현실회피하려는 경향이 나타났으나 자신이 좋아하는 음악과 지지적인 음악을 통하여 공감과 지지를 경험할 수 있었다. 3회기 이후 B는 자신의 현실 문제를 인식하고 직면하였으나 회피와 직면의 양가감정을 갖게 되었다. 4회기 이후 B는 우울로 인한 감정의 변화를 음악 안에서 경험하고, 자신의 문제에 직면하였다. 5, 6회기에서는 긍정적인 자원을 통해 내적인 힘을 키우고 해결하려는 태도와 미래에서의 내가 좀 더 당당하고 건강하게 살아가려는 의지가 나타났다. 이와 같이 MI 프로그램은 GIM 프로그램보다 좀 더 현실적이고 짧은 회기수로 내담자의 문제들을 해결할 수 있다는 가능성을 제기한다. GIM처럼 깊은 무의식속으로 접근 하지 않고도, MI는 현실주의 상담과도 같이 내담자의 현실적인 문제를 근거로 하여 문제인식 및 통찰, 해결해 나갈 수 있다. 특히 음악의 사용에 있어서도 다양한 장르의 곡을 내담자에게 맞게 사용할 수 있으며, 음악감상 시간도 GIM에 비해 짧고 곡의 기능들도 구조화되어 내담자의 감정을 심상으로 잘 표현 할 수 있다. 그러므로 MI는 내담자의 음악선호도와 음악의 다양한 기능들을 활용하여 개인과 그룹으로 성인뿐만 아니라 아동 및 청소년에게도 알맞게 수정 보완하여 사용할 수 있음을 시사한다.

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Relationship between erb-B2 mRNA Expression in Blood and Tissue of Invasive Ductal Carcinoma Breast Cancer Patients and Clinicopathological Characteristics of the Tumors

  • Moazzezy, Neda;Ebrahimi, Fatemeh;Sisakht, Mahsa Mollapour;Yahyazadeh, Hossein;Bouzari, Saeid;Oloomi, Mana
    • Asian Pacific Journal of Cancer Prevention
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    • 제17권1호
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    • pp.249-254
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    • 2016
  • Molecular detection methods such as RT-PCR for detecting breast cancer-associated gene expression in the peripheral blood have the potential to modify breast cancer (BC) staging and therapy. In this regard, we evaluated the potential of erb-B2 molecular marker in BC detection and analyzed the expression of erb-B2 mRNA in the peripheral blood and fresh tissue samples of 50 pretreated female BC patients and 50 healthy females by reverse transcription-PCR (RT-PCR) method. We also assessed the correlation of erb-B2 mRNA marker positivity in peripheral blood and tumor tissue samples with clinical and pathological factors in BC patients in order to evaluate its prognostic value. It was shown that there is a significant difference between healthy females and BC patients with expression of the erb-B2 molecular marker (p<0.01). A significant difference between the expression of erb-B2 in the peripheral blood and tissue samples of BC patients (p<0.01) and the frequency of circulating erb-B2 mRNA expression in peripheral blood and in tissue was detected by RT-PCR. No correlation was found between erb-B2 mRNA expression in blood or tumor tissue samples and lymph node, tumor grade, tumor stage, tumor size, patient's age, ki67, estrogen receptor (ER), progesterone receptor (PGR), P53, and HER-2 status. However, in a small subset of 31 BC patients we found that expression of erb-B2 in peripheral blood or in both peripheral blood and tumor tissue was directly correlated with lympho-vascular invasion and perineural invasion as poor prognostic features. The highest rates of erb-B2 expression in peripheral blood or tumor tissue were in the ER and PR negative and HER-2 positive group. This study suggests that the application of the RT-PCR and immunohistochemical methods for erb-B2 molecular marker detection would provide a higher detection rate, especially in early stage BC.