• Journal of Digestive Cancer Research
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• v.3 no.1
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• pp.39-41
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• 2015

We report a case of long term survival on trastuzumab based treatment. A 51-year-old man with dyspepsia received esophagogastroduodenoscopy on another hospital and was transferred for further evaluation under the impression of advanced gastric cancer, Borrmann type III, antrum, lesser curvature. After further studies in our hospital, the patient was diagnosed with advanced gastric cancer, adenocarcinoma, moderately differentiated with pancreas invasion and lymph node metastasis. Though he was recommended with chemotherapy, he refused and left for oriental herbal medicine. After 4 months, the patient was admitted through emergency room for hematemesis. Diagnosed with gastric outlet obstruction due to gastric cancer in the antrum, he underwent the placement of pyloric metal stent insertion. Immunohistochemical staining showed HER2-positive finding, and he was treated with palliative chemotherapy of trastuzumab, capecitabine, and cisplatin, 16 times during 11 months. The patient showed neutropenia after the therapy, so cisplatin was left out, and he received combination chemotherapy of trastuzumab and capecitabine, 34 times during 25 months. Response evaluation showed no remarkable change in extent of primary stomach cancer, lymph node metastasis, and regression of metastasis site, and the patient is continuing chemotherapy.

• Human Ecology Research
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• v.61 no.2
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• pp.263-280
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• 2023

This study examined four ecological systems, namely individual, family, school, and media environments. A series of moderator analyses were conducted to examine variations in effect size estimates across the study characteristics. The current study estimated that the effect size results were gleaned from 360 primary studies, including 90 journal articles and 270 thesis/dissertations, published between 2011 and 2022. The current meta-analysis results supported the ecological framework. That is, the impact of each ecological system on the development of positive and negative peer relationships varies depending on age groups and protective-risk factors. Specifically, for positive peer relationships, the largest effect size of the protective factor was found at the individual level for young and school- aged children, but at the school level for adolescents. Regarding the risk factors for positive peer relationships, the media was the ecological system with the strongest effect size for both young children and adolescents, while the individual-level demonstrating the strongest effect for school-aged children. Results from this meta-analysis allow us to identify some vital intervention areas in terms of healthy peer-relationship development, which should be of considerable interest to the educators and policymakers who are responsible for assessing and intervening with at-risk young children, school-aged children, and adolescents. From a practical standpoint, the current meta-analysis results are expected to contribute to developing effective prevention initiatives by targeting specific protective and risk factors for peer relationship development on the ecological system level.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.6
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• pp.499-510
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• 2006

Malignant tumors of the human salivary glands may arise from major or minor salivary glands. Adenoid cystic carcinoma (ACC) is the second most common malignant neoplasm in the salivary glands. ACC is occasionally highly aggressive tumor that readily invades adjacent tissues and metastasize to distant organs at early stages of the disease. Although ACC tends to grow slowly, treatment outcome may be poor due to wide local infiltration, perineural or intraneural spread and a propensity for hematogenous metastasis. Therefore, knowledge of cellular and molecular characteristics that influence the growth, survival and metastasis of tumor cells, is important for new treatment strategies of salivary ACC. I determined expressions of epiderma growth factor (EGF)-signaling molecules using surgical specimens of human ACCs. Protein expressions of EGF, transforming growth $factor(TGF)-{\alpha}$, EGF receptor (EGFR), phosphorylated EGFR (pEGFR), and human EGF receptor (HER)-2 were assessed in 18 cases of salivary ACC by immunohistochemical staining. Adjacent normal salivary tissues and mucosal tissues, uninvolved by the malignant tumor, served as internal controls. Most of the tumors, especially ACC with a tubulocribriform pattern, were positive for EGF signaling molecules. The overall percentages of the 18 specimens expressing EGF, $TGF-{\alpha}$, EGFR, pEGFR, and HER2 were 50, 89, 61, 61 and 83% respectively. Moreover, tumor-associated endothelial cells and infiltrating immune-related cells in the stroma of ACC, also expressed these biomarkers. Taken together, EGF-signaling molecules are actively expressed in salivary ACC. Therefore, we suggest that these biomarkers can be molecular targets for new treatment strategies of salivary tumors.

• The Journal of the Korea Contents Association
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• v.11 no.4
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• pp.361-377
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• 2011

This study has three primary purposes, firstly to identify how leader's personal characters influence to his/her transformational leadership, secondly to find how transformational leadership influences to innovative behavior, finally to explore how organizational cultures moderate between transformational leadership and innovative behavior. The first part of the study, based on literature study on transformational leadership, provides insight into what are antecedents, moderators and dependent variable in transformational leadership. Firstly, leader's personal characters are selected as antecedent variables such as extroversion and self-efficacy. Secondly, innovative behavior is introduced as a dependent variable. Thirdly, two types of organizational culture are considered as moderators between leader's personal character and leadership In this study, a comprehensive research model and hypothesis were empirically tested based on data from three types of questionnaires involving 663 employees in Korean organizations. In order to test the hypotheses, we have used Structural Equations Model (SEM) from AMOS7.0. In this analysis, we have employed raw data as it is instead of correlation matrix or covariance matrix. We have tested hypotheses by examining the significance of each path of the model, and gone through the process of testing the goodness of fit of the model itself. The results of statistical analysis show the following. Firstly, one of leader's personalities, self-efficacy has positive effect on his/her transformational leadership, but extroversion does not have positive effect. Secondly, transformational leadership has positive effect on innovative behavior. Finally, there was not any cultural moderating effects between transformational leadership and innovative behavior.

• Journal of the Korean Home Economics Association
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• v.44 no.3 s.217
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• pp.51-59
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• 2006

The purpose of this study is to determine the relevant variables of parent-leadership that influence family strength based on the transformational leadership and transactional leadership proposed by Bernard M. Bass and to investigate the primary impact of leadership on the subordinate's job satisfaction and job involvement to his/her supervisor. Therefore, this study will provide implications for the family through a diagnosis of the effect by leadership. The results of this research are as follows : 1) How is the relationship of parent-leadership and family strength? A positive correlation was found between transformational leadership scores and family strength. A negative correlation was found between nontransactional leadership scores and family strength. 2) How had transformational leadership and transactional leadership affected on the family strength? Transformational leadership had the strongest effect on family strength. How had the 7 sub- factors of transformational/transactional leadership affected family strength? Idealized influence and contingent reward had strong effect on family strength but management by except had a negative effect on family strength.

• Journal of Families and Better Life
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• v.18 no.1
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• pp.139-152
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• 2000

The purpose of this study was to explore family member's perceived attitude toward housewife's volunteer activities and examined the realated-influences on their family lives. The major findings were that(1) men had more conservative attitudes. and some reluctance to the wives' volunteer activities compared to the adolescent (2) education and the personal experiences of the volunteer activity were the most influential factor to family member's attitudinal difference(3) family members had some ambivalent attitudes toward the wive(mother)'s volunteer activities more positive to the general perception and more negative to their daily life chores resulted from her social activities (4) the longer the volunteer activities continued the more functionalized and satisfied the family members and lives were.

• The Journal of Internal Korean Medicine
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• v.24 no.4_2
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• pp.1080-1086
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• 2003

As the use of anticonvulsant increases in neurologic field, more studies are needed to reveal various harmful effects of this medication. Especially as for carbamazepine, thrombocytopenia may appear during administration of the medication, regardless of dosage. We, the authors, report that we diagnosed the patient as Bigiheo and Eumheohyeolheo, who was suffering from insomnia, diarrhea, papura, and serious thrombocytopenia. We presumed that the symptoms could be induced by carbamazepine, and used Samulgwibitanggamibang to treat her and obtained positive results.

• Health Policy and Management
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• v.5 no.2
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• pp.18-34
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• 1995

To clarify the relationship between the medical supply(medical persons and goods) and the use of bed, the author has made comparison among OECD 24 countries. Per Capita Bed-days can be divided into Average Length of Stay and Admission Rate, and these three variables were regressed upon both In-patient Care Beds of all medical institutions including acute somatic, psychiatric, special, nursing homes and other long-term care and Share of Total Health Employment in Total Employment. The result of regression analysis shows a statistically significant positive relationship between In-patient Care Beds and Average Length of Stay, and negative relationship between Share of Total Health Employment and Admission Rate. In addition to Ordinary Least Square(OLS) estimation, amended Bounded Influence Estimation(BIE) was also made to adjust the influence of outliers. Japan shows a very large number of In-patient Care Beds and a very low Share of Total Health Employment, and this medical situation is judged to have close relation to her long Average Length of Stay and low Admission Rate.

• Journal of Distribution Research
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• v.1 no.2
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• pp.221-251
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• 1996

The retail industry of Korea has, owing to the increase of purchasing power of her people and the changing pattern of consumption appetite, marked a considerable development. Nevertheless the retail industry of Korea is still in primitive stage with its smallness of size, density of stores and inefficiency of management compared to those in the developed countries. It is a high time for Korean distribution market to boost its competitive power in the wake of the opening of distribution industry since January of 1996. Accordingly, it should be the goal of these markets to maximize its positive aspects while trying their best to minimize the negative aspect in this transition time for globalization.

• The Journal of Information Systems
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• v.10 no.2
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• pp.65-88
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• 2001

The purpose of this study is to examine the relationship between CIO's characteristics and CIO's role. The CIO's characteristics include CEO/CIO relationship, CIO's power in his/her organization, hire type of CIO, and career background of CIO. The results of this study are as follows: part of the CIO's characteristics has a positive relationship with the CIO's role. In other words, the CIO's role is influenced by the CEO/CIO relationship, the CIO's power, and the hire type of CIO. However, the relationship between the career background of the CIO and the CIO's role is not statistically significant.