• Biomedical Science Letters
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• v.20 no.4
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• pp.221-226
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• 2014

High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL) as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPL gene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjects from Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene was associated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect per allele -18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower risk of having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed by gender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variants in LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.

• Journal of Society of Preventive Korean Medicine
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• v.10 no.1
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• pp.67-74
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• 2006

Objectives: This study was carried out to establish the normal values of Serum Total Cholesterol, HDL-cholesterol by age and sex for healthy adult and the frequency of dyslipidemia as a risk factor of coronary atherosclerosis. Methods: Total cholesterol, and HDL-cholesterol measured among 14,485 in general growing people (8,712 males and 5,773 females) aged 20 to 69 years and analyzed to use the auto-analyzer Hitach 7600 in enzyme method. Result: 1. The levels of total cholesterol, HDL-cholesterol and atherogenic index were slightly positively correlated with age in both sexes. The mean values of serum lipid profiles were $190{\pm}32.9mg/dl$ in men and $181{\pm}32.8mg/dl$ in women for cholesterol, $50.1{\pm}11.4mg/dl$ in men and $54.5{\pm}12.0mg/dl$ in women for HDL-cholesterol, $3.9{\pm}1.0$ in men and $3.4{\pm}0.8$ in women for atherogenic index. 2. Mean values of total cholesterol and atherogenic index higher in men than in women at the age 20-40 years but significantly higher in women than in men at the age group 60 years.(p<0.001) 3. The frequency of hypercholesterolemia(${\geq}200mg/dl$) and low HDL-cholesterol(<35mg/dl) were increased with age in both sexs, significantly higher in women at the age group 60 years. The frequency of hypercholesterolemia(${\geq}200mg/dl$) and low HDL-cholesterol(<35mg/dl) in men and women was 37.5%, 25.3%, and 5.5%, 2.8%. Their requencies were higher in men than in women. Conclusion: Theses findings suggest that the mean concentrations of total cholesterol and HDL-cholesterol in men and women vary with age. The frequency of hypercholesterolemia(${\geq}200mg/dl$) in men and women was about 31.4% and increased with age.

• Korean Journal of Adult Nursing
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• v.20 no.6
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• pp.917-931
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• 2008

Purpose: This study was aimed to determine the optimum low-density lipoprotein : high-density lipoprotein-cholesterol (LDL : HDL-C) ratio for predicting coronary heart disease(CHD) in Korean people. Methods: It was analyzed this data of 5,431 adults who had undergone health examinations in a hospital in Gyeonggi-do between January 2006 and December 2007. The covariation of the coronary risk factors such as age, HbA1C, systolic blood pressure(SBP), and waist-to-stature ratio(WSR) were analyzed by using logistic regression analysis. Results: The LDL : HDL-C ratio in the male and female groups was mostly distributed between 1.5 and 4.0. The LDL : HDL-C ratio was the most significant cholesterol-related parameter influencing CHD (male: B = .306, p = .054, female : B = .940, p = .010), followed by LDL-C and total cholesterol. It was observed a sharp increase in the odds ratios for LDL : HDL-C ratios of 2.25 - 2.50(male) and 2.00 - 2.25(female). A significant difference was observed in both male(2.25 : $x^2$ = 2.494, p = .072) and female(2.00 : $x^2$ = 413.742, p = .000) groups. Conclusion: The risk level of CHD was set to 2.25 for males and 2.00 for females. Therefore, the optimum LDL : HDL-C ratio for Koreans should be far lower than that for the people in western countries.

• Journal of Pharmaceutical Investigation
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• v.19 no.3
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• pp.137-143
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• 1989

This study was attempted to investigate the effect of Tricholoma matsutake on experimentally induced hyperlipemia in rats. The levels of cholesterol, triglyceride and phospholipid were measured. Diagnostic attention has been paid to the cholesterol concentration associated with high density lipoprotein (HDL), which appears to be inversely related to the incidence of coronary artery disease. For these reasons, determination of HDL-cholesterol has significant meaning. Total cholesterol was determined by Abell-Kindall method, and to measure HDL-cholesterol, serum low density lipoproteins (LDL) were first selectively precipitated by HDL-precipitating reagent. The results obtained were as follows : 1) The level of total cholesterol in serum of hyperlipemic rats was decreased by oral administration of Tricholoma matsutake extract. 2) The level of HDL-cholesterol was increased by the mushroom extract. 3) The level of triglyceride was significantly decreased by the mushroom extract. 4) The level of phospholipid was slightly decreased by the mushroom extract.

• Journal of Nutrition and Health
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• v.16 no.3
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• pp.200-208
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• 1983

The present studies were designed to compare the effects of both dietary fat levels and P / S ratio on lipid components in plasma and tissues. Changes in plasma HDL-cholesterol, cholesterol and TG, and also in tissue cholesterol and TG were determined in young rats fed diets providing total dietary fat as 10%, 25% or 45% of calories and P / S ratio as 0.2 or 4.0. Plasma cholesterol levels were getting higher as dietary fat levels increased at P / S 0.2. Plasma cholesterol was lower in rats fed dietary fat either 25% or 45 %, each with P / S 4.0. But at 10% no change in plasma cholesterol were observed by P / S 4.0 because of a possible insufficiency of the absolute amount of PUFA. HDL-cholesterol was rather less sensitive to the modification of dietary fat level, but was reduced in rats fed diets of P / S 4.0 at either 25% or 45% fat, even though HDL-cholesterol were increased in the group of 10% with P / S 0.2. Total cholesterol per g- liver were significantly increased as dietary fat levels increased. Liver cholesterol levels were higher in rats fed diets of P / S 4.0 at higher fat levels (25% or 45%) which possibly suggested that a reduction of plasma cholesterol by high PUFA diet was not at least from a decreased synthesis of cholesterol in liver. However, in muscle no significant differences were found by feeding high P / S ratio at each levels of fat. At 10% fat level, compared to 25% or 45%, cholesterol level was lower in g-liver but higher in g- muscle. Plasma TG was decreased as more dietary fat were supplied at P / S ratio, but no consistant response obtained at low P / S ratio. TG per g-liver were reduced by feeding P / S 4.0 diet at 10% or 45% fat level but no differences were found in muscle. P / S 4.0 diet was more efficient in lowering plasma cholesterol TG and HDL-cholesterolt levels only if fat level was more than 25% of the total calories And young rats were more resistant to dietary fat modification.

• Journal of the East Asian Society of Dietary Life
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• v.8 no.4
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• pp.379-387
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• 1998

Magnesium(Mg) plays an important role in lipid metabolism and Mg deficiency but Ca sufficiency Increases serum cholesterol and triglyceride. The relationships of serum Mg, Ca, Ca/Mg ratio with lipids was examined in 79 female college students in Choong-Nam area. Subjects were divided into underweight, normal and overweight groups according to their BMI. The average age, body weight, height and BMI were 21.9yr, 55.9kg, 158.5cm and 22.62kg/$m^2$ respectively. Height was not different between groups. Serum cholesterol and LDL-cholesterol concentrations were significantly lower in the underweight group than other groups. BMI had positive correlations with LDL-cholesterol, atherogenic index (AI) and LDL-cholesterol/HDL-cholesterol ratio(LPH), and negative correlations with HDL-cholesterol/total cholesterol ratio. Serum minerals (serum Mg, Ca, Ca/Mg ratio) and serum lipid concentrations were not significantly different between groups. However, there was a tendency of increasing serum Mg level with increasing serum HDL-cholestrol, HDL-cholesterol/total cholesterol ratio and decreasing serum LDL-cholesterol, LPH, total cholesterol/HDL-cholesterol ratio(TPH) and AI. And there was a tendency of increasing serum Ca level with increasing serum HDL-cholesterol/total cholesterol ratio and decreasing serum triglyceride, LDL-cholesterol, LPH, TPH and AI. And there was a tendency of increasing serum Ca /Mg ratio level with decreasing triglyceride, serum LDL-cholesterol and TPH. This study was limited within serum levels of minerals (serum Mg, Ca and Ca/Mg ratio), serum lipids concerned with CHD, therefore I hope there will be wider efforts to consider about the dietary levels of minerals for presentation of the connection between dietary Mg, Ca and serum lipids.

• Journal of Korean Biological Nursing Science
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• v.19 no.2
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• pp.107-112
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• 2017

Purpose: The purpose of this study was to identify the lipid profile ratios as factors affecting disease progress in patients with high-grade primary brain cancers undergoing concurrent chemoradiotherapy (CCRT) and adjuvant chemotherapy. Methods: The levels of lipid profile ratios were evaluated by looking at the total cholesterol (TC) to high-density lipoprotein (HDL)-cholesterol (TC/HDL-c), low-density lipoprotein (LDL)-cholesterol to HDL-cholesterol (LDL-c/HDL-c), and triglycerides to HDL-cholesterol (TG/HDL-c). This descriptive research was conducted 7 months after the initiation of CCRT and adjuvant chemotherapy. Results: A total of 36 patients with newly diagnosed primary malignant brain cancer were included in the study. The levels of lipid profile ratios such as TC/HDL-c, LDL-c/HDL-c, TG/HDL-c were significantly different between the patients with and without disease progress at 7 months after initiation of CCRT and adjuvant chemotherapy. Conclusion: The lipid profile ratios were indicators affecting disease prognosis with tumor-related factors at 7 months after initiation of CCRT and adjuvant chemotherapy. Therefore, lipid profile ratios indicating hyperlipidemia in patients with high-grade brain cancers should be carefully monitored during and after cancer-related therapy.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.201-204
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• 2003

Plasma lipoproteins transporting cholesterol through blood vessels are divided into three major classes, VLDL, LDL, and HDL. The ratio of HDL cholesterol over the total can be used as an indicator for prognosis of coronary artery diseases. In this study, we have developed two analytical systems for %HDL cholesterol with different flow modes toward gravity and analyzed them for their characteristics and performances.

• The Korean Journal of Food And Nutrition
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• v.5 no.2
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• pp.123-131
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• 1992

This study was designed to find out the effects of aerobic exercise on the serum lipids in the middle-aged women. The effects of aerobic dancing on serum total cholesterol(TC), triglyceride(TG) and HDL-cholesterol (HDL-C) were studied in eight sedentary women(control group) and twenty seven aerobic exercising women(aerobic group) , aged 35∼45%. Aerobic exercising subjects were divided into 3 group; 2 to 3 months exercising group(Al), 4 to 10 months exercising group(AH), over 1 year exercising group(AIII) according to the periods of exercise. The serum lipid levels of aerobic exercising groups(AI, AII, AIIII) were compared with those of control group. The results statistically analyzed were summarized as follows : 1) The serum TG levels of aerobic groups decreased very significantly compared with those of control group(p< 0.001) and tended to be lower with the increase in aerobic periods. But there were no significant differences among aerobic groups by ANOVA. 2) The serum TC levels of aerobic groups decreased compared with those of control group and tended to be lower with the increase of aerobic periods. But there were no significant differences among groups. 3) Serum HDL-cholestrol level of A I group was elevated significantly compared with that of control group and significant difference was observed according to the aerobic periods : AR group exhibited higher serum HDL-cholesterol values than AH group, and AH group higher than A I group.

• Journal of Nutrition and Health
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• v.26 no.7
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• pp.819-828
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• 1993

The reaction of lecithin cholesterol acyltransferase(LCAT) and cholesteryl ester transfer protein (CETP) are important in cholesterol esterification and transfer for the reverse cholesterol transport(RCT) system. The purpose of this study were to assess the effects of fatty acid unsaturation on RCT system. After 12 female human subjects consumed a prescribed high saturated fat diet prior to the period, two groups of six subjects were provided with a high PUFA(corn oil) or a high SFA(butter) as major fats in a 40 en % fat diet. Butter feeding increased plasma total-(34%), esterified-(96%), HDL_3$-(23%), LDL-(20%), and VLDL plus LDL(35%) cholesterol while corn oil feeding decreased esterified-(25%), LDL(15%) cholesterol and TG(27%). There were significant differences of fats on total-(p=0.0001), esterified-(p=0.0001), total HDL-(p=0.005), $HDL_2$-(p=0.01)and LDL-(p=0.0001) cholesterol. LCAT activity did not change during the period but highly correlated to apo A-I in HDL which was increased in the corn oil group. The 2.5 fold increased CETP activity in the butter group during the period might be related to changes in plasma VLDL plus LDL cholesterol level which were increased in the butter group.