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A Lipid-derived Endogenous Inducer of COX-2: a Bridge Between Inflammation and Oxidative Stress

  • Uchida, Koji
    • Molecules and Cells
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    • v.25 no.3
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    • pp.347-351
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    • 2008
  • Several lines of evidence indicate that the oxidative modification of protein and the subsequent accumulation of the modified proteins have been found in cells during aging, oxidative stress, and in various pathological states including premature diseases, muscular dystrophy, rheumatoid arthritis, and atherosclerosis. The important agents that give rise to the modification of a protein may be represented by reactive aldehydic intermediates, such as ketoaldehydes, 2-alkenals and 4-hydroxy-2-alkenals. These reactive aldehydes are considered important mediators of cell damage due to their ability to covalently modify biomolecules, which can disrupt important cellular functions and can cause mutations. Furthermore, the adduction of aldehydes to apolipoprotein B in low-density lipoproteins (LDL) has been strongly implicated in the mechanism by which LDL is converted to an atherogenic form that is taken up by macrophages, leading to the formation of foam cells. During the search for an endogenous inducer of cyclooxygenase-2 (COX-2), an inducible isoform responsible for high levels of prostaglandin production during inflammation and immune responses, 4-hydroxy-2-noennal (HNE), one of the most representative lipid peroxidation product, has been identified as the potential inducer of COX-2. In addition, the following study on the molecular mechanism of the COX-2 induction by HNE has unequivocally established that a serum component, which is eventually identified to be denatured LDL, is essential for COX-2 induction. Here I review current understanding of the mechanisms by which HNE in cooperation with the serum component activates gene expression of COX-2.

Solubility and Diffusivity of CS2 in DEA Solution

  • Park, Moon-Ki;Moon, Yung-Soo;Park, Jong-Kil
    • Journal of Environmental Science International
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    • v.12 no.5
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    • pp.551-557
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    • 2003
  • An experimental study of the absorption of CS$_{2}$ in the secondary amine diethanolamine(DEA) was performed in this work. The primary objectives were to investigate an analogy between N2O and CS$_{2}$ permitting estimation of the physical solubility and diffusivity of the sulfur gases in the reacting amino solutions. The solubilities of CS$_{2}$ in water at 25, 40 and 6$0^{\circ}C$ has been measured. The data show fair agreement with previous literature values. The solubility of CS$_{2}$ in 5-25 weight % polyethylene glycol has been measured in order to investigate a possible analogy between CS$_{2}$ and N$_{2}$O The diffusivities of CS$_{2}$ in water and the reaction rate between CS$_{2}$ and DEA has been measured at 25 and 4$0^{\circ}C$, using a wetted sphere apparatus operated at approximately 1/3 atmospheres pressure, which is a previously untried method.

An experimental study on carbonation and compressive strength of cementitious materials containing CO2 reactive materials (CO2 반응물질을 혼입한 시멘트계 재료의 탄산화 진행 및 압축강도 발현에 관한 실험적 연구)

  • Seong, Myung-Jin;Kim, Yeung-Kwan;Lee, Han-Seung
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2015.05a
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    • pp.30-31
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    • 2015
  • Usually, carbonation of concrete causes pH reduction and corrosion of steel, it leads to decrease of durability. However, CaCO3, as results of reaction with hydrates products and CO2, can contribute to improvement of compressive strength. Based on this theory, using carbonation depth, the researches about CO2 absorption of plain concrete and concrete containing CO2 reactive materials has been performed. But, the researches has limitation about using one material, therefore, for this study, considering various CO2 reactive materials, experiment has been proceeded. With water to binder ratio 50%, after initial curing for 2days, accelerated carbonation was performed for 28days, and carbonation depth and compressive strength were measured. As results of carbonation depth, specimen containing desulfurized slag, zeolite showed the highest CO2 absorption, in case of compressive strength, specimens with MgO were indicated as highest compressive strength.

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A Design of P2P Cloud System Using The Super P2P

  • Jung, Yean-Woo;Cho, Seongsoo;Lee, Jong-Yong;Jeong, KyeDong
    • International Journal of Internet, Broadcasting and Communication
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    • v.7 no.1
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    • pp.42-48
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    • 2015
  • Generally, the current commercial cloud system is hosted by the centralization large datacenter. However, the other clouding forms existed and one of them is the P2P cloud. The P2P Cloud is a distributed systems, is freedom to join and leave and is possible to provide the IaaS. Commonly, P2P Cloud System is based on Pure-P2P System. Since a number of connection paths exist, it has a high reliability and easily scalability of the network. However, there are disadvantages of the slow rate of route because of looking up the all peers in order to search for the peer. In this paper, it proposes the P2P cloud system based on super-peer P2P. Super-peer P2P system has fast routing time, because of searching for cluster unit and it also can has high reliability and high scalability. We designs the super Peer cloud service and proposes the system model and Resource Allocation Algorithm for IaaS in Super peer P2P environment.

Development of cold weather concrete by using do-icing agency (방동제를 이용한 한중 콘크리트 개발 연구)

  • 유성원;서정인
    • Proceedings of the Korea Concrete Institute Conference
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    • 2001.05a
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    • pp.953-958
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    • 2001
  • The concrete which has placed under cold weather has some defects such as the decrease of initial strength by hydration delay, strength unrecover at unhardened concrete freezing and structural failure and crack by expansion pressure. So, in this study, we tried to develope the concrete which can be made under cold weather without defect by using of do-icing agency In concrete test, the used do-icing agency has the characteristics of de-icing and rapid hydration. By test results, Co{$NH_{2}$$]_{2}$is unsuitable for workability, and NaN$O_{2}$ is the most suitable agency for cold weather. And for curing, the cured concrete at $21^{\circ}C$ for 24 hours has the safe strength.

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Studies on the Inflammability and Heat Resistance of Conveyer Rubber Belts (콘베어 고무벨트의 난연성(難燃性) 및 내열성(耐熱性)에 관(關)한 연구(硏究))

  • Oh, Pyoung-Je
    • Elastomers and Composites
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    • v.16 no.4
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    • pp.211-216
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    • 1981
  • A series of conveyer rubber belts has been made by blending natural rubber(NR), styrene butadiene rubber(SBR), chloroprene rubber(CR) and additives on nylon cords, and their respective flammability has been investigated. It has been observed that: 1. By adding an antiflame agent to the belt, in addition to 70% chlorinated paraffine and antimony oxide($Sb_{2}O_{3}$), the inflammability is improved remarkably to O - 2 seconds due to the synergistic effect, while a sample without antiflame B fails to pass the KS M 6678 test. 2. Physical properties, such as tensile strength, elongation at break and adhesion strength, of the sample belts have been studies by varying ratios of NR/CR from 20 to 100, and it has been observed that the higher ratios have the better physical properties.

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Control of Robot Manipulators Using PD-Sliding Mode hybrid Controller (PD-슬라이딩 모드 복합 제어기를 이용한 로봇 매니퓰레이터의 제어)

  • Lee, Kyu-Joon;Kyung, Tai-Hyun;Kim, Jong-Shik
    • Journal of Institute of Control, Robotics and Systems
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    • v.8 no.2
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    • pp.89-96
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    • 2002
  • A new chattering free PD-sliding mode hybrid control scheme is proposed for robot manipulators. This hybrid controller is composed of a PD controller and a semi-continuous sliding mode controller. It has a good robust performance in reaching mode which does not possess invariance property of sliding mode, and has chattering free characteristics in sliding mode. Thus, the PD-sliding mode hybrid controller has a good robust performance in the whole region. It is shown that the proposed control has a good transient response and trajectory tracking performance for a 2-link SCARA robot manipulator.

Range Safety Activities for the Launch of an Earth Observation Satellite

  • Im, Jeong-Heum
    • The Bulletin of The Korean Astronomical Society
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    • v.37 no.2
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    • pp.194.2-194.2
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    • 2012
  • Korea Aerospace Research Institute has developed an earth observation satellite and it was launched into its orbit in 2012 by using a foreign commercial launch vehicle. The launch site authority has imposed safety requirements to the spacecraft developer to ensure the safety of the personnel and to protect launch vehicle, spacecraft and facilities from accidents associated with the satellite operation at the launch site. This paper describes the range safety activities implemented for the satellite and supporting equipments during the whole phase of their design, manufacturing/test and operation at the launch site. To ensure the integrated requirements for safety management and design, system safety program plan has been developed. And based upon the plan, spacecraft developer conducted hazard analysis to identify and establish safety requirements to reflect in designs, procedures, operations. The result of the hazard analysis has been complied into safety data packages and it was reviewed by launch site review board at the safety reviews and finally it was approved to launch.

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Enhancement of Power System Dynamic Stability by Designing a New Model of the Power System

  • Fereidouni, Alireza;Vahidi, Behrooz
    • Journal of Electrical Engineering and Technology
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    • v.9 no.2
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    • pp.379-389
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    • 2014
  • Low frequency oscillations (LFOs) are load angle oscillations that have a frequency between 0.1-2.0 Hz. Power system stabilizers (PSSs) are very effective controllers in improvement of the damping of LFOs. PSSs are designed by linearized models of the power system. This paper presents a new model of the power system that has the advantages of the Single Machine Infinite Bus (SMIB) system and the multi machine power system. This model is named a single machine normal-bus (SMNB). The equations that describe the proposed model have been linearized and a lead PSS has been designed. Then, particle swarm optimization technique (PSO) is employed to search for optimum PSS parameters. To analysis performance of PSS that has been designed based on the proposed model, a few tests have been implemented. The results show that designed PSS has an excellent capability in enhancing extremely the dynamic stability of power systems and also maintain coordination between PSSs.

Behavior of steel-concrete composite beam using angle shear connectors at fire condition

  • Davoodnabi, Seyed Mehdi;Mirhosseini, Seyed Mohammad;Shariati, Mahdi
    • Steel and Composite Structures
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    • v.30 no.2
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    • pp.141-147
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    • 2019
  • Fire is one of the environmental parameters affecting the structure causing element internal forces to change, as well as reducing the strength of the materials. One of the common types of floors in tall steel structures is the steel concrete composite slab. Shear connectors are used in steel and concrete composite beam in various shapes also has played significant role in a burning fire event of building with a steel concrete composite beam. The current study has reviewed the effects of temperature raising on the angle connector behavior through the use of push out tests and monotonic static force. The results have shown (1) the ductility of the samples is acceptable based on EC4 standard; (2) temperature raising has reduced the stiffness; (3) the shear ductility increment; and (4) the shear capacity reduction. Also, the amount of angle shear connector resistance has been decreased from 18.5% to 41% at ambient temperature up to $850^{\circ}C$.