• Clinical and Experimental Pediatrics
• /
• v.45 no.5
• /
• pp.629-636
• /
• 2002

Purpose : Our study was aimed to investigate the characteristics of seizures as well as to determine whether the expression of neuronal nitric oxide synthase expression(nNOS) of hippocampus has an affect in the hyperthermic seizure in developing rat. Methods : Hyperthermic seizures were repeatedly induced twice a week for four weeks in 20-day old Spraque-Dowley rats. Fifty two rats were used as a hyperthermic group and 30 rats used as a normothermic control group. Hyperthermic seizures were induced in a water bath at $45^{\circ}C{\pm}1$ for 4 min. The characteristics of seizures were recorded. Using western blot, hippocampal nNOS expression was measured in normothermic control, hyperthermic non-seizure, and hyperthermic seizure groups, respectively. Results : Eighty seven percent of hyperthermia exposed rats showed generalized tonic-clonic seizure most frequently. The duration of seizure was ranged from 12 to 145 sec(mean 55 sec) and the latency to seizure ranged from 158 to 240 sec(mean 204 sec). The duration of seizure was prolonged but there was no significant difference in the seizure latency as the rat exposed more number of hyperthermia. Interestingly, the expression level of hippocampal nNOS in hyperthermic seizure and hyperthermic non-seizure groups was not different from each other, however, the expression in these groups was lower than that of the control group. Conclusion : Our results indicate that nNOS do not have an affect in this repeated hyperthermic seizures. Further studies are required to clarify a role of nNOS in hyperthermic seizure.

• Journal of the Korea Organic Resources Recycling Association
• /
• v.16 no.4
• /
• pp.64-73
• /
• 2008

The cDNA of CCF (coelomic cytolytic factor)-like gene (EC 3.2.1.16), a kind of glycosyl hydorlase, was isolated and cloned from the midgut of the earthworm Eisenia anderi. The size of nucleotide sequence appeared to be 1,152 bp and its predicted coding region was composed of 384 amino acid residues including the initiation methionine. The 17 residues at N-terminal end in the deduced amino acid sequence were regarded to be a signal peptide. Based on the amino acid sequence analysis, it appeared that this CCF-like protein could belong to glycosyl hydrolase family 16 (GHF16) and showed a high sequence homology of about 79~99% with CCF and CCF-like proteins from other earthworm species. The CCFs and CCF-like proteins from various earthworm species exhibited a 100% homology in the polysacchride-binding motif and glucanase motif. It has been reported that the CCFs isolated from E. fedita appeared to show a broader pattern recognition specificity than those from other earthworm species because this species resides in decaying organic matter showing very high microbial activity, implying that CCF-like protein isolated in this study from E. andrei might exhibit a broad substrate specificity that is a useful characteristic for industrial application. A phylogenetic analysis using the deduced amino acid sequences of CCF-related proteins through the BLASTX revealed that GHF16 families could be divided into three groups of metazoa, viriplantae and eubacteria subfamily. Subsequently the CCF-related proteins of metazoa subfamily could clearly be subgroup into lophotrochozoan and edysozoan type including a deuterostome origin. Further understanding of the biological properties of E. andrei CCF-like protein should be addressed to regulate the ${\beta}$-D-glucan hydrolysis and production for the industrial uses.

• Korean Journal of Psychosomatic Medicine
• /
• v.16 no.2
• /
• pp.95-102
• /
• 2008

Objectives : Diabetes patients suffer from severe stress in maintaining the diet therapy and exercise therapy as well as the disease itself, and this stress has bad effects on controlling the glucose level and causes high prevalence rate of depressive and anxiety disorders. These symptoms again have deleterious effects on blood glucose control. A lot of researches about the relationship between glycemic control and symptoms of depression and anxiety and about the positive effects of the treatments of depression and anxiety disorder on glycemic control in diabetic patients are being performed. In Korea, the research regarding the relationship between glycemic control and depression and anxiety symptoms are seldom performed. In this study, we tried to find out the correlation between the glycemic control and depressive symptom and anxiety symptom. Methods : The study included 65 patients(male 34, female 31) with Diabetes in outpatient clinic of the Department of Endocrinology in Dankook University Hospital. We used the HbA1c levels to check glycemic control through blood sample analysis and used Beck Depression Inventory(BDI) and Beck Anxiety Inventory(BAI). Results : Among the 65 Diabetes patients, 21(32.30%) had mild depressive symptoms, and 6(9.23%) had moderate or severe depressive symptoms. The relation of HbA1c and BDI was not statistically significant, but was significant between HBA1c and BAI, (R=0.567, P<0.001). In the linear regression analysis, BAI had an effect on HbA1c($\beta=0.533$, T=5.012, P=0.00), but BDI, diabetes complications, diabetic morbid period and BMI had no effect on HbA1C. The relationship between HbA1c and BDI was not statistically significant, but the relationship between HbA1c and BAI was statistically significant(R=0.254, P<0.001). Conclusions : In this study, the rates of diabetic patients with depressive symptoms were higher, but those with anxiety symptoms were not higher than the general population. We could not find out significant relationship between depressive symptom and glycemic control, but found the significant relationship between the anxiety symptom and glycemic control in diabetic patients.

• Journal of the Korean Society of Hazard Mitigation
• /
• v.9 no.4
• /
• pp.71-80
• /
• 2009

Although desire for living without hazardous damages grows these days, threats from natural disasters which we are currently exposed to are quiet different from what we have experienced. To cope with this changing situation, it is necessary to assess the characteristics of the natural disasters. Therefore, the main purpose of this research is to suggest a methodology to estimate the potential property loss and assess the flood risk using a regional regression analysis. Since the flood damage mainly consists of loss of lives and property damages, it is reasonable to express the results of a flood risk assessment with the loss of lives and the property damages that are vulnerable to flood. The regional regression analysis has been commonly used to find relationships between regional characteristics of a watershed and parameters of rainfall-runoff models or probability distribution models. In our research, however, this model is applied to estimate the potential flood damage as follows; 1) a nonlinear model between the flood damage and the hourly rainfall is found in gauged regions which have sufficient damage and rainfall data, and 2) a regression model is developed from the relationship between the coefficients of the nonlinear models and socio-economic indicators in the gauged regions. This method enables us to quantitatively analyze the impact of the regional indicators on the flood damage and to estimate the damage through the application of the regional regression model to ungauged regions which do not have sufficient data. Moreover the flood risk map is developed by Flood Vulnerability Index (FVI) which is equal to the ratio of the estimated flood damage to the total regional property. Comparing the results of this research with Potential Flood Damage (PFD) reported in the Long-term Korea National Water Resources Plan, the exports' mistaken opinions could affect the weighting procedure of PFD, but the proposed approach based on the regional regression would overcome the drawback of PFD. It was found that FVI is highly correlated with the past damage, while PFD does not reflect the regional vulnerabilities.

• Journal of Korea Technology Innovation Society
• /
• v.10 no.4
• /
• pp.654-686
• /
• 2007

To estimate and analyze an interested science and technology level in any case requires three basic informations: (1) relative positions of our technology level, (2) other relevant technology level of the world best country holding the state of the art technology, and (3) its theoretical or practical maximum level within a certain period of time. Further, additional information from analyzing its respective rate of technology changes is necessary. It seems that most previous empirical or case studies on technology level have not considered third and fourth informations seriously, and thus critically have missed important findings from a dynamic point of view on the matter. A dynamic approach considering types of development processes and paths as well as current position needs an application of a concept of technology development stages and respective growth curves. This paper proposes a new method of approach and application by implementing relatively simple types of the growth curve(S-curve) such as logistic and Comports curves and applying estimation results of these curves to ten core technologies of the growth engines for the next future generation in Korea. The study implies that Korean science and technology level in general clearly gets higher as it approaches to a recent time of period, but relative technology gap from the world best in terms of catching-up period does not get better or narrower in case of at least part of the concerned technologies such as bio new drugs and human organs, and intelligence robots. The possibility does exist that some of our concerned technologies shooting for the next future generation may not come to the world highest level in the near future. The purpose of this study is to propose possibilities of catching-up, if any, by estimating its relevant type of growth pattern by way of measuring and analyzing technology level and by analyzing the technology development process through a position analysis. At this stage this study tries to introduce a new theoretical approach of estimating technology level and its application to existing case study results(data) from Korea Institute of Science and Technology Planning and Evaluation(KISTEP) and Korea Institute of Industrial Technology Evaluation and Planing(ITEP), for years of 2004 and 2006 respectively. The study has some limitations in terms of accuracy of measuring(estimating) a relevant growth curve to a particular technology, feasibility of applying estimated results, accessing and analyzing panel experts opinions. Hence, it is recommended that further study would follow soon enough to verify practical applicability and possible expansion of the study results.

• Cartoon and Animation Studies
• /
• s.41
• /
• pp.75-106
• /
• 2015

Animations characterize space as a strategy to effectively show the inner conflicts of characters and to highlight the theme. During the process of inner conflict, characters unconsciously use defense mechanism to protect their egos from the fear that came from deficiency, and because of the self-deceptive quality of self-defense mechanism, the reality is distorted and conflicts get intensified. This study focuses on the concept of anti-house, the space where conflicts get intensified, analyzes animations to find out the aspect of inner conflict, and interprets the characteristic of space that is used for metaphoric structure frame. Also, it aims to reveal how the defense mechanism, which intensifies the inner conflict of characters, is characterized as anti-house. The analysis in this study was mainly done with the TV series, , and the theater version of . It is because the characters have serious deficiency from broken home and have a psychological quality of closed boundary that is symbolized as 'A.T. field'. Especially, the core character, 'Shinji Ikari', shows how a character uses compulsive self-defense mechanism to deal with inner conflict and as a result, goes through ego-collapse and then introspection. This process of the character's experience is the core of the whole plot. Through analysis, the relationship between the character's self-defense mechanism and the space, anti-house(which expands to Anti-city), was inferred. The space is made up of three axes, x-axis of horizontal space, y-axis of vertical space, and in the sense that all the space has no exit, z-axis of deeper contradictory space. This thesis started with the decision that is the most suitable work in analyzing the metaphorical relationship between self-defense mechanism and anti-house. There was limitation, however, as the typical characteristics of Japanese animations, pedantic composition and the possibility of broad interpretation, hindered clear verification. Hopefully, this limitation will be overcome by following studies and this study is expected to show the importance of space in interpreting the text of animations, and to serve as database for other creative works.

• Journal of Korean Society of Environmental Engineers
• /
• v.32 no.2
• /
• pp.165-174
• /
• 2010

The numerical modeling of a coal gasification reaction occurring in an entrained flow coal gasifier is presented in this study. The purposes of this study are to develop a reliable evaluation method of coal gasifier not only for the basic design but also further system operation optimization using a CFD(Computational Fluid Dynamics) method. The coal gasification reaction consists of a series of reaction processes such as water evaporation, coal devolatilization, heterogeneous char reactions, and coal-off gaseous reaction in two-phase, turbulent and radiation participating media. Both numerical and experimental studies are made for the 1.0 ton/day entrained flow coal gasifier installed in the Korea Institute of Energy Research (KIER). The comprehensive computer program in this study is made basically using commercial CFD program by implementing several subroutines necessary for gasification process, which include Eddy-Breakup model together with the harmonic mean approach for turbulent reaction. Further Lagrangian approach in particle trajectory is adopted with the consideration of turbulent effect caused by the non-linearity of drag force, etc. The program developed is successfully evaluated against experimental data such as profiles of temperature and gaseous species concentration together with the cold gas efficiency. Further intensive investigation has been made in terms of the size distribution of pulverized coal particle, the slurry concentration, and the design parameters of gasifier. These parameters considered in this study are compared and evaluated each other through the calculated syngas production rate and cold gas efficiency, appearing to directly affect gasification performance. Considering the complexity of entrained coal gasification, even if the results of this study looks physically reasonable and consistent in parametric study, more efforts of elaborating modeling together with the systematic evaluation against experimental data are necessary for the development of an reliable design tool using CFD method.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.31 no.5
• /
• pp.645-653
• /
• 1998

Twenty seven species of pufferfishes (family Tetraoaontidae) have been examined to find their generic characters based on vertebrae and pterygiophore characters of specimens collected in 20 localities along the coast of Korea from March, 1991 to March, 1994. It was divided by 3 groups based on vertebrae number as follow : the genera Lagocephalus, Pleurancanthus, Spheoides, Arothron, Chelonoeon and Canthigaster have 17$\~$19 vertebrae, genera Ephippion, Boesemanichthys and Feroxodon have 20 vertebrae, and genus Takifugu have 19$\~$25 vertebrae, The number of vertebrae ranged from 17 to 25 with the maximum of 25 in Takifugu obscurus. The modal number of vertebrae in Lagocephalus is 17 (L. lunaris), 18 (L. inermis), and 19 (L. gloveri, L. wheeleri, L. larigatus), with the lower number more specialized. Paired neural spines appear at number of the 1st$\~$5th vertebrae in Takifugu pardalis, Takifugu obscurus and at number of the 1 st$\~$4 th vertebrae in the other species and genera. All of the species of Lagocephalus and Pleurancanthus have dorsal and ventral pterygiophores processes, and flat-shaped epural, while none of the abdominal vertebrae processes complete haemal arches. The neural and haemal spines of the last few caudal vertebrae aye shorter in Pleurancanthus than in the other genera, associated with the depressed caudal peduncle. The genus Canthigaster is distinguished the first pterygiophores of the dorsal and ventral fins is always much larger than the others genera. Based on the haemal arches and spines of the abdominal vertebrae, genus Canthigaster has different characters from the other genera of the family Tetraodontidae.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.30 no.3
• /
• pp.393-407
• /
• 1997

A survey of biological and chemical characteristics in the middle-northern East Sea of Korea was carried out at 28 stations in October, 1995 on board R/V Tam-Yang. On the basis of the vertical profiles of temperature, salinity and dissolved oxygen, water masses in the study area were divided into 5 major groups; (1) Low Saline Surface Water (LSSW), (2) Tsushima Surface Water (TSW), (3) Tsushima Middle Water (TMW), (4) North Korean Cold Water (NKCW), (5) last Sea Porper Water (ESPW). Other 4 mixed water masses were also observed. It is highly possible that the LSSW which occured at depths of $0\~30m$ in the most southern part of the study area is originated from the Yangtze River (Kiang) of China due to very low salinity $(<32.0\%_{\circ})$ relatively high concentration of dissolved silicate and no sources of freshwater input into that area. Oxygen maximum layer in the vertical profile was located near surface at northern cold waters and became deeper at the warm southern area. Oxygen minimum layer af depths $50\~100m$, which is TMW, were found in only southern area. In the vortical profiles of nutrients, the concentrations were very low in the surface layer and increased drammatically near the thermocline. The highest concentration occurred in the ESPW. The relatively low value of Si/P ratio in the ESPW (13.63) compared to other reports in the East Sea was due to continuous increase of P with depth as well as Si. The N : P ratio was about 6.92, showing that nitrogenous nutrient is the limiting factor for phytoplankton growth. The exponential relationship between Si and P, compared to the linear relationship between N and P, indicates that nitrate and phosphate have approximately the same regenerative pattern, but silicate has delayed regenerative pattern.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.34 no.6
• /
• pp.691-696
• /
• 2001

The first bloom of Cochlodinium polykrikoides was observed in the estuary of Nak-dong river near Pusan in Korea in 1982. Since then, there have been irregular blooms, sometimes spread over the adjoining .to Jinhae Bay even though it was confined to the bay and its vicinites until 1988. It had been outbroken frequently in the adjacent to Tongyeong, Geoje, Namhae and Yeosu coast since 1989. It became widespread along the coast of the South Sea to the East Sea of Korea in 1995. And in October in 1998 and 1999, the bloom had been taken place in Kunsan coast of Yellow Sea. According to the observations in situ, the frequency of occurrence has been increased year by year. The prevailing bloom season was from July to October with peak in September. The duration of the bloom became longer with the year, and sometimes lasted more than one month. The density of the bloom did not exceed 5,000 cells $mL^{-1}$until 1991, but it increased year by year to the highest of 43,000 cells $mL^{-1}$ in 1999. With respect to the assembleges of species in dinoflagellate blooms, C. polykrikoides was one of the important species with diatoms and the other dinoflagellates in 1980s. But since then, C. polykrikoides made an almost monospecific bloom. Based on two decadal observations of C. polykrikoides blooms, it became widespread throughout whole coast of the Korea, persistent for about one or two month long in some year, and monospecisc high density blooms. It was reported that significant fish mortalities were caused by this harmful dinoflagellate blooms especially in the fishfarms accomodating intensive fish cages such as Tongyeong, Namhae-do, Geoje, Yeosu and Geomun-do fishfarming yards. This widespread and persistent harmful algal blooms impede the development of marine aquaculture industries.