• Toxicological Research
• /
• v.34 no.4
• /
• pp.325-332
• /
• 2018

The mechanism of the previously reported antidiabetic effect of Basella alba is unknown. This study investigated the role of B. alba aqueous leaf extract in the modulation of inflammatory cytokines and islet morphology in streptozotocin-induced diabetic rats. Forty male Wistar rats, between 8 and 10 weeks old, were randomly divided into four groups (n = 10) and administered the following treatments: Healthy control (H-c) and Diabetic control (D-c) animals received normal saline 0.5 mL/100 g body weight daily, while Healthy Treatment (H-Ba) and Diabetic Treatment (D-Ba) rats received the plant extract 200 mg/kg body weight daily. All treatments were administered by oral gavage. Diabetes was induced in D-c and D-Ba rats by a single intraperitoneal injection of streptozotocin (55 mg/kg body). The body weight and fasting blood sugar (FBS) levels were recorded every week for 4 weeks, after which the rats were euthanized and samples collected for further analysis. After the experiment, FBS level was significantly reduced (p < 0.0001) in rats in the D-Ba group, but increased (p < 0.001) in rats in the D-c group. The absolute (H-c and H-Ba vs D-c, p < 0.05) and relative (D-Ba vs H-c, p < 0.05; D-Ba vs H-Ba, p < 0.005) weights of the pancreases were significantly higher after the experiment. The rats in the D-c group had significantly higher levels of serum interleukin-$1{\beta}$ (p < 0.001 vs H-c; p < 0.05 vs H-Ba and D-Ba) and monocyte chemotactic protein-1 (p < 0.0001), but lower levels of interleukin-10 (p < 0.05) in comparison with the other groups. Histopathological examination revealed severe interstitial congestion, reduced islet area (p < 0.0001), and increased islet cell density in the D-c group compared with those in the D-Ba group. From these findings, it was concluded that the aqueous extract of B. alba stimulates the recovery of beta-islet morphology in streptozotocininduced diabetic rats by modulating the peripheral production of inflammatory cytokines.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.34 no.4
• /
• pp.496-502
• /
• 2005

The chemical properties and nitrite scavenging ability were analyzed which on a citron (Citrus junos) of 4 kinds purchased in different regions [Namhae (I, II), Tongyoung and Koheung] in Korea. Four kinds of organic acids were determined. Citric acid contents in flesh and peel of citron were $10.2\pm0.14\~17.7\pm0.17\;g/100g$. The organic acid content was the highest in citron purchased from Koheung. Total mineral content in citron was in a range of $2,844.3\~4,022.4$ mg/100 g, the potassium content was the highest in the range of $1,332.4\pm2.31\~2,308.5{\pm}3.25\;mg/l00g$. The major free amino acid from citron were proline, asparagine and glutamic acid. And the highest in peel of citron purchased from Tongyoung by 326.9 mg/100 g. However, the kinds and contents of chemical components in citron were somewhat different among various regions. The electron donating ability using DPPH method of citron juice was more than $80.0\%$ at the concentration of $0.1\~0.2\%$ and it was stronger by increased the juice concentration in the reaction mixture. SOD-like activity showed $10.2\pm0.50\~20.1\pm0.77\%$ at the concentration of $0.01\~0.2\%$. The nitrite scavenging ability was pH and sample concentration dependent. It was the highest at the pH 1.2 and more than $73\%$ in $0.1\~0.2\%$ citron juice. On the contrary in all concentration of added citron juice lower than $27\%$ at pH 4.2.

• Journal of Korean Ophthalmic Optics Society
• /
• v.9 no.2
• /
• pp.323-332
• /
• 2004

This study researched the visual acuity test object and Auto-refractormeter, visual of near power. The object were composed of middle aged, the old men and women who in habit Daegu. The results were as follows : 1. The subjects consisted of 537 people, 29.98% men, 70.02% women. 2. The emmetropia was 1.12% for myopia, 2.79% for hyperopia, 96.09% for astigmatism. 3. The abnormal refraction was composition for myopic compound astigmatism(16.57%), hyperopia compound astigmatism(45.62%), Mixed astigmatism(33.89%). 4. On the Myopic Spherical Equivalent(S.E) power, the range of -0.50D ${\leq}$ M.S.E < -1.00D was 21.67%, -1.00D ${\leq}$ M.S.E < -2.00D was 48.89%, -2.00D ${\leq}$ M.S.E < -6.00D was 29.44%. 5. On the Hyperopic Spherical Equivalent(S.E) power, the range of +0.50D ${\leq}$ H.S.E < +1.00D was 28.57%, +1.00D ${\leq}$ H.S.E < +2.00D was 49.30%, +2.00D ${\leq}$ H.S.E < +6.00D was 23.13%. 6. The addition power was 1.00D(8.01%), 1.50D(8.57%), 2.00D(13.78%), 2.50D(16.57%), 3.00D(16.95%), 3.50D(17.88%), 4.00D(18.25%).

• Proceedings of the Korean Society for Technology of Plasticity Conference
• /
• 2009.10a
• /
• pp.332-337
• /
• 2009

Recently, boss and rib test based on backward extrusion process was proposed to quantitative evaluate the interfacial friction condition in bulk forming process. In this test, the tube-shaped punch with hole pressurizes the workpiece so that the boss and rib are formed along the hole and outer surface of the punch. It was experimentally and numerically revealed that the height of boss is higher than that of the rib under the severe friction condition. This work is focused on the effect of the punch design and friction condition on deformation pattern in boss and rib test. From the boss and rib test simulations, it was found that there is slight variation in both the heights of boss and rib according to the length of punch land, nose radius, and face angle. However the hole diameter of the punch and the clearance between the punch and die have a significant influence on the heights of the boss and rib. In addition, the effect of flow stress was also investigated on the deformation patterns through FE simulations.

• Korean Journal of Medicinal Crop Science
• /
• v.10 no.5
• /
• pp.327-332
• /
• 2002

This study was conducted to investigate the immuno-regulatory effect and apoptosis of L1210 and HL60 leukemia cells of methanol-extracts of Cornus kousa Burg(CKB). The proliferation of mouse splenocytes and thymocytes enhanced by the addition of $10\;{\mu}g/ml$ of CKB. CKB were administered p.o. once a day for 7 days in adult male BALB/c mice. CKB increased the splenic and thymic T lymphocytes, especially the number of $T_H$ cells markedly increased by the treatment of CKB. CKB treatment induced the apoptotic cell death in L1210 mouse leukemia and HL60 human leukemia cells. In addition, CKB also accelerated the phagocytic activity in peritoneal macrophages and increased the production of plaque forming cells. These results suggest that CKB have an various immuno-regulatory property.

• Journal of Environmental Science International
• /
• v.3 no.4
• /
• pp.317-332
• /
• 1994

Based on the Results of Marine Meteorological and Oceanographical Observations (1966 ~ 1987), oceanographic conditions of the Japan Sea in winter was studied in relation to the Japan Sea Proper Water (JSPW). The mean and dispersion of the deep water above 1000 m depth are 0.26$\pm$0.2$^{\circ}C$ in temperature and 5.1$\pm$0.25 ml/h in oxygen. The mean and dispersion of the bottom water below 1000m depth are 0.07$\pm$$0.04^{\circ}C$ in temperature and 5.1$\pm$0.15ml/1 in oxygen. The distributions of the temperature and dissolved oxygen in the deep water above 1000m depth are ranged wider than 각one of the bottom water below 1000m depth in T-S and T-$ extrm{O}_2$ diagrams. The bottom water are showed more homogeneous and smaller variations than the deep water in the characteristics of water mass. The deep water above 1000m depth is active in contact with the atmosphere. The JSPW similar to the above characteristics is showed in the open ocean of the north of $40^{\circ}$30""N, west of $138^{\circ}$E. Therefore, the deep water is formed probably by the open-ocean convection.tion.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2007.05a
• /
• pp.332-339
• /
• 2007

As the economy has grown and the main industry in Korea has been changed from secondary industry to tertiary industry, the importance of indoor environment has been a matter of common concern, in which one of the main concerns is to improve the indoor acoustic conditions. However, even though this is required more than before, there are no measures to protect the human being from the noise of electric home appliances. This is owing to the absence of the data about sound power level of electric home appliances. So, we investigate the sound power level of them and analyze the acoustical characteristics of each one. First, we tried to investigate the sound power measurement method of each electric home appliance. After it we test the sound power level of them. From the survey, we can know that the vacuum cleaner is the most noisy electric home appliance, and the refrigerator is the least noisy one. The noise of a range hood is distributed over a wide range frequency. Lastly, we intented to propose the proper method measuring sound power level on each electric home appliance.

• Journal of Microbiology and Biotechnology
• /
• v.18 no.8
• /
• pp.1401-1407
• /
• 2008

The roles of conserved amino acid residues (Va1329-Ala330-Asn331-Glu332), constituting an extra sugar-binding space (ESBS) of Thermus maltogenic amylase (ThMA), were investigated by combinatorial saturation mutagenesis. Various ThMA mutants were firstly screened on the basis of starch hydrolyzing activity and their enzymatic properties were characterized in detail. Most of the ThMA variants showed remarkable decreases in their hydrolyzing activity, but their specificity against various substrates could be altered by mutagenesis. Unexpectedly, mutant H-16 (Gly-Leu-Val-Tyr) showed almost identical hydrolyzing and transglycosylation activities to wild type, whereas K-33 (Ser-Gly-Asp-Glu) showed an extremely low transglycosylation activity. Interestingly, K-33 produced glucose, maltose, and acarviosine from acarbose, whereas ThMA hydrolyzed acarbose to only glucose and acarviosine-glucose. These results propose that the substrate specificity, hydrolysis pattern, and transglycosylation activity of ThMA can be modulated by combinatorial mutations near the ESBS.

• Journal of the Korea Society of Computer and Information
• /
• v.21 no.10
• /
• pp.157-166
• /
• 2016

The aims of this study are to contribute to efficient revenue management by analysis of the scale in elderly long-term care facilities. The data was used for input of the elderly long-term care costs Scale, and calculated the staffing standards and social welfare facilities workers with living wage guidelines in the Department of Health and Human Services. Revenue efficiency is the highest order of size are as follows. I8(98 people) \43,517,010, H6(86 people) \36,568,332, G8(78 people) \29,426,532, F8(68 people) \23,227,532, E8(58 people) \19,701,254, D8(48 people) \19,155,187, C6( 36) \14,389,109, B8(28 people) \9,920,031, A8(18 people) \3,721,031. It seems that its revenue efficiency even higher than the larger the scale. Meanwhile, The researchers focused on C6 (36 patients) model. Suggestion of this study are following; First, the arrangement can be provided based on needs of the elderly care facility staffing standards. Secondly, an elderly care facility selected wage guidelines. Thirdly, the elderly efficiency guidelines established by the size of a nursing facility. This study and other financial income factor are not the applicable limits.

• The Korean Journal of Food And Nutrition
• /
• v.22 no.3
• /
• pp.332-337
• /
• 2009

This study was performed to investigate the physiochemical and sensory characteristics of Kimchi with added Houttuynia cordata Thunb(HC). According to measurements for physicochemical characteristics, the three groups of tested Kimchi(HC juice, HC powder, control) did not show any significant differences in pH and hardness. However, the acidity of the Kimchi with added HC juice was found to be significantly higher. Regarding lightness, L values were not different among the three groups, while a and b values showed significant decreases. In descriptive analysis, Kimchi redness was lowest in the HC juice group, and difference in redness was identified between the HC juice and powder groups. One survey indicated that the Kimchi with added HC juice had a unique odor, but no difference was found between the HC powder group and the control group. Also, a survey on preference characteristics indicated there were no differences between the three groups. For the saltiness and acidity of the Kimchi with added HC, there was a significant negative correlation(p<0.05), in which stronger saltiness lower acidity. On the other hand, acidity and HC odor showed a significantly positive correlation(p<0.05). Furthermore, the L value showed a significantly negative correlation(p<0.05) with HC odor.