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Immuno-regulatory Property of Fruit-Extracts of Cornus kousa Burg.  

Kim, Jong-Suk (Dept. of Life Resource Science, Woosuk University)
Oh, Chan-Ho (Division of Biotechnology, Woosuk University)
Jeon, Hoon (Dept. of Oriental Pharmacy, Woosuk University)
Lee, Kie-Seung (Dept. of Chemistry, Woosuk University)
Ma, Sang Yong (Dept. of Life Resource Science, Woosuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.10, no.5, 2002 , pp. 327-332 More about this Journal
Abstract
This study was conducted to investigate the immuno-regulatory effect and apoptosis of L1210 and HL60 leukemia cells of methanol-extracts of Cornus kousa Burg(CKB). The proliferation of mouse splenocytes and thymocytes enhanced by the addition of $10\;{\mu}g/ml$ of CKB. CKB were administered p.o. once a day for 7 days in adult male BALB/c mice. CKB increased the splenic and thymic T lymphocytes, especially the number of $T_H$ cells markedly increased by the treatment of CKB. CKB treatment induced the apoptotic cell death in L1210 mouse leukemia and HL60 human leukemia cells. In addition, CKB also accelerated the phagocytic activity in peritoneal macrophages and increased the production of plaque forming cells. These results suggest that CKB have an various immuno-regulatory property.
Keywords
Cornus kousa Burg. (CKB); immuno-regulatory; lymphocyte proliferation; subpopulation; phagocytic activity; apoptosis;
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