• Proceedings of the Korea Water Resources Association Conference
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• 2005.05b
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• pp.816-820
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• 2005

본 연구에서는 해안 도시 하천의 범람으로 인한 홍수 재해 발생시 예상될 수 있는 피해에 대해 적절한 홍수예경보 및 피난대책을 수립하고자 대표적인 해안 도시 하천의 특성을 가지는 부산시 온천천 유역을 대상으로 수치지도에서 각종 지형자료를 추출하였고 수문 GIS 자료를 구축하였다. 그리고, 하천 수리 분석을 위한 한계유출량 산정을 위해 HEC-RAS 모형을 이용 조위의 영향을 고려하여 홍수위 및 한계유출량을 산정하였고 수문 분석을 위한 도시 돌발 홍수 기준 우량 산정을 위해 PCSWMM 2002를 이용하여 기준 우량을 산정하였다. 전형적인 해안 도시 지역 유역 특성을 나타내는 부산시 온천천 유역에 대한 경보발령 기준을 설정하기 위하여 선정지점 세 곳의 한계수심 $H_{c1},\;H_{c2},\;H_{c3},\;H_{c4}$가 발생할 수 있는 강우량(위험 홍수량을 유발하는 위험 강우량(Trigger Rainfall))을 산정하였고 PCSWMM을 이용한 모형화 기법으로 해안 도시 돌발 홍수 기준 우량을 산정하였다. 산정 결과 온천천 유역의 홍수예경보 시스템과 이에 따른 홍수예경보 발령흐름도, 운영체계가 결정되어 해안 도시 돌발 홍수예경보 방안이 구축되었다. 해안 도시의 홍수 관리는 도시 우수 시스템, 하천, 해안 특성이 복합된 문제이다. 현재 해안 도시 지역의 홍수예경보 시스템 구축 실적이 전무한 실정임을 볼 때 현실적으로 실용화 할 수 있는 시스템 개발을 해내는 것이 무엇보다도 시급하고 중요한 문제이다. 앞으로 더욱 심도있게 연구하여 주요 하천에 대한 홍수예경보 시스템 구축이 절실히 요구된다.

• Journal of Aquaculture
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• v.21 no.3
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• pp.125-132
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• 2008

Seed production of olive flounder Paralichthys olivaceus was performed in a pilot RAS. The growth of juvenile olive flounder and changes in water quality were monitored for the entire production period. The pilot RAS consisted of 8 circular culture tanks($4.0mD{\times}1.0mH$), 2 trickling biofilters($1.7mD{\times}2.0mH$), 2 protein skimmers ($0.8mD{\times}2.5mH$), and 4 sedimentation chambers($0.7mD{\times}1.5mH$). The culture surface area was about $100.5m^2$ and the actual working volume was about $106.9m^3$. As many as 300,000 fertilized olive flounder eggs were initially distributed into 2 culture tanks with the water temperature at $19.0^{\circ}C$. Live feeds such as rotifers and Artemia nauplii were fed until the 32nd day after hatching, and a commercial diet was fed from the 19th day to the end of the experiment. After 70 days, 150,256 juveniles with a body length of $65.8{\pm}3.9mm$ were produced in the RAS, with a daily growth rate for body length of 4.7%/day. At this time, the final culture density was 1,495 individuals $m^{-2}$, and 13.6 L of makeup water, 0.071 kW of electricity and 0.025 L of diesel fuel were used to produce a juvenile olive flounder. During metamorphosis of the larvae, the TAN concentration increased to 0.99 mg/L, which made the larvae sensitive to result in some mortality. However no more massive mortality occurred at the juvenile stage after metamorphosis even at a TAN concentration of 4.25 mg/L and a ${NO_2}^{-}-N$ concentration of 2.45 mg/L.

• Korean Journal of Pharmacognosy
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• v.34 no.1 s.132
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• pp.91-99
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• 2003

Ras proteins play an important role in intracellular signal transduction pathways involved in cell growth and the mutated twas genes have been found in thirty percent of human cancers. Ras proteins (H-, K- and N-Ras) are small guanine nucleotide binding proteins that undergo a series of posttranslational modifications including the farnesylation onto cysteine 186 at C-terminal of Ras by farnesyl protein transferase (FPTase). This is a mandatory process for retention of transforming ability. Therefore, inhibitors of FPTase have a promising to be effective antitumor agents. In our screening program for FPTase inhibitors, the methanol extracts of 193 plants were screened for the inhibitory activity against FPTase partially purified from the rat brain. Extracts of 7species plants including Areca catechu, Saururus chinensis, Curcuma longa, Artemisa princeps, Paeonia suffruticosa, Spatholobus suberectus, Cinnamomum cassia, Cinnamomum japonicum inhibited more than 60% of FPTase activity at a concentration of $100\;{\mu}g/ml$.

• Korean Journal of Animal Reproduction
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• v.17 no.4
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• pp.305-310
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• 1994

These expriments were carried out to investigate existence of H-Y antibody in the rat serum immunized against H-Y antigen from rat spleen cells and effect of H-Y antiserum on development of mouse male embryos. The results obtained were summerized as follows : 1. When mouse embryos were cultured for 48∼72 hrs in the Ham's F10 containing 16% of FBS(fetal bovine serum) or RNS(rat normal serum), percentages of embryos developed from 2, 4, 8 and 16-cell embryo to morulae were 20, 27, 94 and 100%, respectively, in FBS and 8, 7, 94 and 100%, respectively, in RNS. Eight to 16-cell embryos showed no difference in development rate between FBS adn RNS. 2. When 8∼16-cell mouse embryos were cultured for 24∼48 hrs in the Ham's F10 containing FBS, RNS＋GPC(guinea pig complement) and RAS(rat antiserum)＋GPC, proportions of embryos developed to the expanded blastocyst stage were 100, 82.4 and 52.1∼53.6%(ave.52.9), respectively, so that it was suggested that rat antiserum suppressed development of male embryos. 3. When 8∼16-cell mouse embryos were cultured for 24∼48 hrs in the Ham's F10 containing FBS, RNS, RNS＋GPC and RAS＋GPC, proportions of embryos developed to the expanded blastocyst stage were 94.5, 90.9, 82.3 and 47%, respectively, and the embryos developed in the medium containing RAS＋GPC seemed to be female. These results indicated that the antisera prepared through immunized against H-Y antigen from rat spleen cell, possessed H-Y antibody which supressed development of male embryos.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.103.1-103.1
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• 2000

• Journal of Life Science
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• v.22 no.4
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• pp.538-544
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• 2012

Ethanol is known as being carcinogenic to humans. In addition, the anti-proliferative effects of ethanol have been described for a variety of tissues and cells. In this study, we investigated the anti-proliferative effects of ethanol on various cancer cells, particularly on oncogenic $ras$-transformed or-injected cells. Ethanol treatment inhibited the cell proliferation of normal control cells, but did not suppress the proliferation of various cancer cells and oncogenic $ras$-transformed cells. Furthermore, ethanol treatment did not interfere with DNA synthesis, which was induced by microinjecting the oncogenic $H-Ras^{V12}$ protein. The anti-proliferative effect of ethanol was rescued by antioxidants, such as $N$-acetylcysteine and 4-methlpyrazole. These results suggest that ethanol cytotoxicity is exerted through free radical formation, and that the anti-proliferative action site of ethanol cytotoxicity either lies upstream, or is independent of Ras.

• Proceedings of the Korean Society of Toxicology Conference
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• 2005.05a
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• pp.171-171
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• 2005

• 한국지구물리탐사학회:학술대회논문집
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• 2011.10a
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• pp.197-198
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• 2011

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2004.11a
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• pp.58-81
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• 2004

• Proceedings of the Korean Society of Toxicology Conference
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• 2004.11a
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• pp.58-81
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• 2004