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Recent Trends in Access to and Sharing of the Benefits of Genetic Resources (ABS) in Japan - in connection with the adoption of the Nagoya Protocol (일본의 '유전자원 접근 및 이익 공유(ABS)'에 관한 최근 동향 - "나고야의정서"의 채택과 관련하여 -)

  • Lee, Min-Ho
    • Korean Journal of Oriental Medicine
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    • v.18 no.2
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    • pp.1-16
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    • 2012
  • Objectives : The 10th Conference of the Parties to the Convention on Biological Diversity (COP 10) was held in Nagoya, Japan in October 2010, during which an international convention on access to genetic resources and conventional knowledge and sharing of benefits thereof was adopted. The Oriental Medicine field uses medicinal herbs based on genetic resources, as well as traditional knowledge about genetic resources. As such, if Korea, China and Japan compete over the ownership of such traditional knowledge, it will almost certainly trigger disputes over the payment of royalties among other problems. Notably, since the traditional medicine industry is closely related with China, it is highly likely this will adversely affect Korea's production of medicines using natural materials, including Korean herbal doctors' prescription, formulation and preparation of medicinal herbs. Methods : This study also analyzed the recent situation in Japan, which is the chair nation of the Nagoya Protocol and a member nation like Korea. It analyzed the Japanese people's awareness of the Nagoya Protocol and its strategies in the two years since its adoption, as well as the Guidelines for Genetic Resources, which were newly revised in 2012. Conclusions : The Nagoya Protocol requires the preparation of legislative and administrative measures and policies in order to pave the way for sharing the benefits deriving from the use of genetic resources and the relevant traditional knowledge with the providers of such resources. Thus, corresponding domestic legal measures need to be taken. Such measures include the refining of the procedure of accessing genetic resources, the designation of liaison offices, a competent agency and a supervisory agency, and the building of a system designed to issue internationally acknowledged certificates. It is also important to operate related professional consulting offices, as is the case in Japan. In addition, in the case of genetic resources, there is a need to seek multinational and bilateral cooperation including free trade agreements. Regarding traditional knowledge about genetic resources, measures need to be prepared to enable the three East Asian countries, namely, Korea, China and Japan, to commonly use ancient literature on Oriental medicine and to claim exclusive rights to such intellectual properties. Notably, with China now moving to expand the scope of traditional knowledge through the WIPO, Korea needs to prepare response measures.

Effects of Methyl Ethyl Ketone and Methanol on the Survival and Reproduction of Paronychiurus kimi (Collembola: Onychiuridae) (메틸에틸케톤과 메탄올이 김어리톡토기의 사망 및 번식에 미치는 영향)

  • Wee, June;Lee, Yun-Sik;Son, Jino;Kim, Yongeun;Mo, Hyoung-ho;Cho, Kijong
    • Korean Journal of Environmental Biology
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    • v.35 no.2
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    • pp.169-174
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    • 2017
  • Acute and chronic toxicities of methyl ethyl ketone and methanol were investigated on Paronychiurus kimi (Collembola), for evaluating the potential effects of accidental exposures of these chemical substances on the terrestrial environments. This study was undertaken to establish a toxicity database for these chemical substances, which was required for the preparation of the response compensation and liability act for agricultural production and environmental damage. The 7-d acute toxicity and 28-d chronic toxicity were conducted using the OECD artificial soil spiked with varying, serially diluted concentrations of methyl ethyl ketone and methanol. Mortality was recorded after 7-d and 28-d of exposures, and the number of juveniles were determined after 28-d of exposure in the chronic toxicity test. In both assessments, methanol was more toxic than methyl ethyl ketone in terms of mortality ($LC_{50}$) and reproduction ($EC_{50}$). The 7-d $LC_{50}$ of methyl ethyl ketone and methanol were 762 and $2378mg\;kg^{-1}$ soil dry wt., respectively, and the 28-d $LC_{50}s$ were 6063 and $1857mg\;kg^{-1}$ soil dry wt., respectively. The 28-d $EC_{50}$ of methyl ethyl ketone and methanol were 265 and $602mg\;kg^{-1}$ soil dry wt., respectively. Comparison of results obtained in this study with literature data revealed that P. kimi was more sensitive to methanol than other soil invertebrates. However, given the high volatility of the chemicals tested in this study, further studies are necessary to improve the current test guideline, or to develop new test guidelines for an accurate assessment of chemicals that require toxicity databases for chemical accidents.

Evaluation of Toxicological Data on Food Additives and Guideline for ADI establishment - Polydimethylsiloxane as emulsifier - (식품첨가물의 독성자료 고찰과 ADI 평가지침 - 소포제 Polydimethylsiloxane를 사례로 -)

  • Choi, Chan-Woong;Jeong, Ji-Yoon;Park, Hyoung-Su;Moon, Jin-Hyun;Lee, Kwang-Ho;Lee, Hyo-Min
    • Journal of Food Hygiene and Safety
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    • v.24 no.4
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    • pp.352-356
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    • 2009
  • The purpose of this study was to introduce the toxicological study review to evaluate the safety of PDMS on the 69th JECFA meeting. Polydimethylsiloxane is a polymer and its ADI was established at 23rd JECFA meeting in 1979. The ADI was maintained although the specification was expanded at its 26th, 29 th, 37 th meetings. Recently, it was reported that PDMS with low molecular weight and viscosity has high absorption rate and different toxicity, so it was submitted at 69th meeting. Toxicological studies of PDMS were submitted from the sponsor and additional information is collected from a document searching. The toxicological studies were reviewed in accordance with the 'Guidelines for the preparation of toxicological working papers for the Joint FAO/WHO Expert Committee on Food Additives'. In the available acute, sub-chronic and chronic toxicity studies on PDMS, dose-related increases in incidence and severity of ocular lesions(corneal crystal, inflammation of the corneal epithelium etc.) were consistently observed after oral dosing. It seems to be a local irritant effect, but the mechanism by which the ocular lesions arose is unclear, although the lack of absorption of PDMS indicates that it is unlikely to be a direct systemic effect. Consequently, the relevance of the ocular lesions for food use of PDMS could not be determined. The ADI of PDMS was re-established from 0-1.5 mg/kg bw/day to 0-0.8 mg/kg bw/day by applying additional safety factor 2 based on its ocular toxicity. The result of 0-0.8 mg/kg bw/day is a temporary ADI until further data are provided to 2010.

Effects of Customized Nutritional Education 'Change 10 Habits' Program According to Stage of Behavior Change in Mildly Obese Adults (경도비만 성인에서 행동변화단계에 따른 'Change 10 Habits' 개인별 영양교육의 효과)

  • Kim, Bo Hyung;Lim, Hyunjung
    • Journal of the Korean Dietetic Association
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    • v.21 no.3
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    • pp.215-226
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    • 2015
  • The prevalence of obesity is increasing worldwide and has become a serious epidemic health problem. We developed the 'Change 10 Habits' educational program based on obesity treatment and dietary guidelines and examined its effects on customized nutrition education in mildly obese adults. The study was approved by the Institutional Review Board. Study subjects were excluded if they had several major diseases, if had consumed an anti-obesity drug, or if they practiced an obesity-related program within 30 days. The subjects (n=87, $25{\leq}BMI$ <30) were each exposed to the customized nutrition education program with four lessons according to the stage of the transtheoretical model (TTM). The stage-matched program was administered for 12 weeks and was run by a clinical dietitian. Overall, subjects who were in the precontemplation/contemplation stage at baseline made progress in the preparation and action/maintenance stage after 12 weeks (P<0.05). For 'Alcohol is consumed, up to 2 drinks per day', the proportion of subjects who belonged in the action/maintenance stage increased from 34.5% to 49.4% at 12 weeks. In addition, scores of all items significantly increased after the program (P<0.05). 'Chew more than 10 times and eat slowly' score significantly increased from $3.9{\pm}2.4$ to $5.8{\pm}2.3$ (P<0.05). In conclusion, behavioral stage-matched nutrition education using the 'Change 10 Habits' program was effective in improving eating behaviors and enhancing healthy lifestyles in mildly obese adults.

Management Methods of Bone Mineral Density Examination Using Dual Energy X-ray Absorptiometry (이중에너지 엑스선 흡광분석법을 이용한 골밀도검사의 관리법)

  • Kim, Ho-Sung;Kim, Tae-Hyung;Kim, Sang-Hyun
    • Journal of radiological science and technology
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    • v.41 no.4
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    • pp.351-360
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    • 2018
  • In recent years, demand for examination of bone mineral density (BMD) is increasing in Korea according aging society. Therefore, it is required to develop an efficient management program that can increase the safety and reliability of Dual Energy X-ray Absorptiometry (DXA) that can be applied to the criteria of the World Health Organization. It is necessary to develop a management program that can design a program to improve the accuracy and precision of the results of the analysis and to improve the accuracy of diagnosis of osteoporosis by development a high quality DXA report. It is recommended to prepare the examination manuals and to establish procedures of standard operating including the program to prevent the pitfalls during the examination, the compatibility evaluation of the examination data, and the contents of the radiation safety. In addition, relevant regulations on the production of high-quality DXA reports are required and government and related agencies should introduce individual and facility recognition programs through DXA measurement and education programs and training. It is considered that efforts should be made to prepare high quality DXA report by guidelines on all aspects of BMD for preparation about aging society.

Preparation of Radiological Environmental Impact Assessment for the Decommissioning of Nuclear Power Plant in Korea (국내 원전 해체시 방사선환경영향평가 방안)

  • Lee, Sang-Ho;Seo, Hyung-Woo;Kim, Chang-Lak
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.16 no.1
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    • pp.107-122
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    • 2018
  • Kori unit 1, the oldest commercial nuclear power plant in South Korea, was permanently shut down in June 2017. There are a lot of things to consider in decommissioning nuclear power plants, and one of them is the radiological environmental impact assessment. Performed to promote the health and safety of residents around the nuclear power plant, radiological environmental impact assessment aims to confirm that off-site radiological dose from radioactive material released from the facility does not exceed the regulatory criteria. There are three main parts of environmental impact assessment: pre-decommissioning environmental monitoring, environmental monitoring during decommissioning, and impact on nearby residents. At present, although the Korea Nuclear Safety Act stipulates that radiological environmental impact assessment resulting from decommissioning should be carried out, the details have not been specified. Therefore, this paper compares and analyzes guidelines for evaluation of radiological environmental impacts of nuclear power plants overseas, and presents a draft on the assessment of radiological dose resulting from decommissioning according to the Korean situation.

A Study for the Improvement of the Sanitary Condition as well as Quality of Foods Served in Various Types of Restaurants in Seoul City Area (서울 시내 요식 업소의 위생 상태 및 급식되는 음식의 미생물적 품질 개선을 위한 연구)

  • 곽동경;박경해
    • Journal of Food Hygiene and Safety
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    • v.1 no.2
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    • pp.121-131
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    • 1986
  • Four types of restaurants in Seoul city area were aSsessed in terms of the sanitary conditions and practices, and the microbiological quality. Sanitary check-lists were developed to evaluate the sanitary condition of sampled restaurants. Subjective samples were randomly selected based on the distribution factors of areas, types, and sizes. Microbiological tests on foods, equipments, and utensils were done according to standard procedures and included total plate count and coli forms. Singnificant differences among types or sizes were determined by using one-way analysis of variance. Correlation coefficients were calculated to determine significant relationships between sanitary scores and microbiological counts. The results of the study are summarized as follows: 1) Sanitary condition of kitchen and dining areas as well as the sanitary practices of employees were evaluated as the unsatisfactory state with potentially hazardous practices observed. 2) The microbiological quality of food items with high cooking temperature was in good condition, but most food items showed high levels of microbiological counts mainly due to the improper food handling practices of employees. 3) The sanitary conditions of equipment and utensils which were used at preparation and cooking phases, and food containers which were used at the serving phase, were crucial. Serveal guidelines were suggested for the improvement of the working environment as well as the food Quality.

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A Simple and Efficient Method to Determine Montelukast in Rat Plasma Using Liquid-Liquid Extraction and Tandem Mass Spectrometry

  • Kim, Dong Yoon;Lee, Hyo Chun;Jang, Yong Jin;Kim, Jin Hee;Lee, Ha Ryeong;Kang, Myung Joo;Choi, Yong Seok
    • Mass Spectrometry Letters
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    • v.11 no.4
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    • pp.71-76
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    • 2020
  • While montelukast (ML), a cysteinyl-leukotriene type 1 receptor (CysLT1) antagonist is widely used to treat symptoms of rhinitis or asthma, its formulations are mainly limited to solid preparation due to its instability. Recently, there have been attempts to develop various ML dosage forms, and this situation increases the demand of sensitive and creditable methods to determine ML in various samples such as plasma. Thus, here, a simple and efficient method to determine ML in rat plasma using liquid-liquid extraction (LLE) and multiple reaction monitoring was presented. The mixture of DCM:EtOAc (25:75, v/v), the optimized extract solvent for LLE was found to be effective to extract ML without hydrophilic salts and proteins from the sample with limited volume. Also, the use of zafirlukast, instead of expensive ML-d6, as the internal standard makes the present method economical. The developed method was successfully validated in terms of selectivity, matrix effects (-14.8--6.9%), linearity (r230.998 within 0.5-500 ng/mL), sensitivity (the limit of detection and the lower limit of quantitation, ≤0.5 ng/mL), accuracy (88.4-100.6%), precision (3.0-13.3%), and recovery (80.8-86.3%) by following the FDA guidelines. Finally, the applicability of the validated method to pharmacokinetics (PK) studies was confirmed by the successful determination of PK parameters through it following oral administration of Singulair® granule in rats. Therefore, the present method can contribute to the development of new ML formulations through its performance to determine ML in rat plasma efficiently and sensitively.

A Study on the Priorities in the Roles of Community Pharmacists in Aged Society Using AHP (AHP를 이용한 고령사회 약국약사의 역할에 대한 우선순위 연구)

  • Kang, Eunjeong;Jang, Sunmee;Kil, Tae Soo
    • The Journal of the Korea Contents Association
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    • v.19 no.6
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    • pp.402-411
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    • 2019
  • This study aimed to identify priorities in community pharmacist's roles in aged society using Analytic Hierarchy Process. We developed a survey questionnaire for AHP, which consisted of 19 pharmacist's roles selected from the FIP/WHO guidelines. The AHP survey questionnaire was self-administered by 127 pharmacists. The results showed that pharmacists put medication therapy management at the highest priority, preparation, dispense, distribution of medication at the second priority, and efficient healthcare system at the lowest priority. Among the 19 roles, new roles such as monitoring of medication therapy results, team-based health care, and transitions of care obtained relatively high priority.

Knowledge, Attitude, and Practice of Radiation Management among Radiation Generating Device Manufacturers and Medical Personnel (방사선 발생장치 제조업체 및 의료기관 종사자의 방사선 관리에 대한 지식, 태도 및 실천)

  • Kim, Kyu-Hwan;Bae, Seok-Hwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.2
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    • pp.418-426
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    • 2021
  • This study investigates the perception of radiation safety management in radiation generator manufacturing workers and medical institutions. The basic data obtained is further applied to improve active coping ability and safety levels. The knowledge and attitude practice score of radiation was found to be related to gender, age, marital status, occupation, position, current work period, total work period, radiation related work period, the manual available, defense facility maintenance, number of defense equipment, radiation safety education, special health examination, and recognition of radiation terms. In particular, the knowledge score of radiologists was highest among the radiation-related occupations (<0.05). Radiation safety management requires active defense endeavors to prevent radiation exposure, by both workers of radiation manufacturers and medical institutions. Moreover, institutional devices such as compliance with guidelines, periodic education, facility reinforcement, manual preparation, and special health checkups are required for efficient radiation safety management.