• 대한한의학회지
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• 제30권3호
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• pp.1-14
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• 2009

Objectives : Alzheimer's disease (AD) is characterized by neuronal loss and extracellular senile plaque. Moreover, the cellular actions of ${\beta}$-amyloid (A${\beta}$ play a causative role in the pathogenesis of AD. This study was designed to determine whether Woo-Gui-Um, a commonly used Korean herbal medicine, has the ability to protect cortical and hippocampal neurons against A${\beta}_{25-35}$ neurotoxicity Methods : In the present study, the authors investigated the preventative effects of the water extract of Woo-Gui-Um in a mouse model of AD. Memory impairment was induced by intraventricularly (i.c.v.) injecting A${\beta}_{25-35}$ peptides into mice. Woo-Gui-Um extract was then administered orally (p.o.) for 14 days. In addition, A${\beta}_{25-35}$ toxicity on the hippocampus was assessed immunohistochemically, by staining for Tau, MAP2, TUNEL, and Bax, and by performing an in vitro study in PC12 cells. Results : Woo-Gui-Um extract had an effect to improve learning ability and memory score in the water maze task. Woo-Gui-Um extract had significant neuroprotective effects in vivo against oxidative damage and apoptotic cell death of hippocampal neurons caused by i.c.v. A${\beta}_{25-35}$. In addition, Woo-Gui-Um extract was found to have a protective effect on A${\beta}_{25-35}$-induced apoptosis, and to promote neurite outgrowth of nerve growth factor (NGF)-differentiated PC12 cells. Conclusions : These results suggest that Woo-Gui-Um extract reduces memory impairment and Alzheimer's dementia via an anti-apoptotic effect and by regulating Tau and MAP2 in the hippocampus.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2018년도 제58차 하계학술대회논문집 26권2호
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• pp.381-382
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• 2018

게임 초기 진입에 있어 사용자들이 거치는 프로세스를 알아보고, 매력적인 게임 GUI는 어떻게 정의하는 가에 대한 것도 제시한다. 본 논문에서는 게임을 선호하는 유저들의 성향과 매력적인 게임 GUI는 무엇인지에 관해 다양한 방법 및 분석한 결과를 제시한다. 게임 UI의 외형이나 기능 등의 요소가 게임을 선택하는 데에 있어 어떠한 영향을 끼치는가에 대해서 알 수 있다. GUI의 통일성 및 컨셉 분석을 통해 요인을 알아보고, GUI가 사용자에게는 어떤 의미를 가지는가에 대한 것을 알 수 있다.

• 혜화의학회지
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• 제14권1호
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• pp.101-112
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• 2005

As a result of studing on the "Joa-gui Em", we could reach conclusions as follows. 1. "Joa-gui Em" shows in vivo effect of that it supplement Kidney-Um essence and nomalize a physiological function of Kidney-Qi. 2. "Joa-gui Em" supplement Kidney-Um essence, it does not use in The Rise of Insubstantial Fire(음허화왕) body condition. 3. "Joa-gui Em" use in many ways women disease, in case of menstruation and meonpause disorder. 4. "Joa-gui Em" and "Joa-gui Hwan" are modification prescription of "Uk-mi-ji-hwang-hwan. 5. "Joa-gui Em" is a pure prescription in supplement Kidney-Um essence, Roast Glycyrrhizae Radix of prescription has effect of supplement Sam-cho Qi. 6. "Joa-gui Hwan" is similarly "Joa-gui Em." Colla Cornus Cervi and a Colla Cornus Glemmys of prescription have effect of supplement DUMAI and RENMAI CHONGMAI.

• 동아시아식생활학회지
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• 제22권6호
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• pp.860-867
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• 2012

Codonopsis lanceolata serves as, an appetizing health food for its, characteristic flavor, taste, and texture:however, it requires a long and complicated cooking process. Therefore, this study conducted pre-processing procedures to improve the cooking process and Codonopsis lanceolata more easily. For processing efficiency, freezing and blanching were efficient for peeling and the rate of peel disuse. In addition the freezing process, effectively reduced the time spent in beating raw material. In the salinity test, freezing and blanching quickly increased salinity over 28 days. As the result of SEM cross-section tests showed that frozen Codonopsis lanceolata become porous, it's assumed that seasoning permeates into this cross-section efficiently. As the appearance of Deodeok-gui as significant differences according to the pre-processing methods, this study examined pre-processing methods(time spent in peeling, rate of peel disuse, time spent in beating out material, salinity, moisture content, texture, and the color) of Codonopsis lanceolata. After testing Deodeok-gui, it was found that freezing is effective, not only for process efficiency and cooking time reduction, but also for improving its qualities.

• 대한한방종양학회지
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• 제7권1호
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• pp.99-107
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• 2001

In the present studies, decursinol angelate, decursin isolated from Angelica gignatis radix and oil fraction of Cnidii rhizoma was analyzed by normal phase HPLC and GC/MS respectively. The standardized water extracts of Angelica gignatis radix, Cnidii rhizoma and its complex named Gung-gui-tang was tested the anti mutagenic effects by in vitro genotoxicity using Salmonella reversion assay (Ames test) and micronucleus test in chinese hamster ovary(CHO) cells. Angelica gignatis radix, Cnidii rhizoma and Gung-gui-tang was not exhibited the antimutagenic effects in the Salmonella reversion assays with or without metabolic activation. However, the micronucleus test assays, Angelica gignatis radix and Gung-gui-tang was showed the antimutagenic effects significantly. The maximum inhibition observed with Gung-gui-tang was reduced by 59% in the micronucleus test without metabolic activation. In this paper, results are presented on the availability of potential antimutagenic activity of the water extracts of Gung-gui-tang.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2009년도 춘계 종합학술대회 논문집
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• pp.635-641
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• 2009

본 논문에서는 다양한 휴대형 단말기기의 플랫폼 친화적이며 컨텐츠 개발의 신속성, 확장성 및 용이성이 고려된 3D 컨텐츠 플랫폼 엔진과 Application Frame 기술을 Convergence하였으며, Mobile Device에 탑재 가능한 3D 그래픽 사용자 인터페이스(GUI)의 시제품을 제작 및 응용하고, Mobile Game 등 컨텐츠의 개발을 효과적으로 빠르고 쉽게 구현할 수 있는데 필요한 3D GUI 객체(widget) 및 툴킷을 포함하는 Frame을 표준화 하는데 기본이 되는 연구를 하였다.

• 대한한방체열의학회지
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• 제7권1호
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• pp.22-29
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• 2009

Purpose: This study intends to report the effects of Koong Gui Tang on Cold Hypersensitivity caused by acute and chronic Blood Deficiency. Methods: The patients having Cold Hypersensitivity were treated with oriental medicine including herbal medication therapy. Thereafter their health status was analyzed with their own empirical assessments and VAS. Results: After the series of medical treatment, Cold Hypersensitivity caused by acute and chronic Blood Deficiency has shown considerable improvement. Conclusion: This case study shows that Koong Gui Tang therapies are medically effective on Cold Hypersensitivity caused by acute and chronic Blood Deficiency.

• 대한한방부인과학회지
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• 제22권2호
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• pp.222-230
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• 2009

Purpose: This study intends to report the effects of Koong Gui Tang on Cold Hypersensitivity caused by acute and chronic Blood Deficiency. Methods: The patients having Cold Hypersensitivity were treated with oriental medicine including herbal medication therapy. Thereafter their health status was analyzed with their own empirical assessments and VAS. Results: After the series of medical treatment, Cold Hypersensitivity caused by acute and chronic Blood Deficiency has shown considerable improvement. Conclusion: This case study shows that Koong Gui Tang therapies are medically effective on Cold Hypersensitivity caused by acute and chronic Blood Deficiency.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
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• pp.315-317
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• 2003

Power system is becoming more and more complex and large. And power consumption increases rapidly according to the industry development. There is an ample possibility for a fault in proportion to these facts. Therefore power system engineer is requested to abilities, fault analysis and fault prevent. This paper handling result data by Object Oriented Database(OODB) because OODB has advantages abut flexibleness and recycling. Besides this paper presents fault analysis program by Graphic User Interface(GUI) to understand easily program using method.

• Journal of Nutrition and Health
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• 제40권5호
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• pp.428-434
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• 2007

본 연구에서는 무철분식이로 철분결핍성 빈혈 유발을 시킨 흰쥐에게 3주간 무철분식이를 섭취시키면서 saline, 참당귀 추출물 및 철분보충제를 투여한 후, 무철분식이를 일반식이로 대체하여 다시 3주간 같은 처리를 한 후 혈액학적 빈혈지표를 조사하여 결과를 요약하면 다음과 같다. 1) 실험동물의 체중은 무철분식이군에서 일반식이군에서 보다 유의적으로 낮게 나타났다. 무철분식이로 인한 저체중은 참당귀 추출물과 철분 보충제에 의해서 회복되지 않았다. 2) 혈액분석 결과 무철분식이는 모든 혈액 빈혈지표를 저하시켰으며, 철분보충제의 투여는 헤모글빈, 헤마토크릿, 평균 혈구 부피, 평균 혈구혈색소, 평균 혈구혈색소 농도, 총철결합능력이 유의적으로 회복시켰다. 무철분식이와 함께 투여한 참당귀 추출물은 혈액지표를 개선시키지 못하였다. 한편, 일반식이와 함께 섭취하였을 경우, 헤모글로빈, 헤마토크릿, 평균 혈구부피, 평균 혈구혈색소, 평균 혈구혈색소 농도, 총철결합능력 모두 유의적인 회복효과를 보였으나 일반식이만을 섭취한 군에서도 같은 회복효과를 보였다. 결론적으로, 장기간에 걸쳐 철분 섭취가 불량할 경우, 체중증가가 지연되며 후에 철분을 보충할 경우에도 체중의 회복은 개선되지 않았다. 철분결핍으로 인한 저체중의 경우, 철분보충제의 복용은 체중을 만회시키지 못하였으나 혈액학적 빈혈 지표들은 회복시키는 것으로 나타났다. 철분결핍 빈혈에서 식이철분이 부족할 경우, 참당귀의 회복효과는 미비한 것으로 나타났다. 향후 철분결핍 빈혈의 치료를 위한 생약제의 다양한 작용을 밝히기 위하여서는 영양학적인 관점에서 체내 이용률에 관한 심도 깊은 연구가 이루어져야 할 것으로 사료된다.