THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY (대한한방종양학회지)

Korean Association of Traditional Oncology (대한암한의학회)
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Antimutangenicity of the water extract of Gunguitang

궁귀탕의 항 돌연변이 활성

  • Yu, Young-Beob (Dept. of Oriental Pathology, College of Oriental Medicine, Kyung-Hee University) ;
  • Shim, Bum-Sang (Dept. of Oriental Pathology, College of Oriental Medicine, Kyung-Hee University) ;
  • Ahn, Kyu-Suk (Dept. of Oriental Pathology, College of Oriental Medicine, Kyung-Hee University) ;
  • Choi, Seung-Hun (Dept. of Oriental Pathology, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Ho-Cheol (Dept. of Herbal Pharmacology, Graduate School of East-West Medical Science, Kyung-Hee University) ;
  • Park, Jong-Cheol (Dept. of Oriental Medicine Resource, Sunchon National University) ;
  • Jo, Sung-Kee (Team for Radiation Food Science and Biotchnology , Korean Atomic Energy Research Institute)
  • 유영법 (경희대학교 한의과대학 병리학교실) ;
  • 심범상 (경희대학교 한의과대학 병리학교실) ;
  • 안규석 (경희대학교 한의과대학 병리학교실) ;
  • 최승훈 (경희대학교 한의과대학 병리학교실) ;
  • 김호철 (경희대학교 동서의학대학원 한약리학교실) ;
  • 박종철 (순천대학교 한약자원학과) ;
  • 조성기 (한국원자력연구소 방사선식품생명공학팀)
  • Published : 2001.12.30
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Abstract

In the present studies, decursinol angelate, decursin isolated from Angelica gignatis radix and oil fraction of Cnidii rhizoma was analyzed by normal phase HPLC and GC/MS respectively. The standardized water extracts of Angelica gignatis radix, Cnidii rhizoma and its complex named Gung-gui-tang was tested the anti mutagenic effects by in vitro genotoxicity using Salmonella reversion assay (Ames test) and micronucleus test in chinese hamster ovary(CHO) cells. Angelica gignatis radix, Cnidii rhizoma and Gung-gui-tang was not exhibited the antimutagenic effects in the Salmonella reversion assays with or without metabolic activation. However, the micronucleus test assays, Angelica gignatis radix and Gung-gui-tang was showed the antimutagenic effects significantly. The maximum inhibition observed with Gung-gui-tang was reduced by 59% in the micronucleus test without metabolic activation. In this paper, results are presented on the availability of potential antimutagenic activity of the water extracts of Gung-gui-tang.

Keywords

References

  1. 한국식품영양과학회지 v.29 no.2 감마선 조사 당귀(Angelica gigas Nakai)의 유효성분 안정성 및 유전독성학적 안전성 연구 유영법;조성기
  2. 경희약대논문집 v.28 중국산 당귀 천궁의 정유성분(2) 육창수;강찬구;장우현;정남일;인문교;뢰영상
  3. 대조생약에 제조에 관한연구 육창수;황관균;김호철;백완숙
  4. 대한본초학회지(본초분과학회지) v.14 no.1 토천궁과 일천궁의 효능 및 품질비교에 관한 연구(2)-두 유형의 천궁과 천궁-당귀 배합시의 혈관 이완효능 이항우;박용기;조현국
  5. 魯兆麟 主校(1999)丹溪心法 沈陽 洙震亭(原著)
  6. 동의보감(잡병편) 허준
  7. 생약학회지 v.21 no.1 당귀의 Coumarin 성분연구 Decursin의 구조이성체 Decursinol Angelate 의 분리 및 정량 홍남두;김남재;류경수;공영윤
  8. Planta Med v.62 Decursin:a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Ahn, K.S.;Sim, W.S.;Kim, I.H.
  9. Planta Med v.63 Decursinol angelate:a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Ahn, K.S.;Sim, W.S.;Lee, I.f.;Seu, Y.B.;Kim, I.H.
  10. Int J Rad Appl Instrum [A] v.38 The present state and perspectives of micronucleus assay in radiation protection. A review. Almassy, Z.;Krepinsky, A.B.;Bianco, A.;Koteles, G.J.
  11. Mutat Res v.31 Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Ames, B.N.;Mccann, J.;Yamasaki, I.
  12. Mutat Res v.222 Antimutagenicity of some citrus fruits in Salmonella typhimurium Bala, S.;Glover, I.S.
  13. Int J Radiat Biol v.57 Micronuclei in cytokinesis-blocked Iymphocytes of cancer patients following fractionated partial-body radiotherapy. Fenech, M.;Denham, J.;Francis, W.;Morley, A.
  14. Mutat Res v.303 Higashimoto, M.;Purintrapiban, J.;Kataoka, K.;Kinouchi, T.;Vinitketkurnnuen, Mutagenicity and antimutagenicity of extracts of threes pices and a medicinal plant in Thailand. U.;Akimoto, S.;Matsumoto, H.;Ohnishi, Y.
  15. J Environ Pathol Toxicol Oncol v.20 Antimutagenic potential of extracts Isolated from Terminalia arjuna Kaur, S.;Glover, I.S.;Kumar, S.
  16. Mutat Res v.474 Antimutagenic activity of green tea and black tea extracts studied in a dynamic in vitro gastrointestinal model. Krul, C.;Luiten-Schuite, A.;Tenfelde, A.;Van Ommen B.;Verhagen, H.;Havenaar, R.
  17. Proc Natl Acad Sci v.81 Spontaneous and mutagen-induced deletions:mechanistic studies in Salmonella testerstrain TA102. Levin, D.E.;Marnett, L.J.;Ames, B.N.
  18. Proc Natl Acad Sci v.79 A new Salmonella tester strain(TA102) with AXT base pairs at the site of mutation detectsoxidative mutagens. Levin, D.E.;Hollstein, M.;Christman, M.F.;Schwiers, E.A.;Ames, B.N.
  19. Mutat Res v.113 Revised methods for the Salmonella mutagenicity test. Maron, D.M.;Ames, B.N.
  20. Mutat Res v.174 Antimutagenicity of extracts from crude drugs in Chinese medicines Sakai, Y.;Nagase, H.;Ose, Y.;Sato, T.;Yamada, A.;Hibi, M.;Yamada, F.