• 제목/요약/키워드: Gu-Chang

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촌구인영대비맥법화오장맥법적결합(寸口人迎对比脉法和五脏脉法的结合) (A combination of the Chon-gu/Inyeong Pulse Comparison Diagnosis and the Five Viscera Pulse)

  • 정창현
    • 대한한의학원전학회지
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    • 제23권5호
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    • pp.51-54
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    • 2010

  • Since ${\ll}$Hwangjenaegyeong(黃帝內經)${\gg}$ and ${\ll}$Nangyeong(難經)${\gg}$, there has been various methods in pulse diagnosis. The Chon-gu(寸口)/Inyeong(人迎) Pulse Comparison Diagnosis which is dealt with in many chapters of the ${\ll}$Hwangjenaegyeong${\gg}$, has not been as widely applied as the Chon-gu Pulse Diagnosis due to several limitations. In this paper, we will review these limitations and suggest an alternative method. In the Chon-gu/Inyeong Pulse Comparison Diagnosis, we compare the Chon-gu Pulse and the Inyeong Pulse to see which is larger than the other by times, and diagnose illness of the 12 Meridian Pulse. It is fairly clear which is larger than the other, but to determine by how much accurately is quite difficult to say. However if we combine the Five Viscera Pulse in application, it becomes far more easier to determine which viscera and bowel is ill. First, study the pulse of the Chon-gu and In-yeong, then determine the Viscera Pulse. Next, determine the larger pulse between the Chon-gu and In-yeong pulse.

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18세기(世紀) 조선(朝鮮)의 구고술(句股術) (Gou Gu Shu in the 18th century Chosun)

  • 홍성사;홍영희;김창일
    • 한국수학사학회지
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    • 제20권4호
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    • pp.1-21
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    • 2007

  • 18세기 초 중인(中人) 홍정하(洪正夏)($1684{\sim}?$)의 구일집(九一集)과 양반(兩班) 조태구(趙泰耉)($1660{\sim}1723$)의 주서관견(籌書管見)에 들어 있는 구고술(句股術)을 조사한다. 구조적 접근과 천원술(天元術)을 통하여 홍정하(洪正夏)는 동양(東洋)에서 가장 앞선 구고술(句股術)의 결과를 얻어내었다. 또 17세기 중엽에 서양(西洋) 수학(數學)이 조선(朝鮮)에 유입된 후 조선(朝鮮) 산학(算學)에 이론적 접근이 이루어지는 과정을 조태구(趙泰耉)의 구고술(句股術)을 통하여 연구한다.

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팔진탕합화적환(八珍湯合化積丸)과 Adriamycin의 병용처리시 나타나는 synergistic 항종양(抗腫瘍) 효과(效果)에 관(關)한 작용기전 연구(硏究) (Study on Synergistic Anti-tumor Effect of Combination with Adriamycin and Palginhonhapwhajucwhan)

  • 문구;문석재;원진희;조정연;박상구;송봉길;박래길;이병구
    • 대한한방내과학회지
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    • 제21권3호
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    • pp.443-452
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    • 2000

  • Objective : This study was designed to evaluate the synergistic effect on cytotoxicity of combination with adriamycin and Palginhonhapwhajucwhan, a traditional prescription for cancer treatment in oriental medicine, in Chang, HL-60, Hep-3B and Alexander cells. Methods : We observed cell viability in Chang, HL-60, Hep-3B, and Alexander cells by crystal violet staining. Those cells were treated with various concentrations of adriamycin alone, Palginhonhapwhajucwhan alone and combination of two medications for 10 hr. On condition of $0.5{\mu}l/ml$ adriamycin alone, $15.6{\mu}l/ml$ Paljintanghapwhajucwhan alone and combination of two medications, at first, we observed colony forming of Chang and HL-60 cells. Second, we observed DNA fragmentation by agarose electrophoresis in Chang, HL-60, Hep-38 and Alexander cells. Third, we measured the catalytic activation of caspase-1, 2, 3, 6, 8, and 9 protease in Chang cells and caspase-3 protease in Chang, HL-60, Hep-3B and Alexander cells by using fluorogenic substrate. Finally, we isolated mRNA of Fas in Chang, HL-60, Hep-38 and Alexander cells and observed that Fas gene was amplified by RT-PCR Results : 1. The combination of adriamycin and Palginhonhapwhajucwhan synergistically augmented the cytotoxicity of Chang and HL-60 cells whereas did not in Hep-38 and Alexander cells. 2. Cotreatment of two drugs also markedly inhibited the colony forming ability both in Chang and HL-60 cells. 3. The cytotoxicity of these medicatons was revealed as apoptosis characterized by high molecular wight DNA fragmentaton. 4. The apoptotic cytotoxicity was mediated by activation of caspase-3 protease in Chang cells. 5. Synergistic increase in apoptotic cytotoxicity by combination of two medications was dependent on the expression of Fas in cancer cells. Conclusions : Combination of adriamycin and Palginhonhapwhajucwhan significantly augmented apoptotic cytotoxicity of Fas-positive cells such as Chang and HL-60 cells via acticaton of apoptosis signaling pathway.

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