• 한국항만경제학회지
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• 제24권4호
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• pp.47-70
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• 2008

본 연구의 목적은 확률적 생산변경함수를 이용하여 총요소생산성 성장을 도출하고 그 내부요소를 기술효율성 변화, 기술진보, 규모효율변화, 배분적 효율변화로 구분하여 생산성 성장의 요인을 파악해 보고자 함이다. 1990-2003년간 항만물류산업의 총요소생산성 증가율은 연간 0.019 (1.9%)로서 전산업의 증가율 0.010보다 높다. 그 내부의 주된 기여요인은 기술진보이고 기술효율성변화는 감소하였다. 총요소생산성의 주된 기여요인으로는 항만산업은 배분효율성, 해운산업은 기술진보, 수송장비산업은 규모효율변화를 들 수 있다. 총요소생산성 변화는 1990년대 후반이후에 감소하는 추이를 보였다. 항만물류산업은 전산업에 비하여 매우 낮은 수준의 기술효율성수준을 보여주고 있고 산출탄력성 관점에서는 1990-2003년간 자본의 탄력성(0.391)이 노동의 탄력성(0.227)보다 높지만 규모에 대한 보수는 0.618로서 최적규모에 상당히 벗어나 있다.

• 지역연구
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• 제14권1호
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• pp.47-64
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• 1998

This paper attempts to forecast regional economic changes and to analyze government polices for interregional balanced economic growth in case of Korea Reunification. It begins with be reunified at the year 2010. The model is largely neoclassical. Since the future of North Korea is unclear, two possible scenarios are presented. The paper projects economic growth of regions, specifically forecasting growth of regions, specifically forecasting GRDP, the number of migrants and the quantity of moving capital. The results obtained show that spatially unbalanced economic growth will take place in the reunified Korea through factor movement. Two polices including public capital provision policy and income subsidy policy are thus suggested and analyed.

• 대한후두음성언어의학회지
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• 제23권1호
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• pp.28-32
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• 2012

Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.

• 한국안전학회지
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• 제15권3호
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• pp.1-6
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• 2000

In fatigue crack growth test, it is important not only to analyze characteristics of fatigue crack growth but also to determine the threshold stress intensity factor, ${\Delta}K_{th}$. which is the threshold value of fatigue crack growth. Linear regression analysis using fatigue test data near the threshold is suggested to determine the ${\Delta}K_{th}$ in the standard test method but the ${\Delta}K_{th}$ can be affected by a fitting method. And there are some limitations on the linear regression analysis in the case of small number of test data near the threshold. The objective of this study is to investigate differences of the ${\Delta}K_{th}$ due to regression analysis method and to evaluate the relative error range of the ${\Delta}K_{th}$ in same fatigue crack growth test data.

• Archives of Pharmacal Research
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• 제22권2호
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• pp.108-112
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• 1999

Recombinant murine stem cell factor (rmSCF) or recombinant murine nerve growth factor (rmNGF) induced the morphological change of large numbers of rat peritoneal mast cells (RPMC). We investigated the role of phosphatidylinositol $3^{l}-kinase$ (PI3-kinase) in receptors-mediated morphological change in RPMC. Exposure of RPMC to PI3-kinase inhibitor, wortmannin, before the addition of rmSCF and rmNGF antagonized those factors-induced morphological change. These results suggest that the PI3-kinase is involved in the signal transduction pathway responsible for morphological change following stimulation of rmSCF and rmNGF and that wortmannin blocks these responses.

• 대한기관식도과학회지
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• 제8권1호
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• pp.35-41
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• 2002

Background and Objectives : Angiogenesis within malignant tumors has been considered to be essential for the growth and expansion of cancer cells, especially for solid tumors, and has been implicated in the overall growth and metastases of tumors. Such angiogenesis within tumors depends upon the secretion of vascular growth factor to allow the growth of newly formed vessels from peripheral tissue into the malignant tumor. %n, an exploration of the relations between cancer cells and vascular growth factors is absolutely critical to understanding the growth of malignant tumors. According to recent reports, vascular endothelial growth factor(VEGF) has been found to play a role in lymphatic metastases, tumor recurrence and survival in various human tumors. To evaluate the role of VEGF in head and neck squamous cell carcinoma(HNSCC) we performed this study. Materials and Methods : We examined the expression of VEGF and microvessel density in 39 HNSCC by immunohistochemistry and correlated them with various clinical data such as stage, cervical lymphatic metastasis, recurrence, and overall survival. Results : The expression of VEGF was not correlated with overall stage, T stage and N stage. There was no statistical correlation between the expression of VEGF and recurrence in the Primary site, cervical lymph node, and the distant metastases. There was no statistical correlation between the expression of VEGF and microvessel density. Conclusion : Based on these results, it is suggested that the expression of vascular endothelial growth factor is not a major prognostic factor for head and neck squamous cell carcinoma. Further studies are needed to evaluate significance of VEGF expression in head and neck squamous cell carcinoma.

• BMB Reports
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• 제29권3호
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• pp.205-209
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• 1996

To investigate the role of heparin in keratinocyte growth factor (KGF) and acidic fibroblast growth factor (aFGF) high affinity binding to the KGF receptor (KGFR), a cell free system was established which utilized a secreted chimeric molecule between the KGFR extracellular domain and the immunoglobulin heavy chain Fc domain (KGFR-HFc). KGFR-HFc was purified from NIH 3T3 cells and demonstrated the binding of $[^3H]-heparin$ as well as heparin Sepharose. Scatchard analysis showed that the dissociation constant for heparin binding to KGFR-HFc was 140 nM. High affinity KGF and aFGF binding to KGFR-HFc remained unchanged after treatment with 0.6 M NaCl, which is the concentration sufficient to release any bound heparin to the KGFR-HFc. These results strongly suggest that although the KGFR interacts with heparin, the presence of heparin is not absolutely required for high affinity binding of either KGF or aFGF to the KGFR.

• 한국전기전자재료학회논문지
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• 제27권7호
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• pp.428-432
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• 2014

The Hall factor in a two-dimensional device with indirect conduction valleys is calculated for several growth on various strain conditions. In the [001] or [111] growth direction, the two-dimensional constant energy surfaces of occupied valleys are shown to be isotropically distributed. However, in the [110] growth direction, the distribution of occupied valleys on the plane is not isotropic. This fact is the reason for the anisotropic Hall factor on the sample plane.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.261-266
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• 2003

The growth behavior of the transverse crack, which was one of the most dangerous damages of rail defects, was investigated under mode I and mixed mode loading in rail steel. In the case of variable amplitude loading, the fatigue crack growth behavior was discussed using characteristic stress intensity factor ranges ${\Delta}_{rms}$. In addition, characteristic comparative stress intensity factor ranges ${\Delta}_{V,rms}$ was proposed to evaluate the quantitative effects of the variable amplitude under mixed mode loading. As a result, crack growth rate under variable amplitude loading was faster than that under constant amplitude loading.

• Biomolecules & Therapeutics
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• 제2권1호
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• pp.77-81
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• 1994

The acute toxicity of recombinant human epidermal growth factor, DWP-401 was evaluated in ICR mice of both sexes. Six groups of mice were administered orally or subcutaneously with 0, 0.125, 0.25, 0.5, 1 and 2 mg/kg of DWP-401. Abnormal clinical signs related to the compound were not observed, and no deaths occurred. Gross findings of necropsy revealed no evidence of specific toxicity related to DWP-401. LD$_{50}$ values for both male and female mice were evaluated to be over 2 mg/kg, which is approximately 2, 000 fold of presumed clinical dose.e.