• Journal of Ecology and Environment
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• v.44 no.4
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• pp.264-274
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• 2020

Background: Climate change has altered the various ecosystem processes including forest ecosystem in Himalayan region. Although the high mountain natural forests including treelines in the Himalayan region are mainly reported to be temperature sensitive, the temperature-related water stress in an important growth-limiting factor for middle elevation mountains. And there are very few evidences on growth performance of planted forest in changing climate in the Himalayan region. A dendrochronological study was carried out to verify and record the impact of warming temperature tree growth by using the tree cores of Pinus roxburghii from Batase village of Dhulikhel in Central Nepal with sub-tropical climatic zone. For this total, 29 tree cores from 25 trees of P. roxburghii were measured and analyzed. Result: A 44-year long tree ring width chronology was constructed from the cores. The result showed that the radial growth of P. roxburghii was positively correlated with pre-monsoon (April) rainfall, although the correlation was not significant and negatively correlated with summer rainfall. The strongest negative correlation was found between radial growth and rainfall of June followed by the rainfall of January. Also, the radial growth showed significant positive correlation with that previous year August mean temperature and maximum temperature, and significant negative correlation between radial growth and maximum temperature (Tmax) of May and of spring season (March-May), indicating moisture as the key factor for radial growth. Despite the overall positive trend in the basal area increment (BAI), we have found the abrupt decline between 1995 and 2005 AD. Conclusion: The results indicated that chir pine planted population was moisture sensitive, and the negative impact of higher temperature during early growth season (March-May) was clearly seen on the radial growth. We emphasize that the forest would experience further moisture stress if the trend of warming temperatures continues. The unusual decreasing BAI trend might be associated with forest management processes including resin collection and other disturbances. Our results showed that the planted pine forest stand is sub-healthy due to major human intervention at times. Further exploration of growth climate response from different climatic zones and management regimes is important to improve our understanding on the growth performance of mid-hill pine forests in Nepal.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10181-10185
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• 2015

Background: MicroRNAs, small noncoding RNA molecules, can regulate mammalian cell growth, apoptosis and differentiation by controlling the expression of target genes. The aim of this study was to investigate the function of miR-323-5p in the glioma cell line, U251. Materials and Methods: After over-expression of miR-323-5p using miR-323-5p mimics, cell growth, apoptosis and migration were tested by MTT, flow cytometry and cell wound healing assay, respectively. We also assessed the influence of miR-323-5p on the mRNA expression of IGF-1R by quantitative real-time reverse transcriptase PCR (qRT-PCR), and on the protein levels by Western blot analysi. In addition, dual-luciferase reporter assays were performed to determine the target site of miR-323-5p to IGF-1R 3'UTR. Results: Our findings showed that over-expression of miR-323-5p could promote apoptosis of U251 and inhibit the proliferation and migration of the glioma cells. Conclusions: This study demonstrated that increased expression of miR-323-5p might be related to glioma progression, which indicates a potential role of miR-323-5p for clinical therapy.

• Korean Journal of Medicinal Crop Science
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• v.24 no.1
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• pp.27-30
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• 2016

Background : This text was conducted to evaluate the distribution, shape characteristics and habitat condition of Crypsinus hastatus in Buyeo Korea. Methods and Results : In Buyeo, Crypsinus hastatus was distributed at an altitude of 31.2 m, a slope of 82.5% and a distance from river water of 27.2 m. The leaf blade was oblong, 2.7 cm long, 1.2 cm wide with a petiole length of 2.3 cm. The total population comprised 2,100 individuals, with the highest proportion being individuals with a leaf blade of length 0.5 - 1 cm. The temperature and light intensity of the growth point were lower, but the humidity higher, than that of growth around. The chemical properties of the soil were as follows: pH 4.42, organic matter 77.99 g/kg, electrical conductivity 0.50 dS/m, nitrate nitrogen 20.50 mg/kg and available phosphate 165.7 mg/kg. Exchangeable cation content of potassium, magnesium, sodium and calcium was 0.35, 0.70, 0.09 and $2.04cmol^+/kg$, respectively. Conclusions : In Buyeo, Crypsinus hastatus was distributed in $5.3m^2$ area of Nakhwaam, Naeseongri and Jeongamri. However, the population of the medicinal resources seemed to decrease owing to the poor environmental conditions of the habitat.

• The Korean Journal of Nuclear Medicine
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• v.36 no.1
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• pp.8-18
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• 2002

Early and accurate diagnosis of tumors using positron omission tomography (PET) has been the focus of considerable interest due to its high metastasis and mortality rates at late detection. PET radiopharmaceuticals-which exhibit a high tumor-to-background uptake ratio, and appropriate metabolic characteristics, and pharmacokinetics-are attractive tools for tumor imaging. Tumor imaging by these radiopharmaceuticals are based on metabolic and receptor imaging. The former is based on accelerated metabolism in tumor tissue compared to normal tissue and the rate roughly corresponding to the rate of growth of tumors. Radiopharmaceuticals for this purpose include radiolabeled sugars, amino acids, and nucleosides which detect increased glucose utilization, protein synthesis, and DNA synthesis, respectively. Tumor receptor imaging is based on the proliferation of tumor cells regulated by many hormones and growth factors, which bind to the corresponding receptors and exhibit the biological responses Radiopharmaceuticals used to image the tumor receptor systems may be ligands for the specific receptors and antibodies for the growth factor receptors. Some antitumor agents have been labeled with radionuclides and used to study in vivo biodistribution and pharmacokinetics in humans. This overview describes typical PET radiopharmaceuticals used for tumor imaging based on their uptake mechanisms.

• Journal of Ginseng Research
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• v.40 no.2
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• pp.169-175
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• 2016

Background: Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo. Methods: We examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC). Results: 4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HC-induced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression. Conclusion: Overall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.4
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• pp.317-324
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• 2020

The study aims to analyze the theoretical background of the economic growth and sustainable development; systematization of scientists view on monitoring and economic and innovative evaluation, analysis and diagnosis of factors affecting these processes. Rating characteristics of the level of innovative resources development obtained based on the comparative analysis of Kazakhstan regions. Calculations were done based on official statistics during 2010 and 2015-2017. Based on obtained data there has been grading of the country regions and their ratings were determined by the level of development of innovative resources. This research identifies areas and mechanisms to ensure balanced sustainable development of the national economy. The findings suggest that sustainable development of the state is affected by the innovative activity of the regions, the sustainable development of which is ensured by innovative enterprises. Transition to the model of sustainable territorial development involves the formation of such conditions and the use of mechanisms under which the natural base of this development is not destroyed, the environment suitable for human existence is preserved and reproduced. The findings of this research support for pursuing a national policy of reducing regional imbalances, and promoting a more balanced and sustainable development of the whole country.

• The Journal of the Korea Contents Association
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• v.20 no.2
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• pp.522-533
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• 2020

In order to understand the symbolic meaning of the dog in my dream more broadly, this paper aims to examine the symbolic meaning of the dog in various cultures and to understand the inner side in depth through such a process. Just as the growth of a person's character can be achieved through the conscious of the unconsciousness, looking at the contents of dreams made up of symbolic images is an important part of the growth of a person's character. In this paper, I first looked at the biological background of dogs and looked at various cultural symbols of dogs that appear in fairytales, myths, religions and folklore. Next, I reflected how Jung psychology looked at the symbol of the dog and finally discussed what the symbol of the dog in my dream had in the process of analyzing the dream.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.5
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• pp.823-833
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• 2001

In recent years, the subject of remaining life assessment has drawn considerable attention in chemical plants, where various structural components typically operate at high temperature an pressure. Thus a life prediction methodology accounting for high temperature creep fracture is increasingly needed for the components. Critical defects in such structures are generally found in the form of semi-elliptical surface crack, and the analysis of which is consequently an important problem in engineering fracture mechanics. On this background, we first develop an auto mesh generation program for detailed 3-D finite element analyses of axial and circumferential semi-elliptical surface cracks in a piping system. A high temperature creep fracture parameter C-integral is obtained from the finite element analyses of generated 3-D models. Post crack growth module is further appended here to calculate the amount of crack growth. Finally the remaining lives of surface cracked pipes for various analytical parameters are assessed using the developed life assessment program.

• Korean Journal of Medicinal Crop Science
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• v.26 no.5
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• pp.354-361
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• 2018

Background: This study was conducted to investigate the growth characteristics, root yield and curcuminoid content of turmeric (Curcuma longa L.), cultivated using mother seed rhizomes (MR) and finger seed rhizome (FR) of different sizes. MR are attached to the stem, and FR are connected to the MR, and are used as a general seed rhizome. Methods and Results: Seed rhizomes of different types and sizes were used: large, medium and small for FR, and large, half-sized, and small for MR. These were assigned to the experimental groups and cultivated under greenhouse conditions. The growth characteristics, root yield, and curcuminoid content did not show clear difference between MR and FR, but suggest that the larger seed rhizomes (above 30 g) could have higher root yields. On average, harvested mother rhizomes (HMR) contained more curcuminoid than harvested finger rhizomes (HFR), while the yield of HFR was higher than that of HMR. The higher weight of harvested roots correlated significantly with elevated curcuminoid content. Conclusions: The two seed rhizomes, MR and FR, did not differ in root yield and curcuminoid contents, but larger seed rhizomes may produce better root yields. This suggest that the optimum seed rhizome is larger FR, to produce higher yields and quality in turmeric root production.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.43 no.2
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• pp.65-71
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• 2020

Worldwide plant market keeps maintaining steady growth rate and along with this trend, domestic plant market and its contractors also maintain such growing tendency. However, in spite of its external growth, win-win growth of domestic material industry that occupies the biggest share in plant industry cost portion is extremely marginal in reality. Domestic plant material suppliers are required to increase awareness of domestic material brand by securing quality and reliability of international standard through improvement of design quality superior to that of overseas material suppliers. Improvement of design quality of plant material becomes an essential element, not an option, for survival of domestic plant industry and its suppliers. Under this background, in this study, priority and importance by each evaluation index was analyzed by materializing plant design stage through survey of experts and defining evaluation index by each design stage and based on this analysis result, evaluation index of stage-gate based decision-making process that may improve design quality of plant material was suggested. It is considered that by utilizing evaluation index of stage-gate based decision-making process being suggested in this study, effective and efficient decision-making of project decision-makers would be enabled and it would be contributory to improve design quality of plant material.