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http://dx.doi.org/10.1016/j.jgr.2015.07.004

Protective effect of Korean Red Ginseng against chemotherapeutic drug-induced premature catagen development assessed with human hair follicle organ culture model  

Keum, Dong In (Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine)
Pi, Long-Quan (Department of Dermatology, Yanbian University Hospital)
Hwang, Sungjoo Tommy (Dr. Hwang's Hair-Hair Clinic)
Lee, Won-Soo (Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine)
Publication Information
Journal of Ginseng Research / v.40, no.2, 2016 , pp. 169-175 More about this Journal
Abstract
Background: Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo. Methods: We examined whether KRG can prevent premature hair follicle dystrophy in a human hair follicle organ culture model during treatment with a key cyclophosphamide metabolite, 4-hydroperoxycyclophosphamide (4-HC). Results: 4-HC inhibited human hair growth, induced premature catagen development, and inhibited proliferation and stimulated apoptosis of hair matrix keratinocytes. In addition, 4-HC increased p53 and Bax protein expression and decreased Bcl2 protein expression. Pretreatment with KRG protected against 4-HC-induced hair growth inhibition and premature catagen development. KRG also suppressed 4-HC-induced inhibition of matrix keratinocyte proliferation and stimulation of matrix keratinocyte apoptosis. Moreover, KRG restored 4-HC-induced p53 and Bax/Bcl2 expression. Conclusion: Overall, our results indicate that KRG may protect against 4-HC-induced premature catagen development through modulation of p53 and Bax/Bcl2 expression.
Keywords
alopecia; chemotherapy; hair growth; Korean Red Ginseng;
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Times Cited By KSCI : 4  (Citation Analysis)
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