• Journal of Animal Science and Technology
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• v.49 no.3
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• pp.415-428
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• 2007

To investigate the detoxification effect of pork on the lead toxicity, the comparison tests were performed, in which Sprague Dawley(SD) rats were clinically treated with lead during the first 7 weeks and observed the detoxification effects induced by pork feeding during the second 7 weeks. As results of lead intoxication, decreases of body weight, hemoglobin and hematocrit and the increases of weight and relative organ weight of liver and kidney were observed. Also the accumulation of lead in tibia, kidney and liver was recognized. In case of pork feeding at detoxification stage the feed efficiency was significantly increased in pork feeding group rats than the those of control rats. The pork feeding seemed to be a factor affecting relative organ weight of liver and kidney(p<0.05). It was shown that the factors affecting the accumulation of lead in liver included the lead intoxication(p<0.0005), pork feeding(p<0.0005) and interaction of above two(p<0.0005). It was observed that the content of DALAD in liver increased with significance in pork fed group compared with control group regardless of lead treatment levels. From this result, it was considered that pork feeding improved the detoxification process of SD rats intoxicated with lead.

• Journal of Service Research and Studies
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• v.12 no.2
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• pp.38-47
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• 2022

The user interface is a very important factor in application usability. The user interface of a typical application has a navigation system and the selection of the item takes place to move the movement. In this study, we would like to see if there are differences in user satisfaction depending on the location of the navigation and the number of items. The methods of in this study, a random group of 135 adult men and women who randomly selected four to six items as independent variables was conducted on the top, bottom, side, and three locations of navigation in a typical application. As a result, the navigation system rejected the null hypothesis of 0.000 and 0.008 respectively, with a significant probability of 0.05 or less than 0.000 and 0.008, respectively. It was also confirmed that the study theory of whether the interaction of navigation location and number of items creates a difference in satisfaction was significant with a significant probability of 0.016. In the post-analysis (Schefe), there were significant differences in the position of navigation, as each group was classified as a new group at the top <bottom <, and in the number of items, there were significant differences between the two groups of six <4 . Conclusion of this research, depending on the results of some significant differences in satisfaction with the location of the navigation and the number of items, it can be seen that the satisfaction of the interface increases when the navigation position is located at the bottom. However, follow-up research is needed on whether side-type navigation is suitable for different mobile sizes.

• YAKHAK HOEJI
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• v.36 no.6
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• pp.518-528
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• 1992

To determine the optimal conformation of sulfonylureas, the correlation between conformation and hypoglycemic activity of the two sulfonylureas of tolbutamide and chlorpropamide as hypoglycemic agent was studied using an empirical potential function (ECEPP/2) and the hydration shell model in the unhydrated and hydrated states. The conformational energy was minimized from several starting conformations with possible torsion angles in each molecule. The conformational entropy change of each conformation was computed using a harmonic approximation. To understand the hydration effect on the conformation of the molecules in aqueous solution, the contribution of water-accessible volume of each group or atom in the lowest-free-energy conformation was calculated and compared each other. From comparison of the computed lowest-free-energy conformations of two sulfonylureas, it could be suggested that the hydration of sulfonylurea moiety is related to increase the hypoglycemic activity. From the calculation results, it was known that the conformational entropy is the major contribution to stabilize the low-free-energy conformations of two sulfonylureas in unhydrated state. Whereas, in hydrated state, the hydration free energy largely contributes to the total free energies of low-free-energy conformations of tolbutamide and conformational entropy contributes to stabilize the low-free-energy conformations of chlorpropamide. The torsion angles from phenyl ring to urea moiety of the low-free-energy conformations of the two sulfonylureas were shown the nearly regular trend. On the basis of these results, the conformation exhibiting the optimal hypoglycemic activity of sulfonylureas and the binding direction to pancreatic receptor site A could be predicted. Also, according to the side chain lengthening of urea moiety, tolbutamide showed various conformational change. Therefore, steric effect may be important factor in the interaction between sulfonylureas and the putative pancreatic receptor.

• Research in Community and Public Health Nursing
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• v.14 no.2
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• pp.287-298
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• 2003

The purpose of the study was to develop an integrated prevention program to strengthen elders self-care capability and to examine its effectiveness on their psychological condition. This study used one group pre- and post-test design. Subjects were 85 elderly residents (over 65 years of age) who lived alone, and received free basic medical care and social welfare services in a rural community in Korea. Subject eligibility criteria for this study were to an elders who 1) is not currently taking any anti-depressant medication 2) is able to communicate, and 3) agrees to participate in this study. The integrated program was composed of horticulture, reminiscence, and friendship activities. Twelve sessions were provided for 12 weeks in community-based partnerships to achieve better outcomes. The intervention was case-managed by a public health nurse and aided by six volunteers. The main outcome variable was depression, which was assessed by using 15 items selected from the Geriatric Depression Scale-short form Korean version. Socio-demographic characteristics, functional status, and satisfaction with social support were used as covariates. Results showed that there was a significant intervention effect at post-intervention time point compared to pre-intervention time point(E.S. 0.94). Multiple linear regression analysis showed significant interaction effects between intervention and satisfaction with social support. These findings must be interpreted within the context that an effects of an integrated program could be more synergistically increased when social support factor is considered in the program. A community-based integrated prevention program of depression is effective for vulnerable rural elderly. It is suggested that randomized controlled trials within community setting for better methodological strength as well as multi-level outcomes on community need to be conducted in future.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.6
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• pp.784-793
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• 2004

Major objective was to evaluate three doses of bST (POSILAC(R)) injected into Holstein cows during the transition period and through 56 d of lactation for potential to improve DMI, BCS, BW, metabolites, hormones, IGF-I and milk production. Biweekly injections of bST (0, 5.1, 10.2, or 15.3 mg bST/d) began 28 d before expected parturition and continued through 56 d postpartum. Twenty-three of the 25 multiparous Holstein cows assigned randomly to four groups completed experiment (7, 5, 6 and 5 cows/group, respectively). The DMI, BW and BCS were recorded weekly throughout the prepartum and postpartum periods and blood samples were collected thrice weekly for analyses of ST, insulin, $T_{4}$, $T_{3}$, IGF-I, glucose and NEFA. Milk yields were recorded daily through 60 d postpartum and milk components measured once weekly. Mathematical model for data analyses for prepartum and postpartum periods included treatment, calving month, and the two-factor interaction. Cows injected with 10.2 and 15.3 mg bST prepartum had greater mean prepartum concentrations of ST and IGF-I. Prepartum injections of bST did not affect prepartum BW or BCS. On average, cows injected postpartum better maintained their BCS during first 60 d of lactation (3.15$\pm$0.06, 3.12$\pm$0.007, 3.20$\pm$0.006 and 3.58$\pm$0.009). Treatments did not affect mean prepartum DMI but cows injected with 15.3 mg bST/d had greatest DMI and greatest mean daily MY during the first 3 wk and tended to be greater during first 60 d of lactation. Cows injected with two highest bST doses (10.1 and 15.2 mg/d) had greater mean postpartum concentrations of ST and $T_{3}$, but IGF-I, $T_{4}$, glucose and NEFA did not differ across groups. No adverse effects of bST treatment were observed.

• Journal of Fisheries and Marine Sciences Education
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• v.25 no.2
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• pp.510-525
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• 2013

The purpose of this study is to investigate adult learners' experience by studying Humanities & General Education and get to know types and characteristics by classifying their learning experiences. This study uses grounded theory method which is suitable to investigate subjective experiences. In this study, data is collected from 13 adult learners by using Focus Group Interview(FGI) who participate in learning experience of Humanities & General Education of D university in Busan region. The data is categorized by open coding, axial coding and selective coding based on data analysis method of grounded theory and analysis processes. This study provides several outcomes as follows: 113 concepts, 38 subcategories and 16 upper categories are derived through the process of abbreviation and categorization of learning experience of Humanities & General Education. In a process of learning experience, this study shows interrelationship in a frame of paradigm and derives results of a process of abbreviation and categorization casual condition, contextual condition, phenomenon and interaction(help/obstruction factor). Tree types of learning experiences and characteristics are drawn as follows: 1) "Self-realization" is the type who participate in Humanities & General Education with desire of learning and they want to find identity and plan detailed future. 2) "The pursuit of happiness" has less desire on learning than "self-realization" and they are types who participate in Humanities & General Education because of someone else's help and suggestion. 3) "Local community" is the type who participate in Humanities & General Education because they feel necessity of social role and they expect local development based on their interest in local community. Several conclusions and suggestions are provided for further studies.

• Journal of the Korean Society of Groundwater Environment
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• v.4 no.4
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• pp.212-222
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• 1997

Geochemistry of metasedimentary groundwaters and spar waters has been studied in comparison with that of granitic groundwaters in Korea. Metasedimentary groundwaters show $Ca^{2+]$-${HCO_3}^-$ type at depth and low sodium concentrations compared with granitic groundwaters, which is due to the lack of plagioclase in their aquifer mineralogy and, therefore, the predominant reaction of calcite dissolution. According to factor analysis, metasedimentary groundwaters at 100~300 m depth are represented by 1) the dissolution of calcite and Mg-carbonates, 2) transformation of kaolinite to illite, and 3) the presence of sodium as not the product of plagioclase dissolution but a artificial pollutant. Discriminant function between the granitic and metasedimentary groundwaters shows a good discriminating ability with 81.8%, and groundwaters of volcanic aquifer, which has abundant plagioclase, are included in the granitic group by this function. Spa water samples show the result of active water-rock interaction due to high temperature.

• Korean Journal of Occupational Health Nursing
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• v.9 no.1
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• pp.62-71
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• 2000

In order to investigate the social support and the job satisfaction of the public health nurse, questionnaire survey was carried out on 297 nurses who were working in 25 public health centers in Seoul. The results of the study were as follows; 1. Mean score of job satisfaction was the highest in interaction(3.55) followed by-professional position(3.46), relationship between nurses and doctors(3.23), autonomy(2.85), administration(2.60), requirements(2.43) and pay(2.30) in descending order, and total mean score was 2.92. 2. The level of the job satisfaction was significantly higher in group with longer than 20 years' career and 15 years' in Public Health Center, 5th job rank and income more than two million won a month. 3. The mean score of social support was 3.57 out of 5. The social support tended to be higher in direct social support(3.61) than in indirect social support(3.54). 4. Job satisfaction was significantly correlated with social support(r=0.407). 5. The primary factor which influenced the job satisfaction was the social support which had the 25.5% explaining efficacy. The total explaining efficacy which included pay(6.4%) was 31.0%. In conclusion, it was found out that there existed Pearson's correlation between the job satisfaction and the social support of nurses of Public Health Centers in Seoul. Therefore, what is needed to increase the job satisfaction of nurses of public Health Centers is the politic support for the systems of the social support such as nurse's family, the system of Public Health Center, and the working environment. Finally it is important to increase the job satisfaction of nurses of Public Health Centers through the politic support.

• BMB Reports
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• v.35 no.1
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• pp.116-126
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• 2002

Nitric oxide (NO), synthesized from L-arginine by NO synthases, is a small, lipophilic, diffusible, highly reactive molecule with dichotomous regulatory roles in many biological events under physiological and pathological conditions. NO can promote apoptosis (pro-apoptosis) in some cells, whereas it inhibits apoptosis (anti-apoptosis) in other cells. This complexity is a consequence of the rate of NO production and the interaction with biological molecules such as metal ion, thiol, protein tyrosine, and reactive oxygen species. Long-lasting overproduction of NO acts as a pro-apoptotic modulator, activating caspase family proteases through the release of mitochondrial cytochrome c into cytosol, up-regulation of the p53 expression, and alterations in the expression of apoptosis-associated proteins, including the Bcl-2 family. However, low or physiological concentrations of NO prevent cells from apoptosis that is induced by the trophic factor withdrawal, Fas, $TNF{\alpha}$/ActD, and LPS. The anti-apoptotic mechanism is understood on the basis of gene transcription of protective proteins. These include: heat shock protein, hemeoxygenase, or cyclooxygenase-2 and direct inhibition of the apoptotic executive effectors caspase family protease by S-nitrosylation of the cysteine thiol group in their catalytic site in a cell specific way. Our current understanding of the mechanisms by which NO exerts both pro- and anti-apototic action is discussed in this review article.

• Journal of Digital Convergence
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• v.12 no.2
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• pp.69-78
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• 2014

This study aims to analyze the current state and causes of digital media literacy divide according to its sub-factors. The effects of the generation and the economic status, among other variables, have been explored using empirical data from a large-scale survey of 2,171 media users including children, adolescents, adults and the elderly. The results showed that the effects of generation and economic status varied according to 8 components of digital media literacy. The economic status of media users has also been found to influence the divide among adults group and through the interaction effect with the generation factor. Policy suggestions for the solution of digital media literacy divide were discussed in conclusion.