• BMB Reports
• /
• v.31 no.5
• /
• pp.459-467
• /
• 1998

A new set of functional group interaction energy descriptors relevant to the ACE (Angiotensin-Converting Enzyme) inhibitory peptide, QSAR (Quantitative Structure Activity Relationships), is presented. The functional group interaction energies approximate the charged interactions and distances between functional groups in molecules. The effective energies of the computationally derived geometries are useful parameters for deriving 3D-QSAR models, especially in the absence of experimentally known active site conformation. ACE is a regulatory zinc protease in the renin-angiotensin system. Therapeutic inhibition of this enzyme has proven to be a very effective treatment for the management of hypertension. The non bond interaction energy values among functional groups of six-feature of ACE inhibitory peptides were used as descriptor terms and analyzed for multivariate correlation with ACE inhibition activity. The functional group interaction energy descriptors used in the regression analysis were obtained by a series of inhibitor structures derived from molecular mechanics and semi-empirical calculations. The descriptors calculated using electrostatic and steric fields from the precisely defined functional group were sufficient to explain the biological activity of inhibitor. Application of the descriptors to the inhibition of ACE indicates that the derived QSAR has good predicting ability and provides insight into the mechanism of enzyme inhibition. The method, functional group interaction energy analysis, is expected to be applicable to predict enzyme inhibitory activity of the rationally designed inhibitors.

• The Journal of the Korea Contents Association
• /
• v.19 no.12
• /
• pp.471-482
• /
• 2019

The purpose of this study was to analyze the effect on the level of subject interest and interaction when supporting scaffolding considering learner characteristics in PBL. For the study, the participants were 86 college students. The research procedure was as follows. First, we divided the experimental group and the comparative group. A primary PBL was used to measure prior levels of subject interest and interaction. Secondary PBL was performed to verify treatment effect. In the second PBL, the experimental group received cognitive, metacognitive, and motivation scaffolding that reflected the learner's characteristics. The control group received random scaffolding. Subject interest and interaction were measured after the end of the second PBL. Collected data were analyzed using ANCOVA. As a result, the interest and interaction level of the experimental group was analyzed to be higher than that of the control group.

• Asia Marketing Journal
• /
• v.7 no.1
• /
• pp.43-65
• /
• 2005

In most leading companies, new product development is one of the most important corporate activities which affects the very existence of them. Therefore, CFT(cross-functional team) is frequently used to utilize knowledge and experiences of its members from various teams. To ensure the successful operation of CFT, various structural assistances, such as committee and Task Force Team, are made which will coordinate smooth interactions among members. Many researches show that the increase of interaction among team members affects the performance. This research is exploratory research intend to show the effects of relational characteristics such as group efficacy and participation on the perceived performance of new product development. This research examines the performance mechanism that lies in between CFT and its members by expanding the understandings on the relationship between interaction and performance in new product development CFT. Results show that the level of interaction affect group efficacy. and group efficacy affect participation. Finally, participation affect perceived performance. However. it shows that the level of interaction and group efficacy do not have direct effect on perceived performance.

• Child Health Nursing Research
• /
• v.15 no.1
• /
• pp.88-96
• /
• 2009

Purpose: This study was done to investigate effects of Meridian massage on the growth of the infant and on mother-infant interaction, mother-infant attachment, and the mother's satisfaction with her mothering role. Method: The participants were 39 mothers of infants who were seen at one of two urban public health centers located in Yangju or Seoul. Data were collected from February 2008 to December 2008. Infants in the experimental group were given Meridian massage for 50 minutes (lecture 20 minutes, practice 15 minutes, preparation and arrangement 15 minutes) once a week for 6 weeks. Percentages, means with standard deviation, $X^2$-test, repeated measured ANOVA, and ANCOVA were used with the SPSS program to analyze the data. Results: Infants in the experimental group showed an increase in weight & height compared to those in the control group. Mother-infant interaction, mother-infant attachment, and satisfaction with mothering role were significantly higher in the experimental group than the control group. Conclusion: The above finding suggest that Meridian massage should be applied in clinical practice to improve growth of infants, interaction and attachment between infants and their mothers, and the mother's satisfaction with her mothering role.

• Journal of Korea Entertainment Industry Association
• /
• v.13 no.8
• /
• pp.573-581
• /
• 2019

This study was to investigate the effects of group program on interactions and activity performance and among chronic stroke patients living in the community. This study was performed on 8 chronic stroke patients living in the community for 40 weeks for group program once a week for 60 minutes. group programs consisted of gross motor, fine motor, and cognitive activities that led to interactions among group members. Results were assessed by using the Social Interaction Anxiety Scale(SIAS) and Canadian Occupational Performance Measure(COPM), and evaluation of the task performance and social interaction was conducted. There was statistically significant decrease in social interaction anxiety level of subjects after group program intervention and statistically significant improvement in task performance. In addition, all of the subjects showed positive satisfaction with the program after the intervention. group program provided by the to chronic stroke patients living in the community is a approach that enhances the interacts with the members, task performance of the subjects and helps them design a meaningful life.

• Journal of The Korean Association For Science Education
• /
• v.22 no.3
• /
• pp.660-670
• /
• 2002

The purposes of this study were to categorize the type of student-student interaction and analyze the pattern of group interaction by cognitive level in interactive science inquiry experiments. For this study, two homogeneous and two heterogeneous groups by cognitive level were selected. Social interactions during group discussions were audio/video taped. The types of student's interaction were classified as intellectual and emotional aspects. Intellectual aspects were consisted of asking question, response, making suggestion, receiving opinion and then further coded by interaction level. Emotional aspects were consisted of relevance to behavioral participation, relevance to students' feeling, reaction to opinion. Interaction frequency in the intellectual and emotional aspect between homogeneous and heterogeneous group were compared to analyze interaction pattern. The results of this study showed that in intellectual aspect the frequency and quality of interaction in homogeneous group was higher than that in heterogeneous group. In emotional aspect. homogeneous group more showed such negative attitude as lack of confidence and dissatisfaction than heterogeneous group, on the other hand showed acceptable mood to be able to accept or object to peer's opinion. Some educational implications were drawn.

• Asia Marketing Journal
• /
• v.17 no.2
• /
• pp.73-96
• /
• 2015

This paper investigates how servicescape perception influences customer experience quality in hedonic service settings. In addition to the direct effect of servicescape quality on customer experience quality, the indirect effects of servicescape quality on customer experience quality via employee-to-customer interaction quality and peer-to-peer interaction quality are also investigated. We collected data through a self-administered survey. The proposed relationships were tested using structural equation modeling. The results show that servicescape quality influences customer experience quality both directly and indirectly through employee-to-customer interaction quality and peer-to-peer interaction quality, and customer experience quality influences customer loyalty. Additionally, we find that the indirect path via peer-to-peer interaction quality is significant only in a low-satisfaction customer group. The indirect effect of servicescape quality perception through peer-to-peer interaction quality is significant only in low-satisfaction customer groups. Therefore, if evaluations for this indirect effect fall below an acceptable level, it should be addressed first before improving on other attributes. However, after this point, further improvements offer few if any gains; therefore, service firms should allocate their resources to quality improvements to other factors. This study is the first to investigate the indirect effects of servicescape quality on customer experience quality via peer-to-peer interaction quality in hedonic service settings. Additionally, this study demonstrates that the significance of this indirect effect applies only to a low-satisfaction customer group.

• The Journal of Industrial Distribution & Business
• /
• v.10 no.2
• /
• pp.25-37
• /
• 2019

Purpose - The goal of this study is to analyze the differences in education performances between students of the government's financial support program and those who do not receive support at a local university in Korea. Research design, data, and methodology - The questionnaire used was NASEL. NASEL is considered a highly suitable survey tool for professors, courses, and performances in Korean universities. The 290 students who participated and 44 students do not participate in the financial support program were surveyed for 10 days. The characteristics of students were investigated by frequency analysis and technical statistics. The analysis of student collective characteristics used independent t and f-tests,and one-way ANOVA with IBM SPSS Statistics 22.0 for statistical purposes. Results - The p-value of the group receiving financial support and the group without financial support in active-collaborative learning is 0.167. The p-value of the economically supported group and the non-supported group of the faculty-student interaction is 0.281. The confidence coefficient of the active-collaborative learning questionnaire is 0.861. The reliability coefficient of the questionnaire for the faculty-student interaction questionnaire is 0.871. Conclusions - There are no clear differences in active-collaborative learning and faculty-student interaction between participating and non-participating students in the economic program.

• Women's Health Nursing
• /
• v.9 no.4
• /
• pp.351-358
• /
• 2003

Purpose: The aim of this study was to examine the effect of Desexualization Care guided by dramaturgical interaction on women's embarrassment during cervical cancer screening. Method: This study was carried out in a nonequivalent control group non-synchronized post-test only design. 62 women who had cervical cancer screening were' conveniently recruited from a university hospital health promotion center. Embarrassment was measured under four distinctive sub-dimensions by the method of self-reported questionnaire and blood pressure and pulse rates monitoring. The data of control group had a conventional pap smear were collected in advance and then those of experimental group were gathered after completing data collection in the control group. Women in experimental group were provided with a newly developed cervical cancer screening programme in which interdisciplinary team conducted dramaturgical interaction. Result: There was no significant difference in the scores of VAS between the two groups. The score of physiological response of Embarrassment Measurement Scale was significantly lower in experimental group than in the control group (p <.05), while no significant difference was found in cognitive-emotional, non-verbal and verbal behavioral responses between the two groups. There was also no significant difference in blood pressure and pulse rates between the two groups during cervical s creening. Conclus ion: Desexualization Care guided by dramaturgical interaction during cervical screening was found to have positive effect on physiological response of women's embarrassment. Further research for identifying other main variables which might have influenced on women's embarrassment is needed.

• Journal of Korean Physical Therapy Science
• /
• v.19 no.2
• /
• pp.25-33
• /
• 2012

Purpose : The purpose of this study was to investigate, The Effects of Massage and Taping on Muscle Strength and Flexibility and Pain with Delayed Onset Muscle Soreness(DOMS). DOMS is a common problem that can interfered with rehabilitation as well as activities of daily living. Methods : Thirty subjects untrained were randomly assigned into Massage group, Taping group, Massage and Taping group. Treatment were applied at 24 hours, 48 hours and 72 hours after induction DOMS. The effects of Massage and Taping and Muscle strength and flexibility on DOMS were evaluated by a goniometer and dynamometer and taping and VAS sheet. Results : The results of this study were as follow : 1) There was a significant difference among Taping group, Massage group, Taping and massage group in the case of using graduator. The interaction of group shown a significance (p<.05). 2) In the case of using goniometer, all three groups had the significant difference in period (p<.05) and the interaction of group-period shown a significance(p<.05). 3) In the case of using VAS, all three group had the significant differences in period(p<.05) and the interaction of group-period shown a significance(p<.05). Conclusions : These findings suggested that Taping and Massage had effect on DOMS.