• Journal of Korean Academy of Nursing
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• v.45 no.2
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• pp.280-292
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• 2015

Purpose: In this study a system dynamics methodology was used to identify correlation and nonlinear feedback structure among factors affecting unplanned extubation (UE) of ICU patients and to construct and verify a simulation model. Methods: Factors affecting UE were identified through a theoretical background established by reviewing literature and preceding studies and referencing various statistical data. Related variables were decided through verification of content validity by an expert group. A causal loop diagram (CLD) was made based on the variables. Stock & Flow modeling using Vensim PLE Plus Version 6.0b was performed to establish a model for UE. Results: Based on the literature review and expert verification, 18 variables associated with UE were identified and CLD was prepared. From the prepared CLD, a model was developed by converting to the Stock & Flow Diagram. Results of the simulation showed that patient stress, patient in an agitated state, restraint application, patient movability, and individual intensive nursing were variables giving the greatest effect to UE probability. To verify agreement of the UE model with real situations, simulation with 5 cases was performed. Equation check and sensitivity analysis on TIME STEP were executed to validate model integrity. Conclusion: Results show that identification of a proper model enables prediction of UE probability. This prediction allows for adjustment of related factors, and provides basic data do develop nursing interventions to decrease UE.

• Bulletin of the Korean Chemical Society
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• v.33 no.3
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• pp.869-880
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• 2012

Identification of the selective chemical features for Aurora-B inhibitors gained much attraction in drug discovery for the treatment of cancer. Hence to identify the Aurora-B critical features various techniques were utilized such as pharmacophore generation, virtual screening, homology modeling, molecular dynamics, and docking. Top ten hypotheses were generated for Aurora-B and Aurora-A. Among ten hypotheses, HypoB1 and HypoA1 were selected as a best hypothesis for Aurora-B and Aurora-A based on cluster analysis and ranking score, respectively. Test set result revealed that ring aromatic (RA) group in HypoB1 plays an essential role in differentiates Aurora-B from Aurora-A inhibitors. Hence, HypoB1 used as 3D query in virtual screening of databases and the hits were sorted out by applying drug-like properties and molecular docking. The molecular docking result revealed that 15 hits have shown strong hydrogen bond interactions with Ala157, Glu155, and Lys106. Hence, we proposed that HypoB1 might be a reasonable hypothesis to retrieve the structurally diverse and selective leads from various databases to inhibit Aurora-B.

• Bulletin of the Korean Chemical Society
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• v.34 no.9
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• pp.2711-2719
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• 2013

Hydrogen bonding interaction between alcohols and water molecules is an important characteristic in the aqueous solutions of alcohols. In this paper, a series of molecular dynamics simulations have been performed to investigate the aqueous solutions of low molecular weight alcohols (methanol, ethylene glycol and glycerol) at the concentrations covering a broad range from 1 to 90 mol %. The work focuses on studying the effect of the alcohols molecules on the hydrogen bonding of water molecules in binary mixtures. By analyzing the hydrogen bonding ability of the hydroxyl (-OH) groups for the three alcohols, it is found that the hydroxyl group of methanol prefers to form more hydrogen bonds than that of ethylene glycol and glycerol due to the intra-and intermolecular effects. It is also shown that concentration has significant effect on the ability of alcohol molecule to hydrogen bond water molecules. Understanding the hydrogen bonding characteristics of the aqueous solutions is helpful to reveal the cryoprotective mechanisms of methanol, ethylene glycol and glycerol in aqueous solutions.

• Bulletin of the Korean Chemical Society
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• v.33 no.7
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• pp.2238-2246
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• 2012

Molecular dynamics simulations have been performed to investigate hydrogen bonding characteristics of hydroxyl groups in glucose aqueous solutions with different concentrations. The hydrogen bonding abilities and strength of different O and H atom types have been calculated and compared. The acceptor/donor efficiencies have been predicted and it has been found that: (1) O2-HO2 and O3-HO3 are more efficient intramolecular hydrogen bonding acceptors than donors; (2) O1-HO1, O4-HO4 and O6-HO6 are more efficient intramolecular hydrogen bonding donors than acceptors; (5) O1-HO1 and O6-HO6 are more efficient intermolecular hydrogen bonding acceptors than donors while hydroxyl groups O2-HO2 and O4-HO4 are more efficient intermolecular hydrogen bonding donors than acceptors. The hydrogen bonding abilities of hydroxyl groups revealed that: (1) the hydrogen bonding ability of OH2-$H_w$ is larger than that of hydroxyl groups in glucose; (2) among the hydroxyl groups in glucose, the hydrogen bonding ability of O6-HO6 is the largest and the hydrogen bonding ability of O4-HO4 is the smallest; (3) the intermolecular hydrogen bonding ability of O6-HO6 is the largest; (4) the order for intramolecular hydrogen bonding abilities (from large to small) is O2-HO2, O1-HO1, O3-HO3, O6-HO6 and O4-HO4.

• Advances in environmental research
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• v.2 no.2
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• pp.81-98
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• 2013

Mercury (Hg) dynamics in the boreal environment have been a subject of concern in recent decades, due to the exposure of local populations to the contaminant. Land use, because of its impact on mercury inputs, has been highlighted as a key player in the sources and eventual concentrations of the heavy metal. In order to evaluate the impact of watershed disturbances on Hg dynamics in frequently fished, large boreal lakes, we studied sediment cores retrieved at the focal point of eight large lakes of Qu$\acute{e}$bec (Canada), six with watersheds affected by land uses such as logging and/or mining, and two with pristine watersheds, considered as reference lakes. Using a Geographical Information System (GIS), we correlated the recent evolution of land uses (e.g., logging and mining activities) and morphological characteristics of the watershed (e.g., mean slope of the drainage area, vegetation cover) to total Hg concentrations (THg) in sedimentary records. In each core, THg gradually increased over recent years with maximum values between 70 and 370 ng/g, the lowest mercury concentrations corresponding to the pristine lake cores. The Hg Anthropogenic Sedimentary Enrichment Factor (ASEF) values range from 2 to 15. Surprisingly, we noticed that the presence of intense land uses in the watershed does not necessarily correspond to noticeable increases of THg in lake sediments, beyond the normal increment that can be attributed to Hg atmospheric deposition since the beginning of the industrial era. Rather, the terrestrial Hg inputs of boreal lakes appear to be influenced by watershed characteristics such as mean slopes and vegetation cover.

• Journal of Drive and Control
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• v.15 no.4
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• pp.1-10
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• 2018

Spool displacement of a direction control valve is the standard signal to measure the bandwidth frequency of the direction control valve. When the spool displacement signal is not available, it is suggested in this study to use the metering hydraulic line as an alternative way to measure - 90 degree phase bandwidth frequency of the hydraulic direction control valve. Dynamics of the hydraulic line is composed of inertia, capacitance, and friction effects. The effect of oil inertia is dominant in common hydraulic line dynamics and the line dynamics is close to a derivative action in a range of high frequency; such as a range of bandwidth frequency of common directional control valves. Phase difference between spool displacement and line load pressure is nearly constant as a valve close to 90 degree. If phase difference is compensated from the phase between valve input and pressure, compensated phase may be almost same as the phase of spool displacement that is a standard signal to measure phase bandwidth frequency of the directional control valve. A series of experiments were conducted to examine the possibility of using line pressure in to measure phase bandwidth frequency of a directional control valve. Phase bandwidth frequency could be measured with relatively high precision based on metering hydraulic line technique and it reveals consistent results even when valve input, oil temperature, and supply pressure change.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.539-545
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• 2013

Although individual-level factors (e.g., attitudes, personality) have long been associated with day-to-day attendance decisions, increasingly researchers have recognized "the social nature of attendance dynamics and their susceptibility to social control (Johns, 2008)." Implications of this social approach for research would be to focus attention on the causes and effects of absence culture (i.e., absence-related perceptions, beliefs, values), and the effects of absence culture on individual and group attendance within social units. Construction projects typically require workers to work in teams or crews on highly interdependent projects, and, thus, are particularly relevant contexts to study absence culture. In this paper we apply a system dynamics (SD) model to study absence culture by utilizing the advantages of SD in capturing a feedback process and state changes. We were particularly interested in: (a) the awareness of social norms within construction crews that pertained to attendance, (b) the interplay between formal attendance rules (policy) and these social norms, and (c) how these sources of influence affected the decision-making process of construction crew members. We expect that the results of this work will help construction organizations evaluate (or re-consider) the effects of their attendance control policies (e.g., timing, strength, and frequency) within a social context. Moreover, our findings suggest that the key to reducing excessive absences might be to invest time in influencing absence culture directly rather than imposing frequent and strict regulations - which, in turn, may inadvertently fortify a culture that works against the organization's interests.

• Journal of computational fluids engineering
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• v.19 no.3
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• pp.1-7
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• 2014

One of the most important factors in sailing yacht design is an accurate velocity prediction. Velocity prediction programs (VPPs) are widely used to predict velocity of sailing yachts. VPPs, which are primarily based on experimental data and experience of long years, suffer limitations applied in realistic conditions. Thus, in the present study, a high fidelity velocity prediction method using the computational fluid dynamics (CFD) is proposed. Using the developed method, velocity and motion of a 30 feet sloop yacht, which was developed by Korea Research Institute of Ship and Ocean (KRISO) and termed KORDY30, were predicted in upwind sailing condition.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.10
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• pp.99-106
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• 2008

5kWh FESS(Flywheel Energy Storage System) using AMB(Active Magnetic Bearing) has been under development and 1st trial system has been finished and run the operating test. Unfortunately, the test result was not satisfactory because FESS could increase the rotational speed up to 9,000 rpm only although the target rotational speed is 18,000rpm. It's because 1st bending mode frequency of flywheel shaft was too low and imbalance response was too big. To achieve the target speed, 1st bending mode and imbalance response must be improved and the whole FESS needed to be designed again. This paper presents the newly designed FESS and what has been changed from the 1st trial FESS to improve 1st bending mode and imbalance response. The experimental results to see how much 1st bending mode frequency was improved are presented, too.

• Bulletin of the Korean Chemical Society
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• v.32 no.4
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• pp.1187-1194
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• 2011

The hydrogen abstraction reaction of $CF_3CH_2CHO$ + OH has been studied theoretically by dual-level direct dynamics method. Two stable conformers, trans- and cis-$CF_3CH_2CHO$, have been located, and there are four distinct OH hydrogen-abstraction channels from t-$CF_3CH_2CHO$ and two channels from c-$CF_3CH_2CHO$. The required potential energy surface information for the kinetic calculation was obtained at the MCG3-MPWB//M06-2X/aug-cc-pVDZ level. The rate constants, which were calculated using improved canonical transitionstate theory with small-curvature tunneling correction (ICVT/SCT) were fitted by a four-parameter Arrhenius equation. It is shown that the reaction proceeds predominantly via the H-abstraction from the -CHO group over the temperature range 200-2000 K. The calculated rate constants were in good agreement with the experimental data between 263 and 358 K.