• Tuberculosis and Respiratory Diseases
• /
• 제74권1호
• /
• pp.32-36
• /
• 2013

A 43-year-old woman with breast cancer who was on neoadjuvant chemotherapy presented with cough, sputum and mild fever. High-resolution computed tomography showed diffuse ground glass opacities in bilateral lungs and subpleural patchy consolidations. Initially, she was thought to have pneumonia or interstitial lung diseases such as drug-induced pneumonitis and treated with antibiotics and steroids. She subsequently got breast cancer surgery because of disease progression, and concurrent thoracoscopic lung biopsy revealed metastatic carcinoma of the lung from breast cancer. The diagnosis of suspected interstitial lung disease can be made without lung biopsy, but malignancy should always be considered and lung biopsy should be performed in the absence of a definitive clinical diagnosis.

• Tuberculosis and Respiratory Diseases
• /
• 제49권2호
• /
• pp.246-252
• /
• 2000

저자들은 양측성 신혈관근지방종, 경련, 지능저하 및 피지선종을 동반한 결절성 경화증으로 진단된 26세 여자 환자에서 객혈을 주증상으로 하여 흉부 X-선 및 고해상도 흉부전산화단층 촬영상 폐림프관평활근종증이 의심되었던 1예와 분만후 호흡곤란과 객혈을 주소로 내원한 30세 여자 환자에서 흉부 X-선 촬영, 고해상도 흉부전산화단층 촬영 및 폐생검을 통해 확진한 폐임파관 평활근종증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한핵의학회지
• /
• 제31권4호
• /
• pp.452-458
• /
• 1997

저자들은 섬유성 이형성증으로 진단받은 14명 환자의 16병변에서 단순 X-선사진의 소견에 따른 부위별 방사능 집적 정도를 알아보고 그 의의를 평가하기 위해 바늘구멍 골스캔과 단순 X-선사진 소견을 후향적으로 분석하여 비교하여 보았다. 10병변은 수술하여 조직학적으로 확진되었고, 6병변은 방사선학적으로 진단 받았다. 평균연령은 41.1세이며, 두 검사간의 간격은 평균 1.1일이었다. 병소의 위치는 늑골 7예, 골반골 4예, 쇄골 1예, 대퇴골 2예, 장골 1예, 상완골 1예였다. 바늘구멍골스캔 소견상 중심부에서 1+로 정상 방사능 집적을 보인예는 6예(방사선투과성 병변 5예, 간유리모양 병변 1예)이고, 2+로 중등도로 증가된 방사능 집적을 보인 경우는 7예(방사선투과성 병변 4예, 간유리모양 병변 3예)이며 3+로 현저히 증가된 경우는 3예(간유리모양 병변 1예, 경화성 병변 2예)가 있었다. 16예 중 15예에서 주변부 병소에 한 군데 이상의 증가된 방사능 집적이 불규칙한 환상이나 결절모양으로 나타났는데, 2+의 중등도 방사능 집적이 경화성테두리 5예와 비가시성 피질 1예에서, 그리고 3+의 현저한 방사능 집적증가는 격막과 피질천공을 보인 모든 예(7예, 8예)에서, 그리고 비가시성 피질 9예 중 8예에서 나타났다. 16예 중 1예는 중심부와 주변부 병소가 균일한 2+의 집적증가를 보였다. 바늘구멍 골스캔상 섬유성 이형성증의 방사선투과성병변은 이제까지 보고된 것과는 다르게 많은 예에서 인접 정상골과 비슷한 집적을 보였다. 또한, 격막, 피질골절 또는 비가시성 피질 등의 소견을 보이는 부분에 방사능 집적이 현저히 증가되어 주변부의 불규칙한 환상 또는 결절모양의 방사능 집적형태를 보였으며, 이들 병소는 골대사가 활발한 부위로 생각된다. 이와 같은 골의 섬유성 이형성증의 바늘구멍 골스캔 소견을 분석함으로써 부위별 활성도를 평가하여 진단, 예후 추정 및 치료방침을 결정하는데 유용하리라 사료된다.

• Tuberculosis and Respiratory Diseases
• /
• 제77권2호
• /
• pp.81-84
• /
• 2014

A patient treated with venlafaxine for major depression developed an interstitial lung disease (ILD) with the characteristic clinical, radiological and pathological features of chronic hypersensitivity pneumonitis. A high resolution computed tomography scan demonstrated ground glass opacity, mosaic perfusion with air-trapping and traction bronchiectasis in both lungs. The pathological findings were consistent with a nonspecific interstitial pneumonia pattern. Clinical and radiological improvements were noted after the discontinuation of venlafaxine and the administration of a corticosteroid. This report provides further evidence that the anti-depressant venlafaxine can cause ILD.

• Tuberculosis and Respiratory Diseases
• /
• 제59권1호
• /
• pp.109-113
• /
• 2005

저자들은 중증 폐렴으로 인한 ARDS양상으로 내원한 임신 3개월의 속립성 결핵 환자를 경기관지 폐생검과 방사선 소견 및 임상양상을 종합적으로 고려하여 속립성 결핵에 의한 ARDS로 확진할 수 있었던 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권2호
• /
• pp.657-662
• /
• 2014

Background: The epidermal growth factor receptor (EGFR) mutation status of lung cancer is important because it means that EGFR-tyrosine kinase inhibitor treatment is indicated. The purpose of this prospective study is to determine whether EGFR mutation status could be identified with reference to preoperative factors. Materials and Methods: One hundred-forty eight patients with lung cancer (111 adenocarcinomas, 25 squamous cell carcinomas and 12 other cell types) were enrolled in this study. The EGFR mutation status of each lung cancer was analyzed postoperatively. Results: There were 58 patients with mutant EGFR lung cancers (mutant LC) and 90 patients with wild-type EGFR lung cancers (wild-type LC). There were significant differences in gender, smoking status, maximum tumor diameter in chest CT, type of tumor shadow, clinical stage between mutant LC and wild-type LC. EGFR mutations were detected only in adenocarcinomas. Maximum standardized uptake value (SUVmax:$3.66{\pm}4.53$) in positron emission tomography-computed tomography of mutant LC was significantly lower than that ($8.26{\pm}6.11$) of wild-type LC (p<0.0001). Concerning type of tumor shadow, the percentage of mutant LC was 85.7% (6/7) in lung cancers with pure ground glass opacity (GGO), 65.3%(32/49) in lung cancers with mixed GGO and 21.7%(20/92) in lung cancers with solid shadow (p<0.0001). For the results of discriminant analysis, type of tumor shadow (p=0.00036) was most significantly associated with mutant EGFR. Tumor histology (p=0.0028), smoking status (p=0.0051) and maximum diameter of tumor shadow in chest CT (p=0.047) were also significantly associated with mutant EGFR. The accuracy for evaluating EGFR mutation status by discriminant analysis was 77.0% (114/148). Conclusions: Mutant EGFR is significantly associated with lung cancer with pure or mixed GGO, adenocarcinoma, never-smoker, smaller tumor diameter in chest CT. Preoperatively, EGFR mutation status can be identified correctly in about 77 % of lung cancers.

• Korean Journal of Radiology
• /
• 제21권7호
• /
• pp.859-868
• /
• 2020

Objective: To investigate the value of initial CT quantitative analysis of ground-glass opacity (GGO), consolidation, and total lesion volume and its relationship with clinical features for assessing the severity of coronavirus disease 2019 (COVID-19). Materials and Methods: A total of 84 patients with COVID-19 were retrospectively reviewed from January 23, 2020 to February 19, 2020. Patients were divided into two groups: severe group (n = 23) and non-severe group (n = 61). Clinical symptoms, laboratory data, and CT findings on admission were analyzed. CT quantitative parameters, including GGO, consolidation, total lesion score, percentage GGO, and percentage consolidation (both relative to total lesion volume) were calculated. Relationships between the CT findings and laboratory data were estimated. Finally, a discrimination model was established to assess the severity of COVID-19. Results: Patients in the severe group had higher baseline neutrophil percentage, increased high-sensitivity C-reactive protein (hs-CRP) and procalcitonin levels, and lower baseline lymphocyte count and lymphocyte percentage (p < 0.001). The severe group also had higher GGO score (p < 0.001), consolidation score (p < 0.001), total lesion score (p < 0.001), and percentage consolidation (p = 0.002), but had a lower percentage GGO (p = 0.008). These CT quantitative parameters were significantly correlated with laboratory inflammatory marker levels, including neutrophil percentage, lymphocyte count, lymphocyte percentage, hs-CRP level, and procalcitonin level (p < 0.05). The total lesion score demonstrated the best performance when the data cut-off was 8.2%. Furthermore, the area under the curve, sensitivity, and specificity were 93.8% (confidence interval [CI]: 86.8-100%), 91.3% (CI: 69.6-100%), and 91.8% (CI: 23.0-98.4%), respectively. Conclusion: CT quantitative parameters showed strong correlations with laboratory inflammatory markers, suggesting that CT quantitative analysis might be an effective and important method for assessing the severity of COVID-19, and may provide additional guidance for planning clinical treatment strategies.

• Journal of Veterinary Science
• /
• 제23권4호
• /
• pp.52.1-52.7
• /
• 2022

This paper reports a presumptive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a cat. A cat with respiratory disease living with three individuals with coronavirus disease 2019 showed bilateral ground-glass opacities in the lung on X-ray and computed tomography. The clinical swabs were negative for SARS-CoV-2 RNA, but the serum was positive for SARS-CoV-2 antibodies. Interstitial pneumonia and prominent type 2 pneumocyte hyperplasia were noted on histopathology. Respiratory tissues were negative for SARS-CoV-2 RNA or antigen, but the cat was positive for feline parvovirus DNA. In conclusion, the respiratory disease and associated pathology in this cat could have been due to exposure to SARS-CoV-2.

• Clinical and Experimental Pediatrics
• /
• 제45권4호
• /
• pp.529-534
• /
• 2002

저자들은 1개월 전부터 시작된 호흡 곤란과 마른 기침이 주증상인 10세 된 여아에서 조직학적 소견에서 비특이성 간질성 폐렴으로 진단된 1례를 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
• /
• 제67권2호
• /
• pp.127-130
• /
• 2009

Bilateral interstitial infiltration in chest radiography, which may be fine granular, reticular or of ground glass opacity, is the typical radiographic findings of Pneumocystis jiroveci pneumonia. Recently, atypical radiographic features, including cystic lung disease, spontaneous pneumothorax or nodular opacity, have been reported intermittently in patients with P. jiroveci pneumonia. We report the case of a 29-year-old woman with a transplanted kidney whose simple chest radiography and HRCT scan showed numerous miliary nodules in both lungs, mimicking miliary tuberculosis (TB). Under the presumptive diagnosis of miliary TB, empirical anti-TB medication was started. However, Grocott methenamine silver nitrate staining of a transbronchial lung biopsy tissue revealed P. jiroveci infection without evidence of TB. These findings suggest that even in TB-endemic area other etiology such as P. jiroveci as well as M. tuberculosis should be considered as an etiology of miliary lung nodules in mmunocompromised patients.