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Bicalutamide-induced Interstitial Lung Disease (전립선 암에서 Bicalutamide 사용으로 생긴 간질성 폐질환 1예)

  • Kim, Yang-Kyun;Kim, Yee-Hyung;Lee, Jae-Jin;Choi, Cheon-Woong;Yoo, Jee-Hong;Park, Myung-Jae;Kang, Hong-Mo
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.4
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    • pp.226-230
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    • 2010
  • Androgen deprivation therapy, which is the standard treatment for metastatic prostate cancer, includes nonsteroidal antiandrogenic drugs, such as flutamide, nilutamide and bicalutamide. Of them, bicalutamide rarely induces interstitial pneumonia. We report a case of bicalutamide-induced interstitial pneumonia. A 68-year old male diagnosed with prostate cancer and multiple bone metastases presented with dry cough and low grade fever for 3 days. He had taken bicalutamide (50 mg/day) for 13 months. High resolution computed tomography revealed ground glass opacity in his right upper lung. The laboratory studies showed no eosinophilia in the serum and bronchoalveolar lavage fluid. Despite the use of antimicrobial agents for 2 weeks, the extent of the lung lesions increased to the left upper and right lower lung. He had no environmental exposure, collagen vascular disease and microbiological causes. Under the suspicion of bicalutamide-induced interstitial pneumonia, bicalutamide was stopped and prednisolone (1 mg/kg/ day) was initiated. The symptoms and radiologic abnormalities were resolved with residual minimal fibrosis.

Characteristics of Korean ginseng varieties of Gumpoong, Sunun, Sunpoong, Sunone, Cheongsun, and Sunhyang

  • Lee, Jang-Ho;Lee, Joon-Soo;Kwon, Woo-Saeng;Kang, Je-Yong;Lee, Dong-Yun;In, Jun-Gyo;Kim, Yun-Soo;Seo, Jiho;Baeg, In-Ho;Chang, Il-Moo;Grainger, Keith
    • Journal of Ginseng Research
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    • v.39 no.2
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    • pp.94-104
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    • 2015
  • Background: Ginseng (Panax ginseng Meyer) is an important medicinal herbs in Asia. However, ginseng varieties are less developed. Method: To developed ginseng varieties, a pure line selection method was applied in this study. Results: Gumpoong was testing of 4-yr-old specimens in 2002, the proportions of the below-ground roots that were rusty colored for Gumpoong was 1.29 in Daejeon and 1.45 in Eumseong, whereas the proportions for its yellow berry variant were 2.60 and 2.45 in the two regions, respectively. Thus the Gumpoong was resistant to root rust. Sunpoong has a high yielding property. Its average root weight is 70.6 g for 6-yr-old roots. Its yield is 2.9 kg/$1.62m^2$ and the rate of heaven- and earth-grade product is 20.9%, which is very high compared to 9.4% for Yunpoong. Sunone is resistance to root rot and the survival rate of 4-yr-old roots was 44.4% in 1997, whereas that of the violet-stem variant landrace was 21.7%. Sunhyang has content of arginyl-fructosyl-glucose (AFG), which produces the unique scent of red ginseng, is $95.1{\mu}mol/g$ and greater than the $30.8{\mu}mol/g$ of Chunpoong in 6-yr-old plants. Sunun and Cheongsun are being nurtured to protect genetic resources. Conclusion: Developed ginsneg varieties will be used as the basis for the protection of genetic resources and breeding.

A Study on the Changes of Planning Factors of Apartment Houses in Newspaper Advertisements - Focused on the comparison in times of deregulation of the price ceiling - (신문광고에 나타난 아파트 계획요소의 변화에 관한 연구 - 분양가 자율화 전.후의 비교를 중심으로 -)

  • Park, Joo-Yeon;Kim, Yu-Hee;Yoo, Chang-Geun;Cho, Yong-Joon
    • Journal of the Korean housing association
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    • v.17 no.6
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    • pp.73-81
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    • 2006
  • This study focused on the fact that changes of policies have influence on housing culture of Korea and analyzed changes in apartment houses planning since the deregulation of the price ceiling through newspaper advertisement. The research compared and analyzed advertisements of apartment houses sales appeared in the 'Gwangju Il-Bo' daily newspaper from 1990 to 2003 by planning factors. : The results are as follows. Reliability and economy were important factors in deciding apartment before the deregulation of the price ceiling policy, but as apartment houses were merchandised after the deregulation of the price ceiling policy, brand of enterprise and image of apartment houses were highlighted more. In the environment of apartment complex, the concerns of location after the deregulation of the price ceiling policy were more increased than before its policy and it means emphasis on living environment for better life. The apartment housing unit and building showed change of the apartment housing unit plan considering residents, high quality of interior design and high-tech and differentiation of equipment since the deregulation of the price ceiling policy. The ground space has been parked or afforested and the underground space is used for parking lot as a part of environment-friendly in the apartment complex planning. The deregulation of the price ceiling policy made brand, image, high-grade and differentiation, and got many changes in the planning side of the apartment sales advertisement.

The Study on the design and implementation of a X-band 25W Power Amplifier Module using GaAs MMIC (GaAs MMIC를 이용한 X대역용 25W급 전력증폭모듈의 설계 및 구현에 대한 연구)

  • Kim, Ki-Jung;Kim, Bong-Soo
    • The Journal of the Korea institute of electronic communication sciences
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    • v.9 no.11
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    • pp.1311-1316
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    • 2014
  • To be used in a transmitter of a satellite transponder of this paper, X band 25W power amplifier module, a part constituting of high-power amplifier is transmitted to the equipment for transmitting to geostationary communications satellites(36,000Km distance). PAM consisted a total of four power amplifier module has a high output characteristic of the high-output amplifier is used in the ground station. Used in conjunction with the structured type power amplifier module is composed of Serial Combining Structure. This PAM(Power Amplifier Module) configured by combining the circuit with the power amplifier, 10 MMIC chips and the Al2O3 thin film substrate using a Hybrid Technique of power amplifier module, was implemented at X band PAM(Power Amplifier Module) of 25W grade.

The Effects of Gel-type Insole on Patients with Knee Osteoarthritis during Gait (겔-타입 인솔이 무릎 골관절염 환자의 보행에 미치는 영향)

  • Eun, Seon-Deok;Yu, Yeon-Joo;Shin, Hak-Soo
    • Korean Journal of Applied Biomechanics
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    • v.17 no.3
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    • pp.181-188
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    • 2007
  • The purpose of this study was to investigate the biomechanical effects of wearing different type of insole shoes on gait characteristics in patients with knee osteoarthritis. Seven patients with knee osteoarthritis (Grade 3 & 4 by Kellgren & Lawrence) were participated in the study. They wore two different type of shoes (with Gel-type Insole: GIS, with Normal insole: NIS) during gait. Three dimensional cinematography and Ground Reaction Force(GRF) data were used to get the maximal value of horizontal distance between the center of pressure in GRF and knee joint center, GRF in mediolateral direction, peak value of GRF in frontal plane, vertical compressive force and adduction moment in knee joint. The results were as follows: The maximal value of horizontal distance between the center of pressure in GRF and knee joint center was smaller in GIS than NIS. The peak value of GRF in mediolateral direction was found in 30% of gait cycle, five subjects wearing GIS showed lower value of peak GRF in mediolateral direction than wearing NIS. The peak value of GRF in frontal plane and vertical compressive force in knee joint did not show any difference between GIS and NIS. The adduction moment in GIS decreased in the late stance of gait and the mean value of the adduction moment in GIS smaller than that in NIS. GIS may help to move quickly knee joint center to the center of pressure in GRF, therefore it may prevent increasing the adduction moment in knee joint.

Development of Airframe Structure for Disaster and Public Safety Multicopter UAV (재난치안용 멀티콥터 무인기 기체구조 개발)

  • Shin, Jeong Woo;Lee, Seunggyu;Noh, Jeong Ho
    • Journal of Aerospace System Engineering
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    • v.14 no.3
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    • pp.69-77
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    • 2020
  • Airframe structure development of the 35 kg class 'Disaster and Public Safety Multicopter' UAV is described in this paper. To reduce the airframe weight, T-700 grade CFRP composite material was used, and the fuselage was designed with the semi-monocoque structure and plate installed with the control and communication devices designed in a sandwich structure. The specimen tests for the laminated plate and pipe were conducted to verify the strength and stiffness of the designed parts. The stacking sequence of composite materials was determined by the static strength and vibration analysis, and landing gear strut was designed by the nonlinear analysis with decent speed and ground clearance requirements. The static strength test was performed to evaluate the structural integrity and to verify the landing gear behavior.

A Novel Short Delay Multipath Mitigation Algorithm for a GNSS based Land Vehicle in Urban Environment (도심환경에서의 GNSS 기반 육상 이동체를 위한 짧은 지연 다중경로 감쇄 기법)

  • Lim, Deok Won;Chun, Sebum;Heo, Moon Beom
    • Journal of Advanced Navigation Technology
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    • v.22 no.6
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    • pp.557-565
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    • 2018
  • For GNSS navigation in urban environment, a novel short delay multipath mitigation algorithm is proposed in this paper. This algorithm detects which satellite's signal is the multipath signal by using the constraint that GNSS receiver is equipped in a ground vehicle, then estimate new position after separating the measurement of that satellite. A criterion for detecting and validating the multipath signal depends on the performance grade of the GNSS receiver and the dynamics of the vehicle. In order to evaluate the proposed algorithm, the real data had been collected at the multipath environment of 4 scenarios. By post-processing the real data with both of the multipath mitigation algorithm in the receiver and the proposed algorithm, it can be checked that the position errors were less than 5 meters except the case that the number of visible satellite is lower than 5.

Density Effects on the Size of 2-1 Korean Pine and 1-1 Jack Pine Nursery Stock (잣나무 2-1 묘(苗)와 방크스소나무 1-1 묘(苗)의 생장(生長)에 미치는 밀도효과(密度効果))

  • Ma, Sang Kyu
    • Journal of Korean Society of Forest Science
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    • v.32 no.1
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    • pp.1-8
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    • 1976
  • One of the most common needle leaf species used in planting in Korea is korean pine (Pinus koraiensis S. et Z.), and jack pine (Pinus banksiana Lamb.) is one of the test species for suitability. The relation of nursery bed density of 2-1 korean pine and 1-1 jack pine was studied at the Kwang Nung Nursery, Central Branch Station of Forest Research Institute, and about 40km north of Seoul. Nursery bed density of 2-1 korean pine, which ranged from 36 to 324 trees per square meters and of 1-1 jack pine, which ranged from 25 to 169 trees per square meters, had a marked effect on caliper, height, dry weight and percent and amount of plantable stock. The soil physical and chemical properties is silt plus clay, 50.55 percent; organic matter, 2.09 percent; total nitrogen, 0.13 percent; available phosphorus, 253.25 ppm; exchangeable potash, 0.46 m.e/100g; and pH, 5.58. As the density of the nursery seedling stand of 2-1 korean pine increases, the average tree height increases (Fig. 1A), but in 1-1 jack pine density do not affect to increase or decrease the average tree height. As the density of nursery bed increases, the average stem caliper (at 2cm above ground line) and dry weight decrease (Fig. 1B), but the decreasing rate is more seriously in 1-1 jack pine than 2-1 korean pine (Fig.5). As increasing the density of nursery bed, the T/R ratio of trees of the test species increase. Also the dry weight of leaf, stem and root parts are decreasing in proportion to the increase of stand density, but the drop rate of jack pine is more rapid than korean pine (table. 1) The patent facts of difference of growth characteristics between 2-1 korean pine and 1-1 jack pine were studied. These facts should be used to select the scale of stand density at the nursery bed or the plantable site. Korean pine is demanded high density, on the other hand in jack pine low density are more suitable to manage the stand density. Stands of comparatively low density had the greatest percentage of high-quality stock, and the stands of high density had less than the high quality trees of low density. An important criterion of the best density is percent and number of high-quality trees produced per square meter of bed area. Stem caliper and stem height of seedling is used in most public nurseries to sort seedling into plantable grades. The stock grade standard has set at 4.5mm caliper and 16cm height of 2-1 korean pine as the minimum desired stem caliper and height. By the result studies, the plantable stock grade standards of 2-1 korean pine used at stem height 16cm and stem caliper 4.5mm from public nurseries should be reformed to stem height 18cm and stem caliper 4.0mm by the growth characteristics and the tree distribution of stem height and caliper of relation to density. For the 2-1 korean pine, best density should be about 160 to 200 trees per square meter according to soil fertility. For the 1-1 jack pine, the suitable standard of plantable stock should be at stem height 25cm and caliper 6mm (at 2cm above ground line) and best density was about 100 to 120 trees.

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A study on the optimization of tunnel support patterns using ANN and SVR algorithms (ANN 및 SVR 알고리즘을 활용한 최적 터널지보패턴 선정에 관한 연구)

  • Lee, Je-Kyum;Kim, YangKyun;Lee, Sean Seungwon
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.24 no.6
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    • pp.617-628
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    • 2022
  • A ground support pattern should be designed by properly integrating various support materials in accordance with the rock mass grade when constructing a tunnel, and a technical decision must be made in this process by professionals with vast construction experiences. However, designing supports at the early stage of tunnel design, such as feasibility study or basic design, may be very challenging due to the short timeline, insufficient budget, and deficiency of field data. Meanwhile, the design of the support pattern can be performed more quickly and reliably by utilizing the machine learning technique and the accumulated design data with the rapid increase in tunnel construction in South Korea. Therefore, in this study, the design data and ground exploration data of 48 road tunnels in South Korea were inspected, and data about 19 items, including eight input items (rock type, resistivity, depth, tunnel length, safety index by tunnel length, safety index by rick index, tunnel type, tunnel area) and 11 output items (rock mass grade, two items for shotcrete, three items for rock bolt, three items for steel support, two items for concrete lining), were collected to automatically determine the rock mass class and the support pattern. Three machine learning models (S1, A1, A2) were developed using two machine learning algorithms (SVR, ANN) and organized data. As a result, the A2 model, which applied different loss functions according to the output data format, showed the best performance. This study confirms the potential of support pattern design using machine learning, and it is expected that it will be able to improve the design model by continuously using the model in the actual design, compensating for its shortcomings, and improving its usability.

A Study on Growth Condition and Management of Protected Trees in Kimpo (김포시 보호수의 생육실태와 관리방안 연구)

  • Doo, Chul-Eon;Lee, Jong-Bum;Lee, Jae-Keun
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.30 no.1
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    • pp.125-134
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    • 2012
  • This study is determined by tree vigor of analyzing of each object's growth condition in Locational Characteristics and compare the result with impediment extent rate in crown area to provide the management Study about the influence of man-made structures in numbers of protected trees. 68 places where are in the list of Kimpo protected trees were researched in Natural environments, vital degree of trees, number of trees. Crown area was calculated surveying it around the directions of North, East, South and West branching out. Impediment in the area was analyzed after classified into artificial impediment like paved surface(ascon, concrete, block, etc.), a building and a breast wall and natural impediment like soil, stonework and gravel and conclusions are as follow. In analyzing of natural environments, he ground where protected trees have located is consist of 72.05 of manmade structure and artificial in all. There are many protected trees which have less space than crown area for growth suggested by Woo-kyung Sim and Se-kyun Shin in 1992. And it was analyzed that making growth space for protected trees and management of impediment are urgently needed because of that the proportion of impediment covering the crown area has increased as cities are becoming more urbanized results in transforming of trees and weakness of tree vigor. This research shows that under 20% of in crown area is tree vigor determination 1-2 grade 21-50% under is 2-3 grade, higher than 50% is 3-5 grade. More impediment have more difficulty for growing, with the management of root system of protected trees need to be under 20% of rate of land is necessary was improved. As follows are suggested about the standard of management in artificial impediment which influence the number of trees. Firstly, impediment in crown area must be restricted under 20%, but in case outside of the area is not artificial the rate could be higher considerable. Secondly, protected trees growth space secured as much as crown area and impediment must be installed outside the crown area. Thirdly, to move the protected trees, condition of growth space secure must be considered. Fourthly, to develope land, the area around protected trees should be utilized in a park, the area of impediment installation in crown area should be limited as well. Fifthly, As many shown in previous research, for the improvement of old big trees and protected trees, need the tax favor of landowner and purchase of around land, to manage, it needs the budget of local government and advice of expert. Also the study on how various kind of impediment nearby protected trees influence on them has to be continued.