• Journal of Chest Surgery
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• v.46 no.5
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• pp.328-339
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• 2013

Background: Ischemic injury and the rejection process are the main reasons for graft failure in tracheal transplantation models. To enhance the acceptance, we investigated the influence of mesenchymal stem cells (MSCs) on tracheal allografts. Methods: Extracted tracheal grafts from New Zealand white rabbits were cryopreserved for 4 weeks and orthotopically transplanted (control group A, n=8). In group B (n=8), cyclosporin A (CsA, 10 mg/kg) was injected daily into the peritoneal cavity. In group C (n=8), MSCs ($1.0{\times}10^7$ cells/kg) from the same donor of the tracheal allograft, which had been pre-cultured for 4 weeks, were infused intravenously after transplantation. In group D (n=8), MSCs were infused and CsA was injected daily. Four weeks after transplantation, gross and histomorphological assessments were conducted for graft necrosis, measuring the cross-sectional area of the allograft, determining the degree of epithelization, lymphocytic infiltration, and vascular regeneration. Results: The morphologic integrity of the trachea was retained completely in all cases. The cross-sectional areas were decreased significantly in group A (p=0.018) and B (p=0.045). The degree of epithelization was enhanced (p=0.012) and the lymphocytic infiltration was decreased (p=0.048) significantly in group D compared to group A. The degree of vascular regeneration did not differ significantly in any of the groups. There were no significant correlations among epithelization, lymphocytic infiltration, and vascular regeneration. Conclusion: The administration of MSCs with concurrent injections of CsA enhanced and promoted epithelization and prevented lymphocytic infiltration in tracheal allografts, allowing for better acceptance of the allograft.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.46 no.4
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• pp.466-475
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• 2010

This study intends to present a direction for the better reforming of fishers'onboard living conditions and proposals for preparing for ratification of the Work in Fishing Convention by means of making a comparison between standards on recent national fishing vessel accommodation facilities and standards on the Work in Fishing Convention and Its Recommendation, 2007, ILO. For the most part of standards on national fishing vessel accommodation facilities are somewhat insufficient to satisfy the provisions in Annex III of the Convention. Considering by items on fishing vessel accommodation facilities, the standards on insect protector, noise and vibration, heating and air conditioning, lighting, persons per sleeping room, recreational facility are not provided in national law. Headroom, separation of accommodation, sleeping room floor area, mattress size, mess room, galley and food storage are partially sufficient for the Convention. In case of sanitary facilities, national standards are not sufficient for the Convention. The other side, facilities related safety of ship and crew such as emergency escape etc., are fully sufficient for the Convention. These insufficiencies caused by different types of fishing vessel depend on originality of fishing method and practices. In the comparison between equivalent tonnage about vessel's length on convention and calculated tonnage of national existing fishing vessel, the difference are 226tons about length 24m and 501tons about length 45m. For that reason, headroom, persons per sleeping room, cabin of sicker and injured, sanitary facilities may decide to use gross tonnage in place of length (L) and the alleviating measure basis of convention. But in case of standards on sanitary facilities which are unsufficient for the Convention, specially in coastal fishing vessel length basis should be adopted with alleviating basis for less than length 24m.

• Fire Science and Engineering
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• v.13 no.3
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• pp.35-42
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• 1999

A occupant load density of contemporary office buildings were surveyed by a building w walk through procedure in Korea. The survey results of ten office buildings are range from 1 2 2 2 213.14 m !person 041.4 ft !person) to 22.69 m /person (244.34 ft !person) with 95% confidence l level and the mean occupant load density is 17.92 m2/person 092.87 ft2/야rson). The impacts of occupant load on evacuation flow time was analyzed by applying time-based egress m model, SIMULEX with various occupant load densities from previous studies. I In order to demonstrate the validation of egress modeling method, fire evacuation exercise a and computer simulation were used to simulate the actual evacuation plan for a high-rise office building. An analysis and comparison of the results of these approaches was made to i illustrate the influence of model limitations on the result of prediction The result of the study shows that the introduction of occupant load concept in building c code of Korea is essential to achieving resonable building life safety design in future.

• Clinical and Experimental Reproductive Medicine
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• v.26 no.2
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• pp.281-285
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• 1999

Kallmann's syndrome has both a general and specific connotation in describing general condition of gonadotropin-releasing hormone (GnRH) deficiency or a particular cluster of anomalies associated with primary eunuchoidism. The familial occurrence of hypogonadotropic hypogonadism associated with anosmia, color blindness, synkinesia, and mental defect is the classic Kallmann's syndrome. Interestingly, anosmia, or lack of smell, was not found in the absence of gonadal deficiency in the original study of this disorder. This disorder was found on both sexes, but the male to female ratio was 11:1, and Kallmann's syndrome is more often listed under disorders of male hypogonadism for this reason. Gross anatomy has shown disorders of the olfactory bulbs associated with Kallmann's syndrome and it was demonstrated a failure of GnRH-containing cells to migrate from the olfactory placode to the hypothalamus and preoptic area. We have experienced a case of Kallmann's syndrome which showed a hypoplasia of olfactory bulb in MRI during the workup of primary amenorrheic patient. So we report this case with a brief review of literatures.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.2
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• pp.9-17
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• 2017

Objectives This study was aimed to evaluate the effects of Daeyoungjeon (hereinafter referred to DYJ) treatment on the injury of articular cartilage induced by monosodium iodoacetate in rats. Methods Twenty-four male rats were divided into normal, osteoarthritic control and DYJ group. Rats of normal group were injected with 0.1 ml physiological saline, rats of control and DYJ groups were injected with 0.1 ml monosodium iodoacetate (3 mg/ml) into each left and right knee joint cavities. Rats of DYJ group were administrated extracts of DYJ during 60 days per orally. At 60 days after treatment, gross lesions, area and proteoglycan contents of articular cartilage, histopathological lesions, immunohistochemistry on matrix metalloproteinases (MMP-2, MMP-3, MMP-7) were evaluated. Results Grossly, degenerative changes of articular cartilages were observed weak in DYJ group. The areas of articular cartilages were broader significantly in DYJ group. The proteoglycan contents in articular cartilages were lesser significantly in DYJ group. Histopathologically, the chondrocyte score was lesser significantly in DYJ group. MMP-3 expression in articular cartilages was observed weak in DYJ group. Conclusions From above results, DYJ treatment has inhibitory effects on the injuries of articular cartilage induced by monosodium iodoacetate in rats, and it's effects may be related with down regulation of MMP-3.

• Korean Journal of Construction Engineering and Management
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• v.7 no.4 s.32
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• pp.91-99
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• 2006

The purpose of this study is propose an Artificial Neural Network(ANN) model for the construction estimate of the public educational facility at conceptual stage. The current method for the preliminary cost estimate of the public educational facility uses a single-parameter which is based on basic criteria such as a gross floor area. However, its accuracy is low due to the nature of the method. When the difference between the conceptual estimate and detailed estimate is huge, the project has to be modified to meet the established budget. Thus, the ANN model is developed by using multi-parameters in order to estimate the project budget cost more accurately. The result of the research shows 6.82% of the testing error rates when the developed model was tested. The error rates and the error range of the developed model are smaller than those of the general preliminary estimating model at conceptual stage. Since the proposed ANN model was trained using the detailed estimate information of the past 5 years' school construction data, it is expected to forecast the school project cost accurately.

• Journal of The Korean Society of Agricultural Engineers
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• v.53 no.2
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• pp.1-8
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• 2011

In this study, In order to evaluate reliable of MODIS GPP, the MODIS GPP and Flux tower measured GPP were compared to evaluate the use of method on 8 days composite MODIS GPP. The 2008 Flux data ($CO_2$ Flux and air temperature) measured in Seolmacheon watershed ($8.48\;km^2$) were used. The Flux tower GPP was estimated as the sum of $CO_2$ Flux and $R_{ec}$ (ecosystem respiration) by Lloyd and Taylor method (1994). The summer Monsoon period from June to August mostly contributed the underestimation of MODIS GPP by cloud contamination on MODIS pixels. The 2008 MODIS GPP and Flux tower GPP of the watershed were $1133.2\;g/m^2/year$ and $1464.3\;g/m^2/year$ respectively and the determination coefficient ($R^2$) after correction of cloud-originated errors was 0.74 (0.63 before correction). Even though effect of Cloud-Originated Errors was eliminated, Solar radiation and Temperature are affected at GPP. Measurement of correct GPP is difficult. But, If errors of MODIS GPP analyze on Cloud Moonsoon Climate in korea and eliminated effect of Cloud-Originated Errors, MODIS GPP will be considered GPP increasing of 9 %. There, Our results indicate that MODIS GPP show reliable and useful data except for summer period in Moonsoon Climate.

• Journal of the Korean Geosynthetics Society
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• v.13 no.4
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• pp.57-68
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• 2014

This study categorizes the distributed sand around coastal area of Jeju volcanic Island into three groups according to their components, and arranges their characteristics. In the case of basic physical properties, the silicate sand has slightly greater specific gravity than general sand, and the carbonate sand with widespread distribution has a lower specific gravity. In the gross, the carbonate sand has poor particle classifying and low uniformity coefficient because carbonate minerals of relatively large grain size are mixed. The relation between compressive strength and components shows conflicting tendency that silicate and carbonate components have positive correlation and negative correlation with compressive strength, respectively. Based on the components ratio of one to one, the sand having low carbonate component ratio is expected to be able to utilize in construction fine aggregate. To compare between square root (ACI 308) and cube root (KCI 2012) of compressive strength at computation of elastic modulus, it is considered to non-dimensional elastic modulus.

• Journal of Veterinary Clinics
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• v.32 no.6
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• pp.548-550
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• 2015

A 1-year-old female hedgehog was presented with subcutaneous mass in the right forelimb. Grossly, an elevated subcutaneous mass approximately 4 cm in diameter was located in forelimb. Central dark brown area was surrounded by peripheral milky white zone in the cut surface of mass. Histopathologically, numerous neoplastic cells formed irregular cords or sheets in dermis. Most of neoplastic cells showed palisading features to basement membrane with or without central caseous necrosis. These neoplastic cells showed invasive tendency to adjacent tissues. According to immunohistochemistry, the neoplastic cells demonstrated strong positive signals for pancytokeratin, and negative for vimentin. Based on the gross, histopathology and immunohistochemistry, this mass was diagnosed as basal cell carcinoma in a hedgehog.

• Archives of Reconstructive Microsurgery
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• v.26 no.1
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• pp.9-13
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• 2017

Purpose: Fingertip amputations are the most common type of upper limb amputations. Composite grafting is a simple and cost-effective technique. Although many factors have investigated the success of composite grafting, the success rate is not high. Therefore, this study was conducted to investigate whether the microscopic procedure process during composite grafts improves the success rate. Materials and Methods: Thirteen cases of unreplantable fingertip amputation underwent a microscopic resection procedure for composite graft in the operating room. The principle of the procedure was to remove the least devitalized tissue, maximize the clean tissue preservation and exact trimming of the acral vessel and to remove as many foreign bodies as possible. Results: All fingertips in the thirteen patients survived completely without additional procedures. Conclusion: Composite grafting allows for the preservation of length while avoiding the donor site morbidity of locoregional flaps. Most composite grafts are performed as quickly as possible in a gross environment. However, we take noticed the microscopic resection. This process is thought to increase the survival rate for the following reasons. First, the minimal resection will maximize the junction surface area and increase serum imbibition. Second, sophisticated trimming of injured distal vessels will increase the likelihood of inosculation. Third, accurate foreign body removal will reduce the probability of infection and make it possible to increase the concentration and efficiency in a microscopic environment. Although there is a need for more research into the mechanisms, we recommend using a composite graft under the microscopic environment.