• Archives of Pharmacal Research
• /
• v.29 no.10
• /
• pp.911-920
• /
• 2006

Phenolic antioxidant butylated hydroxyanisole (BHA) is a commonly used food preservative with broad biological activities, including protection against chemical-induced carcinogenesis, acute toxicity of chemicals, modulation of macromolecule synthesis and immune response, induction of phase II detoxifying enzymes, as well as its undesirable potential tumor-promoting activities. Understanding the molecular basis underlying these diverse biological actions of BHA is thus of great importance. Here we studied the pharmacokinetics, activation of signaling kinases and induction of phase II/III drug metabolizing enzymes/transporter gene expression by BHA in the mice. The peak plasma concentration of BHA achieved in our current study after oral administration of 200 mg/kg BHA was around $10\;{\mu}M$. This in vivo concentration might offer some insights for the many in vitro cell culture studies on signal transduction and induction of phase II genes using similar concentrations. The oral bioavailability (F) of BHA was about 43% in the mice. In the mouse liver, BHA induced the expression of phase II genes including NQO-1, HO-1, ${\gamma}-GCS$, GST-pi and UGT 1A6, as well as some of the phase III transporter genes, such as MRP1 and Slco1b2. In addition, BHA activated distinct mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase (JNK), extracellular signal-regulated protein kinase (ERK), as well as p38, suggesting that the MAPK pathways may play an important role in early signaling events leading to the regulation of gene expression including phase II drug metabolizing and some phase III drug transporter genes. This is the first study to demonstrate the in vivo pharmacokinetics of BHA, the in vivo activation of MAPK signaling proteins, as well as the in vivo induction of Phase II/III drug metabolizing enzymes/transporters in the mouse livers.

• Journal of Korean Home Economics Education Association
• /
• v.29 no.1
• /
• pp.125-143
• /
• 2017

This program aimed at preparing the pre-service teachers to teach about North Korean family life culture to secondary school students, by promoting the understanding and acceptance of cultural differences between the two Koreas. Based on the literature review, the educational contents were developed to reflect general aspects of North Korean family life. The program was implemented with 35 undergraduate students in a home economics teacher education program. The program consists of 15 units of 150-minute instructional sessions. The first three introductory sessions dealt with the definitions of family life culture and multiculturalism, as well as a historical review of South-North relationship. The following nine sessions were devoted to North Korean family life culture in five different domains: consumption and leisure, family and child-caring, food and dietary life, housing and neighborhood life, and clothing/fashion. During the final two weeks, pre-service teachers conducted mock-teaching. For evaluation, pre- and post-session scores on general teaching efficacy and understanding of cultural differences were compared using paired t-tests. The pre-/post-test results confirmed that the program was successful in promoting the understanding and acceptance of cultural differences between two Koreas of pre-service teachers.

• Journal of Engineering Education Research
• /
• v.20 no.1
• /
• pp.10-17
• /
• 2017

This study proposes a means of guiding undergraduate research assistants programs in a more positive direction. This will be achieved by researching the reality of the programs operated in engineering departments for graduate school students and by analyzing the problems thereof. To achieve this objective, a literature study and research were conducted, which comprised of a survey on 204 graduate school students within the metropolitan area of Korea. The results of the study demonstrated that experience as an undergraduate research assistant has a positive influence on the adaptation to and life in graduate school. However, the role of the student and the level of salary varied depending on the role of the student, based on the capacity and support of individual professors. Thus, it is deemed that there will be a need for systematic program improvement and the development of a program that can provide significant academic activities, rather than simple experimental assistance.

• Structural Engineering and Mechanics
• /
• v.41 no.6
• /
• pp.735-750
• /
• 2012

This paper presents a comparison between two different procedures to deal with the geometric nonlinear analysis of space trusses, considering its structural stability aspects. The first nonlinear formulation, called positional, uses nodal positions rather than nodal displacements to describe the finite elements kinematics. The strains are computed directly from the proposed position concept, using a Cartesian coordinate system fixed in space. The second formulation, called corotational, is based on the explicit separation between rigid body motion and deformed motion. The numerical examples demonstrate the performances and the convergence of the responses for both analyzed formulations. Two numerical examples were compared, including a lattice beam with postcritical behavior. Despite the two completely different approaches to deal with the geometrical nonlinear problem, the results present good agreement.

• The KSFM Journal of Fluid Machinery
• /
• v.18 no.4
• /
• pp.22-29
• /
• 2015

In this study, an in-house program to predict steady state operation of micro gas turbines is constructed using MATLAB. The program consists of two parts: design and off-design simulations. The program is fully modular in its structure, and performance of each component (compressor, combustor, turbine, recuperative heat exchanger and pipe elements) is calculated in a separate calculation module using mass and energy balances as well as models for off-design characteristics. The off-design modules of compressor and turbine use performance maps, which are program inputs. The off-design operation of a micro gas turbine under development was predicted by the program. The prediction results were compared with those by commercial software, and the validity of the in-house program was confirmed.

• Proceedings of the PSK Conference
• /
• 2001.10a
• /
• pp.321.1-321.1
• /
• 2001

• Computers and Concrete
• /
• v.18 no.5
• /
• pp.1019-1039
• /
• 2016

In this paper, a parallel algorithm of nonlinear dynamic analysis of three-dimensional (3D) reinforced concrete (RC) frame structures based on the platform of graphics processing unit (GPU) is proposed. Time integration is performed using Newmark method for nonlinear implicit dynamic analysis and parallelization strategies are presented. Correspondingly, a parallel Preconditioned Conjugate Gradients (PCG) solver on GPU is introduced for repeating solution of the equilibrium equations for each time step. The RC frames were simulated using fiber beam model to capture nonlinear behaviors of concrete and reinforcing bars. The parallel finite element program is developed utilizing Compute Unified Device Architecture (CUDA). The accuracy of the GPU-based parallel program including single precision and double precision was verified in comparison with ABAQUS. The numerical results demonstrated that the proposed algorithm can take full advantage of the parallel architecture of the GPU, and achieve the goal of speeding up the computation compared with CPU.

• Journal of Engineering Education Research
• /
• v.15 no.4
• /
• pp.8-13
• /
• 2012

The Engineering school of Tohoku University has been offering a Team-based Engineering Design Course to its first year students since 1996 in order to increase the level of both motivation and interest in engineering. Freshmen are required to select one of approximately 150 topics and do some research on this topic. This course also provides opportunities for students to participate in exchange programs with the University of Washington (UW) and the University of Science and Technology Beijing (USTB). In the Tohoku-UW exchange program, which began in 1999, between 10 and 25 students of Tohoku visit the UW annually to present the results of the subjects the school has appointed in advance in the Team-based Engineering Design Course. In the Tohoku-USTB exchange program, which began in 2007, about 15 students from each university participate in a one day meeting organized by the students themselves. They give a presentation on either the results of the subject they selected in the course, or on an engineering related topic both groups have agreed to in advance. In this paper, a detailed history, the objectives, a schedule and the budget in these unique exchange programs is introduced together with an outline of the course and its contribution to the engineering design education.

• Journal of Korean Society of Rural Planning
• /
• v.19 no.2
• /
• pp.149-162
• /
• 2013

This study intended to suggest Voluntourism as a solution for alternative rural tourism for regional activation. Voluntourism is a form of alternative tourism on values of variety of tourism demand from pleasure to virtue. This study analyzed actual state of WWOOF(World-Wide Opportunities on Organic Farms) activities being operated in Korean rural village, one of representative of Voluntourism. Study aimed to explore the possibility of WWOOF activity as one of model of alternative rural tourism. We apply grounded theory method one of qualitative study methods for analysis of WWOOF Activities because WWOOF is still small activity in Korea. In result, we figure out the actual condition of WWOOF Korea activities as a vouluntourism through paradigm model of host and guest who had experience in WWOOF Korea. WWOOF activity is in its early stage so there many tasks. We suggested ideas for improving WWOOF activities to be one of new rural tourism business.

• Korean Journal of Agricultural Science
• /
• v.37 no.1
• /
• pp.37-43
• /
• 2010

This study carried out to develop barrier-free certification program in forest trail. It is done to provide the certification system presented about certification organized, certification standard and indexes, evaluation method and operation plan. In order to develop certification program in forest trail, detailed measurement index must be developed earlier based on an accessbility, a stability, a preservation and a walking continuity. The suitable forest trail for weak pedestrian was investigated that running slope should be 1/20(5%) maximum, cross slope cannot exceed 1/50(2%) maximum and clear tread width should be above of minimum 90cm. In addition, the trail type is designed as a mixed trail system which is a combination of the loop and the line form and its distance should be 225~675m. Finally, forest trail should be manage sustainably by having regular monitoring and evaluation.