• The Korean Journal of Health Service Management
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• 제8권4호
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• pp.1-12
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• 2014

This study is designed to develop a hospital communication program and to verify its effectiveness in graduate nurses self-esteem, communication conflicts, turnover intention and early resignation rate. The study method is a randomized control group with a pre-post test design. In order to help new graduate nurses adapt to the hospital, eight week hospital communication program is developed. The study participants are 104 nurses(47 experiment, 57 control) who have been working for less than six months. The data on self-esteem, communication conflict, and turnover intention was collected one week before the program and four weeks after the program. Then, the early resignation rate of the participating nurses was surveyed one year after the start of employment. The nurses who participated in the hospital communication program exhibit higher self-esteem, fewer communication conflicts, and lower early resignation rates than those who did not. However, effect in the turnover intention is not observed. Overall, the hospital communication program will help new graduate nurses adapt to hospitals.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1385-1391
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• 2016

Background: To investigate the prevalence of and factors associated with performance of annual mammography by women above 40 years of age. Materials and Methods: This cross-sectional retrospective study was conducted at an oncology reference service in Southern Brazil from October 2013 to October 2014 with 525 women aged 40 years or older. Results: The prevalence of annual mammography was 54.1%; annual mammographic screening was performed for women without private medical insurance, who were under hormone replacement therapy and who had used contraception in the past. An association was found between non-performance of breast clinical and self-examination and non-performance of mammographic screening. Conclusions: Use of mammography for breast cancer screening in the public health care setting proved to be accessible; nevertheless, the proportion of screened women was low, and they exhibited poor adherence to the basic measures of care recommended for breast assessment. Thus, control of breast cancer requires implementing actions targeting the population most vulnerable to non-adherence to screening in addition to continuously monitoring and assessing that population to reduce the prevalence of this disease.

• Journal of Korean Academy of Nursing
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• 제32권1호
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• pp.100-113
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• 2002

This study was designed to analyze the nursing curricula in graduate programs and suggest the direction of future nursing curricula. Thirty-two nursing curricula for a master's degree and fifteen curricula for a doctoral degree from general graduate programs, fifteen nursing curricula for a master's degree from fifteen educational graduate programs, eight nursing curricula for master degree from eight out of twelve public health graduate programs, three nursing curricula for a master's degree from three administrative graduate programs, and four nursing curricula for a master's degree from four clinical nursing graduate programs, were analyzed. Consequently, It was hard to find a clear difference between the educational goals and objectives, the subjects open in nursing curricula for a master's degree and those for a doctoral degree of graduate programs. The educational graduate programs, public health graduate programs, administrative graduate programs, and clinical nursing graduate programs, each program showed ittle different in each educational goal and objective. However, because the various kinds of subjects open in each program were not based on the core curricula, the quality of the nursing curricula need to be evaluated and develope　the curricula to difference are the goal and objective. Accordingly, future studies need to be focused on developing core nursing curricula reflecting the characteristics of each graduate program.

• Molecules and Cells
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• 제27권4호
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• pp.467-473
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• 2009

Our previous study suggested that OsBWMK1, a gene which encodes a member of the rice MAP kinase family, generates transcript variants which show distinct expression patterns in response to environmental stresses. The transcript variants are generated by alternative splicing and by use of alternative promoters. To test whether the two alternative promoters, pOsBWMK1L (promoter for the OsBWMK1L splice variant) and pOsBWMK1S (promoter for the OsBWMK1S splice variant), are biologically functional, we analyzed transgenic plants expressing GUS fusion constructs for each promoter. Both pOsBWMK1L and pOsBWMK1S are biologically active, although the activity of pOsBWMK1S is lower than that of pOsBWMK1L. Histochemical analysis revealed that pOsBWMK1L is constitutively active in most tissues at various developmental stages in rice and Arabidopsis, whereas pOsBWMK1S activity is spatially and temporally restricted. Furthermore, the expression of pOsBWMK1S::GUS was upregulated in response to hydrogen peroxide, a plant defense signaling molecule, in both plant species. These results suggest that the differential expression of OsBWMK1 splice variants is the result of alternative promoter usage and, moreover, that the mechanisms controlling OsBWMK1 gene expression are conserved in both monocot and dicot plants.

• Translational and Clinical Pharmacology
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• 제25권2호
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• pp.67-73
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• 2017

Glimepiride, a third generation sulfonylurea, is an antihyperglycemic agent widely used to treat type 2 diabetes mellitus. In this study, an untargeted urinary metabolomic analysis was performed to identify endogenous metabolites affected by glimepiride administration. Urine samples of twelve healthy male volunteers were collected before and after administration of 2 mg glimepiride. These samples were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS), and then subjected to multivariate data analysis including principal component analysis and orthogonal partial least squares discriminant analysis. Through this metabolomic profiling, we identified several endogenous metabolites such as adenosine 3', 5'-cyclic monophosphate (cAMP), quercetin, tyramine, and urocanic acid, which exhibit significant metabolomic changes between pre- and posturine samples. Among these, cAMP, which is known to be related to insulin secretion, was the most significantly altered metabolite following glimepiride administration. In addition, the pathway analysis showed that purine, tyrosine, and histidine metabolism was affected by pharmacological responses to glimepiride. Together, the results suggest that the pharmacometabolomic approach, based on LC-MS/MS, is useful in understanding the alterations in biochemical pathways associated with glimepiride action.

• Journal of Korean Society of Industrial and Systems Engineering
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• 제34권1호
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• pp.60-66
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• 2011

This study looks at a company which introduced SAP program, one type of ERP systems, and how the firm copes with the problems which happen in business process. The research tried to solve the problem by IDEAL method of process software improvement methodology. As a result, receipt account program for credit sales could be developed; the program was applied to the actual business work and operated.

• BMB Reports
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• 제54권8호
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• pp.437-437
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• 2021

• Structural Engineering and Mechanics
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• 제69권3호
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• pp.269-281
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• 2019

This work addresses a three-dimensional nonlinear structural analysis of the constructive phases of a cable-stayed segmental concrete bridge using The Finite Element Method through ANSYS, version 14.5. New subroutines have been added to ANSYS via its UPF customization tool to implement viscoelastoplastic constitutive equations with cracking capability to model concrete's structural behavior. This numerical implementation allowed the use of three-dimensional twenty-node quadratic elements (SOLID186) with the Element-Embedded Rebar model option (REINF264), conducting to a fast and efficient solution. These advantages are of fundamental importance when large structures, such as bridges, are modeled, since an increasing number of finite elements is demanded. After validating the subroutines, the bridge located in Rio de Janeiro, Brazil, and known as "Ponte do Saber" (Bridge of Knowledge, in Portuguese), has been numerically modeled, simulating each of the constructive phases of the bridge. Additionally, the data obtained numerically is compared with the field data collected from monitoring conducted during the construction of the bridge, showing good agreement.

• International Journal of Contents
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• 제15권1호
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• pp.39-51
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• 2019

Spontaneous speech provides rich information defining the linguistic characteristics of individuals. As such, computational analysis of speech would enhance the efficiency involved in evaluating patients' speech. This study aims to provide a method to differentiate the persons with and without aphasia based on language usage. Ten aphasic patients and their counterpart normal controls participated, and they were all tasked to describe a set of given words. Their utterances were linguistically processed and compared to each other. Computational analyses from PCA (Principle Component Analysis) to machine learning were conducted to select the relevant linguistic features, and consequently to classify the two groups based on the features selected. It was found that functional words, not content words, were the main differentiator of the two groups. The most viable discriminators were demonstratives, function words, sentence final endings, and postpositions. The machine learning classification model was found to be quite accurate (90%), and to impressively be stable. This study is noteworthy as it is the first attempt that uses computational analysis to characterize the word usage patterns in Korean aphasic patients, thereby discriminating from the normal group.

• Structural Engineering and Mechanics
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• 제85권2호
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• pp.163-177
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• 2023

The design of segmental bridges, a structure that typically employs precast prestressed concrete elements and the balanced cantilever construction method for the deck, may demand a highly complex structural analysis for increased precision of the results. This work presents a comprehensive numerical analysis of a 3D finite element model using the software ANSYS, version 21.2, to simulate the constructive deck stages of the New Guaiba Bridge, a structure located in Porto Alegre city, southern Brazil. The materials concrete and steel were considered viscoelastic. The concrete used a Generalized Kelvin model, with subroutines written in FORTRAN and added to the main model through the customization tool UPF (User Programmable Features). The steel prestressing tendons used a Generalized Maxwell model available in ANSYS. The balanced cantilever constructive steps of a span of the New Guaiba Bridge were then numerically simulated to follow the actual constructive sequence of the bridge. A comparison between the results obtained with the numerical model and the actual vertical displacement data monitored during the bridge's construction was carried out, showing a good correlation.