• Title/Summary/Keyword: Gout

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Pathophysiology and Treatment of Gout Arthritis; including Gout Arthritis of Hip Joint: A Literature Review

  • Yonghan Cha;Jongwon Lee;Wonsik Choy;Jae Sun Lee;Hyun Hee Lee;Dong-Sik Chae
    • Hip & pelvis
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    • v.36 no.1
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    • pp.1-11
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    • 2024
  • Gout is triggered by the accumulation of uric acid in the body, leading to hyperuricemia. Genetic, metabolic, and environmental factors can influence this condition. Excessive uric acid buildup results in the formation of monosodium urate (MSU) crystals, which precipitate in specific areas of the body, including the joints, where they can cause symptoms of gout. While the acute and chronic symptoms of gout have been well-documented, diagnosis of gout affecting the hip joint poses significant challenges. The global incidence of gout, the most prevalent form of inflammatory arthritis, is on the rise. Evaluation of the clinical signs, laboratory results, and imaging results is generally required for diagnosis of gout in cases where MSU crystals have not been detected. Hyperuricemia is considered a primary cause of arthritis symptoms, and comprehensive guidelines for treatment are available. Therefore, the choice of medication is straightforward, and moderate effectiveness of treatment has been demonstrated. Gout is a chronic disease, requiring lifelong uric acid-lowering medications, thus application of a treatment strategy based on the target blood uric acid concentration is necessary. Consequently, cases of gout will likely be observed more frequently by hip surgeons in clinical scenarios in the future. The objective of this review is to provide an overview of the pathophysiology of gout and subsequently examine recent advances in diagnostic methods and therapeutic agents based on an understanding of its underlying mechanisms. In addition, literature on gout-related issues affecting the hip joint, providing a useful reference for hip surgeons is examined.

The Prevalence of Gout and Its Risk Factors in Healthy Workers

  • Kwon, Gi-Hong;Chun, Byung Yeol;Kwon, Yong Hyun
    • The Journal of Korean Physical Therapy
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    • v.28 no.5
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    • pp.259-263
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    • 2016
  • Purpose: This study was conducted to investigate the prevalence and risk of gout in healthy workers. Methods: This cross-sectional analysis was conducted in 1,876 subjects (1,515 men and 361 women) enrolled in the Healthy Worker Cohort Study at Daegu, South Korea. Relationships between serum uric acid levels and independent risk factors were evaluated using multiple linear regression analysis after adjustment for covariates. Results: Among study participants, the prevalence of gout was 22.9% in men and 2.5% in women (based on a serum uric acid level >7.0 mg/dL for men and >6.0 mg/dL for women). Among men, increased ALT, GGT, total cholesterol, and triglycerides were associated with increased risk of gout (p<0.05) by multiple linear regression analysis; however, increased age and HDL-cholesterol/triglyceride ratio were associated with decreased risk of gout (p<0.05). In women, increased triglycerides were associated with increased risk of gout (p<0.05). Conclusion: Our findings suggest that increased triglycerides were significantly associated with the risk of gout in men and women. Moreover, a high HDL-cholesterol/triglyceride ratio in men may reduce the risk of gout.

A Clinical Case of a Recurrent Polyarticular Gout Patient Treated with Gyeji-tang-gami and Soshiho-tang-gami (계지탕과 소시호탕의 가감방으로 호전된 만성 재발성 다관절 통풍 환자 1례)

  • Kim, Bo-sung;Ahn, Seon-ju;Lee, Young-su
    • The Journal of Internal Korean Medicine
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    • v.43 no.5
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    • pp.1006-1017
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    • 2022
  • Objectives: This study examined a clinical case of a recurrent polyarticular gout patient treated with Korean medicine. Methods: The patient was treated with Korean medicine (Gyejigagye-tang, Soshiho-tang-gami, Gyejigajakyak-tang, acupuncture, and moxibustion), Western medicine, and rehabilitative therapy. Their effects were evaluated using the Visual Analog Scale. Results: After receiving Korean medical treatment for two admission periods, the Visual Analog Scale score for joint pain improved or disappeared. Moreover, Korean medicine was able to manage the symptoms of the gout patient. Conclusions: Proper Korean medicine treatment could be effective in improving the symptoms of recurrent polyarticular gout pain.

Compare Gout with Tongp'ung(痛風) (서양의학의 Gout와 한의학(韓醫學)의 통풍(痛風)의 비교고찰(比較考察))

  • Kim, Dong-Wook;Kim, Kap-Sung
    • Journal of Acupuncture Research
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    • v.17 no.4
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    • pp.100-112
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    • 2000
  • Compare western medicine report and books which refer to Gout with Oriental medicine books which refer to Tongp'ung(痛風). The results of studying about Gout and Tongp'ung(痛風) were summarized as follows. l. Dangyesimbub(丹溪心法) was printed in 1481 and also the first book which referred to Tongp'ung(痛風). 2. Donwonsipjonguiso(東垣十種醫書) was printed in 1592 and also Tongp'ung(痛風) was recorded like gout especially in cause of disease. 3. Ancient times, Affection by exopathogen and six kinds of natural factors were persisted the cause of Tongpung(痛風), later generation drink, diet and labor were persisted. 4. In Beunjungrok(辨證錄) and susyebowon(壽世保元), there were similar expressions about gout, for examples interval phase and chornic tophaceous. 5. In Uihakjongjon(醫學正傳) and Manbeunghoechun(萬病回春) insisted that gout patients had to control their food especially meat, fish snd drink. 6. According to the cause(Pung(風), Han(寒), Sub(濕)), doctor classified Bi(痺) first was Hangbi(行痺), second was Tongbi(痛痺) and last was Chakbi(着痺). 7. Doctors thought that Tongp'ung(痛風,) was not Hangbi(行痺) and Chakbi(着痺) but it was Tongbi (痛痺). Especially in pain, they thought it was similar to Bakhoyeukjolp'ung(白虎歷節風).

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Factors Influencing the Performance of Self-care in Gout Patients (통풍 환자의 자가 간호 수행에 영향을 미치는 요인)

  • Kang, Sung Gum;Lee, Eun Nam;Lee, Seung Won
    • Journal of muscle and joint health
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    • v.21 no.1
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    • pp.55-64
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    • 2014
  • Purpose: This study identified the factors influencing the self-care performance among gout patients to provide the basis of the development of a nursing intervention program that can improve the self-care performance. Methods: A survey was conducted of 132 gout patients who visited the departments of rheumatology and orthopedics from September to November 2013. The data were collected using the instruments for knowledge of gout, self-care performance, and self-efficacy. Results: The gout patients' knowledge, self-efficacy, exercise pattern, and drink pattern accounted for 71.2% of the self-care performance. Among them, the most important factor affecting on self-care behaviors was knowledge levels, showing the variance of 51.0%. Conclusion: The strategy for improving the knowledge and self -efficacy level should be considered in the development of educational programs for gout patients.

Intratendinous Tophaceous Gout Mimicking Cellulitis after Achilles Tendon Repair (봉와직염으로 오인된 아킬레스건 봉합술 후 발생한 아킬레스건 내 결절성 통풍)

  • Shin, Woo Jin;Hong, Sung-Ha;Suh, Seung-Pyo;Lee, Seung Gi
    • Journal of the Korean Orthopaedic Association
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    • v.56 no.3
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    • pp.261-265
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    • 2021
  • A diagnosis of gout is often straightforward because gout has well known clinical presentations, laboratory analyses, and radiologic features. On the other hand, gout can mimic other diseases by showing a range of atypical clinical manifestations. This paper reports a 35-year-old male with no prior history of gout who developed tophaceous gout at his previously repaired Achilles tendon 11 years after surgery. He was initially misdiagnosed with cellulitis because of his atypical clinical features. This case is presented with a review of the relevant literature.

Traumatic Separation of Bipartite Patella Underlying Gout

  • Choi, Eun Seok;Sim, Jae Ang;Go, Jae Yun;Na, Young Gon
    • Journal of Trauma and Injury
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    • v.31 no.3
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    • pp.189-193
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    • 2018
  • Gouty arthritis is a common crystal arthropathy, but gout tophus in the bipartite patella is a rare condition. This report presented a traumatic separation of bipartite patellar fragment caused by mild trauma in a patient with comorbid gout. When a patient with bipartite patella and underlying gouty arthritis complains of pain after trauma, clinical suspicion is needed about fragment separation of the bipartite patella.

Three Cases of Gout Treated with Scolopendrae Corpus Herbal-Acupuncture (오공약침(蜈蚣藥針)을 사용한 통풍(痛風)환자 치험 3례(例))

  • Kim, Sung-Woong;Lim, Seong-Chul;Jung, Tae-Young;Han, Sang-Won;Seo, Jung-Chul
    • Korean Journal of Acupuncture
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    • v.21 no.4
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    • pp.117-123
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    • 2004
  • Objective : The aim of this study is to report the effect of Scolopendrae Corpus Herbal-Acupuncture on three cases of gout. Methods : Scolopendrae Corpus Herbal-Acupuncture was administered one time per 2 days. After Herbal-Acupuncture administrated conventional body-acupuncture was performed. We evaluated the patients through Visual Analogue Scale (VAS). Results : After the treatments, three cases of gout patients showed the improvement in VAS and various symptoms. Conclusions : According to the results, Scolopendrae Corpus Herbal-Acupuncture may have rapid effects on gout. But further studies are required to prove the effect of Scolopendrae Corpus Herbal-Acupuncture.

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A Case Study About Soyangin Yin Exhausted Syndrome Patient Diagnosed as Gout (통풍(痛風)으로 진단된 소양인(少陽人) 망음증(亡陰證) 환자의 사상방 투여에 의한 치험 1례)

  • Choi, Min-Ki;Jung, Woon-Ki;Yoo, Jun-Sang
    • Journal of Sasang Constitutional Medicine
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    • v.19 no.1
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    • pp.203-210
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    • 2007
  • 1. Objectives The primary purpose of this case study is to report that a Soyangin Yin Exhausted Syndrome Patient Diagnosed as Gout was treated with 'Soyangin Hyungbangsabaek-san(荊防瀉白散)' and then his symptoms and Laboratory test(serum) improved. 2. Methods We diagnosed him as Gout on Soyangin Yin Exhausted Syndrome. So we treated his with 'Soyangin Hyungbangsabaek-san(荊防瀉白散)'. 3. Results and Conclusions The constitutional treatment with herb-medicine(Soyangin Hyungbangsabaek-san(荊防瀉白散) on Soyangin Yin Exhausted Syndrome Patient Diagnosed as Gout, his symptoms and Laboratory test(serum) improved. 'Soyangin Hyungbangsabaek-san(荊防瀉白散)' may take efffect Soyangin Yin Exhausted Syndrome.

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Flexor Tendon Rupture Secondary to Gout

  • Jeremy V. Lynn;Amy L. Strong;Kevin C. Chung
    • Archives of Plastic Surgery
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    • v.50 no.5
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    • pp.492-495
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    • 2023
  • Extra-articular deposition of monosodium urate crystals is a widely recognized manifestation of gout. However, gouty infiltration of flexor tendons in the hand resulting in tendon rupture is exceedingly rare. This case report highlights a patient with gouty infiltration of flexor tendons in the right middle finger resulting in rupture of both the flexor digitorum profundus and flexor digitorum superficialis. Given the extent of gouty infiltration and need for pulley reconstruction, the patient was treated with two-stage flexor tendon reconstruction. Febuxostat was prescribed preoperatively to limit further deposition of monosodium urate crystals and continued postoperatively to maximize the potential for long-lasting results. Prednisone was prescribed between the first- and second-stage operations to prevent a gout flare while the silicone rod was in place. In summary, tendon rupture secondary to gouty infiltration is the most likely diagnosis in patients with a history of gout presenting with tendon insufficiency.