• 대한의용생체공학회:의공학회지
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• 제30권3호
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• pp.185-190
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• 2009

Biomedical mobile devices for ubiquitous healthcare consist of biomedical sensors and communication terminal. They have two types of configuration. One is the sensor-network type device using wired or wireless communication with intelligent sensors to acquire biomedical data. The other is the sensor embedded type device, where the data can be acquired directly by itself. There are many examples of sensor network type, such as, fall detection sensor, blood glucose sensor, and ECG sensors networked with commercial PDA phone and commercial phone terminal for ubiquitous healthcare. On the other hand, sensor embedded type mounts blood glucose sensor, accelerometer, and etc. on commercial phone. However, to enable true ubiquitous healthcare, motion sensing is essential, because users go around anywhere and their signals should be measured and monitored, when they are affected by the motion. Therefore, in this paper, two biomedical mobile devices with motion monitoring function were addressed. One is sensor-network type with motion monitoring function, which uses Zigbee communication to measure the ECG, PPG and acceleration. The other is sensor-embedded type with motion monitoring function, which also can measure the data and uses the built-in cellular phone network modem for remote connection. These devices are expected to be useful for ubiquitous healthcare in coming aged society in Korea.

• 전기화학회지
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• 제17권1호
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• pp.30-36
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• 2014

산화/환원 매개체는 혈당 센서의 구성에서 전극과 효소 반응의 전자 전달 매개체로서 중요한 역할을 담당한다. 본 연구에서는 기존의 산화/환원 매개체보다 전자 전달 반응이 용이하며, 높은 민감도를 위해 페레이트에 아닐린을 결합시켜, 1차 아민기를 갖는 $Fe(CN)_5$-aminopyridine를 합성하였다. 합성된 $Fe(CN)_5$-aminopyridine 는 순환 전압 전류 법과 분광학적 방법을 이용하여 합성 결과를 확인하였다. 합성된 물질과 포도당을 측정하기 위한 당 탈 수소 효소를 ITO 전극위에 고정시켜 효소전극을 제작하였고, 또한 신호 증폭을 위하여 금 나노 입자를 함께 고정시켰다. 금 나노 입자가 고정된 효소 전극은 그렇지 않은 전극에 비해 약 2배 가량의 전류 밀도가 증가함을 확인하였다. 만들어진 효소 전극에서 포도당의 농도 별 산화 촉매 전류를 순환 전압 전류 법으로 측정한 결과 0.4 V (vs. Ag/AgCl)에서 전기적 신호가 발생되었으며, 포도당 0~10 mM의 농도 범위에서 전기적 신호가 선형 증가함을 확인할 수 있었다.

• 전자공학회논문지SC
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• 제42권2호
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• pp.33-38
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• 2005

신체 내 혈당 변화량과 $^1H$ 원자핵의 스핀-격자 완화시간의 변화량이 관련 있음과 원자핵의 스핀-격자 완화시간을 측정하는 방법으로 자기공명흡수법이 제안된 바 있다. 자기공병흡수법에 의하여 신체 내 혈당 변화량을 감지하기 위해서는 검출 영역내 고수준의 자기장의 세기와 균일도의 확보가 필수적이다. 가정에서 손쉽게 혈당의 변화량을 측정할 수 있도록, 본 논문에서는 가정용으로 적합한 크기와 무게를 가지면서 요구되는 자기장의 세기와 균일도를 확보한 무혈혈당측정기를 디자인하였다. 여러 형상과 재질을 갖는 초기 모델들을 설계, 제작하였고, 검출 영역의 자기 특성을 비교하여 최종 재질을 결정하였다. 또한, 유한요소 해석모델을 구축하고 형상 최적화를 통하여 최종 모델을 선정하였다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제7권5호
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• pp.275-280
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• 2002

In order to control glucose concentration during fed-batch culture for antibiotic production, we applied so called “software sensor” which estimates unmeasured variable of interest from measured process variables using software. All data for analysis were collected from industrial scale cultures in a pharmaceutical company. First, we constructed an estimation model for glucose feed rate to keep glucose concentration at target value. In actual fed-batch culture, glucose concentration was kept at relatively high and measured once a day, and the glucose feed rate until the next measurement time was determined by an expert worker based on the actual consumption rate. Fuzzy neural network (FNN) was applied to construct the estimation model. From the simulation results using this model, the average error for glucose concentration was 0.88 g/L. The FNN model was also applied for a special culture to keep glucose concentration at low level. Selecting the optimal input variables, it was possible to simulate the culture with a low glucose concentration from the data sets of relatively high glucose concentration. Next, a simulation model to estimate time course of glucose concentration during one day was constructed using the on-line measurable process variables, since glucose concentration was only measured off-line once a day. Here, the recursive fuzzy neural network (RFNN) was applied for the simulation model. As the result of the simulation, average error of RFNN model was 0.91 g/L and this model was found to be useful to supervise the fed-batch culture.

• Transactions on Electrical and Electronic Materials
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• 제14권5호
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• pp.273-277
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• 2013

A unified potentiostat circuit for both $O_2$- and $H_2O_2$- based electrochemical glucose sensors was proposed and its function was verified by circuit simulations and measurement results of a fabricated chip. This circuit consisted of an operational amplifier, a comparator and current mirrors. The proposed circuit was fabricated with a $0.13{\mu}m$ thick oxide CMOS process and an active area of $360{\mu}m{\times}100{\mu}m$. The measurements revealed an input operation range from 0.5 V to 1.6 V in the $H_2O_2$- based bio-sensor and from 1.7 V to 2.6 V in the $O_2$- based bio-sensor with a supply voltage of 3.3 V. The evaluation results showed that the proposed potentiostat circuit is suitable for measuring the electrochemical cell currents of both $O_2$- and $H_2O_2$- based glucose sensors.

• 센서학회지
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• 제17권4호
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• pp.250-255
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• 2008

A vanadium pentoxide ($V_2O_5$)-based bolometric infrared (IR) sensor has been designed and fabricated using micro electro mechanical systems (MEMS) technology for glucose detection and its resistive characteristics has been illustrated. The proposed bolometric infrared sensor is composed of the vanadium pentoxide array that shows superior temperature coefficient of resistance (TCR) and standard silicon micromachining compatibility. In order to achieve the best performance, deposited $V_2O_5$ thin film is optimized by adequate rapid thermal annealing (RTA) process. Annealed vanadium oxide thin film has demonstrated a linear characteristic and relatively high TCR value (${-4}%/^{\circ}C$). The resistance of vanadium oxide is changed by IR intensity based on glucose concentration.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.730-734
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• 2005

본 연구에서는 광섬유 산소센서를 기반으로 글루코오스 모니터링용 FIA 시스템을 개발하였다. 운반용액의 낮은 유속에서도 검출가능 하였으며, 산소전극을 이용한 글루코오스-FIA 시스템보다 넓은 범위의 글루코오스 농도를 검출할 수 있었다. 향후, 광섬유 센서를 이용하여 생물반응기에서 기질로 사용되는 글루코오스뿐만 아니라 용존산소, pH, $CO_2$와 같이 다양한 인자들의 모니터링 시스템을 개발하고자 한다.

• 한국응용과학기술학회지
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• 제35권4호
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• pp.1379-1385
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• 2018

The hand held voltammetry systems searched diabetic assay using glucose sensor of fluorine nafion doped carbon nanotube electrode (FCNE). An inexpensive graphite carbon pencil was used as an Ag/AgCl reference and Pt counter electrode. Upon combining and using three electrode systems, optimum square wave (SW) stripping results were attained to 1.0-9.0 ug/L with 8 points. Statistic RSD precision was of 6.02 % with n=15 in 0.1 mg/L glucose. After a total of 200 second accumulation times, analytical detection limit of 0.8 ug/L was obtained. This developed technique was applied to urine samples from diabetic patients urine for fluid analysis, it was determined that the sensor can be used with a diagnostics in the ex vivo of live cells and non treated biological fluid.

• 한국광학회지
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• 제19권2호
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• pp.127-131
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• 2008

본 논문에서는 굴절률 감지 방식의 수직 결합형 폴리머 마이크로링 공진기 기반 글루코스 바이오 센서를 제안하고 구현하였다. 이 센서에서 상부 클래딩 역할을 하는 글루코스 분석 대상물의 농도 변화는 링 공진기의 공진파장 이동을 측정함으로써 얻어진다. 특히, 센서의 감도를 향상시키기 위해 다음과 같은 방법을 사용하였다. 첫째로, 분석 대상물에 근접한 유효굴절률을 갖는 폴리머 도파로 구조를 공진기 센서에 도입하였다. 둘째로, 분석 물질의 접촉면적을 확대하기 위해 측면 클래딩층이 충분히 식각된 pedestal 링 도파로 구조를 사용하였다. 제안된 공진기 센서는 빔전파 방법을 사용하여 설계하고 분석하였다. 사용된 코어 및 클래딩용 폴리머의 굴절률은 각각 1.430과 1.375였으며, 링 반경은 $400\;{\mu}m$였다. 이 때 얻어진 도파로의 유효굴절률은 ${\sim}1.390$였으며 글루코스 수용액의 굴절률 1.333와 매우 근접하였다. 제작된 소자의 기본적인 전달특성은 FSR(free spectral range) 0.66 nm, 대역폭 ${\sim}0.15\;nm$, Q 값 10,000 이었다. 1550 nm 광파장 대역에서 얻어진 측정 결과를 살펴보면, 센서 감도는 ${\sim}0.28\;pm$/(mg/dL)였으며, 이에 따른 굴절률 변화 감도는 ${\sim}200\;nm/RIU$였다.

• 한국항만학회지
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• 제14권4호
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• pp.475-479
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• 2000

A possibility of the implementation of a quartz crystal sensor to the determination of chemical oxygen demand is examined by checking the electrochemical behavior of the sensor in a glucose solution. Since the surface of a quartz crystal has to be oxidized, a relatively active metal is coated on the surface of a usual 9 MHz AT-cut crystal. The electrochemical behavior is investigated by measuring the changes of current, resonant frequency and resonant resistance while a constant potential is applied. The crystal is installed in a specially designed container, and a quartz crystal analyzer is utilized to measure the frequency and resistance simultaneously. The variations of the measurements are examined at different concentrations of glucose solution, and a proper relation between the concentrations of glucose solution, and a proper relation between the concentration and the measurements is analyzed. As a result, it is found that a linear relation between the concentration of less than 900 ppm and the peak current when a constant potential of -180 mV (SSCE) is applied. The relation can be utilized for the determination of glucose concentration in sea water, and considering a direct relation between gluose concentration and chemical oxygen demand tells a possibility of the measurement of chemical oxygen demand using quartz crystal oscillators.