• Korean Journal of Radiology
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• 제23권7호
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• pp.742-751
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• 2022

Objective: To assess focal mineral deposition in the globus pallidus (GP) by CT and quantitative susceptibility mapping (QSM) of MRI scans and evaluate its clinical significance, particularly cerebrovascular degeneration. Materials and Methods: This study included 105 patients (66.1 ± 13.7 years; 40 male and 65 female) who underwent both CT and MRI with available QSM data between January 2017 and December 2019. The presence of focal mineral deposition in the GP on QSM (GP_QSM) and CT (GP_CT) was assessed visually using a three-point scale. Cerebrovascular risk factors and small vessel disease (SVD) imaging markers were also assessed. The clinical and radiological findings were compared between the different grades of GP_QSM and GP_CT. The relationship between GP grades and cerebrovascular risk factors and SVD imaging markers was assessed using univariable and multivariable linear regression analyses. Results: GP_CT and GP_QSM were significantly associated (p < 0.001) but were not identical. Higher GP_CT and GP_QSM grades showed smaller gray matter (p = 0.030 and p = 0.025, respectively) and white matter (p = 0.013 and p = 0.019, respectively) volumes, as well as larger GP volumes (p < 0.001 for both). Among SVD markers, white matter hyperintensity was significantly associated with GP_CT (p = 0.006) and brain atrophy was significantly associated with GP_QSM (p = 0.032) in at univariable analysis. In multivariable analysis, the normalized volume of the GP was independently positively associated with GP_CT (p < 0.001) and GP_QSM (p = 0.002), while the normalized volume of the GM was independently negatively associated with GP_CT (p = 0.040) and GP_QSM (p = 0.035). Conclusion: Focal mineral deposition in the GP on CT and QSM might be a potential imaging marker of cerebral vascular degeneration. Both were associated with increased GP volume.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2003년도 가을 학술발표논문집 Vol.30 No.2 (3)
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• pp.361-363
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• 2003

지리적으로 분산된 이 기종의 유휴 자원들을 서로 연결하여 가상의 고성능 컴퓨팅 자원으로 사용하는 그리드에서 자원에 대한 접근 제어 시스템의 구축은 필수적이다. 본 논문에서는 자원에 대한 접근 제어 시스템을 설계 및 구현한다. 특히, 그리드 환경 구축 시 가장 많이 사용되는 Globus Toolkit을 기반으로 하고 각 자원을 제공하는 사이트의 자율성을 보장하는 자원 접근 제어 시스템을 설계 및 구현하였다.

• 대한두경부종양학회지
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• 제23권2호
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• pp.185-187
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• 2007

Angioleiomyomas are a vascular subtype of leiomyomas or benign smooth muscle tumors. The majority of these tumors occur in the extremities. Angioleiomyoma of the larynx has been reported but is exceedingly rare. Laryngeal angiomyomas can present with hoarseness, dyspnea, or globus sensation, and often misdiagnosed as asthma. We report a case of a 74-year old man with laryngeal angioleiomyoma misdiagnosed as asthma.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2005년도 춘계학술대회
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• pp.526-531
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• 2005

D-클래스는 보안에 응용될 수 있는 가능성을 가지고 있으나 D-클래스의 계산은 NP-완전문제로서 행렬크기 증가에 의한 연산 량 증가 문제 해결을 위해 병렬 컴퓨팅 환경에서의 병렬 알고리즘 설계 및 구현이 필요하다. 본 논문은 그리드 컴퓨팅 환경에서의 D-클래스 계산을 위해 Globus 가 설치된 클러스터를 구축하고. MPICH를 이용 효율적인 D-클래스 계산 알고리즘을 설계 및 구현, 실행 결과 그리고 연산 량을 줄일 수 있는 수식 연구와 연구한 수식에 기반한 순차 알고리즘을 논한다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2002년도 가을 학술발표논문집 Vol.29 No.2 (3)
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• pp.472-474
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• 2002

최근 단순한 데이터 공유만이 아니라 모든 자원(중앙 처리 장치, 메모리, 저장 장치, 네트워크)을 공유하는 그리드 컴퓨팅이 주목을 받고 있다. 현재 그리드 응용 시스템들은 대부분 Globus toolkit을 통해 프로세스를 생성 관리하고 있으며 MPICH-G2를 가지고 그 프로세스간의 통신을 하고 있다. 본 논문은 이러한 요소를 가지고 볼륨 랜더링을 분산 처리하는 프로그램을 구현 분석함으로써 그리드 응용 프로그램 작성 시 성능향상을 위해 고려해야할 요소를 지적하고 대안을 이야기하고자 한다.

• 대한기관식도과학회지
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• 제10권2호
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• pp.22-27
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• 2004

Background : LPRD(Laryngopharyngeal reflux disease) gives rise to inflammatory change in the pharyngolaryngeal tissue with various otolaryngologic symptoms. Ranitidine, histamine H2receptor antagonists, are currently used as therapeutic medications. However, the efficacy of Ranitidine on LPRD has not been proven yet. Objectives : We intended to analyze the efficacy of the Ranitidine on LPRD. Materials :md Methods : In 20 multicenter, 607 patients with LPR(laryngopharyngeal reflux) symptom were observed to evaluate their symptoms and laryngoscopic findings after 4 weeks, 8 weeks, and 12 weeks of treatment of Ranitidine. Results : The symptom of LPR including globus sensation, sore throat hoarseness, regurgitatioin are improved after 4 weeks $86.2\%,\;8 weeks\;91.5\%,\;12 weeks\;92.9\%$ of Ranitidine treatment and improved after 4 weeks $91.5\%,\;8 weeks\;94.5\%,\;12 weeks\; 97.2\%$ of Ranitidine combined with prokinetics. The rates of sore throat, chronic cough, globus sensation improvement at 8 weeks after treatment are $26.7\%,\;16.7\%,\;16\%$. Conclusion : In patient with LPR, Ranitidine treatment reduces LPR symptoms very effectively.

• Investigative Magnetic Resonance Imaging
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• 제21권3호
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• pp.125-130
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• 2017

Purpose: To evaluate the clinical significance of T1 high signal intensity on the globus pallidus as a predictor of severe hepatic encephalopathy in patients with acute-on-chronic liver failure (ACLF), which is a distinct syndrome characterized by multi-organ dysfunction including cerebral failure. Materials and Methods: From January 2002 to April 2014, we retrospectively reviewed the magnetic resonance imaging (MRI) findings and clinical and magnetic resonance (MR) features of 74 consecutive patients (44 men and 30 women; mean age, 59.5 years) with liver cirrhosis. The chronic liver failure-sequential organ failure assessment score was used to diagnose ACLF. The pallidal index (PI), calculated by dividing the mean signal intensity of the globus pallidus by that of the subcortical frontal white matter were compared according to ACLF. The PI was compared with the Model for End-Stage Liver Disease (MELD) score in predicting the development of ACLF. Results: Fifteen patients who were diagnosed with ACLF had higher hepatic encephalopathy grades (initial, P = 0.024; follow-up, P = 0.002), MELD scores (P < 0.001), and PI (P = 0.048). In the ACLF group, the mean PI in patients with cerebral failure was significantly higher than that in the patients without cerebral failure (1.33 vs. 1.20, P = 0.039). In patients with ACLF, the area under the curve (AUC) for PI was 0.680 (95% confidence intervals [CI], 0.52-0.85), which was significantly lower than that for the MELD score (AUC, 0.88; 95% CI, 0.77-0.99) (P = 0.04). Conclusion: The PI can be an ancillary biomarker for predicting the development of ACLF and severe hepatic encephalopathy.

• Journal of Korean Neurosurgical Society
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• 제48권2호
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• pp.134-138
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• 2010

Objective : Meige syndrome is the combination of blepharospasm and oromandibular dystonia. We assessed the surgical results of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with medically refractory Meige syndrome. Methods : Eleven patients were retrospectively analyzed with follow-ups of more than 12 months. The mean follow-up period was $23.1{\pm}6.4$ months. The mean age at time of surgery was $58.0{\pm}7.8$ years. The mean duration of symptoms was $8.7 {\pm}7.6$ years. DBS electrodes were placed under local anesthesia using microelectrode recording and stimulation. After $2.4{\pm}1.3$ days of trial tests, the stimulation device was implanted under general anesthesia. Patients were evaluated using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Results : BFMDRS total movement scores improved by 59.8%, 63.5%, 74.1%, 74.5%, and 85.5% during the immediate postoperative period of test stimulation, 3, 6, 12, and 24 months (n = 5) after surgery, respectively. The BFMDRS total movement scores were reduced gradually and the results reached statistical significance in the postoperative period (test period, p < 0.001; 3 months, p < 0.001; 6 months, p = 0.003; 12 months, p < 0.001; 24 months, p = 0.042). There was no statistical difference between 12 months and 24 months. BFM subscores improved by 63.3% for the eyes, 80.9% for the mouth, 68.4% for speech/swallowing, and 87.9% for the neck at 12 months after surgery. The adverse effects were insignificant. Conclusion : The bilateral GPi-DBS can be effective for the treatment of intractable Meige syndrome without significant side effects.

• 컴퓨터교육학회논문지
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• 제11권3호
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• pp.81-89
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• 2008

광범위 분산 컴퓨팅 시스템인 그리드 컴퓨팅에서는 자원 결함의 발생 정도가 기존의 병렬 컴퓨팅보다 더 높다. 그리드 컴퓨팅에서 자원들의 결함은 작업 수행에 있어서 치명적인 영향을 줄 수 있기 때문에 결함 포용 기능은 필수적인 요소이다. 그리고 그리드 서비스들은 바람직한 작업의 수행을 위해 그리드 자원들의 최소한의 서비스 품질을 요구한다. 하지만 그리드 컴퓨팅 서비스를 제공하는 대표적인 미들웨어인 글로버스(Globus)는 결함 탐지 서비스와 관리 서비스 그리고 QoS 요구사항을 만족하는 결함 포용 서비스를 제공하지 않는다. 이에 본 논문에서는 그리드 컴퓨팅에서 QoS 요구사항을 만족하는 결합 포용 서비스를 제안한다. 이를 위해 본 논문에서는 프로세스 결함, 프로세서 결함, 네트워크 결함과 같이 결함의 정의를 확장한다. 그리고 자원 스케줄링 서비스, 결함 탐지 서비스, 결함 관리 서비스를 제안하고 구현 및 실험 결과를 제시한다.

• 대한후두음성언어의학회지
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• 제9권2호
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• pp.115-127
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• 1998

Laryngopharyngeal reflux(LPR) is one firm of the gastroesophageal reflux diseases(GERD). It is known to cause various kinds of otolaryngologic symptoms such as hoarseness, foreign body sensation in throat, chronic throat clearing, chronic cough, etc. Disease entities diagnosed by otolaryngologists as posterior laryngitis, globus pharyngeus should be suspected as LPR-related diseases. In this multi-center trial, we tried to evaluate the effect of cisapride(10mg tid) on LPR-related symptoms as the part I study(CIS-KOR-051) in 19 centers, and as the part II study(CIS-KOR-052) comparative evaluation of effect between cisapride(10mg tid) and ranitidine(150mg bid) on LPR-related symptoms in 4 centers. In part I study, efficacy of cisapride on LPR-related symptoms after 4 weeks was 53.5% and that of after 8weeks was 77.9% in per protocol(PPA) analysis group. In part II study, efficacy of the cisapride was much better than that of ranitidine not only from 8 weeks trial(p<0.001) but also from 4 weeks trial(p<0.021) in PPA group. In the multiple logistic regression analysis among the parameters which affect the efficacy of the treatment, cisapride prescribed group showed 10 times greater than that of ranitidine prescribed group(p<0.0001, Odds ratio : 10) in PPA group. LPR was proved by 24Hr double probe pHmetry in 13 patients out of 19 patients tested(68.4%). Thus these results indicated that inducing the improvement of motility functions could affect the amelioration of the LPR-related symptoms much better than reducing acid secretion from the stomach. And maybe it suggests that LPR-related symptoms mainly developed by the reduced motility functions of the esophagus and/or delayed gastric emptying.