• The Korean Journal of Malacology
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• v.17 no.2
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• pp.117-123
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• 2001

A genetic analysis using starch gel electrophoresis was peformed to clarify the degrees of genetic differentiation among two species of the genus Koreanomelania and Koreoleptoxis (Gastropoda, Pleuroceridae). The average genetic similarity coefficients (S) among the populations of K. nodifila was S=0.848 (0.805-0.905) and K. globus ovalis was S : 0.755 (0.666-0.860). The genetic similarity coefficients between Semisulcospira gottschei and K. nodifila, S. gottschei and K. globus ovalis, and K. nodifila and K. giobus ovalis were 0.194, 0.301, and 0.301, respectively. So between K. nodifila and K. globus ovalis seems to be genetically two distinct taxa.

• Korean Journal of Bronchoesophagology
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• v.2 no.2
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• pp.232-237
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• 1996

Burning and lump sensation in the throat is a common disorder in middle aged woman. It is generally considered to be a neurotic origin but its pathophysiology is still remained unknown. The purpose of this study was to evaluate the prevalence of the Pharyngoesophageal structural lesions and the esophageal motility disorders among the patients with globus pharyngeus and to elucidate whether any specific manometric abnormality might have any causative role in the pathogenesis of the globus sensation, and we also wanted to know whether such tests were necessary in evaluating those patients. Structural lesions were demonstrated in 21 cases(17.5 %) among 120 patients. But among 44 controls, there were also Two cases(4.5 %) of structural lesions, and there was less significantly difference in the prevalence of the structural lesions between the patients and controls(p=0.0625) Manometric abnormalities over the lower esophageal sphincter and the lower esophageal body were demonstrated in 28 cases (23.3 %) of the patients, while only one case (2.3 %) of the controls revealed such abnormality ( p=0.0037). Various manometric parameters of the upper esophageal sphincter and pharynx showed no difference between the patients and controls except the upper esophageal sphincter pressure at lateral sides which was lower in patients than in controls (p=0.0034). Globus sensation is a kind of symptom of esophageal dysmotility, and esophageal manometry is necessary to detect such abnormality in patients with globus sensation, Careful physical examination is also necessary to detect structural lesions in the pharynx and esophagus.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.26 no.2
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• pp.127-129
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• 2015

Background and Objectives : The etiology of globus pharyngeus remains uncertain. It has been known there is a relationship between the presence of air bubbles in esophagus and GERD symptoms. The aim of this study is to identify relationship between the globus symptom and the presence of air column in esophagus. Subjects and Methods : The study population consisted of 46 patients who underwent CT scan as part of evaluation for globus. Controls were chosen from the population consisted of patients with lymphadenopathy who underwent CT scan. The correlation between the presence of globus symptom and diameter, volume, and position of the air column was assessed using t-test. Reproducibility of diameter and volume of the esophageal air column was analyzed using intraclass correlation coefficient. Results : In study group, the mean volume of the air column was $769.56{\pm}983.08mm^3$, the mean diameter was $8.24{\pm}4.90mm$, the mean distance from the inferior border of posterior lamina of cricoid cartilage was $88.86{\pm}28.01mm$. In control group, $682.18{\pm}767.28mm^3$, $8.37{\pm}5.50mm$, $88.34{\pm}21.06mm$, respectively. There were no differences of diameter, volume and distance of the air column between the two groups. We failed to obtain acceptable reliability when we compare the diameter and the volume of the esophageal air column. Conclusion : There was no relationship between air column of esophagus and presence of globus symptom. And the measurement of diameter and volume of the esophageal air column change over time and it should be considered in a further study.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1987.05a
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• pp.22.1-22
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• 1987

인후부, 하인두부 및 경부 등에 종양감각(lump sensation)등의 이상감각을 호소하는 globus 증후군은 Hippocrates가 처음 기술한 이래 많은 저자들에 의해 여러 가지 다양한 원인들이 기술되어 왔지만 아직 뚜렷한 병인이 밝혀지지 않은 상태로 기질적 원인에 대한 다각적인 연구가 진행중이다. 이에 저자들은 1986년 7월부터 1987년 2월까지 연세대학교 의과대학 이비인후과학 교실을 방문한 85명의 globus 증후 환자를 대상으로 전향적 연구를 시행 다음과 같은 결과를 얻었다. 1) 주증상은 무언가 걸린듯한 느낌이 가장 많았고(40.8%), 기타 점액객출 및 종양감각이 있었으며, 증상부위는 하인두부(26.8%) 및 윤상연골부(28.0%)가 많았고. 증상 유발인자로는 피로 및 신경과민증이 동반된 기질적 병변으로는 비후성 설편도염 및 인두염이 가장 많았다. 2) 비데오-식도조영술 검사상 27명(31.8%)에서 윤상인두근 이상수축이 있었으며 기타 식도복(3명), 식도점막이상(1명)등이 있었고 윤상인두근 이상수축이 있었던 환자군과 없었던 환자군 사이에 주증상, 증상부위, 동반증상, 기질적 병변 및 치료경과에는 차이가 없었으며 50% 이상의 수축을 보인 3명의 환자에서 내시경 검사상 이상소견은 관찰되지 않았다. 3) 치료는 특별한 기질적 병변이 없는 한 자세한 설명을 통한 치유의 확신감을 주고 필요에 따라 진정제, 제산제 및 cimetidine을 투여한 결과 65.3%에서 증상의 완전소실 및 현저한 호전이 있었고, 24.5%에서는 어느 전도의 호전이 있었으며, 10.2%에서는 증상의 호전이 없었다.

• The Journal of Internal Korean Medicine
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• v.40 no.3
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• pp.541-550
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• 2019

Objective: The aim of this clinical study was to describe the case of a patient who experienced chronic diarrhea related to seasonal changes that improved with herbal medicine treatment. Methods: A patient with diarrhea and globus hystericus was treated following treatment with Hoehyangbanchong-san-hap-Ukgan-san and Gamisachil-tang. A defecation and urination diary, the Bristol Stool Form Scale, and the Visual Analog Scale (VAS) were used to evaluate the effectiveness of this treatment. Results: During treatment, the patient's Bristol Stool Form Scale score changed from Type 7 to Type 4, and the VAS score was significantly decreased. The symptoms of diarrhea and globus hystericus almost subsided. Conclusion: In this case, Korean traditional herbal medicine reduced the clinical symptoms of diarrhea and globus hystericus.

• Journal of Digital Contents Society
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• v.10 no.1
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• pp.169-175
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• 2009

Grid computing is an application to obtain the most efficient performance from computing resources in terms of cost and convenience. It is also considered as a good method to solve a problem that cannot be settled by conventional computing technologies such as clustering or is requiring supercomputing capability due to its complex and long-running task. In order to run grid computing effectively, it needs to connect high-performance computing resources in real-time which are distributed geographically. Answering to the needs of this grid application, researchers in several universities with Argonne National Laboratory in the USA (ANL) as the main axis have developed Globus. It is noticed, however, that the quality of service (QoS) is not guaranteed when certain jobs are exchanged through networks in the context of Globus. To tackle with this problem, the ANL has invented Globus Architecture for Reservation and Allocation (GARA). The researchers of this paper constructed a testbed for evaluating the ability to reserve resource in the GARA system and implemented the GARA code for it. We analyzed the applied results and discussed future research plans.

• The Journal of Internal Korean Medicine
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• v.42 no.6
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• pp.1245-1254
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• 2021

Objectives: This study investigated the clinical characteristics and symptoms of patients with reflux esophagitis (RE) visiting a Korean medicine hospital. Methods: We retrospectively reviewed the medical records of patients with an RE diagnosis who visited a Korean medicine hospital from June 15, 2020, to April 15, 2021. We analyzed the clinical characteristics and the results of a symptoms questionnaire. Results: Our sample included 1,151 patients (711 females). The median age was 58 years; the most common age bracket was 60-69 years. A total of 837 patients (72.7%) presented with symptoms lasting more than one year, and 1,035 (89.9%) had been prescribed medications for more than three months before visiting a Korean medicine hospital. Belching (77.6%) and acid regurgitation (70.9%) were the most frequent symptoms, followed by epigastric pain (61.6%) and throat globus (58.5%). Throat globus was the most bothersome symptom, and 72.4% of the patients experienced the symptom on more than five days in the preceding two weeks. Patients with a longer symptom duration were older (p<0.01) and more likely to be overweight (p=0.03). Patients experiencing symptoms for more than five years were more likely to report throat globus (p=0.02), hoarseness (p<0.01), and coughing (p<0.01). Conclusions: Most RE patients visiting a Korean medicine hospital were females in their sixties with chronic and refractory RE. Atypical symptoms (belching, epigastric pain, and throat globus) were common. Throat globus was highly prevalent in severe cases, suggesting that it warrants attention when treating RE patients.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.33 no.1
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• pp.20-25
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• 2022

Background and Objectives Globus pharyngeus is one of the most common symptoms of patients visiting otorhinolaryngology out-patient clinic, and usually long-lasting, difficult to treat, and frequently recurrent. Mucomyst^®, N-acetyl cysteine is an inhalation agent mainly used for mucolysis and reducing inflammation in airway via antioxidative effect. The purpose of this study was to evaluate the efficacy of inhaled Mucomyst^® treatment in patients with globus pharyngeus refractory to proton pump inhibitor (PPI). Materials and Method We prospectively evaluated the efficacy of Mucomyst^® in relieving symptoms of globus pharyngeus refractory to PPI in nine medical centers. Three hundred and three patients enrolled and finally 229 patients finished the inhaled Mucomyst^® therapy for 8 weeks. We analyzed the change of Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Visual Analogue Scale (VAS) for globus, and Globus Pharyngeus Symptom Scale (GPS) after use of Mucomyst^® for 4 and 8 weeks. Results The GPS, RSI, RFS, and VAS score significantly decreased serially in patients who finished 8 week-inhalation treatment. The GPS improvement gap was significantly correlated with initial GPS (p<0.001) in multiple regression analysis. Conclusion Inhaled Mucomyst^® therapy was effective for the reduction of both subjective and objective findings in refractory globus patients. This study might suggest new treatment option for patients with globus. However, further thorough studies would be needed to assess the real effect of inhaled Mucomyst^® treatment as a standard treatment for globus.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11a
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• pp.820-822
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• 2005

그리드 컴퓨팅 기술은 이용하여 이종의 분산 자원들을 묶어서 사용할 수 있게 해 준다. 최근의 그리드는 이기종 자원간의 상호 호환성 증대를 위하여 웹 서비스 기술을 도입하여, OGSA와 WSFR 표준을 정의하였다. 그에 따라 그리드 자원과 그 위에서 동작하는 작업들은 웹 서비스의 형태로 구현되고 관리된다. Globus Toolkit은 이 표준들을 구현한 미들웨어로 그리드 연구에서 가장 널리 활용되고 있다. 서비스가 자원을 효율적으로 사용하면서 서비스 성능을 유지하기 위해서는 서비스가 원하는 시점에 원하는 양의 자원을 제공 받을 수 있어야 한다. 이를 위해서 유휴자원을 찾는 기능과 동적으로 자원에 서비스를 설치하는 기능이 반드시 필요하다. 그러나 기존의 Globus Toolkit은 이런 기능을 제공하지 않는다. 따라서, 본 연구에서는 Globus Toolkit에 동적 서비스 설치 기능을 추가하고 그것을 관리할 수 있는 도어 서비스를 구현하여. 동적 자원 제공 기능이 가능하도륵 하였다.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11a
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• pp.1018-1020
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• 2005

그리드 컴퓨팅은 컴퓨팅 자원을 비용편익 측면에서 가장 효율적으로 만들 수 있는 능력을 가지고 있으며, 클러스터링 등의 기술로는 해결하기 어렵거나 시간이 오래 지체되어지는 대량의 컴퓨팅 능력을 요구하는 어려운 문제들을 풀기에 더 없이 좋은 방법 중에 하나이다. 이러한 그리드 컴퓨팅을 효율적으로 수행하기 위해서 지리적으로 분산되어 있는 고성능 컴퓨팅 자원을 실시간으로 상호 연결하기 위해 Grid Application이 필요하게 되었고 이에 미국의 ANL(Argonne National Laboratory)를 주축으로 하여 여러 대학의 연구진에 의해 Globus가 만들어지게 되었다. 그러나. 이러한 Globus상에서 Grid Application을 실행시켜 일정의 Job을 네트워크를 통하여 주고받을 때, QoS가 보장되지 않는 문제점이 발견되었다. 그리하여 이러한 문제점을 해결하기 위하여 GARA(Globus Architecture for Reservation and Allocation)가 ANL에 의해서 개발 되었고, 본 논문은 이러한 GARA의 성능을 테스트 하기 위하여 Testbed를 구성하여 GARA의 자원 예약 명령을 통해 자원을 예약을 수행하고, 그에 따른 적용 결과 및 추후 연구방향에 대하여 논하였다.