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Multi-Institute, Single Group, Prospective Observational Study to Evaluate the Efficacy of Mucomyst® in Relieving Symptoms of Globus Pharyngeus Refractory to Proton Pump Inhibitor

®" 객담제거 및 상기도 염증치료를 통한 증상개선효과 평가 다기관, 단일군, 전향적 관찰 연구"> 양성자펌프억제제에 반응하지 않는 인두이물감 환자에서 "뮤코미스트Mucomyst®" 객담제거 및 상기도 염증치료를 통한 증상개선효과 평가 다기관, 단일군, 전향적 관찰 연구

  • Park, Hannah (Department of Otolaryngology, Ajou University School of Medicine) ;
  • Park, Il-Seok (Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Dongtan Sacred Heart Hospital) ;
  • Lee, Sang Hyuk (Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Lee, Seung-Won (Department of Otorhinolaryngology-Head and Neck Surgery, Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • Lee, Sang Joon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Dankook University) ;
  • Lee, Byung-Joo (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Cheon, Yong-Il (Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Park, Jun-Ook (Department of Otorhinolaryngology-Head and Neck Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Oh, Kyoung Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Shin, Yoo Seob (Department of Otolaryngology, Ajou University School of Medicine)
  • 박한나 (아주대학교 의과대학 이비인후과학교실) ;
  • 박일석 (한림대학교 의과대학 동탄성심병원 이비인후-두경부외과학교실) ;
  • 이상혁 (성균관대학교 의과대학 강북삼성병원 이비인후과학교실) ;
  • 이승원 (순천향대학교 의과대학 부천병원 이비인후-두경부외과학교실) ;
  • 이상준 (단국대학교 의과대학 이비인후-두경부외과학교실) ;
  • 이병주 (부산대학교 의과대학 부산대학교병원 이비인후과학교실) ;
  • 천용일 (부산대학교 의과대학 부산대학교병원 이비인후과학교실) ;
  • 박준욱 (가톨릭대학교 의과대학 은평성모병원 이비인후과학교실) ;
  • 오경호 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 신유섭 (아주대학교 의과대학 이비인후과학교실)
  • Received : 2022.02.20
  • Accepted : 2022.03.23
  • Published : 2022.04.30

Abstract

Background and Objectives Globus pharyngeus is one of the most common symptoms of patients visiting otorhinolaryngology out-patient clinic, and usually long-lasting, difficult to treat, and frequently recurrent. Mucomyst®, N-acetyl cysteine is an inhalation agent mainly used for mucolysis and reducing inflammation in airway via antioxidative effect. The purpose of this study was to evaluate the efficacy of inhaled Mucomyst® treatment in patients with globus pharyngeus refractory to proton pump inhibitor (PPI). Materials and Method We prospectively evaluated the efficacy of Mucomyst® in relieving symptoms of globus pharyngeus refractory to PPI in nine medical centers. Three hundred and three patients enrolled and finally 229 patients finished the inhaled Mucomyst® therapy for 8 weeks. We analyzed the change of Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Visual Analogue Scale (VAS) for globus, and Globus Pharyngeus Symptom Scale (GPS) after use of Mucomyst® for 4 and 8 weeks. Results The GPS, RSI, RFS, and VAS score significantly decreased serially in patients who finished 8 week-inhalation treatment. The GPS improvement gap was significantly correlated with initial GPS (p<0.001) in multiple regression analysis. Conclusion Inhaled Mucomyst® therapy was effective for the reduction of both subjective and objective findings in refractory globus patients. This study might suggest new treatment option for patients with globus. However, further thorough studies would be needed to assess the real effect of inhaled Mucomyst® treatment as a standard treatment for globus.

Keywords

Acknowledgement

This study was financially supported by the Boryung Pharmaceutical Co., Ltd.

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