• Fire Science and Engineering
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• v.21 no.3
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• pp.84-90
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• 2007

The UN recommends to the member of OECD to implement the GHS (Globally Harmonized System of Classification and Labelling of Chemicals) that harmonized the flammable materials for classification, labelling, production, transport, storage, handling, usage and discard. There are no significant differences between UN and GHS because GHS is based on physico-chemical hazard and acute toxity of classification and labelling of UN regulation for the classification and transportation of flammable materials. In this paper it was analyzed that the classification, labelling and test method of flammable materials for GHS and the national law of safety management of flammable materials.

• The monthly packaging world
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• s.220
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• pp.42-44
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• 2011

• The Korean Journal of Pesticide Science
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• v.15 no.2
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• pp.201-207
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• 2011

The use of chemical products to enhance and improve life is a widespread worldwide practice. In spite of the benefits of these products, there is the potential of chemicals for adverse effects to people or the environment. The globally harmonized system (GHS) of classifying and labeling chemicals that was recommended by the United Nations in 2003, has been introduced globally since 2008. Compare to the classification criteria of agricultural formulations today, classification criteria of GHS is different partly. One pictogram is removed and 3 pictograms are introduced newly. The classification criteria of GHS will be changed preferentially and implemented gradationally to hazard products.

• Journal of Applied Biological Chemistry
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• v.56 no.4
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• pp.191-197
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• 2013

To classify the chemical hazard according to globally harmonized system of classification and labeling of chemicals (GHS), we investigated the genotoxicity of three chemicals, methyl myristate, 2-ethylhexanoic acid zinc salt, N,N,N',N'-tetrakis(2-hydroxyethyl) ethylenediamine, using male ICR mice bone marrow cells for the screening of micronucleus induction. Although these three chemicals have already been tested numerous times, a micronucleus test has not been conducted. The seven week-old male ICR mice were tested at three dosages for the three chemicals, respectively. After 24 h of oral administration with the three chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes, all treated groups expressed no statistically significant increase of MNPCE compared to the negative control group. There were no clinical signs related with the oral exposure of these three chemicals. It was concluded that these three chemicals did not induce micronucleus in the bone marrow cells of ICR mice, and there was no direct proportion with dosage. These results indicate that the three chemicals have no mutagenic potential under each test condition, and it is not classified these chemicals as mutagens by GHS.

• Journal of Life Science
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• v.24 no.7
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• pp.804-811
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• 2014

A micronucleus test of cyclohexanone has not yet been conducted. To classify the chemical hazard posed by cyclohexanone according to a globally harmonized system of classification and labeling of chemicals (GHS), we investigated its mutagenicity by micronucleus induction in ICR bone marrow cells of 7-weeek-old male mice. The mice were administered three dosages of the chemical for 24 hr via the oral route. After 24 hr, the mice were sacrificed, and their bone marrow cells were prepared for smearing slides. Based on counts of micronucleated polychromatic erythrocytes (MNPCEs) of 2,000 polychromatic erythrocytes, cyclohexanone did not inhibit bone marrow cell proliferation in any of the treated groups, but it resulted in micronucleus induction. According to the results of the mammalian bone marrow micronucleus test, this chemical is mutagenic and classified as category 2 in the GHS.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2006.05a
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• pp.53-77
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• 2006

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
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• 2005.11a
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• pp.21-34
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• 2005

• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.197-208
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• 2006

The hazards of chemicals can be classified using classification criteria that are based on physical, chemical and ecotoxicological endpoints. These criteria may be developed be iteratively, based on scientific or regulatory processes. A number of national and international schemes have been developed over the past 50 years, and some, such as the UN Dangerous Goods system or the EC system for hazardous substances, are in widespread use. However, the unnecessarily complicated multiplicity of existing hazard classifications created much unnecessary confusion at the user level, and a recommendation was made at the 1992 Rio Earth summit to develop a globally harmonized chemical hazard classification and compatible labelling system, including material safety data sheets and easily understandable symbols, that could be used for manufacture, transport, use and disposal of chemical substances. This became the globally harmonized system for the Classification and Labelling of Chemicals (GHS). The developmental phase of the GHS is largely complete. Consistent criteria for categorizing chemicals according to their toxic, physical, chemical and ecological hazards are now available. Consistent hazard communication tools such as labelling and material safety data sheets are also close to finalizations. The next phase is implementation of the GHS. The Intergovernmental Forum for Chemical Safety recommends that all countries implement the GHS as soon as possible with a view to have the system fully operational by 2008. When the GHS is in place, the world will finally have one system for classification of chemical hazards.

• The monthly packaging world
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• s.245
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• pp.113-121
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• 2013

GHS는 화학물질의 분류 표시에 대한 세계조화시스템(Globally Harmonized System of Classification and Labelling of Chemicals)으로 동일한 화학물질에 대해 국제적으로 동일한 유해 위험성 분류 표시를 하기 위한 새로운 규정이다. 화학물질의 분류 표시는 화학물질이 갖는 여러 가지 유해성, 위험성을 적절히 판별하고, 그 정도에 따라 분류한 다음, 가장 이해하기 쉬운 형태로 표시하는 것이 그 목적이며 올바른 정보제공을 통한 안전관리를 강화하고 국제적인 조화를 통하여 화학물질의 적정 평가 및 국제적 교역을 증대하고자 하는데 있다. 본 고에서는 유독물 등의 분류기준 및 표시방법에 관한 규정과 유독물의 표시규격에 대해 살펴보도록 한다.

• The Korean Journal of Pesticide Science
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• v.12 no.2
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• pp.141-147
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• 2008

Globally Harmonized System (GHS) for classification and labelling will provide an internationally agreed hazard classification system of chemical products and for communication of those hazards. This study aimed for establishment of the oral acute toxic class (ATC) method and application of GHS on pesticides. The ATC method was developed for determining $LD_{50}$ estimates of chemical substances with significantly fewer animals than needed when applying conventional $LD_{50}$ tests. We carried out $LD_{50}$ test and ATC test on 13 pesticides, Although methidathion EC and parathion-ethyl EC showed significantly different in $LD_{50}$ values between $LD_{50}$ test and ATC method, there are no difference in toxicity class by GHS. Both tests on the other pesticides showed almost equal results and toxicity class by GHS. Therefore, this study indicated high possibility of application of ATC method and GHS on pesticides.