• Journal of Microbiology and Biotechnology
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• 제28권11호
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• pp.1771-1781
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• 2018

The emergence of multidrug-resistant microorganisms, as well as fungal infectious diseases that further threaten health, especially in immunodeficient populations, is a major global problem. The development of new antifungal agents in clinical trials is inferior to the incidence of drug resistance, and the available antifungal agents are restricted. Their mechanisms aim at certain characteristics of the fungus in order to avoid biological similarities with the host. Synthesis of the cell wall and ergosterol are mainly targeted in clinical use. The need for new approaches to antifungal therapeutic agents or development alternatives has increased. This review explores new perspectives on mechanisms to effectively combat fungal infections and effective antifungal activity. The clinical drug have a common feature that ultimately causes caspase-dependent cell death. The drugs-induced cell death pathway is associated with mitochondrial dysfunction, including mitochondrial membrane depolarization and cytochrome c release. This mechanism of action also reveals antimicrobial peptides, the primary effector molecules of innate systems, to highlight new alternatives. Furthermore, drug combination therapy is suggested as another strategy to combat fungal infection. The proposal for a new approach to antifungal agents is not only important from a basic scientific point of view, but will also assist in the selection of molecules for combination therapy.

• 한국항행학회논문지
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• 제21권1호
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• pp.138-144
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• 2017

본 논문에서는 INS/GPS결합 시스템에서 GPS가 기만신호 또는 지형지물에 의한 가시선이 제한되어 위성의 기하학적 배치가 저하되는 조건을 고려하였고, 통합항법 성능을 향상시키기 위한 방법을 제안하였다. 먼저 GPS의 DOP에 측정 공분산 이 연동되는 가변 공분산 확장 칼만필터(VCEKF)를 제시하였다. 그리고 몬테칼로 시뮬레이션을 통하여 EKF와 VCEKF를 사용한 통합항법 시스템의 항법성능을 분석하였다. DOP 값이 낮은 경우보다 DOP값이 높을 경우에 VCEKF가 확정 공분산을 사용하는 EKF보다 우수한 추정 성능을 보임을 확인할 수 있었다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.610-614
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• 2006

In this paper the advanced method of geodesic active contours was developed for the task of building detection from aerial and satellite images. Automatic extraction of man-made structures including buildings, building blocks or roads from remote sensing data is useful for land use mapping, scene understanding, robotic navigation, image retrieval, surveillance, emergency management procedures, cadastral etc. A level set method based on a region-driven segmentation model was implemented with which building boundaries were detected, through this curve propagation technique. The essence of this approach is to optimize the position and the geometric form of the curve by measuring information along that curve, and within the regions that compose the image partition. To this end, one can consider uniform intensities inside objects and the background. Thus, given an initial position of the curve, one can determine global, region-driven functions and provide a statistical description of the inside and outside object area. The calculus of variations and a gradient descent method was used to optimize the variational functional by an iterative steady state process. Experimental results demonstrate the potential of the proposed processing scheme.

• 산업클러스터
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• 제4권1호
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• pp.51-61
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• 2010

디지털 사이니지(Digital Signage)란 길가나 점포, 공공시설 등에 표시되어 있는 포스터나 안내표시, 간판 등 기존의 하드웨어 매체가 아닌 디지털 디스플레이를 통해 각종 콘텐츠와 메시지를 제공하는 옥외 미디어를 말한다. 최근 LCD, LED 등을 기반으로 하는 지능형 디지털 영상장치의 급속한 발전으로 디지털 사이니지(Digital Signage)는 보편화되고 있으며, 기존의 단방향 광고 매체가 아닌 쌍방향 의사소통이 가능한 특징으로 인해 디지털 사이니지에 대한 수요 및 시장은 급속한 성장을 보이고 있다. 디지털 광고시장은 전반적인 글로벌 경기침체에도 불구하고 지속적인 성장세를 보일것으로 전망하고 있으며, 융합(Convergence)미디어 관점에서도 간판이 디지털화됨에 따라 정보와 예술, 콘텐츠, 기업 마케팅 니즈가 결합되면서 점차 TV 등 기존 매체광고를 대체하는 새로운 수단으로서의 역할을 수행할 것으로 예상하고 있다.

• 음성과학
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• 제12권2호
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• pp.101-108
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• 2005

Apraxia of phonation (AOP) has often been described as a feature of apraxia of speech or of severe non-fluent type of aphasia. Pure AOP is rare and, to our knowledge, only two cases have been reported. Brain lesion sites of the reported cases were not those sites known to be responsible for apraxia of speech. This study presents a case of AOP which resulted from the secondary stroke in the left corona radiata immediately following the first stroke in the left temporoparietal lobe. A 61-year old right-handed man shwoed a global type of aphasia after the first cerebral infarction, but was able to generate spontaneously some short fragments of speech. On the day after the first infarction, he suffered from the secondary infarction, leaving him a complete loss of voluntary phonation. He did not showed any significant change in language functions. Several occurrences of involuntary phonation were observed upon laughing or crying. He was also able to cough unintentionally. A vidoe-stroboscopic examination failed to reveal any evidence of structural and functional impairment in larynx. Although this case is not of pure form of AOP, AOP appeared after the secondary stroke without significant changes of language impairment since the first stroke. Therefore, AOP may be a consequence of the brain lesion from the secondary stroke even though we cannot rule out the possibility of an additive effect of the secondary to the first stroke.

• Genomics & Informatics
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• 제3권1호
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• pp.30-34
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• 2005

Microarray technology makes it possible to measure the expressions of tens of thousands of genes simultaneously under various experimental conditions. Identifying differentially expressed genes in each single experimental condition is one of the most common first steps in microarray gene expression data analysis. Reasonable choices of thresholds for determining differentially expressed genes are used for the next-stap-analysis with suitable statistical significances. We present a supervised model for identifying DEGs using pathway information based on the global connectivity structure. Pathway information can be regarded as a collection of biological knowledge, thus we are trying to determine the optimal threshold so that the consequential connectivity structure can be the most compatible with the existing pathway information. The significant feature of our model is that it uses established knowledge as a reference to determine the direction of analyzing microarray dataset. In the most of previous work, only intrinsic information in the miroarray is used for the identifying DEGs. We hope that our proposed method could contribute to construct biologically meaningful structure from microarray datasets.

• IEIE Transactions on Smart Processing and Computing
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• 제6권4호
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• pp.262-268
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• 2017

Intelligent video surveillance systems have been developed to monitor global areas and find specific target objects using a large-scale database. However, person re-identification presents some challenges, such as pose change and occlusions. To solve the problems, this paper presents an improved person re-identification method using sparse representation and saliency-based dictionary construction. The proposed method consists of three parts: i) feature description based on salient colors and textures for dictionary elements, ii) orthogonal atom selection using cosine similarity to deal with pose and viewpoint change, and iii) measurement of reconstruction error to rank the gallery corresponding a probe object. The proposed method provides good performance, since robust descriptors used as a dictionary atom are generated by weighting some salient features, and dictionary atoms are selected by reducing excessive redundancy causing low accuracy. Therefore, the proposed method can be applied in a large scale-database surveillance system to search for a specific object.

• 환경영향평가
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• 제11권3호
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• pp.157-172
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• 2002

This work aims to collect a biogeographic informations on the biota, alpine ecosystem, nature reserves, forest ecosystem of North Korea, and also to accumulate a basic data on the current situation and problem of the natural ecosystem of North Korea for the preparation of future cooperation and exchange between South and North Koreas. The obtained findings are as follow. First, North Korean biota contains 18,013 species, and consists of 6,710 plant species, including 3,860 species of vascular plants. Secondly, urgent investigation on the biogeographically important arctic-alpine and alpine plants and ecosystem, those are known to be endangered due to environmental change and global warming, is required. Thirdly, the conservations of diverse nature in North Korea are conducted by the introduction of various systems, such as nature preservation region, reserves for plant, animal and sea bird, and natural monuments. Fourthly, out of 9.5 million hectares of forest, one million hectares have already faced forest denudation, thus caused lots of damages for forest ecosystem. Sharp decline of North Korean forest land are due mainly to the expansion of terraced dry-field farming and deforestation. Recovery of denudated forest land should be approached by both South and North Korean sides to solve the problem of shortage of foods and restoration of natural ecosystem of North Korea.

• 한국전자거래학회:학술대회논문집
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• 한국전자거래학회 2001년도 International Conference CALS/EC KOREA
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• pp.615-624
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• 2001

Internet technology opens up another domain for building future CAD/CAM environment. The environment will be global, network-centric, and spatially distributed. In this paper, we present a new approach to network-centric virtual prototyping (NetVP) in a distributed design environment. The presented approach combines the current virtual assembly modeling and analysis technique with distributed computing and communication technology fur supporting virtual prototyping activities over the network. This paper focuses on interoperability, shape representation, and geometric processing for distributed virtual prototyping. STEP standard and CORBA-based interfaces allow the bi-directional communication between the CAD model and virtual prototyping model, which makes it possible to solve the problems of interoperability, heterogeneity of platforms, and data sharing. STEP AP203 and AP214 are utilized as a means of transferring and sharing product models. In addition, Attributed Abstracted B-rep (AAB) is introduced as 3D shape abstraction for transparent and efficient transmission of 3D models and for the maintenance of naming consistency between CAD models and virtual prototyping models over the network.

• 한국정보통신학회논문지
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• 제16권7호
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• pp.1437-1446
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• 2012

본 논문에서는 스테레오 카메라 환경에서 고속으로 깊이 정보를 얻기 위한 응용분야에 적합한 스테레오 정합 기법을 제안하고자 한다. 이러한 조건을 만족하기 위해서 DWT 영역에서의 주파수 정보와 가변 정합창을 이용하는 적응적인 스테레오 정합 기법을 제안한다. 공간 영역에서 영상의 국부적인 특성을 분석하여 정합창의 크기를 결정하고, 주파수 영역에서 영상의 주파수 특성을 분석하여 정합창의 형태 및 스케일링 요소를 결정한다. 주파수 영역에 대한 정보를 이용하기 위해서 로컬 DWT와 전역 DWT를 활용하는 기법을 모두 적용하였다. 본 논문은 스테레오 정합을 위한 제안한 기법은 유사한 수준의 복잡도에서 고정 정합창 기반의 기법과 비교할 때 PSNR이 향상되는 것을 확인하였다.