• Biomolecules & Therapeutics
• /
• 제26권2호
• /
• pp.201-209
• /
• 2018

G protein-coupled receptor 119 (GPR119) is expressed in the pancreas and gastrointestinal tract, and its activation promotes insulin secretion in the beta cells of the pancreatic islets as well as the secretion of glucagon-like peptide-1 (GLP-1) in intestinal L cells, consequently improving glucose-stimulated insulin secretion. Due to this dual mechanism of action, the development of small-molecule GPR119 agonists has received significant interest for the treatment of type 2 diabetes. We newly synthesized 1,2,4-triazolone derivatives of GPR119 agonists, which demonstrated excellent outcomes in a cyclic adenosine monophosphate (cAMP) assay. Among the synthesized derivatives, YH18968 showed cAMP=2.8 nM; in GLUTag cell, GLP-1secretion=2.3 fold; in the HIT-T15 cell, and insulin secretion=1.9 fold. Single oral administration of YH18968 improved glucose tolerance and combined treatment with a dipeptidyl peptidase 4 (DPP-4) inhibitor augmented the glucose lowering effect as well as the plasma level of active GLP-1 in normal mice. Single oral administration of YH18968 improved glucose tolerance in a diet induced obese mice model. This effect was maintained after repeated dosing for 4 weeks. The results indicate that YH18968 combined with a DPP-4 inhibitor may be an effective therapeutic candidate for the treatment of type 2 diabetes.

• 한국IT서비스학회지
• /
• 제4권2호
• /
• pp.135-144
• /
• 2005

The plenty of successful cases of Multi-national companies has been realized benefits of offshore outsourcing in particular "cost savings" from offshore IT outsourcing services, such as call center, software development, IT support and maintenance etc. A few Korean companies recently started to make the feasibility study of offshore IT outsourcing to catch up with the global trend. The objective of this study is to present the feasibility of offshore IT outsourcing of Korean companies through the analysis of pilot projects results between Indian and Chinese companies. The analysis include key elementsof cost, productivity, quality, practical issues as well as Gartner's framework, "AD Sourcing Cost Model", composed of 7 model factors. The findings of this study are not limited to understand offshore IT outsourcing but also provide useful guidelines covering wide range from the theoretical framework of selecting suitable offshore partner.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2008년도 추계학술대회 논문집 전기기기 및 에너지변환시스템부문
• /
• pp.226-228
• /
• 2008

In recent years, the companies of electric power equipment for MV and HV classes trend to develop the eco-friendly insulated(solid, eco-gas, air etc.) switchgear which replaces existent SF6 gas insulated switchgear due to environmental problems such as global warming and so on. This paper makes reference to the newly developed Solid Insulated Switchgear (SIS) which uses the eco-friendly material such as epoxy for insulation. The insulation of the solid insulated switchgear (SIS) is composed of an epoxy, vacuum and air. The solid insulated switchgear (SIS) is a slate of the art product. The advantages of SIS are advanced reliability, economical efficiency, safety, maintenance free, reduction of installation area and the protection of environment. The solid insulated switchgear (SIS) is FE Analyzed such as electromagnetic, mechanical, thermal and fluid in order to find the optimal design. Thens SIS has been verified by international standard test. (IEC 62271 - 100 and so on.) As a result of this, the solid insulated switchgear (SIS) has been estimated as an alternative for eco-friendly MV class switchgear.

• 방사선산업학회지
• /
• 제8권2호
• /
• pp.133-140
• /
• 2014

The sterilization of health care products is widely used to choose conventional Ethylene Oxide gas sterilization in South Korea. But the method has brought serious issues because of the toxic residual gas and global warming of $CO_2$ evacuation after the sterilization process. This study is carried out to confirm the application possibility of gamma sterilization instead of Ethylene Oxide in sanitary aid products. Four kinds of products (gauze, menstrual pad, bandage, menstrual tampon) were treated with gamma irradiation of 15 kGy, then analyzed the achievement of the sterility assurance level (SAL) $10^{-6}$ through BI test. The cytotoxicity of accelerated samples of 6 months elapse evaluated by means of colony forming rate at various concentration of the extracts. pH and UV measurements at extract concentrations were tested according to the MFDS (Ministry of food & drug safety) guideline to verify a stability & safety of product sterilized. The results revealed that the extracts did not show any significant changes in cytoxicity assay as well as pH and UV values by gamma sterilization. All extract concentration was observed high cell viability, pH and UV values were calculated within the acceptable range prescribed by the guideline. It indicates that gamma sterilization could effectively substitute for conventional sterilization such as Ethylene Oxide sterilization in the sanitary aid products.

• 간호행정학회지
• /
• 제22권1호
• /
• pp.67-79
• /
• 2016

Purpose: To develop strategies for research and development (R&D) in nursing service based on the policy direction of government supported R&D in Korea. Methods: This was a descriptive study to develop strategies for promoting R&D in nursing by analyzing investment trends and status quo, policy directions, and implementation of the details of government supported R&D through government reports, websites of relevant agencies and literature reviews. Results: Few nursing experts participated in clinical research on overcoming major diseases and in R&D for well-being and care. Development of nursing topics that meet the direction of government supported R&D were lacking. Insufficient implementation of nursing service R&D in a timely manner equipped with a performance-based system. Few research studies in R&D projects that included research using big data or contributing to developing medical instruments. Finally, an insufficient number of nursing specialists participated on government R&D advisory committees. Conclusion: For nursing service R&D development efforts should be toward quantitative expansion and qualitative improvements by sensitively recognizing policy direction of government supported R&D. The promotional capacity of nursing service R&D must be reinforced through a multidisciplinary approach and collaborative association with other professionals and the inclusion of nurse specialists on government R&D advisory committees.

• 국제지역연구
• /
• 제14권3호
• /
• pp.290-311
• /
• 2010

본 논문은 다국적기업 R&D랩들의 중국내 비즈니스활동이 활성화됨에 따라, 다국적기업이 중국에 어떤 진출동기로 어떤 유형의 R&D랩을 설립하는지에 대한 분석을 진행하고자하였다. 다국적기업 R&D랩의 중국진출동기를 중국의 시장이나 고객을 확보하기 위한 시장요인, 중국의 훌륭한 인적자원을 활용하기 위한 인적자원요인, 중국내 경쟁에서 경쟁우위를 차지하기 위한 경쟁우위요인과 정치적 환경요인 4가지로 분류하고, R&D랩 유형을 글로벌 기술센타, 현지 시장지원 랩, 현지 기술지원 랩 등 3가지 유형으로 분류하여 진출동기별 선택 가능한 R&D랩 유형을 규명하였다. 그 결과, 시장요인을 지향하거나 경쟁우위를 지향하는 다국적기업들은 현지 시장지원 랩을, 중국의 자원요인을 지향하는 다국적기업들은 글로벌 기술센터를 많이 설립하는 것으로 나타났다. 또한 중국의 감세, 면세 등 정책적 이점을 지향하여 R&D랩을 진출하는 다국적기업들은 현지 기술지원 랩을 선택하는 경우가 많았다.

• 대한수학회논문집
• /
• 제17권1호
• /
• pp.71-80
• /
• 2002

We give a formulation of the large deviation property for rescalings of random measures on the d-dimensional Euclidean space R$^{d}$ . The approach is global in the sense that the objects are Radon measures on R$^{d}$ and the dual objects are the continuous functions with compact support. This is applied to the cluster random measures with Poisson centers, a large class of random measures that includes the Poisson processes.

• 한국세라믹학회지
• /
• 제55권5호
• /
• pp.407-418
• /
• 2018

Increasing demand for portable and wireless electronic devices with high power and energy densities has inspired global research to investigate, in lieu of scarce rare-earth and expensive ruthenium oxide-like materials, abundant, cheap, easily producible, and chemically stable electrode materials. Several potential electrode materials, including carbon-based materials, metal oxides, metal chalcogenides, layered metal double hydroxides, metal nitrides, metal phosphides, and metal chlorides with above requirements, have been effectively and efficiently applied in electrochemical supercapacitor energy storage devices. The synthesis of self-grown, or in-situ, nanostructured electrode materials using chemical processes is well-known, wherein the base material itself produces the required phase of the product with a unique morphology, high surface area, and moderate electrical conductivity. This comprehensive review provides in-depth information on the use of self-grown electrode materials of different morphologies in electrochemical supercapacitor applications. The present limitations and future prospects, from an industrial application perspectives, of self-grown electrode materials in enhancing energy storage capacity are briefly elaborated.

• 공업화학전망
• /
• 제23권5호
• /
• pp.1-11
• /
• 2020

2019년 12월 중국에서 최초 보고된 이후 COVID-19 전염병은 전 세계에 대유행(팬데믹)을 확산하면서 역사적인 변화를 일으키고 있다. 경제, 사회 전반에 코로나 전과 코로나 후에 대한 새로운 규범과 질서를 강요하고 있다. 이에 본 고는 코로나19에 대한 이해와 그 영향 및 파급효과와 이를 대처하기 위한 세계 각국의 정책 현황을 살펴보았다. 특히, 치료제와 백신 등 과학적 해결을 위해 치열한 경쟁을 펼치고 있는 연구개발 현황을 고찰함으로써 한국의 관련 과학기술 정책과 연구개발의 방향을 모색하고자 하였다. 코로나19가 몰고 온 커다란 글로벌 위기를 통해 세계 질서가 재편될 가능성이 높아지고 있다. 현재까지 한국은 K-방역을 통해 모범적 방향을 제시하고 있다. 이는 과학기술과 연구개발 및 관련 정책들이 적절하게 역할을 한 결과로 평가된다. 본 고에서 고찰된 내용은 이러한 긍정적 효과를 지속적으로 유지하고 제고하는데 도움이 되고자 하는 것이다.

• 신재생에너지
• /
• 제10권4호
• /
• pp.29-35
• /
• 2014

Non-used waste heat has recently been paid special attention due to several global warming regulation and energy cost rising. In this study, therefore, thermal energy storage system which uses a solid type heat media has been investigated about the possibility of heat accumulation and heat release for thermal energy storage system. 35kWh of bench-scale thermal storage system was used to investigate the characteristics of the solid type heat media. From the result, it is shown that a solid type heat media should be divided to supply constant heat to the customers' side. It is also shown the flow direction should be considered to reduce temperature difference between top and bottom sides in the thermal storage system.