• 한국노년학
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• v.29 no.4
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• pp.1479-1500
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• 2009

This study examined BMI distributions among older adults in three different countries: the U.S., Japan, and Korea. The paper also explored differences in the factors predicting BMI in the three countries using three data sets: the U.S. Longitudinal Study of Aging (LSOA II, 8,589 persons), the Nihon University Japanese Longitudinal Study of Aging (NUJLSOA, 2,888 persons), and the Korean Longitudinal Study of Ageing (KLoSA, 2,397 persons). Descriptive analysis and multiple regression were performed. Japanese older adults were somewhat lighter than Koreans with fewer people at the upper end of the BMI distribution. Distributions of BMI among both Koreans and Japanese are shifted leftward relative to Americans. There is less dispersion in the distribution of BMI for Koreans and Japanese than among Americans. The association between socioeconomic variables and BMI is stronger in the U.S. and Japan than in Korea. Demographic variables are strong predictors of BMI in Korea. In Japan, all health behaviors have significant effects on BMI. It is concluded that the relationships between behavioral, demographical, and socioeconomic factors and BMI are not the same across countries. Results have policy implications for the involvement of health practitioners in helping older adults to control weight.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.2
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• pp.136-140
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• 2000

A sensitive and quantiative method for the structural analysis of oligosaccharide was established for the glycoform analysis of glconproproteins. Inthis study, n-linked oligosaccharides of human IgG and bovine transferin were analyzed for the evaluation of the methydrate moiety ofthe method. Chrbohydrate moiety of glycoprotein was relased by hydrazinolysis and purified by paper chromatography. The oligosaccharides were labeled with a fluorescent bye, 2-aminobenzamide, for the enhancement of detection sensitivity. sialylated (acidic) oligosaccharides were separated from neutral oligosaccharide by employing a strong anion-exchange column(MonoQ) followed by the treatment with sialidase. Enzymatically desiayated fractions and neutral fractions of oligosaccharides were applied to normal-phase HPLC to resolve the peaks according to glucose unit (GU). The structure of separated molecules was further determined by sequential digestion with exoglycosidases. As a result, disialylated biantennary complextype oligosaccharide was found to be a major sugar chain in bovine transferrin (63%). In human IgG, core fucosylated asialobiantennary complex oligosaccharides were dominant. These results coincided well with reported results.

• Journal of the Korean housing association
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• v.22 no.5
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• pp.21-28
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• 2011

This thesis aims to identify the design guidelines for environmental plans for the facilities for the aged people with a focus on the users' needs and the concept of aging in place. For this purpose major environmental design factors were researched by analyzing spaces and interviewing the managers and supervisor of W nursing home in Jeju Island that was opened in 1980s. Surveyed factors were divided into five categories, and by applying the design guideline theory of age friendly environment and nursing home facilities to them, five municipal composition factors of Kevin Lynch, universal design, environmental behavior model of John Zeisel principles were found. On the other hand, the environmental changes and development process of W nursing home is a showcase that reveals the importance of narrowing the gap in the opinions of the space users, the experts of architecture and administration which is emphasized in the principles of Inquiry by Design of John Zeisel. This research is expected to be used effectively for the researchers who study the space designs for the age-friendly environment.

• IMMUNE NETWORK
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• v.14 no.1
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• pp.30-37
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• 2014

Collaboration of TLR and non-TLR pathways in innate immune cells, which acts in concert for the induction of inflammatory cytokines, can mount a specific adaptive immune response tailored to a pathogen. Here, we show that murine DC produced increased IL-23 and IL-6 when they were treated with LPS together with curdlan that activates TLR4 and dectin-1, respectively. We also found that the induction of the inflammatory cytokine production by LPS and curdlan requires activation of IKK. However, the same treatment did not induce DC to produce a sufficient amount of TGF-${\beta}$. As a result, the conditioned media from DC treated with LPS and curdlan was not able to direct $CD4^+$ T cells to Th17 cells. Addition of TGF-${\beta}$ but not IL-6 or IL-$1{\beta}$ was able to promote IL-17 production from $CD4^+$ T cells. Our results showed that although signaling mediated by LPS together with curdlan is a potent stimulator of DC to secrete many pro-inflammatory cytokines, TGF-${\beta}$ production is a limiting factor for promoting Th17 immunity.

• Journal of The Korea Institute of Healthcare Architecture
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• v.20 no.4
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• pp.27-38
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• 2014

Purpose : The main objective of this paper is, to assess a body of research evidence that articulates the impact of environment-related factors on wayfinding for people with dementia who reside in Long-term care Facilities. The study also aims at identifying design implications that can be incorporated into design process and design decisions to improve wayfinding abilities for people with dementia. Methods : Comprehensive literature review has been conducted to identify empirical studies and carefully investigated peer-reviewed articles published in many different fields including architecture, psychology, nursing to gerontology. Results : The review found a growing body of studies that identified environment-related factors that improve wayfinding of people with Dementia living in long-term care facilities. Implications : The findings of the review can be considered as design guidelines to support the wayfinding abilities of people with dementia living in long-term care Facilities.

• Journal of The Korea Institute of Healthcare Architecture
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• v.21 no.3
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• pp.9-23
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• 2015

Purpose: This paper's main objective is to provide a systematic review of research evidence that articulates the impact of environment-related factors on wandering for people with dementia in the Long-term Care Facilities. Another objective of this study is to identify design implications that can be incorporated into design process and decisions to positively improve wandering abilities for people with dementia. Methods: Comprehensive literature review has been performed to investigate empirical studies and peer-reviewed articles published in many different fields including psychology, architecture, nursing to gerontology. Results: The review found studies that identified environment-related factors, affecting wandering for people with Dementia living in Long-term Care Facilities. Implications: The findings can help us understand wandering behavior and the recommendations in this research can serve as parts of considerations in practice that can help efficiently manage wandering abilities of people with dementia living in Long-term Care Facilities. Further studies with larger samples and various environmental conditions are required to confirm the findings in this study.

• Journal of Korean Home Economics Education Association
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• v.7 no.2
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• pp.67-77
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• 1995

This study aims at seeking the effective career guidance and operational plan. We collected data from questionaries to 305 students of vocational school, and 135 students on vocational course for the recognition of and request for vocational home economics curriculum. Collected data were analysed by frequency, percentage, and X(sup)2, and SPSS/PC(sup)+ program are used for the statistical analysis. 1. The main considerations of students in their decision of course were the accessibility of getting a job, or a higher education aptitude, interest, and so on. They made their own decision in choosing their course, relatively were satisfied with their choices. As for the course after graduation they hoped to come by a job related to their major in order to have3 an opportunity for further education, and teachers stood up for the large extent to which their students are satisfied with vocational training by answering that there would be higher possibility of using their major. 2 The results of the investigation into the desirable home economics vocational training in future showed that students of vocational schools desired for the scientific teaching and learning method. Students on vocational curse requested that the educational system should be supported. And new curricula were those for gerontology. interior design, and cookery and bakery.

• Korean Journal of Rural Living Science
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• v.5 no.2
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• pp.199-205
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• 1994

In the process of industralization, Korea rural aged have played great role. By investing, educating, and supporting their brothers and children, rural aged transferred their economic surplus to non agricultural fields and urban areas. But they did not prepare for their old age. So in every agricultural policy implementation, special concern should be taken to rural aged. The rural home extension should be the major institution for the rural aged. This paper was carried out to find the direction and the policy task of rural guidance project for rural aged. This paper suggested the needs of support for the aged in family, economic status and income, and leisure. To support the aged in family, the rural home extension should teach them how to make good relationship between Mother-in-law and daughter in law and special support to families which composed of only rural aged(no children). The rural home extension program should provide special policy for job opportunity creation for the rural aged. The rural home extension should also make educational programs for useful utilization of leisure time of rural aged. The rural home extension should make major roles in rural aged related policy. So rural home extension workers are well trained in gerontology and more related information should be provided.

• BMB Reports
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• v.51 no.2
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• pp.79-84
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• 2018

Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency of NPC1 gene function, which leads to severe neuroinflammation such as astrogliosis. While reports demonstrating neuroinflammation are prevalent in NP-C, information about the onset and progression of cerebellar astrogliosis in this disorder is lacking. Using gene targeting, we generated vascular endothelial growth factor (VEGF) conditional null mutant mice. Deletion of VEGF in cerebellar Purkinje neurons (PNs) led to a significant increase of astrogliosis in the brain of NP-C mice in addition to the loss of PNs, suggesting PN-derived VEGF as an important factor in NP-C pathology. Moreover, replenishment of VEGF in neurons improved brain pathology in NP-C mice. Overall, our data provide a new pathological perspective on cerebellar astrogliosis in NP-C and suggest the importance of VEGF as a therapeutic target for this disease.

• Journal of the Korean housing association
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• v.8 no.3
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• pp.153-162
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• 1997

Personalities. human relations. living patterns. and so on of the aged have been moulded respectively for a long period of time and their present situation of health. family make-up. economic condition etc. are different individually. Various characteristics - physiological. psychological and social peculiarities - of the aged are analyzed and studied in preceding paper to grope planning factors of architectural spaces by referring to sundry records from many branch gerontology, medical science. psycology. sociology. etc. - of knowledge in a position of architectural planning. So. in this paper. the directions of planning residential environment for the aged are studied on the base of those planning factors of architectural spaces. there are room(X$_1$). unit home(X$_2$), public housing(X$_3$), residential district(X$_4$) as dwelling spaces for the aged in X axis and safety(Y$_1$). hygiene(Y$_2$). convenience (Y$_3$), comfortableness (Y$_4$). psychology ($Y^5$), aesthetics ($Y^6$). society ($Y^7$). economy ($Y^8$) as the terms desired to spaces in Y axis. And the directions of planning residential environment for the elderly are studied by discussing mutual matters relevant to the subject on the cells of matrix formed by X. Y axis. In planning residential environment for the elderly. their physiological. psychological. social characteristics should be considered thoroughly and many types of dwelling spaces should be built. Then they can take up their abode to suit their conditions easily.