• 한국노년학
• /
• 제29권4호
• /
• pp.1479-1500
• /
• 2009

노인들의 체질량지수는 노후 삶의 질을 결정할 수 있는 중요한 변수임에도 불구하고 어떤 요인 들이 이와 관련되어 있는가에 대한 연구는 상대적으로 부족하다. 따라서 본 연구는 미국, 일본, 한국 노인들의 체질량 지수의 분포가 어떻게 다른지 고찰하는데 일차적인 목적을 두었다. 더 나아가, 세 국가 노인들의 체질량지수에 영향을 미치는 요인들이 무엇인지 살펴보고 그 관계가 세 국가에서 어떻게 다르게 나타나는지 살펴보고자 한다. 자료는 미국 (LSOA II, N=8,589), 일본 (NUJLSOA, N=2,888), 그리고 한국의 고령화연구패널 (KLoSA, N=2,397)을 사용하였으며, 기술적인 분석과 체질량지수를 종속변수로 하는 다중회귀분석을 사용하였다. 일본과 한국 노인들의 체질량지수 분포는 매우 유사했지만, 일본 노인들의 체질량지수가 한국 노인들의 그것에 비교하여 좀 더 가벼웠으며 분포의 오른쪽 상단인 비만에 해당하는 부분에서 더 낮은 비율을 보였다. 한국과 일본의 체질량 지수 분포는 미국에 비해서 상대적으로 좌측에 위치하고 있으며, 최빈값에서 덜 퍼져있음이 밝혀졌다. 체질량지수와 사회경제적인 변인의 관계는 한국 노인들에 비해서 미국과 일본 노인들에게서 더 강하게 나타났으며, 한국의 경우 기존연구와 달리 교육 수준이 높을수록 체질량지수가 높은 것으로 나타났다. 한국은 사회경제적 변인이나 건강행태보다 인구학적 변수들이 체질량지수에 좀 더 유의미한 영향을 미쳤으며 일본의 경우 세 가지 건강행태가 모두 체질량지수를 예측할 수 있는 중요한 요인인 것으로 밝혀졌다. 따라서 미국, 일본, 한국에서 노인의 체질량지수에 영향을 미치는 요인들과 그 관계의 방향성은 다르다고 결론지을 수 있다. 본 연구 결과는 상이한 국가에서 노인들과 현장에서 마주하게 되는 노인병 의사, 간호사, 양로원의 책임자, 사회복지사 등이 노인들로 하여금 적절하게 몸무게를 조절하게 하기 위해서는 어떤 요인이 중요한지 파악할 수 있게 해주고 구체적으로 도움을 줄 수 있다는데 그 정책적인 함의가 있다.

• Biotechnology and Bioprocess Engineering:BBE
• /
• 제5권2호
• /
• pp.136-140
• /
• 2000

A sensitive and quantiative method for the structural analysis of oligosaccharide was established for the glycoform analysis of glconproproteins. Inthis study, n-linked oligosaccharides of human IgG and bovine transferin were analyzed for the evaluation of the methydrate moiety ofthe method. Chrbohydrate moiety of glycoprotein was relased by hydrazinolysis and purified by paper chromatography. The oligosaccharides were labeled with a fluorescent bye, 2-aminobenzamide, for the enhancement of detection sensitivity. sialylated (acidic) oligosaccharides were separated from neutral oligosaccharide by employing a strong anion-exchange column(MonoQ) followed by the treatment with sialidase. Enzymatically desiayated fractions and neutral fractions of oligosaccharides were applied to normal-phase HPLC to resolve the peaks according to glucose unit (GU). The structure of separated molecules was further determined by sequential digestion with exoglycosidases. As a result, disialylated biantennary complextype oligosaccharide was found to be a major sugar chain in bovine transferrin (63%). In human IgG, core fucosylated asialobiantennary complex oligosaccharides were dominant. These results coincided well with reported results.

• 한국주거학회논문집
• /
• 제22권5호
• /
• pp.21-28
• /
• 2011

This thesis aims to identify the design guidelines for environmental plans for the facilities for the aged people with a focus on the users' needs and the concept of aging in place. For this purpose major environmental design factors were researched by analyzing spaces and interviewing the managers and supervisor of W nursing home in Jeju Island that was opened in 1980s. Surveyed factors were divided into five categories, and by applying the design guideline theory of age friendly environment and nursing home facilities to them, five municipal composition factors of Kevin Lynch, universal design, environmental behavior model of John Zeisel principles were found. On the other hand, the environmental changes and development process of W nursing home is a showcase that reveals the importance of narrowing the gap in the opinions of the space users, the experts of architecture and administration which is emphasized in the principles of Inquiry by Design of John Zeisel. This research is expected to be used effectively for the researchers who study the space designs for the age-friendly environment.

• IMMUNE NETWORK
• /
• 제14권1호
• /
• pp.30-37
• /
• 2014

Collaboration of TLR and non-TLR pathways in innate immune cells, which acts in concert for the induction of inflammatory cytokines, can mount a specific adaptive immune response tailored to a pathogen. Here, we show that murine DC produced increased IL-23 and IL-6 when they were treated with LPS together with curdlan that activates TLR4 and dectin-1, respectively. We also found that the induction of the inflammatory cytokine production by LPS and curdlan requires activation of IKK. However, the same treatment did not induce DC to produce a sufficient amount of TGF-${\beta}$. As a result, the conditioned media from DC treated with LPS and curdlan was not able to direct $CD4^+$ T cells to Th17 cells. Addition of TGF-${\beta}$ but not IL-6 or IL-$1{\beta}$ was able to promote IL-17 production from $CD4^+$ T cells. Our results showed that although signaling mediated by LPS together with curdlan is a potent stimulator of DC to secrete many pro-inflammatory cytokines, TGF-${\beta}$ production is a limiting factor for promoting Th17 immunity.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제20권4호
• /
• pp.27-38
• /
• 2014

Purpose : The main objective of this paper is, to assess a body of research evidence that articulates the impact of environment-related factors on wayfinding for people with dementia who reside in Long-term care Facilities. The study also aims at identifying design implications that can be incorporated into design process and design decisions to improve wayfinding abilities for people with dementia. Methods : Comprehensive literature review has been conducted to identify empirical studies and carefully investigated peer-reviewed articles published in many different fields including architecture, psychology, nursing to gerontology. Results : The review found a growing body of studies that identified environment-related factors that improve wayfinding of people with Dementia living in long-term care facilities. Implications : The findings of the review can be considered as design guidelines to support the wayfinding abilities of people with dementia living in long-term care Facilities.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
• /
• 제21권3호
• /
• pp.9-23
• /
• 2015

Purpose: This paper's main objective is to provide a systematic review of research evidence that articulates the impact of environment-related factors on wandering for people with dementia in the Long-term Care Facilities. Another objective of this study is to identify design implications that can be incorporated into design process and decisions to positively improve wandering abilities for people with dementia. Methods: Comprehensive literature review has been performed to investigate empirical studies and peer-reviewed articles published in many different fields including psychology, architecture, nursing to gerontology. Results: The review found studies that identified environment-related factors, affecting wandering for people with Dementia living in Long-term Care Facilities. Implications: The findings can help us understand wandering behavior and the recommendations in this research can serve as parts of considerations in practice that can help efficiently manage wandering abilities of people with dementia living in Long-term Care Facilities. Further studies with larger samples and various environmental conditions are required to confirm the findings in this study.

• 한국가정과교육학회지
• /
• 제7권2호
• /
• pp.67-77
• /
• 1995

This study aims at seeking the effective career guidance and operational plan. We collected data from questionaries to 305 students of vocational school, and 135 students on vocational course for the recognition of and request for vocational home economics curriculum. Collected data were analysed by frequency, percentage, and X(sup)2, and SPSS/PC(sup)+ program are used for the statistical analysis. 1. The main considerations of students in their decision of course were the accessibility of getting a job, or a higher education aptitude, interest, and so on. They made their own decision in choosing their course, relatively were satisfied with their choices. As for the course after graduation they hoped to come by a job related to their major in order to have3 an opportunity for further education, and teachers stood up for the large extent to which their students are satisfied with vocational training by answering that there would be higher possibility of using their major. 2 The results of the investigation into the desirable home economics vocational training in future showed that students of vocational schools desired for the scientific teaching and learning method. Students on vocational curse requested that the educational system should be supported. And new curricula were those for gerontology. interior design, and cookery and bakery.

• 한국농촌생활과학회지
• /
• 제5권2호
• /
• pp.199-205
• /
• 1994

In the process of industralization, Korea rural aged have played great role. By investing, educating, and supporting their brothers and children, rural aged transferred their economic surplus to non agricultural fields and urban areas. But they did not prepare for their old age. So in every agricultural policy implementation, special concern should be taken to rural aged. The rural home extension should be the major institution for the rural aged. This paper was carried out to find the direction and the policy task of rural guidance project for rural aged. This paper suggested the needs of support for the aged in family, economic status and income, and leisure. To support the aged in family, the rural home extension should teach them how to make good relationship between Mother-in-law and daughter in law and special support to families which composed of only rural aged(no children). The rural home extension program should provide special policy for job opportunity creation for the rural aged. The rural home extension should also make educational programs for useful utilization of leisure time of rural aged. The rural home extension should make major roles in rural aged related policy. So rural home extension workers are well trained in gerontology and more related information should be provided.

• BMB Reports
• /
• 제51권2호
• /
• pp.79-84
• /
• 2018

Niemann-Pick type C disease (NP-C) is a fatal neurodegenerative disorder caused by a deficiency of NPC1 gene function, which leads to severe neuroinflammation such as astrogliosis. While reports demonstrating neuroinflammation are prevalent in NP-C, information about the onset and progression of cerebellar astrogliosis in this disorder is lacking. Using gene targeting, we generated vascular endothelial growth factor (VEGF) conditional null mutant mice. Deletion of VEGF in cerebellar Purkinje neurons (PNs) led to a significant increase of astrogliosis in the brain of NP-C mice in addition to the loss of PNs, suggesting PN-derived VEGF as an important factor in NP-C pathology. Moreover, replenishment of VEGF in neurons improved brain pathology in NP-C mice. Overall, our data provide a new pathological perspective on cerebellar astrogliosis in NP-C and suggest the importance of VEGF as a therapeutic target for this disease.

• 한국주거학회논문집
• /
• 제8권3호
• /
• pp.153-162
• /
• 1997

Personalities. human relations. living patterns. and so on of the aged have been moulded respectively for a long period of time and their present situation of health. family make-up. economic condition etc. are different individually. Various characteristics - physiological. psychological and social peculiarities - of the aged are analyzed and studied in preceding paper to grope planning factors of architectural spaces by referring to sundry records from many branch gerontology, medical science. psycology. sociology. etc. - of knowledge in a position of architectural planning. So. in this paper. the directions of planning residential environment for the aged are studied on the base of those planning factors of architectural spaces. there are room(X$_1$). unit home(X$_2$), public housing(X$_3$), residential district(X$_4$) as dwelling spaces for the aged in X axis and safety(Y$_1$). hygiene(Y$_2$). convenience (Y$_3$), comfortableness (Y$_4$). psychology ($Y^5$), aesthetics ($Y^6$). society ($Y^7$). economy ($Y^8$) as the terms desired to spaces in Y axis. And the directions of planning residential environment for the elderly are studied by discussing mutual matters relevant to the subject on the cells of matrix formed by X. Y axis. In planning residential environment for the elderly. their physiological. psychological. social characteristics should be considered thoroughly and many types of dwelling spaces should be built. Then they can take up their abode to suit their conditions easily.