• Animal Bioscience
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• v.37 no.1
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• pp.16-27
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• 2024

Objective: The objective of this study was to investigate the effect of heat stress on the growth traits and genetic parameters of Thai native chickens. Methods: A total of 16,487 records for growth traits of Thai native chickens between 2017 and 2022 were used in this study. Data included the body weight at birth, body weight at 4, 8, and 12 weeks of age (BW0, BW4, BW8, BW12), average daily gain during 0 to 4, 4 to 8, and 8 to 12 weeks of age (ADG0-4, ADG4-8, ADG8-12), absolute growth rate at birth, at 4, 8, and 12 weeks of age (AGR0, AGR4, AGR8, AGR12). The repeatability test day model used the reaction-norm procedure to analyze the threshold point of heat stress, rate of decline of growth traits, and genetic parameters. Results: At temperature and humidity index (THI) of 76, Thai native chickens began to lose their growth traits, which was the onset of heat stress in this study. The estimated heritability, genetic correlation between animal and heat stress effect, and correlations between the intercept and slope of the permanent environmental effects were 0.27, -0.85, and -0.83 for BW, 0.17, -0.81, and -0.95 for ADG, 0.25, -0.61, and -0.83 for AGR, respectively. Male chickens are more affected by heat stress than female chickens with a greater reduction of BW, ADG, and AGR, values equal to -9.30, -0.23, -15.21 (in males) and -6.04, -0.21, -10.10 (in females) gram per 1 level increase of THI from the THI of 76. Conclusion: The influence of thermal stress had a strong effect on the decline in growth traits and genetic parameters in Thai native chickens. This study indicated that genetic models used in conjunction with THI data are an effective method for the analysis and assessment of the effects of heat stress on the growth traits and genetics of native chickens.

• Asian-Australasian Journal of Animal Sciences
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• v.27 no.4
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• pp.457-463
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• 2014

Ultrasound measurements of backfat thickness (UBF), longissimus muscle area (ULMA) and marbling score (UMS) and carcass measurements of carcass weight (CW), backfat thickness (BF), longissimus muscle area (LMA), and marbling score (MS) on 7,044 Hanwoo steers were analyzed to estimate genetic parameters. Data from Hanwoo steers that were raised, finished in Hoengseong-gun, Gangwon-do (province) and shipped to slaughter houses during the period from October 2010 to April 2013 were evaluated. Ultrasound measurements were taken at approximately three months before slaughter by an experienced operator using a B-mode real-time ultrasound device (HS-2000, FHK Co. Ltd., Tokyo, Japan) with a 3.5 MHz linear probe. Ultrasound scanning was on the left side between 13th rib and the first lumbar vertebrae. All slaughtering processes and carcass evaluations were performed in accordance with the guidelines of beef grading system of Korea. To estimate genetic parameters, multiple trait animal models were applied. Fixed effects included in the models were: the effects of farm, contemporary group effects (year-season at the time of ultrasound scanning in the models for UBF, ULMA, and UMS, and year-season at slaughter in the models for CW, BF, LMA, and MS), the effects of ultrasound technicians as class variables and the effects of the age in days at ultrasound scanning or at slaughtering as linear covariates, respectively for ultrasound and carcass measures. Heritability estimates obtained from our analyses were 0.37 for UBF, 0.13 for ULMA, 0.27 for UMS, 0.44 for CW, 0.33 for BF, 0.36 for LMA and 0.54 MS, respectively. Genetic correlations were strongly positive between corresponding traits of ultrasound and carcass measures. Genetic correlation coefficient between UBF and BF estimate was 0.938, between ULMA and LMA was 0.767 and between UMS and MS was 0.925. These results suggest that ultrasound measurement traits are genetically similar to carcass measurement traits.

• Journal of Ginseng Research
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• v.37 no.3
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• pp.261-268
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• 2013

The ginseng plant (Panax ginseng Meyer) has a large number of active ingredients including steroidal saponins with a dammarane skeleton as well as protopanaxadiol and protopanaxatriol, commonly known as ginsenosides, which have antioxidant, anticancer, antidiabetic, anti-adipocyte, and sexual enhancing effects. Though several discoveries have demonstrated that ginseng saponins (ginsenosides) as the most important therapeutic agent for the treatment of osteoporosis, yet the molecular mechanism of its active metabolites is unknown. In this review, we summarize the evidence supporting the therapeutic properties of ginsenosides both in vivo and in vitro, with an emphasis on the different molecular agents comprising receptor activator of nuclear factor kappa-B ligand, receptor activator of nuclear factor kappa-B, and matrix metallopeptidase-9, as well as the bone morphogenetic protein-2 and Smad signaling pathways.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.2
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• pp.197-202
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• 2020

Objective: The objective of this study was to identify environmental factors strongly associated with and to estimate genetic parameters of reproductive traits in Japanese Black heifers. Methods: Data included reproduction records of Japanese Black heifers born between 2004 and 2014. First service non-return rate (NRR) to 56 days from first to successful insemination (FS), number of services per conception (IN), age at first calving (AFC) and gestation length were analyzed with the use of the general linear model. Genetic parameters were estimated with the use of the univariate animal model of the residual maximum likelihood. Results: Averages of reproductive traits over eleven years were assessed, and the effects of farm, year, month, artificial insemination technician and interaction of farm×year on the traits were determined. Estimated heritability of FS was very low and that of AFC was higher than that of the other traits. A close genetic relation was observed among NRR, IN, and FS; however, their heritabilities were very low. AFC shows favorable genetic correlation with IN and FS. Conclusion: Low heritabilities of most reproductive traits in Japanese Black heifers are strongly influenced by farm management practices, and that large residual variances make genetic evaluation difficult. Among the reproductive traits, AFC is potentially more useful for genetic improvement of heifer reproductive traits because it has high heritability and favorable genetic correlations with IN and FS.

• Genomics & Informatics
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• v.8 no.3
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• pp.142-149
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• 2010

In recent years, genome-wide association (GWA) studies have successfully led to many discoveries of genetic variants affecting common complex traits, including height, blood pressure, and diabetes. Although GWA studies have made much progress in finding single nucleotide polymorphisms (SNPs) associated with many complex traits, such SNPs have been shown to explain only a very small proportion of the underlying genetic variance of complex traits. This is partly due to that fact that most current GWA studies have relied on single-marker approaches that identify single genetic factors individually and have limitations in considering the joint effects of multiple genetic factors on complex traits. Joint identification of multiple genetic factors would be more powerful and provide a better prediction of complex traits, since it utilizes combined information across variants. Recently, a new statistical method for joint identification of genetic variants for common complex traits via the elastic-net regularization method was proposed. In this study, we applied this joint identification approach to a large-scale GWA dataset (i.e., 8842 samples and 327,872 SNPs) in order to identify genetic variants of obesity for the Korean population. In addition, in order to test for the biological significance of the jointly identified SNPs, gene ontology and pathway enrichment analyses were further conducted.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.569-572
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• 2000

DEA has been effectively applied to various areas which need the evaluation of relative efficiency. We propose a DEA model based on fuzzy LP combined with Genetic Algorithm in order to consider uncertain synergy effects due to M&A of existing organization. We apply the suggested approach to forecasting the efficiency of merged academic departments in a university in Korea. We expect that our approach can be utilized to effectively realign existing departments.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.350-356
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• 2017

This study was conducted to examine the influence of the maternal genetic effect of swine on their economic traits through the estimation of their genetic parameters, breeding value and genetic trends using an animal model. The data on Duroc pigs, Korean Native Pigs and Synthetic pigs (Duroc ${\times}$ Korean Native Pig) from 2000 to 2015 were obtained from the National Institute of Animal Science in Korea and used to estimate the genetic parameters for the average daily gain (ADG) and backfat thickness (BFT). Model 1 included the additive genetic effect of the animals, Model 2 consisted of Model 1 + the maternal genetic effect and Model 3 consisted of Model 2 + the maternal permanent environment effect. The heritability calculated by estimating the additive genetic effect was higher than that calculated by estimating the maternal genetic effect using the maternal animal model. The estimated genetic correlations between the additive and maternal genetic effects for the ADG and BF were strongly negative. Thus, the estimation of the breeding value can be used to select the most appropriate individuals and make an optimal breeding scheme.

• Toxicological Research
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• v.3 no.1
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• pp.55-63
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• 1987

A Peri-and Postnatal Study was Carried out to examine the effects of rHuIFN-${\alpha}A$, produced by gene-manipulated E. coli, on offsprings of Wistar rats. The substance was administered intraperitoneally to dams at dose levels of $1{\times}10^5$, $4{\times}10^5$ and $1.2{\times}10^6$ I.U/kg/day during the period from day 17 of gestation to day 21 after delivery. All the pregnant dams were allowed to deliver naturally, and the postnatal development of the offsprings was observed. No noticeable toxic effects and pathological changes on dams were observed, and no detectable variations in postnatal development of offsprings occured.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.59 no.8
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• pp.1482-1488
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• 2010

Recently to increase the productivity and improve the quality in the industrial process, suppressing the residual vibration in motion control systems becomes the essential problem to solve. One of the methods to suppress the residual vibration is the input shaping technique. It is based on parameters of the system model; however, the parameters are usually difficult to obtain. This paper shows the effects of the residual vibration caused by the variation of the general velocity profile for the system with two vibration modes, and also shows the effects of the input shaping filter based on the parameters of system model. Finally, the simulation results show that the proposed input shaping filter using an artificial immune algorithm is more effective for suppressing residual vibrations than genetic algorithm.

• Journal of Forest and Environmental Science
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• v.25 no.3
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• pp.147-155
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• 2009

Higher plants provide valuable genetic assay systems for screening and monitoring environmental pollutants. They are now recognized as excellent indicators of mutagenic effects of environmental chemicals and are applicable for the detection of environmental mutagens both indoor and outdoor. 2,4-dichlorophenoxyacetic acid (2,4-D) is a herbicide commonly used in agriculture. The residues of 2,4-D are present in air, water, soil and edible plants. It constitutes a real hazard to the public health because it's wide spread use in agriculture. Genotoxic effects of 2,4-D on plant cells and potential of higher plants as a biomonitoring system for detecting chemical mutagens are evaluated. It is recommended that higher plant systems have been accepted by regulatory authorities as an alternative biomonitoring system for the detection of possible genetic damage resulting from pollution and the use of environmental chemicals.