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http://dx.doi.org/10.5808/GI.2010.8.3.142

Joint Identification of Multiple Genetic Variants of Obesity in a Korean Genome-wide Association Study  

Oh, So-Hee (Department of Statistics, Seoul National University)
Cho, Seo-Ae (Department of Statistics, University of California)
Park, Tae-Sung (Department of Statistics, Seoul National University)
Publication Information
Genomics & Informatics / v.8, no.3, 2010 , pp. 142-149 More about this Journal
Abstract
In recent years, genome-wide association (GWA) studies have successfully led to many discoveries of genetic variants affecting common complex traits, including height, blood pressure, and diabetes. Although GWA studies have made much progress in finding single nucleotide polymorphisms (SNPs) associated with many complex traits, such SNPs have been shown to explain only a very small proportion of the underlying genetic variance of complex traits. This is partly due to that fact that most current GWA studies have relied on single-marker approaches that identify single genetic factors individually and have limitations in considering the joint effects of multiple genetic factors on complex traits. Joint identification of multiple genetic factors would be more powerful and provide a better prediction of complex traits, since it utilizes combined information across variants. Recently, a new statistical method for joint identification of genetic variants for common complex traits via the elastic-net regularization method was proposed. In this study, we applied this joint identification approach to a large-scale GWA dataset (i.e., 8842 samples and 327,872 SNPs) in order to identify genetic variants of obesity for the Korean population. In addition, in order to test for the biological significance of the jointly identified SNPs, gene ontology and pathway enrichment analyses were further conducted.
Keywords
genome-wide association study; elastic-net regularization method; obesity;
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1 Tibshirani, R. (1996). Regression shrinkage and selection via the lasso. J. R. Statist. Soc. B. 58, 267-288.
2 Wallace, C., Newhouse, S.J., Braund, P., Zhang, F., Tobin, M., Falchi, M., Ahmadi, K., Dobson, R.J., Marçano, A.C., Hajat, C., Burton, P., Deloukas, P., Brown, M., Connell, J.M., Dominiczak, A., Lathrop, G.M., Webster, J., Farrall, M., Spector, T., Samani, N.J., Caulfield, M.J., and Munroe, P.B. (2008). Genome-wide association analysis study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am. J. Hum. Genet. 82,139-149.   DOI
3 Wang, W.Y., Barratt, B.J., Clayton, D.G., and Todd, J.A. (2005). Genome-wide association studies: Theoretical and practical concerns. Nat. Rev. Genet. 6, 109-118.   DOI
4 Weedon, M. N., Lango, H., Lindgren, C.M., Wallace, C., Evans, D.M., Mangino, M., Freathy, R.M., Perry, J.R., Stevens, S., Hall, A.S., Samani, N.J., Shields, B., Prokopenko, I., Farrall, M., Dominiczak, A., Diabetes Genetics Initiative, Wellcome Trust Case Control Consortium, Johnson, T., Bergmann, S., Beckmann, J.S., Vollenweider, P., Waterworth, D.M., Mooser, V., Palmer, C.N., Morris, A.D., Ouwehand, W.H., Cambridge GEM Consortium, Zhao, J.H., Li, S., Loos, R.J., Barroso, I., Deloukas, P., Sandhu, M.S., Wheeler, E., Soranzo, N., Inouye, M., Wareham, N.J., Caulfield, M., Munroe, P.B., Hattersley, A.T., McCarthy, M.I., and Frayling, T.M. (2008). Genome-wide association analysis identifies 20 loci that influence adult height. Nat. Genet. 40, 575-583.   DOI
5 Wellcome Trust Case Control Consortium (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661-678.   DOI
6 Willer, C.J., Speliotes, E.K., Loos, R.J., Li, S., Lindgren, C.M., Heid, I.M., Berndt, S.I., Elliott, A.L., Jackson, A.U., Lamina, C., Lettre, G., Lim, N., Lyon, H.N., McCarroll, S.A., Papadakis, K., Qi, L., Randall, J.C., Roccasecca, R.M., Sanna, S., Scheet, P., Weedon, M.N., Wheeler, E., Zhao, J.H., Jacobs, L.C., Prokopenko, I., Soranzo, N., Tanaka, T., Timpson, N.J., Almgren, P., Bennett, A., Bergman, R.N., Bingham, S.A., Bonnycastle, L.L., Brown, M., Burtt, N.P., Chines, P., Coin, L., Collins, F.S., Connell, J.M., Cooper, C., Smith, G.D., Dennison, E.M., Deodhar, P., Elliott, P., Erdos, M.R., Estrada, K., Evans, D.M., Gianniny, L., Gieger, C., Gillson, C.J., Guiducci, C., Hackett, R., Hadley, D., Hall, A.S., Havulinna, A.S., Hebebrand, J., Hofman, A., Isomaa, B., Jacobs, K.B., Johnson, T., Jousilahti, P., Jovanovic, Z., Khaw, K.T., Kraft, P., Kuokkanen, M., Kuusisto, J., Laitinen, J., Lakatta, E.G., Luan, J., Luben, R.N., Mangino, M., McArdle, W.L., Meitinger, T., Mulas, A., Munroe, P.B., Narisu, N., Ness, A.R., Northstone, K., O'Rahilly, S., Purmann, C., Rees, M.G., Ridderstrale, M., Ring, S.M., Rivadeneira, F., Ruokonen, A., Sandhu, M.S., Saramies, J., Scott, L.J., Scuteri, A., Silander, K., Sims, M.A., Song, K., Stephens, J., Stevens, S., Stringham, H.M., Tung, Y.C., Valle, T.T., van Duijn, C.M., Vimaleswaran, K.S., Vollenweider, P., Waeber, G., Wallace, C., Watanabe, R.M., Waterworth, D.M., Watkins, N., Wellcome Trust Case Control Consortium, Witteman, J.C., Zeggini, E., Zhai, G., Zillikens, M.C., Altshuler, D., Caulfield, M.J., Chanock, S.J., Farooqi, I.S., Ferrucci, L., Guralnik, J.M., Hattersley, A.T., Hu, F.B., Jarvelin, M.R., Laakso, M., Mooser, V., Ong, K.K., Ouwehand, W.H., Salomaa, V., Samani, N.J., Spector, T.D., Tuomi, T., Tuomilehto, J., Uda, M., Uitterlinden, A.G., Wareham, N.J., Deloukas, P., Frayling, T.M., Groop, L.C., Hayes, R.B., Hunter, D.J., Mohlke, K.L., Peltonen, L., Schlessinger, D., Strachan, D.P., Wichmann, H.E., McCarthy, M.I., Boehnke, M., Barroso, I., Abecasis, G.R., Hirschhorn, J.N., and Genetic Investigation of ANthropometric Traits Consortium. (2008). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25-34.
7 Wu, T., Chen, Y., Hastie, T., Sobel, E., and Lange, K. (2009). Genome-wide association analysis by lasso penalized logistic regression. Bioinformatics 25, 714.   DOI
8 Zou, H. and Hastie, T. (2005). Regularization and variable selection via the elastic net. J.R. Statist. Soc. B. 67, 301-320.   DOI
9 Scherag, A., Dina, C., Hinney, A., Vatin, V., Scherag, S., Vogel, C.I., Muller, T.D., Grallert, H., Wichmann, H.E., Balkau, B., Heude, B., Jarvelin, M.R., Hartikainen, A.L., Levy-Marchal, C., Weill, J., Delplanque, J., Korner, A., Kiess, W., Kovacs, P., Rayner, N.W., Prokopenko, I., McCarthy, M.I., Schafer, H., Jarick, I., Boeing, H., Fisher, E., Reinehr, T., Heinrich, J., Rzehak, P., Berdel, D., Borte, M., Biebermann, H., Krude, H., Rosskopf, D., Rimmbach, C., Rief, W., Fromme, T., Klingenspor, M., Schurmann, A., Schulz, N., Nothen, M.M., Muhleisen, T.W., Erbel, R., Jockel, K.H., Moebus, S., Boes, T., Illig, T., Froguel, P., Hebebrand, J., and Meyre, D. (2010). Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early- onset extreme obesity in French and German study groups. PLoS One 6, e1000916.
10 Scuteri, A., Sanna, S., Chen, W.M., Uda, M., Albai, G., Strait, J., Najjar, S., Nagaraja, R., Orrú, M., Usala, G., Dei, M., Lai, S., Maschio, A., Busonero, F., Mulas, A., Ehret, G.B., Fink, A.A., Weder, A.B., Cooper, R.S., Galan, P., Chakravarti, A., Schlessinger, D., Cao, A., Lakatta, E., and Abecasis, G.R. (2007). Genome-wide association scan shows genetic variants in the FTO Gene are associated with obesity-related traits. PLoS Genet. 3, 1200-1210.
11 Shi, W., Wahba, G., Wright, S., Lee, K., Klein, R., and Klein, B. (2007). Lasso-patternsearch algorithm with application ophthalmology and genomic data. Stat. and its interface 1, 137.
12 Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., Balkau, B., Heude, B., Charpentier, G., Hudson, T.J., Montpetit, A., Pshezhetsky, A.V., Prentki, M., Posner, B.I., Balding, D.J., Meyre, D., Polychronakos, C., and Froguel, P. (2007). A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885.   DOI
13 Thorleifsson, G., Walters, G.B., Gudbjartsson, D.F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., Jonsdottir, T., Olafsdottir, E.J., Olafsdottir, G.H., Jonsson, T., Jonsson, F., Borch-Johnsen, K., Hansen, T., Andersen, G., Jorgensen, T., Lauritzen, T., Aben, K.K., Verbeek, A.L., Roeleveld, N., Kampman, E., Yanek, L.R., Becker, L.C., Tryggvadottir, L., Rafnar, T., Becker, D.M., Gulcher, J., Kiemeney, L.A., Pedersen, O., Kong, A., Thorsteinsdottir, U., and Stefansson, K. (2009) .Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18-24.   DOI
14 Sabatti, C., Service, S.K., Hartikainen, A.L., Pouta, A., Ripatti, S., Brodsky, J., Jones, C.G., Zaitlen, N.A., Varilo, T., Kaakinen, M., Sovio, U., Ruokonen, A., Laitinen, J., Jakkula, E., Coin, L., Hoggart, C., Collins, A., Turunen, H., Gabriel, S., Elliot, P., McCarthy, M.I., Daly, M.J., Järvelin, M.R., Freimer, N.B., and Peltonen, L. (2009). Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat. Genet. 41, 35-46.   DOI
15 Miaczynska, M. and Stenmark, H. (2008). Mechanisms and functions of endocytosis. J. Cell Biol. 180, 7-11.   DOI
16 Must, A., Spadano, J., Coakley, E.H., Field, A.E., Coldotz, G., and Dietz, W.H. (1999). The disease burden associated with overweight and obesity. JAMA 282, 1523-1029.   DOI
17 Rabbee, N. and Speed, T.A. (2006). A genotype calling algorithm for affymetrix SNP arrays. Bioinformatics 22, 7-12.   DOI
18 Saxena, R., Voight, B.F., Lyssenko, V., Burtt, N.P., de Bakker, P.I., Chen, H., Roix, J.J., Kathiresan, S., Hirschhorn, J.N., Daly, M.J., Hughes, T.E., Groop, L., Altshuler, D., Almgren, P., Florez, J.C., Meyer, J., Ardlie, K., Bengtsson Bostrom, K., Isomaa, B., Lettre, G., Lindblad, U., Lyon, H.N., Melander, O., Newton-Cheh, C., Nilsson, P., Orho-Melander, M., Råstam, L., Speliotes, E.K., Taskinen, M.R., Tuomi, T., Guiducci, C., Berglund, A., Carlson, J., Gianniny, L., Hackett, R., Hall, L., Holmkvist, J., Laurila, E., Sjogren, M., Sterner, M., Surti, A., Svensson, M., Svensson, M., Tewhey, R., Blumenstiel, B., Parkin, M., Defelice, M., Barry, R., Brodeur, W., Camarata, J., Chia, N., Fava, M., Gibbons, J., Handsaker, B., Healy, C., Nguyen, K., Gates, C., Sougnez, C., Gage, D., Nizzari, M., Gabriel, S.B., Chirn, G.W., Ma, Q., Parikh, H., Richardson, D., Ricke, D., and Purcell, S. (2007). Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316, 1331-1336.   DOI   ScienceOn
19 Liu, Y.J., Liu, X.G., Wang, L., Dina, C., Yan, H., Liu, J.F., Levy, S., Papasian, C.J., Drees, B.M., Hamilton, J.J., Meyre, D., Delplanque, J., Pei, Y.F., Zhang, L., Recker, R.R., Froguel, P., and Deng, H.W. (2008). Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum. Mol. Genet. 17, 1803-1813.   DOI
20 Li, H., Wetten, S., Li, L., St Jean, P.L., Upmanyu, R., Surh, L., Hosford, D., Barnes, M.R., Briley, J.D., Borrie, M., Coletta, N., Delisle, R., Dhalla, D., Ehm, M.G., Feldman, H.H., Fornazzari, L., Gauthier, S., Goodgame, N., Guzman, D., Hammond, S., Hollingworth, P., Hsiung, G.Y., Johnson, J., Kelly, D.D., Keren, R., Kertesz, A., King, K.S., Lovestone, S., Loy-English, I., Matthews, P.M., Owen, M.J., Plumpton, M., Pryse-Phillips, W., Prinjha, R.K., Richardson, J.C., Saunders, A., Slater, A.J., St George-Hyslop, P.H., Stinnett, S.W., Swartz, J.E., Taylor, R.L., Wherrett, J., Williams, J., Yarnall, D.P., Gibson, R.A., Irizarry, M.C., Middleton, L.T., and Roses, A.D. (2008). Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch. Neurol. 65, 45   DOI
21 Loos, R.J.F., Lindgren, C.M., Li, S., Wheeler, E., Zhao, J.H., Prokopenko, I., Inouye, M., Freathy, R.M., Attwood, A.P., Beckmann, J.S., Berndt, S.I., Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs, K.B., Chanock, S.J., Hayes, R.B., Bergmann, S., Bennett, A.J., Bingham, S.A., Bochud, M., Brown, M., Cauchi, S., Connell, J.M., Cooper, C., Smith, G.D., Day, I., Dina, C., De, S., Dermitzakis, E.T., Doney, A.S., Elliott, K.S., Elliott, P., Evans, D.M., Sadaf Farooqi, I., Froguel, P., Ghori, J., Groves, C.J., Gwilliam, R., Hadley, D., Hall, A.S., Hattersley, A.T., Hebebrand, J., Heid, I.M., KORA, Lamina, C., Gieger, C., Illig, T., Meitinger, T., Wichmann, H.E., Herrera, B., Hinney, A., Hunt, S.E., Jarvelin, M.R., Johnson, T., Jolley, J.D., Karpe, F., Keniry, A., Khaw, K.T., Luben, R.N., Mangino, M., Marchini, J., McArdle, W.L., McGinnis, R., Meyre, D., Munroe, P.B., Morris, A.D., Ness, A.R., Neville, M.J., Nica, A.C., Ong, K.K., O'Rahilly, S., Owen, K.R., Palmer, C.N., Papadakis, K., Potter, S., Pouta, A., Qi, L., Nurses' Health Study, Randall, J.C., Rayner, N.W., Ring, S.M., Sandhu, M.S., Scherag, A., Sims, M.A., Song, K., Soranzo, N., Speliotes, E.K., Diabetes Genetics Initiative, Syddall, H.E., Teichmann, S.A., Timpson, N.J., Tobias, J.H., Uda, M., SardiNIA Study, Vogel, C.I., Wallace, C., Waterworth, D.M., Weedon, M.N., Wellcome Trust Case Control Consortium, Willer, C.J., FUSION, Wraight, Yuan, X., Zeggini, E., Hirschhorn, J.N., Strachan, D.P., Ouwehand, W.H., Caulfield, M.J., Samani, N.J., Frayling, T.M., Vollenweider, P., Waeber, G., Mooser, V., Deloukas, P., McCarthy, M.I., Wareham, N.J., Barroso, I., Jacobs, K.B., Chanock, S.J., Hayes, R.B., Lamina, C., Gieger, C., Illig, T., Meitinger, T., Wichmann, H.E., Kraft, P., Hankinson, S.E., Hunter, D.J., Hu, F.B., Lyon, H.N., Voight, B.F., Ridderstrale, M., Groop, L., Scheet, P., Sanna, S., Abecasis, G.R., Albai, G., Nagaraja, R., Schlessinger, D., Jackson, A.U., Tuomilehto, J., Collins, F.S., Boehnke, M., and Mohlke, K.L. (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768-775.   DOI
22 Lowe, J.K., Maller, J.B., Pe'er, I., Neale, B.M., Salit, J., Kenny, E.E., Shea, J.L., Burkhardt, R., Smith, J.G., Ji, W., Noel, M., Foo, J.N., Blundell, M.L., Skilling, V., Garcia, L., Sullivan, M.L., Lee, H.E., Labek, A., Ferdowsian, H., Auerbach, S.B., Lifton, R.P., Newton-Cheh, C., Breslow, J.L., Stoffel, M., Daly, M.J., Altshuler, D.M., and Friedman, J.M. (2009). Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet. 5, e1000365.   DOI
23 Marsh, M. (2001). Endocytosis. Oxford university press. P.vii.
24 Meyre, D., Delplanque, J., Chevre, J.C., Lecoeur, C., Lobbens, S., Gallina, S., Durand, E., Vatin, V., Degraeve, F., Proenca, C., Gaget, S., Korner, A., Kovacs, P., Kiess, W., Tichet, J., Marre, M., Hartikainen, A.L., Horber, F., Potoczna, N., Hercberg, S., Levy-Marchal, C., Pattou, F., Heude, B., Tauber, M., McCarthy, M.I., Blakemore, A.I., Montpetit, A., Polychronakos, C., Weill, J., Coin, L.J., Asher, J., Elliott, P., Järvelin, M.R., Visvikis-Siest, S., Balkau, B., Sladek, R., Balding, D., Walley, A., Dina, C., and Froguel, P. (2009). Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat. Genet. 41, 157-159.   DOI
25 Hirschhorn, J.N. and Daly, M.J. (2005). Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95-108.
26 Hfker, M. and Wijmenga, C. (2009). A supersized list of obesity genes. Nat. Genet. 41, 139-140.   DOI
27 Hill, J.O. and Peters, J.C. (1998). Environmental contributions to the obesity epidemic. Science 280, 1371-1374.   DOI   ScienceOn
28 Hinney, A., Nguyen, T.T., Scherag, A., Friedel, S., Bronner, G., Muller, T.D., Grallert, H., Illig, T., Wichmann, H.E., Rief, W., Schafer, G., Gebebrand, J. (2007). Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2, e1361.   DOI
29 Hosack, M., Dennis, G., Sherman, B.T., Lane, H.C., and Lempicki, R.A. (20003). Identifying biological themes within lists of genes with EASE. Genome Biol. 4, R70.   DOI
30 Ichihara, S. and Yamada, Y. (2008). Genetic factors for human obesity. Cell. Mol. Life. Sci. 65, 1086-1098.   DOI
31 Klein, R.J., Zeiss, C., Chew, E.Y., Tsai, J.Y., Sackler, R.S., Haynes, C., Henning, A.K., SanGiovanni, J.P., Mane, S.M., Mayne, M.B., Ferris, F.L., Ott, J., Barnstable, C., and Hoh, J. (2005). Complement factor H polymorphism in age-related macular degeneration. Science 308, 335-389.   DOI
32 Kosiol, C., Vinar, T., da Fonseca, R.R., Hubisz, M.J., Bustamante, C.D., Nielsen, R., Siepel, A. (2008). Patterns of positive selection in six mammalian genomes. PLoS Genet 4, e1000144.   DOI
33 Le Cessie, S. and Van Houwelingen, J. (1992). Ridge estimators in logistic regression. App. Statist. 41, 191-201.   DOI   ScienceOn
34 Farooqi, I.S. and O'Rahilly, S. (2007). Genetic factors in human obesity. Obesity Rev. 8 (Suppl. 1) 37-40.
35 Cho, Y.S., Go, M.J., Kim, Y.J., Heo, J.Y., Oh, J.H., Ban, H.J., Yoon, D., Lee, M.H., Kim, D.J., Park, M., Cha, S.H., Kim, J.W., Han, B.K., Min, H., Ahn, Y., Park, M.S., Han, H.R., Jang, H.Y., Cho, E.Y., Lee, J.E., Cho, N.H., Shin, C., Park, T., Park, J.W., Lee, J.K., Cardon, L., Clarke, G., McCarthy, M.I., Lee, J.Y., Lee., J.W., Oh, B., and Kim, H.R. (2009). A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat. Genet. 41, 527-534.   DOI
36 Cotsapas, C., Speliotes, E.K., Hatoum, I.J., Greenawalt, D.M., Dobrin, R., Lum, P.Y., Suver, C., Chudin, E., Kemp, D., Reitman, M., Voight, B.F., Neale, B.M., Schadt, E.E., Hirschhorn, J.N., Kaplan, L.M., Daly, M.J., and the GIANT consortium. (2009). Common body mass index-associated variants confer risk of extreme obesity. Hum. Mol. Genet. 18, 3502-3507.   DOI
37 Das, U.N., and Rao, A.A. (2007). Gene expression profile in obesity and type 2 diabetes mellitus. Lipids in Health and Disease 6, 35.   DOI
38 Feitosa, M.F., Borecki, I.B., Rich, S.S., Arnett, D.K., Sholinsky, P., Myers, R.H., Leppert, M., and Province, M.A. (2002). Quantitative-trait loci influencing body-mass index reside on chromosome 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study. Am. J. Hum. Genet. 70, 72-82.   DOI
39 Heard-Costa, N.L., Zillikens, M.C., Monda, K.L., Johansson, A., Harris, T.B., Fu, M., Haritunians, T., Feitosa, M., Aspelund, T., Eiriksdottir, G., Garcia, M., Launer, L.J., Smith, A.V., Mitchell, B.D., McArdle, P.F., Shuldiner, A.R., Bielinski, S.J., Boerwinkle, E., Brancati, F., Demerath, E.W., Pankow, J.S., Arnold, A.M., Chen, Y.D.I., Glazer, N.L., McKnight, B., Psaty, B.M., Rotter, J.I., Amin, N., Campbell, H., Gyllensten, U., Pattaro, C., Pramstaller, P.P., Rudan, I., Struchalin, M., Vitart, V., Gao, X., Kraja, A., Province, M.A., Zhang, Q., Atwood, L.D., Dupuis, J., Hirschhorn, J.N., Jaquish, C.E., O'Donnell, C.J., Vasan, R.S., White, C.C., Aulchenko, Y.S., Estrada, K., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Witteman, J.C.M., Oostra, B.A., Kaplan, R.C., Gudnason, V., O'Connell, J.R., Borecki, I.B., van Dujin, C.M., Cupples, L.A., Fox, C.S., and North, K.E. (2009). NRXN3 is novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. PLoS One 5, e1000539.
40 Abdi, H. (2007). The Bonferroni and Sidak corrections for multiple comparisons. In Encyclopedia of measurement and statistics . Salkind N, ed. Thousand Oaks, CA: Sage. pp. 1-9.
41 Bell, C.G., Walley, A.J., and Froguel, P. (2005). The Genetics of Human Obesity. Nat. Rev. Genet. 6, 221-234.
42 Benjamini, Y. and Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J.R. Statist. Soc. B. 57, 289-300.
43 Cho, S., Kim, K., Kim, Y.J., Lee, J.K., Cho, Y.S., Lee, J.Y., Han, B.G., Kim, H., Ott, J., and Park, T. (2010). Joint identification of multiple genetic variants via EN variable selection in a genome-wide association analysis. Ann. Hum. Genet. 74, 416-428.   DOI